Incidental Mutation 'R8172:Ptgr2'
ID 634203
Institutional Source Beutler Lab
Gene Symbol Ptgr2
Ensembl Gene ENSMUSG00000072946
Gene Name prostaglandin reductase 2
Synonyms Zadh1, 9630002F03Rik, B830026H24Rik, 1810016I24Rik, PGR-2
MMRRC Submission 067598-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R8172 (G1)
Quality Score 223.009
Status Validated
Chromosome 12
Chromosomal Location 84332011-84362606 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 84360783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 351 (L351Q)
Ref Sequence ENSEMBL: ENSMUSP00000115704 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045931] [ENSMUST00000123614] [ENSMUST00000123693] [ENSMUST00000135001] [ENSMUST00000146377] [ENSMUST00000147363]
AlphaFold Q8VDQ1
PDB Structure Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution [X-RAY DIFFRACTION]
Crystal structure of mouse 15-ketoprostaglandin delta-13-reductase in complex with NADPH [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000045931
SMART Domains Protein: ENSMUSP00000045550
Gene: ENSMUSG00000042472

DomainStartEndE-ValueType
ZnF_C2H2 219 243 1.04e-3 SMART
ZnF_C2H2 249 273 6.88e-4 SMART
ZnF_C2H2 279 303 1.13e-4 SMART
ZnF_C2H2 309 333 1.45e-2 SMART
ZnF_C2H2 339 361 5.59e-4 SMART
low complexity region 400 417 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000123614
AA Change: L351Q

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000115704
Gene: ENSMUSG00000072946
AA Change: L351Q

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 165 5.4e-40 PFAM
Pfam:ADH_zinc_N 166 287 1.3e-15 PFAM
Pfam:ADH_zinc_N_2 200 343 4.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123693
SMART Domains Protein: ENSMUSP00000115506
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 56 1.3e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135001
SMART Domains Protein: ENSMUSP00000114559
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 7.4e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000146377
AA Change: L351Q

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000119981
Gene: ENSMUSG00000072946
AA Change: L351Q

