Incidental Mutation 'R9755:Taar2'
ID |
732689 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Taar2
|
Ensembl Gene |
ENSMUSG00000059763 |
Gene Name |
trace amine-associated receptor 2 |
Synonyms |
Gpr58 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R9755 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
10 |
Chromosomal Location |
23814470-23817481 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 23817038 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 193
(F193L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000078137
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079134]
|
AlphaFold |
Q5QD17 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000079134
AA Change: F193L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000078137 Gene: ENSMUSG00000059763 AA Change: F193L
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
42 |
318 |
2.4e-10 |
PFAM |
Pfam:7tm_1
|
48 |
303 |
2.9e-54 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.1%
- 20x: 97.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acin1 |
A |
T |
14: 54,889,292 (GRCm39) |
M774K |
probably damaging |
Het |
Adamts9 |
T |
C |
6: 92,856,922 (GRCm39) |
R906G |
probably benign |
Het |
Adgrl4 |
A |
T |
3: 151,216,418 (GRCm39) |
T534S |
probably benign |
Het |
Amph |
A |
T |
13: 19,297,325 (GRCm39) |
D357V |
probably damaging |
Het |
Arhgap33 |
C |
T |
7: 30,227,926 (GRCm39) |
V452I |
possibly damaging |
Het |
B4galnt2 |
G |
A |
11: 95,774,801 (GRCm39) |
Q160* |
probably null |
Het |
C1galt1 |
T |
G |
6: 7,867,019 (GRCm39) |
N288K |
probably benign |
Het |
Cacna1c |
T |
C |
6: 118,651,559 (GRCm39) |
D967G |
probably damaging |
Het |
Cacul1 |
C |
T |
19: 60,533,955 (GRCm39) |
E216K |
probably damaging |
Het |
Cenpq |
A |
T |
17: 41,243,712 (GRCm39) |
S45R |
probably benign |
Het |
Cfap54 |
T |
A |
10: 92,757,230 (GRCm39) |
M2216L |
unknown |
Het |
Cfhr1 |
A |
G |
1: 139,487,889 (GRCm39) |
F3S |
probably benign |
Het |
Csf2rb |
T |
G |
15: 78,232,824 (GRCm39) |
Y710* |
probably null |
Het |
Dhh |
A |
G |
15: 98,792,939 (GRCm39) |
V107A |
possibly damaging |
Het |
Etl4 |
A |
T |
2: 20,790,048 (GRCm39) |
T849S |
probably benign |
Het |
Gnrh1 |
G |
A |
14: 67,986,699 (GRCm39) |
E78K |
possibly damaging |
Het |
Golga3 |
A |
G |
5: 110,340,847 (GRCm39) |
T514A |
probably benign |
Het |
Gramd1c |
T |
A |
16: 43,803,879 (GRCm39) |
K393N |
probably benign |
Het |
Kcp |
T |
C |
6: 29,492,460 (GRCm39) |
Y844C |
probably damaging |
Het |
Lrrc15 |
T |
A |
16: 30,093,147 (GRCm39) |
H64L |
possibly damaging |
Het |
Mak |
G |
T |
13: 41,199,623 (GRCm39) |
Q339K |
probably benign |
Het |
Mdfic |
G |
T |
6: 15,799,758 (GRCm39) |
C295F |
probably damaging |
Het |
Mdfic2 |
A |
T |
6: 98,225,147 (GRCm39) |
N45K |
probably benign |
Het |
Mfsd14b |
C |
A |
13: 65,221,414 (GRCm39) |
V293L |
probably benign |
Het |
Miip |
A |
T |
4: 147,950,319 (GRCm39) |
Y92* |
probably null |
Het |
Mycbp2 |
A |
T |
14: 103,551,806 (GRCm39) |
S175T |
probably benign |
Het |
Nacad |
A |
G |
11: 6,549,374 (GRCm39) |
|
probably null |
Het |
Ndnf |
T |
G |
6: 65,680,502 (GRCm39) |
D260E |
probably benign |
Het |
Nphp1 |
G |
A |
2: 127,595,951 (GRCm39) |
Q505* |
probably null |
Het |
Or12e7 |
C |
A |
2: 87,287,719 (GRCm39) |
A70E |
probably damaging |
Het |
Or8g29-ps1 |
A |
G |
9: 39,200,970 (GRCm39) |
V72A |
possibly damaging |
Het |
Plcg1 |
G |
A |
2: 160,573,780 (GRCm39) |
G15D |
probably benign |
Het |
Ppm1h |
A |
G |
10: 122,638,165 (GRCm39) |
Y145C |
probably damaging |
Het |
Prickle2 |
C |
T |
6: 92,399,319 (GRCm39) |
C186Y |
probably damaging |
Het |
Prmt6 |
A |
C |
3: 110,157,359 (GRCm39) |
L310R |
probably damaging |
Het |
Psg25 |
A |
T |
7: 18,260,460 (GRCm39) |
I146N |
probably benign |
Het |
Sapcd1 |
A |
G |
17: 35,245,400 (GRCm39) |
S128P |
probably benign |
Het |
Scart2 |
T |
A |
7: 139,841,544 (GRCm39) |
|
probably null |
Het |
Sema3b |
T |
C |
9: 107,478,784 (GRCm39) |
S331G |
probably damaging |
Het |
Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
Skil |
A |
G |
3: 31,151,544 (GRCm39) |
E22G |
probably benign |
Het |
Slc13a1 |
T |
C |
6: 24,134,407 (GRCm39) |
I159V |
probably benign |
Het |
Slc44a4 |
A |
G |
17: 35,136,331 (GRCm39) |
I41V |
probably benign |
