Incidental Mutation 'R9442:Kcnrg'
ID 713697
Institutional Source Beutler Lab
Gene Symbol Kcnrg
Ensembl Gene ENSMUSG00000046168
Gene Name potassium channel regulator
Synonyms LOC328424, E030012H22Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R9442 (G1)
Quality Score 217.468
Status Validated
Chromosome 14
Chromosomal Location 61844906-61850275 bp(+) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CACAACAA to CACAA at 61845009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039562] [ENSMUST00000051184] [ENSMUST00000165015] [ENSMUST00000225582]
AlphaFold Q2TUM3
Predicted Effect probably benign
Transcript: ENSMUST00000039562
SMART Domains Protein: ENSMUSP00000045009
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000051184
SMART Domains Protein: ENSMUSP00000055327
Gene: ENSMUSG00000046168

DomainStartEndE-ValueType
BTB 5 106 8.7e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165015
SMART Domains Protein: ENSMUSP00000128509
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000225582
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Allele List at MGI

All alleles(1) : Gene trapped(1)
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T A 17: 48,347,580 (GRCm39) K241N possibly damaging Het
Adam5 A T 8: 25,296,510 (GRCm39) S312R probably damaging Het
Atg9a C T 1: 75,163,086 (GRCm39) C338Y possibly damaging Het
Cage1 T C 13: 38,196,447 (GRCm39) E749G possibly damaging Het
Catspere2 C A 1: 177,931,275 (GRCm39) T398K unknown Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Ccndbp1 T C 2: 120,839,013 (GRCm39) V8A probably benign Het
Cenpt T C 8: 106,575,418 (GRCm39) D228G probably benign Het
Cfap57 A G 4: 118,463,731 (GRCm39) probably null Het
Cyp4a32 T A 4: 115,468,422 (GRCm39) N301K probably benign Het
Epha6 T C 16: 60,025,850 (GRCm39) T531A probably benign Het
Gmeb1 A T 4: 131,962,156 (GRCm39) C168S probably damaging Het
H2-DMa G A 17: 34,357,132 (GRCm39) R210H possibly damaging Het
Ighv1-7 T G 12: 114,502,198 (GRCm39) T90P probably damaging Het
Kalrn A C 16: 33,916,249 (GRCm39) M1R probably null Het
Krtap14 T C 16: 88,622,865 (GRCm39) D38G possibly damaging Het
Lrrc8e A G 8: 4,283,964 (GRCm39) N63S probably benign Het
Map4k2 T A 19: 6,392,814 (GRCm39) L152Q probably damaging Het
Mcf2l A G 8: 13,023,048 (GRCm39) D78G possibly damaging Het
Ms4a6c T C 19: 11,449,851 (GRCm39) V81A probably benign Het
Mtnr1b T C 9: 15,785,660 (GRCm39) T33A probably benign Het
Muc16 T A 9: 18,566,624 (GRCm39) Q1965L unknown Het
Nfatc2 A C 2: 168,328,898 (GRCm39) probably benign Het
Nlrp9b C T 7: 19,779,707 (GRCm39) T790I possibly damaging Het
Nol4 A T 18: 22,902,899 (GRCm39) C371S probably damaging Het
Ntn1 A C 11: 68,148,485 (GRCm39) probably benign Het
Or14j3 A G 17: 37,900,633 (GRCm39) S204P possibly damaging Het
Orc1 T C 4: 108,469,357 (GRCm39) V727A probably benign Het
Phf20l1 C T 15: 66,484,888 (GRCm39) Q318* probably null Het
Psg18 A T 7: 18,083,185 (GRCm39) Y323* probably null Het
Ptk2b T C 14: 66,409,189 (GRCm39) Y529C probably damaging Het
Rrm1 A G 7: 102,108,598 (GRCm39) Y374C probably damaging Het
Selp T A 1: 163,964,765 (GRCm39) F476I probably damaging Het
Sema3b A G 9: 107,478,957 (GRCm39) probably null Het
Setdb2 T G 14: 59,639,849 (GRCm39) T665P probably damaging Het
Sorbs3 T C 14: 70,424,387 (GRCm39) Y515C probably damaging Het
St13 G A 15: 81,272,575 (GRCm39) P90S possibly damaging Het
Stag1 T A 9: 100,836,306 (GRCm39) I1197N probably damaging Het
Svs3a A G 2: 164,132,179 (GRCm39) Y250C probably damaging Het
Ticam1 T C 17: 56,577,428 (GRCm39) I556V probably benign Het
Vmn1r180 A G 7: 23,651,620 (GRCm39) probably benign Het
Xirp2 T A 2: 67,342,235 (GRCm39) L1492* probably null Het
Zfp438 A G 18: 5,214,379 (GRCm39) V193A probably benign Het
Zfp729b A G 13: 67,739,337 (GRCm39) V976A probably benign Het
Other mutations in Kcnrg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Kcnrg APN 14 61,845,359 (GRCm39) missense probably damaging 1.00
IGL01311:Kcnrg APN 14 61,849,274 (GRCm39) missense probably damaging 1.00
D4216:Kcnrg UTSW 14 61,849,242 (GRCm39) nonsense probably null
R1081:Kcnrg UTSW 14 61,845,163 (GRCm39) missense possibly damaging 0.87
R1346:Kcnrg UTSW 14 61,849,144 (GRCm39) missense probably benign 0.31
R3147:Kcnrg UTSW 14 61,845,140 (GRCm39) missense probably damaging 1.00
R4690:Kcnrg UTSW 14 61,849,176 (GRCm39) missense probably damaging 1.00
R4820:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R5068:Kcnrg UTSW 14 61,845,266 (GRCm39) missense probably damaging 1.00
R5914:Kcnrg UTSW 14 61,849,280 (GRCm39) missense probably benign
R7234:Kcnrg UTSW 14 61,845,531 (GRCm39) missense unknown
R8232:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R8821:Kcnrg UTSW 14 61,844,981 (GRCm39) missense possibly damaging 0.55
R9475:Kcnrg UTSW 14 61,845,106 (GRCm39) missense possibly damaging 0.95
R9633:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9634:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9703:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- ACTTGCAAACACAGCTATGGATAC -3'
(R):5'- TCTGCAAAGTCCGAGGGTAAC -3'

Sequencing Primer
(F):5'- GGATACACTATTTGTCTTGACGATAG -3'
(R):5'- GGGTAACAGAAGCTCATGATTTCTC -3'
Posted On 2022-06-15