Mutagenetix > Incidental Mutation

Incidental Mutation 'R8330:Vmn2r80'

644310

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r80

Ensembl Gene

ENSMUSG00000091888

Gene Name

vomeronasal 2, receptor 80

Synonyms

EG624765

MMRRC Submission

067799-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R8330 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

78984650-79030767 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 79007550 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 509 (W509R)

Ref Sequence

ENSEMBL: ENSMUSP00000132299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165834]

AlphaFold

E9Q1L0

Predicted Effect

probably damaging
Transcript: ENSMUST00000165834
AA Change: W509R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: W509R

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	1.5e-36	PFAM
Pfam:NCD3G	517	570	7.9e-22	PFAM
Pfam:7tm_3	603	838	6.2e-49	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,381,750 (GRCm39)	D1405V	probably damaging	Het
Acsl6	A	G	11: 54,236,034 (GRCm39)	I514V	probably benign	Het
Adgrv1	C	T	13: 81,593,462 (GRCm39)	R4175H	probably damaging	Het
Ahnak	T	C	19: 8,987,026 (GRCm39)	V2770A	possibly damaging	Het
B4galt1	A	G	4: 40,812,787 (GRCm39)	V246A	probably damaging	Het
Cdr2l	T	C	11: 115,284,939 (GRCm39)	V425A	probably benign	Het
Celsr1	T	A	15: 85,816,501 (GRCm39)	D1814V	probably damaging	Het
Exoc2	A	G	13: 31,061,556 (GRCm39)	V495A	probably benign	Het
Ifi47	A	G	11: 48,986,637 (GRCm39)	T135A	possibly damaging	Het
Klhl23	T	C	2: 69,654,496 (GRCm39)	V122A	probably damaging	Het
Klri2	T	A	6: 129,710,694 (GRCm39)	N142Y	probably damaging	Het
Kmt2c	A	T	5: 25,509,692 (GRCm39)	F3161L	probably null	Het
Mgl2	A	G	11: 70,026,785 (GRCm39)	T144A	probably benign	Het
Mpp3	T	C	11: 101,899,453 (GRCm39)	E356G	probably benign	Het
Neb	T	G	2: 52,117,420 (GRCm39)	T872P		Het
Nek9	A	G	12: 85,376,727 (GRCm39)	M218T	probably damaging	Het
Or10a49	A	T	7: 108,468,046 (GRCm39)	L105H	probably damaging	Het
Or4f14	A	G	2: 111,742,724 (GRCm39)	F184L	probably benign	Het
Or51k2	T	G	7: 103,596,610 (GRCm39)	I279S	possibly damaging	Het
Pabpc1l	G	A	2: 163,869,568 (GRCm39)	G123R	probably damaging	Het
Parp3	T	C	9: 106,352,069 (GRCm39)		probably null	Het
Pcdhga1	A	T	18: 37,796,376 (GRCm39)	Y460F	probably benign	Het
Pclo	A	G	5: 14,725,311 (GRCm39)	T1390A	unknown	Het
Peg10	GC	GCTCC	6: 4,756,452 (GRCm39)		probably benign	Het
Pex6	T	C	17: 47,023,060 (GRCm39)	L212P	possibly damaging	Het
Pigt	CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT	CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT	2: 164,341,589 (GRCm39)		probably null	Het
Ppib	T	C	9: 65,968,755 (GRCm39)	F48L	probably damaging	Het
Psme4	A	G	11: 30,793,583 (GRCm39)	E1228G	probably benign	Het
Ptpdc1	G	T	13: 48,751,390 (GRCm39)	H37N	probably benign	Het
Rab31	A	T	17: 66,003,269 (GRCm39)	I126N	possibly damaging	Het
Rsad2	A	T	12: 26,506,405 (GRCm39)	V5E	probably benign	Het
S1pr3	G	A	13: 51,573,173 (GRCm39)	S118N	probably damaging	Het
Sbsn	T	A	7: 30,451,366 (GRCm39)	I127N	possibly damaging	Het
Scart2	C	T	7: 139,876,231 (GRCm39)	Q568*	probably null	Het
Selenoh	G	T	2: 84,500,691 (GRCm39)	Q50K	probably damaging	Het
Simc1	GCAGTCACTAAGAAGTGTAATGCAGTCATCAGGAGGTGTGACACAGTCACTAAGAAGTGTGATGCAGTCACCAGGAGGTGTGA	GCAGTCACTAAGAAGTGTGATGCAGTCACCAGGAGGTGTGA	13: 54,673,177 (GRCm39)		probably benign	Het
Stkld1	A	T	2: 26,841,515 (GRCm39)	I487L	probably benign	Het
Tep1	T	A	14: 51,085,162 (GRCm39)	I874F	possibly damaging	Het
Tmem43	T	C	6: 91,455,746 (GRCm39)	V119A	possibly damaging	Het
Xpr1	A	C	1: 155,189,001 (GRCm39)	Y290*	probably null	Het
Zfp160	T	C	17: 21,246,313 (GRCm39)	C288R	probably damaging	Het
Zfp955a	C	T	17: 33,463,087 (GRCm39)	V15M	probably damaging	Het

