Incidental Mutation 'R8721:Zfp429'
| ID |
662131 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp429
|
| Ensembl Gene |
ENSMUSG00000078994 |
| Gene Name |
zinc finger protein 429 |
| Synonyms |
2810487A22Rik |
| MMRRC Submission |
068717-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R8721 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
67536024-67547938 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67538331 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 371
(Y371F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105354
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109732]
[ENSMUST00000181071]
[ENSMUST00000224684]
[ENSMUST00000224825]
|
| AlphaFold |
Q7M6Y0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109732
AA Change: Y371F
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000105354
Gene: ENSMUSG00000078994
AA Change: Y371F
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
15 |
75 |
7.16e-34 |
SMART |
|
ZnF_C2H2
|
119 |
141 |
5.12e1 |
SMART |
|
ZnF_C2H2
|
147 |
169 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
175 |
197 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
203 |
225 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
4.62e1 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
1.25e-1 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
5.42e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181071
|
| SMART Domains |
Protein: ENSMUSP00000137755
Gene: ENSMUSG00000078994
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
15 |
75 |
7.16e-34 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224684
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224825
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.1%
- 20x: 96.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca9 |
T |
C |
11: 110,035,115 (GRCm39) |
D684G |
possibly damaging |
Het |
| Abhd16a |
T |
C |
17: 35,310,571 (GRCm39) |
V94A |
possibly damaging |
Het |
| Acly |
A |
T |
11: 100,412,806 (GRCm39) |
|
probably null |
Het |
| Adamts1 |
G |
T |
16: 85,594,775 (GRCm39) |
T621K |
probably damaging |
Het |
| Arhgap24 |
A |
T |
5: 103,023,565 (GRCm39) |
T200S |
possibly damaging |
Het |
| Arhgap31 |
A |
G |
16: 38,427,058 (GRCm39) |
V598A |
probably benign |
Het |
| Ascc1 |
T |
C |
10: 59,933,928 (GRCm39) |
F323S |
possibly damaging |
Het |
| Cdcp3 |
T |
C |
7: 130,879,335 (GRCm39) |
S1785P |
unknown |
Het |
| Ces2b |
T |
A |
8: 105,560,527 (GRCm39) |
V114D |
possibly damaging |
Het |
| Cfap73 |
T |
C |
5: 120,768,089 (GRCm39) |
E223G |
probably benign |
Het |
| Csnk1e |
T |
C |
15: 79,314,015 (GRCm39) |
N78S |
possibly damaging |
Het |
| Cyp7a1 |
G |
T |
4: 6,268,273 (GRCm39) |
A484E |
probably damaging |
Het |
| Dnah9 |
G |
T |
11: 65,986,124 (GRCm39) |
T1170K |
probably damaging |
Het |
| Fam83d |
G |
T |
2: 158,627,522 (GRCm39) |
V404L |
probably benign |
Het |
| Fbxw28 |
C |
T |
9: 109,157,382 (GRCm39) |
V289I |
probably benign |
Het |
| Frs2 |
T |
G |
10: 116,909,935 (GRCm39) |
I476L |
probably benign |
Het |
| Gbp2b |
A |
T |
3: 142,312,705 (GRCm39) |
I363F |
possibly damaging |
Het |
| Gm8267 |
A |
T |
14: 44,959,507 (GRCm39) |
F186I |
possibly damaging |
Het |
| Hand1 |
A |
G |
11: 57,722,605 (GRCm39) |
L3P |
probably damaging |
Het |
| Hmcn2 |
C |
T |
2: 31,315,189 (GRCm39) |
L3671F |
probably damaging |
Het |
| Hspa12b |
A |
G |
2: 130,982,922 (GRCm39) |
D260G |
probably benign |
Het |
| Itih2 |
T |
C |
2: 10,111,619 (GRCm39) |
K440E |
probably damaging |
Het |
| Morn4 |
A |
T |
19: 42,066,439 (GRCm39) |
N49K |
possibly damaging |
Het |
| Mtmr6 |
T |
G |
14: 60,527,128 (GRCm39) |
|
probably null |
Het |
| Mylk |
A |
T |
16: 34,817,176 (GRCm39) |
D1848V |
probably damaging |
Het |
| Myo7b |
A |
G |
18: 32,140,064 (GRCm39) |
V242A |
probably damaging |
Het |
| Or4a74 |
T |
C |
2: 89,440,186 (GRCm39) |
K87E |
probably benign |
Het |
| Or8g19 |
T |
G |
