Incidental Mutation 'R8555:Vmn2r110'
ID |
660076 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r110
|
Ensembl Gene |
ENSMUSG00000091259 |
Gene Name |
vomeronasal 2, receptor 110 |
Synonyms |
EG224582 |
MMRRC Submission |
068518-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.211)
|
Stock # |
R8555 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20794091-20816521 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 20804618 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Proline to Serine
at position 101
(P101S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129347
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169559]
|
AlphaFold |
E9PWD5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000169559
AA Change: P101S
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000129347 Gene: ENSMUSG00000091259 AA Change: P101S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
467 |
3.1e-33 |
PFAM |
Pfam:NCD3G
|
510 |
563 |
5.2e-22 |
PFAM |
Pfam:7tm_3
|
594 |
831 |
4.2e-51 |
PFAM |
|
Meta Mutation Damage Score |
0.6329 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
Validation Efficiency |
100% (35/35) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933405O20Rik |
C |
T |
7: 50,250,010 (GRCm39) |
A348V |
possibly damaging |
Het |
Alk |
A |
T |
17: 72,228,869 (GRCm39) |
V732E |
probably damaging |
Het |
Ccdc88a |
T |
C |
11: 29,380,169 (GRCm39) |
S182P |
probably benign |
Het |
Cyp2c70 |
T |
C |
19: 40,172,345 (GRCm39) |
D99G |
probably benign |
Het |
Dnah8 |
G |
T |
17: 30,940,084 (GRCm39) |
E1677* |
probably null |
Het |
Dop1b |
A |
G |
16: 93,568,698 (GRCm39) |
T797A |
probably damaging |
Het |
Fam181b |
A |
T |
7: 92,729,296 (GRCm39) |
D23V |
probably damaging |
Het |
Fbxo4 |
A |
T |
15: 3,995,273 (GRCm39) |
V357D |
probably damaging |
Het |
Gm4924 |
T |
C |
10: 82,213,224 (GRCm39) |
|
probably benign |
Het |
Grhl2 |
A |
G |
15: 37,233,507 (GRCm39) |
|
probably benign |
Het |
Magee2 |
A |
T |
X: 103,900,087 (GRCm39) |
L188H |
probably damaging |
Het |
Matn2 |
A |
G |
15: 34,423,951 (GRCm39) |
K603R |
probably benign |
Het |
Mfsd6l |
G |
A |
11: 68,447,898 (GRCm39) |
V250I |
probably benign |
Het |
Mroh9 |
T |
C |
1: 162,899,595 (GRCm39) |
|
probably null |
Het |
Ntsr1 |
A |
G |
2: 180,180,470 (GRCm39) |
I259V |
probably benign |
Het |
Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
Or14j3 |
A |
G |
17: 37,900,540 (GRCm39) |
S235P |
possibly damaging |
Het |
Or6d14 |
G |
T |
6: 116,534,289 (GRCm39) |
R301L |
probably damaging |
Het |
Pax2 |
T |
C |
19: 44,750,128 (GRCm39) |
Y72H |
probably damaging |
Het |
Pcdh10 |
A |
T |
3: 45,334,030 (GRCm39) |
I115F |
probably benign |
Het |
Pkp4 |
A |
T |
2: 59,138,379 (GRCm39) |
R210* |
probably null |
Het |
Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
Rpa2 |
A |
G |
4: 132,499,481 (GRCm39) |
|
probably null |
Het |
Sec31a |
T |
C |
5: 100,540,273 (GRCm39) |
N471S |
probably benign |
Het |
Serpinb9g |
A |
T |
13: 33,676,796 (GRCm39) |
T193S |
probably benign |
Het |
Sh3pxd2b |
C |
T |
11: 32,361,469 (GRCm39) |
T227M |
probably benign |
Het |
Speg |
A |
G |
1: 75,378,908 (GRCm39) |
|
probably null |
Het |
Suz12 |
T |
C |
11: 79,922,817 (GRCm39) |
I653T |
probably damaging |
Het |
Thsd7b |
C |
A |
1: 129,523,191 (GRCm39) |
T75K |
probably damaging |
Het |
Trav5-1 |
A |
C |
14: 52,860,276 (GRCm39) |
Q27P |
probably damaging |
Het |
Trim5 |
T |
C |
7: 103,927,330 (GRCm39) |
|
probably null |
Het |
Vmn1r174 |
A |
T |
7: 23,453,970 (GRCm39) |
Y212F |
possibly damaging |
Het |
Vmn2r17 |
A |
G |
5: 109,600,810 (GRCm39) |
T703A |
probably damaging |
Het |
Vmn2r84 |
A |
G |
10: 130,230,100 (GRCm39) |
M4T |
probably benign |
Het |
Zfp709 |
A |
G |
8: 72,643,476 (GRCm39) |
T302A |
probably benign |
Het |
|
Other mutations in Vmn2r110 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01774:Vmn2r110
|
APN |
17 |
20,803,889 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01824:Vmn2r110
|
APN |
17 |
20,794,929 (GRCm39) |
missense |
probably benign |
0.44 |
IGL01879:Vmn2r110
|
APN |
17 |
20,794,122 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02168:Vmn2r110
|
APN |
17 |
20,804,062 (GRCm39) |
splice site |
probably benign |
|
IGL02178:Vmn2r110
|
APN |
17 |