Other mutations in Vmn2r80

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01084:Vmn2r80	APN	10	79,030,433 (GRCm39)	missense	probably damaging	1.00
IGL01325:Vmn2r80	APN	10	79,030,081 (GRCm39)	missense	possibly damaging	0.62
IGL01611:Vmn2r80	APN	10	79,007,488 (GRCm39)	missense	probably damaging	1.00
IGL01799:Vmn2r80	APN	10	79,007,385 (GRCm39)	missense	possibly damaging	0.95
IGL01877:Vmn2r80	APN	10	79,007,334 (GRCm39)	splice site	probably null
IGL02673:Vmn2r80	APN	10	79,005,318 (GRCm39)	missense	probably benign	0.02
IGL02756:Vmn2r80	APN	10	79,030,145 (GRCm39)	missense	probably damaging	1.00
IGL02820:Vmn2r80	APN	10	79,007,439 (GRCm39)	missense	probably benign	0.04
IGL03382:Vmn2r80	APN	10	79,005,362 (GRCm39)	missense	probably damaging	1.00
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0129:Vmn2r80	UTSW	10	79,005,330 (GRCm39)	missense	probably damaging	1.00
R0325:Vmn2r80	UTSW	10	78,984,773 (GRCm39)	missense	possibly damaging	0.89
R0567:Vmn2r80	UTSW	10	79,030,665 (GRCm39)	missense	possibly damaging	0.89
R1510:Vmn2r80	UTSW	10	79,005,553 (GRCm39)	missense	possibly damaging	0.69
R1519:Vmn2r80	UTSW	10	79,030,053 (GRCm39)	missense	probably damaging	1.00
R1520:Vmn2r80	UTSW	10	79,030,594 (GRCm39)	missense	probably damaging	1.00
R1627:Vmn2r80	UTSW	10	79,030,249 (GRCm39)	missense	probably damaging	1.00
R1709:Vmn2r80	UTSW	10	79,030,223 (GRCm39)	missense	probably benign	0.04
R2116:Vmn2r80	UTSW	10	79,030,558 (GRCm39)	missense	probably benign	0.09
R2237:Vmn2r80	UTSW	10	79,004,104 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r80	UTSW	10	79,007,455 (GRCm39)	missense	probably damaging	1.00
R2893:Vmn2r80	UTSW	10	78,984,699 (GRCm39)	missense	possibly damaging	0.63
R3408:Vmn2r80	UTSW	10	79,004,227 (GRCm39)	missense	possibly damaging	0.95
R4502:Vmn2r80	UTSW	10	78,984,764 (GRCm39)	missense	probably benign	0.00
R4685:Vmn2r80	UTSW	10	79,030,162 (GRCm39)	missense	possibly damaging	0.95
R4851:Vmn2r80	UTSW	10	79,030,156 (GRCm39)	missense	possibly damaging	0.68
R4947:Vmn2r80	UTSW	10	79,030,532 (GRCm39)	missense	probably damaging	1.00
R5112:Vmn2r80	UTSW	10	79,030,292 (GRCm39)	missense	possibly damaging	0.61
R5217:Vmn2r80	UTSW	10	79,004,980 (GRCm39)	missense	possibly damaging	0.62
R5226:Vmn2r80	UTSW	10	79,029,874 (GRCm39)	missense	probably benign	0.36
R5512:Vmn2r80	UTSW	10	79,004,066 (GRCm39)	missense	probably benign	0.00
R5618:Vmn2r80	UTSW	10	78,984,755 (GRCm39)	missense	probably benign