9: 39,055,386 (GRCm39) |
|
probably benign |
Het |
| Rmdn3 |
T |
A |
2: 118,969,846 (GRCm39) |
Q405L |
possibly damaging |
Het |
| Robo2 |
A |
G |
16: 73,703,798 (GRCm39) |
S30P |
|
Het |
| Suclg1 |
G |
T |
6: 73,246,362 (GRCm39) |
L218F |
probably damaging |
Het |
| Tas2r134 |
T |
C |
2: 51,517,571 (GRCm39) |
S17P |
probably damaging |
Het |
| Tdrd9 |
T |
C |
12: 112,002,889 (GRCm39) |
L846P |
probably damaging |
Het |
| Tgfbi |
A |
G |
13: 56,773,599 (GRCm39) |
N199S |
probably benign |
Het |
| Traj35 |
C |
T |
14: 54,421,272 (GRCm39) |
T14I |
|
Het |
| Tril |
A |
G |
6: 53,797,183 (GRCm39) |
V13A |
probably benign |
Het |
| Tshz2 |
T |
A |
2: 169,727,278 (GRCm39) |
S625T |
probably benign |
Het |
| Ttll12 |
A |
G |
15: 83,464,784 (GRCm39) |
F464L |
probably damaging |
Het |
| Wdr35 |
T |
C |
12: 9,075,044 (GRCm39) |
|
probably null |
Het |
| Zfp346 |
A |
G |
13: 55,261,491 (GRCm39) |
S94G |
possibly damaging |
Het |
| Zscan4-ps2 |
A |
T |
7: 11,251,522 (GRCm39) |
E186V |
probably benign |
Het |
|
| Other mutations in Zfp429 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01160:Zfp429
|
APN |
13 |
67,539,132 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01913:Zfp429
|
APN |
13 |
67,544,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02343:Zfp429
|
APN |
13 |
67,538,844 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Zfp429
|
APN |
13 |
67,547,855 (GRCm39) |
intron |
probably benign |
|
|
IGL03396:Zfp429
|
APN |
13 |
67,544,159 (GRCm39) |
splice site |
probably benign |
|
|
FR4342:Zfp429
|
UTSW |
13 |
67,544,769 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0012:Zfp429
|
UTSW |
13 |
67,538,796 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1232:Zfp429
|
UTSW |
13 |
67,538,751 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1330:Zfp429
|
UTSW |
13 |
67,544,262 (GRCm39) |
splice site |
probably null |
|
|
R1653:Zfp429
|
UTSW |
13 |
67,538,043 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1761:Zfp429
|
UTSW |
13 |
67,544,195 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1813:Zfp429
|
UTSW |
13 |
67,538,505 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2356:Zfp429
|
UTSW |
13 |
67,538,746 (GRCm39) |
missense |
probably benign |
|
|
R4280:Zfp429
|
UTSW |
13 |
67,538,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4283:Zfp429
|
UTSW |
13 |
67,538,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4464:Zfp429
|
UTSW |
13 |
67,538,617 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4789:Zfp429
|
UTSW |
13 |
67,538,523 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5187:Zfp429
|
UTSW |
13 |
67,538,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5250:Zfp429
|
UTSW |
13 |
67,538,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6688:Zfp429
|
UTSW |
13 |
67,544,249 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6772:Zfp429
|
UTSW |
13 |
67,538,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6989:Zfp429
|
UTSW |
13 |
67,538,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Zfp429
|
UTSW |
13 |
67,538,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7101:Zfp429
|
UTSW |
13 |
67,538,931 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7593:Zfp429
|
UTSW |
13 |
67,538,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Zfp429
|
UTSW |
13 |
67,538,558 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp429
|
UTSW |
13 |
67,538,828 (GRCm39) |
nonsense |
probably null |
|
|
R8891:Zfp429
|
UTSW |
13 |
67,538,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9364:Zfp429
|
UTSW |
13 |
67,538,531 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9554:Zfp429
|
UTSW |
13 |
67,538,531 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATGTTGTACAAAGCATGAGGATG -3'
(R):5'- CCCTACAAGTGTGGAGAACG -3'
Sequencing Primer
(F):5'- TGATGCTCCTGAAGACTTCCAGAG -3'
(R):5'- TCTGAAGACAACCCTTACAAGTGTG -3'
|
| Posted On |
2021-03-08 |
Incidental Mutation