Incidental Mutation 'R7463:Ptgr2'
ID578580
Institutional Source Beutler Lab
Gene Symbol Ptgr2
Ensembl Gene ENSMUSG00000072946
Gene Nameprostaglandin reductase 2
SynonymsPGR-2, Zadh1, B830026H24Rik, 9630002F03Rik, 1810016I24Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.193) question?
Stock #R7463 (G1)
Quality Score176.009
Status Validated
Chromosome12
Chromosomal Location84285232-84315832 bp(+) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) A to T at 84292298 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000123614] [ENSMUST00000123693] [ENSMUST00000135001] [ENSMUST00000146377] [ENSMUST00000147363]
Predicted Effect probably benign
Transcript: ENSMUST00000123614
SMART Domains Protein: ENSMUSP00000115704
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 165 5.4e-40 PFAM
Pfam:ADH_zinc_N 166 287 1.3e-15 PFAM
Pfam:ADH_zinc_N_2 200 343 4.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123693
SMART Domains Protein: ENSMUSP00000115506
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 56 1.3e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135001
SMART Domains Protein: ENSMUSP00000114559
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 7.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146377
SMART Domains Protein: ENSMUSP00000119981
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.4e-16 PFAM
Pfam:ADH_zinc_N_2 200 343 6.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147363
SMART Domains Protein: ENSMUSP00000114766
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.2e-18 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.7%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,323,772 V435E probably damaging Het
Acta2 G A 19: 34,252,531 T8I probably benign Het
Adcy2 T C 13: 68,730,280 D413G probably damaging Het
Adgrg6 T A 10: 14,434,396 D727V possibly damaging Het
Aebp2 C T 6: 140,637,726 Q309* probably null Het
Amy1 A T 3: 113,569,884 C43* probably null Het
Bpifc T C 10: 85,979,334 E256G probably benign Het
Bysl A T 17: 47,602,471 S296T probably benign Het
Carmil3 C T 14: 55,502,396 P980L probably damaging Het
Coch T A 12: 51,593,625 M1K probably null Het
Cpt2 A T 4: 107,908,157 F137I probably damaging Het
Crem T C 18: 3,295,094 I112V probably benign Het
Cul9 A G 17: 46,520,476 probably null Het
Cyp3a41a T A 5: 145,713,564 I90F probably damaging Het
Cyp4f16 C T 17: 32,550,787 A457V possibly damaging Het
Ddx6 A G 9: 44,628,729 E318G probably damaging Het
Dip2b A G 15: 100,154,157 E213G probably benign Het
Dlx5 T C 6: 6,878,316 H238R probably damaging Het
Dnaic2 A C 11: 114,754,406 I556L probably benign Het
Dnmt1 C T 9: 20,912,225 V1147M possibly damaging Het
Egf G T 3: 129,740,015 Q59K probably benign Het
Ermp1 A T 19: 29,646,262 Y109* probably null Het
Fer1l6 T A 15: 58,573,601 Y573* probably null Het
Fmnl1 T C 11: 103,193,128 L503P probably damaging Het
Gnptab T G 10: 88,431,389 I447M probably damaging Het
Hgf G A 5: 16,578,450 D253N probably benign Het
Hjurp CTCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCT C 1: 88,266,277 probably benign Het
Igf2r T C 17: 12,710,645 T958A probably benign Het
Kcnd2 T A 6: 21,216,498 L67Q probably damaging Het
Kif5a A G 10: 127,243,724 V248A probably damaging Het
Krt33b A G 11: 100,029,563 I88T probably damaging Het
Lhx2 G A 2: 38,351,846 E25K possibly damaging Het
Mex3d C T 10: 80,381,698 G562R Het
Myom2 A T 8: 15,117,679 Y1088F probably null Het
Ncapg T A 5: 45,694,092 probably null Het
Nudc A C 4: 133,534,403 V190G possibly damaging Het
Obscn G T 11: 59,122,860 R1054S probably benign Het
Olfr1045 T C 2: 86,197,838 M305V probably benign Het
Olfr1510 A G 14: 52,410,711 W54R probably benign Het
Olfr651 T C 7: 104,553,482 S188P possibly damaging Het
Olfr683 T A 7: 105,143,937 M119L probably benign Het
Olfr710 A T 7: 106,944,173 V276E probably damaging Het
Olfr979 A G 9: 40,000,564 V221A probably benign Het
Pcdh10 A T 3: 45,383,572 R891S possibly damaging Het
Pcdh15 C T 10: 74,631,770 S1873L possibly damaging Het
Pcdh7 A G 5: 57,720,998 K632E probably benign Het
Pcdhgb8 G A 18: 37,763,427 A517T probably damaging Het
Ptpn18 G A 1: 34,473,364 D417N possibly damaging Het
Racgap1 T A 15: 99,642,958 T4S probably benign Het
Rb1cc1 A G 1: 6,249,180 H941R probably benign Het
Reln T C 5: 22,103,435 H312R probably damaging Het
Rnf166 T A 8: 122,467,987 H208L probably damaging Het
Theg T C 10: 79,576,715 E314G probably damaging Het
Timeless T C 10: 128,250,426 S999P probably benign Het
Tmem94 G T 11: 115,786,256 R118L possibly damaging Het
Tor1aip1 A T 1: 156,007,609 H349Q possibly damaging Het
Ttn T A 2: 76,920,460 E3415V probably benign Het
Vmn2r102 A T 17: 19,676,624 N78Y probably damaging Het
Wdr11 A T 7: 129,607,086 D427V probably damaging Het
Zer1 A T 2: 30,113,437 probably benign Het
Zfp516 T A 18: 82,957,108 M477K probably benign Het
Other mutations in Ptgr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02382:Ptgr2 APN 12 84313948 missense probably damaging 0.99
IGL03176:Ptgr2 APN 12 84307894 missense probably damaging 1.00
R1914:Ptgr2 UTSW 12 84302322 missense probably benign 0.11
R1915:Ptgr2 UTSW 12 84302322 missense probably benign 0.11
R4624:Ptgr2 UTSW 12 84308354 missense possibly damaging 0.70
R5827:Ptgr2 UTSW 12 84295336 critical splice donor site probably null
R5978:Ptgr2 UTSW 12 84295258 nonsense probably null
R5986:Ptgr2 UTSW 12 84308346 missense possibly damaging 0.85
R6019:Ptgr2 UTSW 12 84298146 missense probably damaging 1.00
R6320:Ptgr2 UTSW 12 84302337 missense probably benign 0.05
R6526:Ptgr2 UTSW 12 84313952 missense probably damaging 1.00
R7369:Ptgr2 UTSW 12 84292306 start gained probably benign
R7401:Ptgr2 UTSW 12 84292329 start gained probably benign
R7583:Ptgr2 UTSW 12 84308405 missense probably damaging 1.00
R7793:Ptgr2 UTSW 12 84307801 missense probably damaging 1.00
R8172:Ptgr2 UTSW 12 84314009 missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- CAGTGGACTTGTTCCTATTAGCTAAG -3'
(R):5'- TGCTACCCTGACATCATGTTGG -3'

Sequencing Primer
(F):5'- TGTGTACCACATGCATGCG -3'
(R):5'- ACCCTGACATCATGTTGGTTTTG -3'
Posted On2019-10-07