R5959:Vmn2r80	UTSW	10	79,005,313 (GRCm39)	missense	probably benign	0.00
R6104:Vmn2r80	UTSW	10	78,984,854 (GRCm39)	missense	probably benign	0.00
R6110:Vmn2r80	UTSW	10	79,017,837 (GRCm39)	missense	probably damaging	1.00
R6270:Vmn2r80	UTSW	10	79,030,159 (GRCm39)	missense	probably benign	0.00
R6508:Vmn2r80	UTSW	10	79,030,290 (GRCm39)	missense	probably benign	0.03
R6843:Vmn2r80	UTSW	10	79,005,502 (GRCm39)	missense	probably benign	0.08
R6894:Vmn2r80	UTSW	10	79,005,438 (GRCm39)	missense	probably benign	0.06
R7048:Vmn2r80	UTSW	10	79,030,153 (GRCm39)	missense	probably damaging	1.00
R7149:Vmn2r80	UTSW	10	79,030,654 (GRCm39)	missense	probably benign	0.00
R7262:Vmn2r80	UTSW	10	79,005,579 (GRCm39)	missense	probably damaging	0.98
R7559:Vmn2r80	UTSW	10	79,030,459 (GRCm39)	missense	probably benign	0.00
R7622:Vmn2r80	UTSW	10	79,030,097 (GRCm39)	missense	probably damaging	1.00
R8003:Vmn2r80	UTSW	10	78,984,711 (GRCm39)	missense	probably benign	0.16
R8207:Vmn2r80	UTSW	10	79,030,150 (GRCm39)	nonsense	probably null
R8337:Vmn2r80	UTSW	10	78,984,707 (GRCm39)	missense	probably benign	0.00
R8354:Vmn2r80	UTSW	10	78,984,710 (GRCm39)	missense	probably benign
R8688:Vmn2r80	UTSW	10	79,004,069 (GRCm39)	missense	probably damaging	1.00
R8903:Vmn2r80	UTSW	10	79,017,928 (GRCm39)	missense	probably damaging	1.00
R9088:Vmn2r80	UTSW	10	79,005,378 (GRCm39)	missense	probably benign	0.05
R9125:Vmn2r80	UTSW	10	78,984,760 (GRCm39)	missense	probably benign	0.12
R9147:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9148:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9187:Vmn2r80	UTSW	10	79,030,438 (GRCm39)	missense	probably benign	0.20
R9218:Vmn2r80	UTSW	10	79,030,270 (GRCm39)	missense	possibly damaging	0.61
R9553:Vmn2r80	UTSW	10	78,984,743 (GRCm39)	missense	probably benign
R9612:Vmn2r80	UTSW	10	79,030,712 (GRCm39)	missense	probably damaging	1.00
R9677:Vmn2r80	UTSW	10	78,984,672 (GRCm39)	missense	probably benign	0.15
R9769:Vmn2r80	UTSW	10	79,005,443 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,441 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,232 (GRCm39)	missense	possibly damaging	0.65
Z1176:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run
Z1176:Vmn2r80	UTSW	10	79,030,605 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run

Predicted Primers

PCR Primer
(F):5'- AAATTCTGTTGGTGACCACGTGG -3'
(R):5'- ACTAAGATTCTTCTCAGGGAATTGC -3'

Sequencing Primer
(F):5'- CACGTGGTTCTGGACTGGAAAAG -3'
(R):5'- TCTCAGGGAATTGCAATTTATGTTC -3'

Posted On

2020-09-02