Mutagenetix > Incidental Mutation

Incidental Mutation 'R9390:Or6c210'

710552

Institutional Source

Beutler Lab

Gene Symbol

Or6c210

Ensembl Gene

ENSMUSG00000108114

Gene Name

olfactory receptor family 6 subfamily C member 210

Synonyms

GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.202) question?

Stock #

R9390 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

129495677-129496612 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 129495938 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 88 (T88A)

Ref Sequence

ENSEMBL: ENSMUSP00000151047 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000104903] [ENSMUST00000217094]

AlphaFold

Q8VFH7

Predicted Effect

probably benign
Transcript: ENSMUST00000104903
AA Change: T88A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000100499
Gene: ENSMUSG00000108114
AA Change: T88A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	307	7.3e-43	PFAM
Pfam:7tm_1	38	287	6.9e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217094
AA Change: T88A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	A	T	16: 90,853,096 (GRCm39)	S13R	probably benign	Het
Amn1	A	T	6: 149,084,983 (GRCm39)	D32E	probably damaging	Het
Asph	T	C	4: 9,635,927 (GRCm39)	D108G	probably damaging	Het
C1rb	T	C	6: 124,557,336 (GRCm39)	L491P	probably damaging	Het
Cep120	G	A	18: 53,839,984 (GRCm39)	R759*	probably null	Het
Chmp6	C	T	11: 119,806,288 (GRCm39)	T38M	possibly damaging	Het
Comtd1	A	G	14: 21,898,867 (GRCm39)	F25S	possibly damaging	Het
Dthd1	G	A	5: 62,975,904 (GRCm39)	G193R	possibly damaging	Het
Dyrk1a	T	A	16: 94,474,330 (GRCm39)	S362R	probably damaging	Het
Ecm2	A	G	13: 49,683,792 (GRCm39)	D590G	probably benign	Het
Exd1	A	T	2: 119,354,180 (GRCm39)	W293R	probably damaging	Het
Fam110a	C	T	2: 151,812,116 (GRCm39)	R218Q	probably benign	Het
Fga	A	T	3: 82,940,610 (GRCm39)	N755Y	probably damaging	Het
Fstl4	C	A	11: 52,891,102 (GRCm39)	T80K	probably benign	Het
Gbp5	A	G	3: 142,208,783 (GRCm39)	K109E	probably benign	Het
Gucy2g	A	G	19: 55,190,607 (GRCm39)	V1009A	probably null	Het
Herc6	C	T	6: 57,602,955 (GRCm39)	Q545*	probably null	Het
Hpd	T	A	5: 123,318,794 (GRCm39)		probably null	Het
Il4	C	T	11: 53,504,837 (GRCm39)	R76H	probably damaging	Het
Inpp4b	T	C	8: 82,497,522 (GRCm39)	V114A	probably damaging	Het
Ints14	A	G	9: 64,891,314 (GRCm39)	T432A	probably benign	Het
Isoc1	G	A	18: 58,804,350 (GRCm39)	R126H	probably damaging	Het
Klb	G	T	5: 65,533,044 (GRCm39)	R451L	possibly damaging	Het
Lrtm2	C	T	6: 119,297,948 (GRCm39)	C31Y	probably benign	Het
Mga	C	T	2: 119,794,332 (GRCm39)	S2672F	probably damaging	Het
Mkrn3	T	C	7: 62,069,288 (GRCm39)	I168V	probably benign	Het
Mlph	C	T	1: 90,867,088 (GRCm39)	T370I	probably benign	Het
Naaladl1	A	T	19: 6,162,725 (GRCm39)	I478F	probably damaging	Het
Neb	A	T	2: 52,065,157 (GRCm39)	H6251Q	probably benign	Het
Nom1	C	T	5: 29,639,766 (GRCm39)	R31C	probably benign	Het
Nup153	A	C	13: 46,840,642 (GRCm39)	F989V	probably damaging	Het
Nup188	T	C	2: 30,220,777 (GRCm39)		probably null	Het
Or4c12	T	C	2: 89,773,569 (GRCm39)	K297E	probably benign	Het
Or5aq6	A	T	2: 86,923,390 (GRCm39)	M117K	possibly damaging	Het
Ovgp1	T	C	3: 105,893,883 (GRCm39)		probably benign	Het
Pcare	T	C	17: 72,057,983 (GRCm39)	T565A	probably benign	Het
Pcdhb4	T	C	18: 37,442,781 (GRCm39)	V697A	possibly damaging	Het
Pds5a	G	T	5: 65,823,600 (GRCm39)	Q64K	probably benign	Het
Pmpcb	T	C	5: 21,953,810 (GRCm39)	F353L	probably damaging	Het
Pus10	G	A	11: 23,656,937 (GRCm39)	C221Y	probably damaging	Het
Qrfp	A	G	2: 31,698,749 (GRCm39)	V61A	possibly damaging	Het
Runx1t1	A	G	4: 13,865,932 (GRCm39)	I393M	probably benign	Het
Sh2d5	T	G	4: 137,985,481 (GRCm39)	S310A	probably benign	Het
Shisa9	A	G	16: 12,085,408 (GRCm39)	E339G	possibly damaging	Het
Slc26a10	C	T	10: 127,009,239 (GRCm39)	E641K	probably benign	Het
Slc5a6	A	G	5: 31,197,803 (GRCm39)	V302A	possibly damaging	Het
Tdrd7	T	A	4: 46,005,416 (GRCm39)	D407E	probably damaging	Het
Trp53	A	T	11: 69,478,394 (GRCm39)	Q101L	probably benign	Het
Tsc2	T	A	17: 24,823,824 (GRCm39)	N994Y	probably damaging	Het
Ttc16	T	G	2: 32,657,195 (GRCm39)	K577Q	possibly damaging	Het
Vmn1r195	A	G	13: 22,462,535 (GRCm39)	I2V	probably benign	Het
Vmn2r83	G	T	10: 79,317,322 (GRCm39)	E522*	probably null	Het
Wdr48	T	A	9: 119,746,245 (GRCm39)	F450L	probably benign	Het
Wnt9a	G	A	11: 59,218,592 (GRCm39)	E100K	possibly damaging	Het
Zfp729b	A	T	13: 67,739,182 (GRCm39)	S1028T	probably benign	Het
Zfp729b	C	T	13: 67,742,014 (GRCm39)	V84I	possibly damaging	Het