20,804,706 (GRCm39) |
splice site |
probably null |
|
IGL02322:Vmn2r110
|
APN |
17 |
20,794,197 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r110
|
APN |
17 |
20,816,399 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02415:Vmn2r110
|
APN |
17 |
20,804,033 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02491:Vmn2r110
|
APN |
17 |
20,816,400 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02876:Vmn2r110
|
APN |
17 |
20,794,558 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03141:Vmn2r110
|
APN |
17 |
20,803,976 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL03270:Vmn2r110
|
APN |
17 |
20,803,778 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03286:Vmn2r110
|
APN |
17 |
20,804,468 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL03379:Vmn2r110
|
APN |
17 |
20,803,906 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4243001:Vmn2r110
|
UTSW |
17 |
20,802,379 (GRCm39) |
missense |
probably benign |
0.01 |
R0040:Vmn2r110
|
UTSW |
17 |
20,816,346 (GRCm39) |
missense |
probably benign |
0.10 |
R0195:Vmn2r110
|
UTSW |
17 |
20,794,317 (GRCm39) |
missense |
probably benign |
0.31 |
R0716:Vmn2r110
|
UTSW |
17 |
20,794,165 (GRCm39) |
missense |
probably damaging |
0.99 |
R1199:Vmn2r110
|
UTSW |
17 |
20,803,525 (GRCm39) |
missense |
probably benign |
0.03 |
R1767:Vmn2r110
|
UTSW |
17 |
20,800,840 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2212:Vmn2r110
|
UTSW |
17 |
20,794,209 (GRCm39) |
splice site |
probably null |
|
R3056:Vmn2r110
|
UTSW |
17 |
20,803,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R4093:Vmn2r110
|
UTSW |
17 |
20,803,642 (GRCm39) |
missense |
possibly damaging |
0.83 |
R4418:Vmn2r110
|
UTSW |
17 |
20,803,951 (GRCm39) |
nonsense |
probably null |
|
R4598:Vmn2r110
|
UTSW |
17 |
20,804,029 (GRCm39) |
nonsense |
probably null |
|
R4754:Vmn2r110
|
UTSW |
17 |
20,816,458 (GRCm39) |
missense |
probably benign |
0.00 |
R5283:Vmn2r110
|
UTSW |
17 |
20,800,899 (GRCm39) |
missense |
probably benign |
0.00 |
R5421:Vmn2r110
|
UTSW |
17 |
20,803,882 (GRCm39) |
missense |
probably damaging |
1.00 |
R5672:Vmn2r110
|
UTSW |
17 |
20,816,494 (GRCm39) |
missense |
probably benign |
|
R5865:Vmn2r110
|
UTSW |
17 |
20,804,557 (GRCm39) |
missense |
probably benign |
0.00 |
R6642:Vmn2r110
|
UTSW |
17 |
20,803,779 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6799:Vmn2r110
|
UTSW |
17 |
20,803,798 (GRCm39) |
missense |
probably benign |
|
R7167:Vmn2r110
|
UTSW |
17 |
20,794,441 (GRCm39) |
missense |
probably benign |
0.01 |
R7291:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
probably benign |
0.13 |
R7320:Vmn2r110
|
UTSW |
17 |
20,816,316 (GRCm39) |
missense |
probably benign |
|
R7519:Vmn2r110
|
UTSW |
17 |
20,804,524 (GRCm39) |
missense |
probably benign |
|
R8089:Vmn2r110
|
UTSW |
17 |
20,803,807 (GRCm39) |
missense |
probably benign |
0.00 |
R8234:Vmn2r110
|
UTSW |
17 |
20,804,691 (GRCm39) |
missense |
probably benign |
0.12 |
R8272:Vmn2r110
|
UTSW |
17 |
20,816,490 (GRCm39) |
missense |
probably damaging |
0.97 |
R8307:Vmn2r110
|
UTSW |
17 |
20,803,319 (GRCm39) |
missense |
probably benign |
0.00 |
R8506:Vmn2r110
|
UTSW |
17 |
20,804,627 (GRCm39) |
missense |
probably benign |
0.00 |
R8516:Vmn2r110
|
UTSW |
17 |
20,794,875 (GRCm39) |
missense |
probably damaging |
1.00 |
R8691:Vmn2r110
|
UTSW |
17 |
20,803,404 (GRCm39) |
missense |
probably benign |
0.19 |
R8859:Vmn2r110
|
UTSW |
17 |
20,794,560 (GRCm39) |
missense |
probably damaging |
0.99 |
R8935:Vmn2r110
|
UTSW |
17 |
20,803,957 (GRCm39) |
missense |
probably benign |
0.40 |
R8986:Vmn2r110
|
UTSW |
17 |
20,803,823 (GRCm39) |
missense |
probably damaging |
0.97 |
R9012:Vmn2r110
|
UTSW |
17 |
20,803,627 (GRCm39) |
missense |
probably damaging |
1.00 |
R9101:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
|
|
R9744:Vmn2r110
|
UTSW |
17 |
20,794,848 (GRCm39) |
missense |
probably damaging |
0.98 |
R9803:Vmn2r110
|
UTSW |
17 |
20,803,730 (GRCm39) |
missense |
probably benign |
0.00 |
Z1088:Vmn2r110
|
UTSW |
17 |
20,803,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CCAATTTGGGCAGATGTTGTC -3'
(R):5'- CAAGCTAGTCCCACATATTTATGG -3'
Sequencing Primer
(F):5'- CAGATGTTGTCCATGATGTTCC -3'
(R):5'- AGTCCCACATATTTATGGTGAATAAG -3'
|
Posted On |
2021-01-18 |