Incidental Mutation 'R8518:Or6y1'
ID 656234
Institutional Source Beutler Lab
Gene Symbol Or6y1
Ensembl Gene ENSMUSG00000066671
Gene Name olfactory receptor family 6 subfamily Y member 1
Synonyms EG546747, Olfr413-ps1, GA_x6K02T2P20D-20731742-20730694, Olfr220, MOR103-13P, MOR103-17, GA_x6K02SYWY4V-595-239
MMRRC Submission 067850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R8518 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 174276191-174277168 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 174276742 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 184 (C184*)
Ref Sequence ENSEMBL: ENSMUSP00000141919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085861] [ENSMUST00000194229]
AlphaFold E9Q050
Predicted Effect probably null
Transcript: ENSMUST00000085861
AA Change: C184*
SMART Domains Protein: ENSMUSP00000083023
Gene: ENSMUSG00000066671
AA Change: C184*

DomainStartEndE-ValueType
Pfam:7tm_4 36 314 1.2e-51 PFAM
Pfam:7tm_1 46 295 3.6e-25 PFAM
low complexity region 315 325 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000194229
AA Change: C184*
SMART Domains Protein: ENSMUSP00000141919
Gene: ENSMUSG00000066671
AA Change: C184*

DomainStartEndE-ValueType
Pfam:7tm_1 46 295 6e-33 PFAM
Pfam:7tm_4 144 288 1.4e-44 PFAM
low complexity region 315 325 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A G 16: 20,223,398 (GRCm39) V170A possibly damaging Het
Adamts2 A G 11: 50,666,957 (GRCm39) E418G probably damaging Het
Adra2b T C 2: 127,206,056 (GRCm39) L191P probably damaging Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Bag2 T C 1: 33,787,358 (GRCm39) I55V probably benign Het
Bltp2 T C 11: 78,156,064 (GRCm39) L192P possibly damaging Het
Bmpr1b T C 3: 141,563,343 (GRCm39) I200M possibly damaging Het
Cacna1i C A 15: 80,243,095 (GRCm39) Y417* probably null Het
Cdc7 T A 5: 107,120,864 (GRCm39) I162N probably damaging Het
Chchd1 T C 14: 20,754,211 (GRCm39) I89T probably benign Het
Cxcl16 T C 11: 70,346,510 (GRCm39) N224S probably benign Het
Dync1i1 T G 6: 5,913,330 (GRCm39) L188V probably damaging Het
Dync2h1 A G 9: 7,051,452 (GRCm39) V3161A probably benign Het
E2f3 T A 13: 30,097,453 (GRCm39) K303N probably damaging Het
Fermt1 T C 2: 132,748,635 (GRCm39) T663A probably benign Het
Fhod3 A G 18: 25,189,390 (GRCm39) R611G probably damaging Het
Frem3 A T 8: 81,339,224 (GRCm39) S506C probably damaging Het
Gm10318 T A 10: 77,688,712 (GRCm39) M6K unknown Het
Gm6563 T A 19: 23,653,480 (GRCm39) V90E probably damaging Het
Gpc6 T C 14: 117,163,384 (GRCm39) S13P probably benign Het
Gpr107 C A 2: 31,066,939 (GRCm39) H196Q probably benign Het
Heatr1 T G 13: 12,425,415 (GRCm39) D618E probably benign Het
Lrrc27 T C 7: 138,808,690 (GRCm39) V391A probably benign Het
Mindy3 T G 2: 12,360,154 (GRCm39) K349N probably damaging Het
Mllt10 T C 2: 18,151,670 (GRCm39) V261A probably damaging Het
Mrpl48 G A 7: 100,232,269 (GRCm39) probably benign Het
Msantd5f5 T A 4: 73,542,641 (GRCm39) L47Q probably damaging Het
Muc16 T C 9: 18,430,927 (GRCm39) I8062V probably benign Het
Myo7a T C 7: 97,740,270 (GRCm39) N575D possibly damaging Het
Nfrkb T C 9: 31,311,261 (GRCm39) L370P probably damaging Het
Numbl T C 7: 26,964,361 (GRCm39) V57A probably benign Het
Or51t4 T C 7: 102,597,804 (GRCm39) V44A probably damaging Het
Or5b12 G A 19: 12,896,959 (GRCm39) T238I probably damaging Het
Pdia2 A T 17: 26,417,144 (GRCm39) L100* probably null Het
Prpf31 A T 7: 3,635,742 (GRCm39) N105I probably damaging Het
Rbm20 A G 19: 53,839,923 (GRCm39) N971D probably benign Het
Rnf213 T A 11: 119,353,043 (GRCm39) M3980K Het
Skint6 A G 4: 113,095,465 (GRCm39) F65L possibly damaging Het
Smpd4 T A 16: 17,458,884 (GRCm39) C536S possibly damaging Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tfpt A G 7: 3,632,065 (GRCm39) F15S possibly damaging Het
Tnp2 A G 16: 10,606,372 (GRCm39) C32R possibly damaging Het
Tns3 A T 11: 8,442,971 (GRCm39) V464E probably damaging Het
Tpp2 T A 1: 44,019,545 (GRCm39) L824H probably damaging Het
Trav15-1-dv6-1 A G 14: 53,797,666 (GRCm39) D105G probably benign Het
Ttc3 T C 16: 94,258,238 (GRCm39) S1679P probably benign Het
Xpo7 A G 14: 70,944,837 (GRCm39) Y19H probably damaging Het
Zswim4 G A 8: 84,938,586 (GRCm39) R1099W probably damaging Het
Other mutations in Or6y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00096:Or6y1 APN 1 174,276,233 (GRCm39) missense probably benign 0.00
IGL03369:Or6y1 APN 1 174,276,435 (GRCm39) missense probably damaging 1.00
R1792:Or6y1 UTSW 1 174,276,303 (GRCm39) missense probably benign
R4090:Or6y1 UTSW 1 174,276,500 (GRCm39) missense probably benign 0.01
R4169:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R4769:Or6y1 UTSW 1 174,276,524 (GRCm39) missense possibly damaging 0.80
R6652:Or6y1 UTSW 1 174,276,627 (GRCm39) missense probably damaging 1.00
R6930:Or6y1 UTSW 1 174,276,677 (GRCm39) missense probably damaging 1.00
R7237:Or6y1 UTSW 1 174,276,905 (GRCm39) missense probably benign 0.05
R8039:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R8187:Or6y1 UTSW 1 174,276,838 (GRCm39) frame shift probably null
R9177:Or6y1 UTSW 1 174,276,923 (GRCm39) missense probably damaging 1.00
R9453:Or6y1 UTSW 1 174,276,233 (GRCm39) missense probably benign 0.00
R9757:Or6y1 UTSW 1 174,276,866 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGTCATGGCCTTTGATCG -3'
(R):5'- TTACAACTGTCAGATGAGAGGCAC -3'

Sequencing Primer
(F):5'- GATCGCTATGTAGCCATTTGCAATC -3'
(R):5'- TGGAGAAGGCCTTTTGACGACC -3'
Posted On 2020-10-20