Other mutations in Or6c210

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01322:Or6c210	APN	10	129,495,995 (GRCm39)	missense	probably benign	0.26
IGL01915:Or6c210	APN	10	129,496,519 (GRCm39)	missense	probably benign	0.05
IGL02458:Or6c210	APN	10	129,496,475 (GRCm39)	missense	probably benign	0.38
IGL02721:Or6c210	APN	10	129,495,824 (GRCm39)	missense	probably benign
R0032:Or6c210	UTSW	10	129,496,269 (GRCm39)	missense	probably benign	0.05
R0442:Or6c210	UTSW	10	129,495,693 (GRCm39)	missense	probably benign	0.00
R1564:Or6c210	UTSW	10	129,495,884 (GRCm39)	missense	probably benign	0.22
R1580:Or6c210	UTSW	10	129,496,184 (GRCm39)	missense	probably benign	0.10
R1593:Or6c210	UTSW	10	129,496,094 (GRCm39)	nonsense	probably null
R1911:Or6c210	UTSW	10	129,495,981 (GRCm39)	missense	probably benign	0.07
R2001:Or6c210	UTSW	10	129,496,290 (GRCm39)	missense	probably benign	0.02
R2223:Or6c210	UTSW	10	129,495,678 (GRCm39)	start codon destroyed	probably null	1.00
R3876:Or6c210	UTSW	10	129,496,143 (GRCm39)	missense	probably benign	0.39
R3884:Or6c210	UTSW	10	129,496,407 (GRCm39)	missense	probably damaging	1.00
R4366:Or6c210	UTSW	10	129,496,400 (GRCm39)	missense	probably benign	0.02
R4689:Or6c210	UTSW	10	129,496,185 (GRCm39)	missense	probably benign	0.01
R4909:Or6c210	UTSW	10	129,496,589 (GRCm39)	missense	probably benign	0.01
R5638:Or6c210	UTSW	10	129,495,969 (GRCm39)	missense	possibly damaging	0.80
R5835:Or6c210	UTSW	10	129,495,803 (GRCm39)	missense	probably benign	0.39
R5838:Or6c210	UTSW	10	129,495,907 (GRCm39)	missense	probably benign	0.41
R6150:Or6c210	UTSW	10	129,495,803 (GRCm39)	missense	probably benign	0.39
R6248:Or6c210	UTSW	10	129,496,532 (GRCm39)	missense	probably benign	0.39
R8094:Or6c210	UTSW	10	129,495,933 (GRCm39)	missense	probably damaging	0.99
R9013:Or6c210	UTSW	10	129,495,702 (GRCm39)	missense	probably damaging	1.00
R9224:Or6c210	UTSW	10	129,496,007 (GRCm39)	missense	probably damaging	1.00
R9726:Or6c210	UTSW	10	129,495,920 (GRCm39)	missense	possibly damaging	0.67
R9777:Or6c210	UTSW	10	129,495,705 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- CTACGTGCTGAGTATGACTGG -3'
(R):5'- AGAATTCCAGCTTGAGGCCC -3'

Sequencing Primer
(F):5'- GGAACCTCACGATCATATCCCTTAC -3'
(R):5'- TTGAGGCCCAGGCTAAGTG -3'

Posted On

2022-04-18