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.4e-16 PFAM
Pfam:ADH_zinc_N_2 200 343 6.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147363
SMART Domains Protein: ENSMUSP00000114766
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.2e-18 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy5 T A 16: 34,977,427 (GRCm39) L320Q probably damaging Het
Adgre4 A T 17: 56,104,769 (GRCm39) L278F probably benign Het
Agfg2 C A 5: 137,665,431 (GRCm39) R108L probably damaging Het
Arap2 A T 5: 62,779,324 (GRCm39) probably null Het
Ascl2 G T 7: 142,522,336 (GRCm39) N37K possibly damaging Het
Baiap3 C A 17: 25,463,096 (GRCm39) D1043Y probably damaging Het
Cby2 T A 14: 75,829,241 (GRCm39) probably null Het
Ccdc18 T C 5: 108,311,640 (GRCm39) probably null Het
Cemip T A 7: 83,646,433 (GRCm39) D205V probably damaging Het
Cenpn G A 8: 117,658,333 (GRCm39) G93D probably benign Het
Clpsl2 T A 17: 28,768,556 (GRCm39) S23R possibly damaging Het
Cnot3 T A 7: 3,661,724 (GRCm39) I672N possibly damaging Het
Crygs A G 16: 22,625,292 (GRCm39) Y50H probably damaging Het
Cyp4x1 T C 4: 114,968,874 (GRCm39) T403A possibly damaging Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Fam184b C T 5: 45,741,709 (GRCm39) G174D possibly damaging Het
Fat2 T A 11: 55,178,638 (GRCm39) D1474V probably damaging Het
Flg2 T A 3: 93,108,468 (GRCm39) D165E possibly damaging Het
Fpr-rs7 A T 17: 20,334,443 (GRCm39) F16I probably benign Het
Gpr176 G A 2: 118,114,615 (GRCm39) T65I probably damaging Het
H2-Q10 C T 17: 35,781,996 (GRCm39) T206I probably null Het
Hadha C G 5: 30,350,285 (GRCm39) A88P probably damaging Het
Hlcs A T 16: 94,068,485 (GRCm39) L245Q probably damaging Het
Hnrnph1 T C 11: 50,270,732 (GRCm39) V113A probably damaging Het
Hsd3b7 G A 7: 127,401,546 (GRCm39) V224M probably damaging Het
Igha T C 12: 113,223,592 (GRCm39) D88G Het
Iqca1l T C 5: 24,748,608 (GRCm39) M803V probably benign Het
Kdm7a T C 6: 39,125,965 (GRCm39) K610R probably benign Het
Krt87 C T 15: 101,383,284 (GRCm39) C474Y probably benign Het
Lrrc74a T A 12: 86,788,530 (GRCm39) L170H probably damaging Het
Lyg2 T C 1: 37,946,748 (GRCm39) T178A probably benign Het
Map2k2 T A 10: 80,959,442 (GRCm39) probably null Het
Mast4 C T 13: 103,089,633 (GRCm39) probably null Het
Mtmr14 T A 6: 113,216,529 (GRCm39) D8E probably benign Het
Neu2 C T 1: 87,524,633 (GRCm39) P206L probably damaging Het
Oga C T 19: 45,765,339 (GRCm39) R156H probably damaging Het
Or10al6 A G 17: 38,083,326 (GRCm39) T261A probably benign Het
Or4c105 A T 2: 88,647,986 (GRCm39) Q157L probably damaging Het
Poc1b C A 10: 98,980,338 (GRCm39) probably null Het
Proser1 T A 3: 53,386,272 (GRCm39) V718E possibly damaging Het
Ptprf A G 4: 118,068,275 (GRCm39) Y1754H probably benign Het
Scgb2b3 T C 7: 31,058,476 (GRCm39) K109R possibly damaging Het
Scn2a A T 2: 65,520,672 (GRCm39) H556L probably benign Het
Scn7a A T 2: 66,506,191 (GRCm39) M1566K possibly damaging Het
Slco5a1 A T 1: 13,060,490 (GRCm39) L77* probably null Het
Stk31 T C 6: 49,394,261 (GRCm39) F208L possibly damaging Het
Tbcd C T 11: 121,384,711 (GRCm39) T315M probably benign Het
Tbx4 A G 11: 85,801,933 (GRCm39) I189V probably benign Het
Tia1 T A 6: 86,404,682 (GRCm39) Y306N probably benign Het
Ttc21b T A 2: 66,082,500 (GRCm39) Y33F probably benign Het
Usp47 T A 7: 111,687,133 (GRCm39) L677* probably null Het
Other mutations in Ptgr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02382:Ptgr2 APN 12 84,360,722 (GRCm39) missense probably damaging 0.99
IGL03176:Ptgr2 APN 12 84,354,668 (GRCm39) missense probably damaging 1.00
R1914:Ptgr2 UTSW 12 84,349,096 (GRCm39) missense probably benign 0.11
R1915:Ptgr2 UTSW 12 84,349,096 (GRCm39) missense probably benign 0.11
R4624:Ptgr2 UTSW 12 84,355,128 (GRCm39) missense possibly damaging 0.70
R5827:Ptgr2 UTSW 12 84,342,110 (GRCm39) critical splice donor site probably null
R5978:Ptgr2 UTSW 12 84,342,032 (GRCm39) nonsense probably null
R5986:Ptgr2 UTSW 12 84,355,120 (GRCm39) missense possibly damaging 0.85
R6019:Ptgr2 UTSW 12 84,344,920 (GRCm39) missense probably damaging 1.00
R6320:Ptgr2 UTSW 12 84,349,111 (GRCm39) missense probably benign 0.05
R6526:Ptgr2 UTSW 12 84,360,726 (GRCm39) missense probably damaging 1.00
R7369:Ptgr2 UTSW 12 84,339,080 (GRCm39) start gained probably benign
R7401:Ptgr2 UTSW 12 84,339,103 (GRCm39) start gained probably benign
R7463:Ptgr2 UTSW 12 84,339,072 (GRCm39) start gained probably benign
R7583:Ptgr2 UTSW 12 84,355,179 (GRCm39) missense probably damaging 1.00
R7793:Ptgr2 UTSW 12 84,354,575 (GRCm39) missense probably damaging 1.00
R9005:Ptgr2 UTSW 12 84,344,873 (GRCm39) missense possibly damaging 0.86
R9495:Ptgr2 UTSW 12 84,354,647 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCAGTGTGCTCTCTCCTGC -3'
(R):5'- GGCAGGCAATCACATGTTAAATG -3'

Sequencing Primer
(F):5'- ATGTCCTCTGCAAGAGTGAC -3'
(R):5'- GAATCAAGAACTATCTGTACAGA -3'
Posted On 2020-07-13