Het |
Taar8a |
A |
G |
10: 23,952,995 (GRCm39) |
I200V |
probably benign |
Het |
Trpc4 |
A |
G |
3: 54,223,215 (GRCm39) |
Y717C |
probably damaging |
Het |
Vmn2r116 |
A |
T |
17: 23,620,065 (GRCm39) |
T600S |
probably damaging |
Het |
Vwa1 |
G |
A |
4: 155,857,336 (GRCm39) |
P154L |
probably damaging |
Het |
Zfp318 |
A |
G |
17: 46,722,055 (GRCm39) |
T1353A |
probably damaging |
Het |
Zfp830 |
C |
T |
11: 82,655,805 (GRCm39) |
T203I |
possibly damaging |
Het |
|
Other mutations in Taar2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00229:Taar2
|
APN |
10 |
23,817,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL00807:Taar2
|
APN |
10 |
23,816,573 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01346:Taar2
|
APN |
10 |
23,816,997 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01433:Taar2
|
APN |
10 |
23,816,657 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01782:Taar2
|
APN |
10 |
23,817,042 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03106:Taar2
|
APN |
10 |
23,817,195 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03372:Taar2
|
APN |
10 |
23,817,069 (GRCm39) |
missense |
probably benign |
0.03 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0046:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0090:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0101:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0103:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0157:Taar2
|
UTSW |
10 |
23,817,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R0189:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0190:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0226:Taar2
|
UTSW |
10 |
23,816,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R0265:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0267:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0349:Taar2
|
UTSW |
10 |
23,817,407 (GRCm39) |
missense |
probably benign |
0.01 |
R0349:Taar2
|
UTSW |
10 |
23,817,327 (GRCm39) |
missense |
possibly damaging |
0.79 |
R0426:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R0556:Taar2
|
UTSW |
10 |
23,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
R0698:Taar2
|
UTSW |
10 |
23,817,393 (GRCm39) |
missense |
probably benign |
0.00 |
R1191:Taar2
|
UTSW |
10 |
23,816,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R2919:Taar2
|
UTSW |
10 |
23,817,454 (GRCm39) |
missense |
probably benign |
0.00 |
R4615:Taar2
|
UTSW |
10 |
23,817,263 (GRCm39) |
missense |
probably benign |
0.43 |
R4658:Taar2
|
UTSW |
10 |
23,817,401 (GRCm39) |
missense |
probably benign |
0.04 |
R4766:Taar2
|
UTSW |
10 |
23,816,669 (GRCm39) |
missense |
probably damaging |
0.98 |
R4872:Taar2
|
UTSW |
10 |
23,816,591 (GRCm39) |
missense |
probably benign |
0.02 |
R5205:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
0.42 |
R5271:Taar2
|
UTSW |
10 |
23,816,930 (GRCm39) |
missense |
probably damaging |
0.97 |
R5517:Taar2
|
UTSW |
10 |
23,816,627 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6033:Taar2
|
UTSW |
10 |
23,816,874 (GRCm39) |
missense |
probably benign |
|
R6325:Taar2
|
UTSW |
10 |
23,816,615 (GRCm39) |
missense |
probably benign |
0.05 |
R6398:Taar2
|
UTSW |
10 |
23,817,177 (GRCm39) |
missense |
probably benign |
0.00 |
R6762:Taar2
|
UTSW |
10 |
23,817,300 (GRCm39) |
missense |
probably damaging |
0.98 |
R7121:Taar2
|
UTSW |
10 |
23,816,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R7209:Taar2
|
UTSW |
10 |
23,816,597 (GRCm39) |
missense |
possibly damaging |
0.57 |
R7709:Taar2
|
UTSW |
10 |
23,816,621 (GRCm39) |
missense |
probably benign |
0.00 |
R8045:Taar2
|
UTSW |
10 |
23,817,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R8223:Taar2
|
UTSW |
10 |
23,817,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R8743:Taar2
|
UTSW |
10 |
23,817,369 (GRCm39) |
missense |
probably damaging |
1.00 |
R9307:Taar2
|
UTSW |
10 |
23,817,237 (GRCm39) |
missense |
probably damaging |
1.00 |
R9350:Taar2
|
UTSW |
10 |
23,817,345 (GRCm39) |
missense |
probably damaging |
1.00 |
R9351:Taar2
|
UTSW |
10 |
23,816,900 (GRCm39) |
missense |
probably benign |
0.14 |
Z1176:Taar2
|
UTSW |
10 |
23,817,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCATAACGTCCATTTTCCACC -3'
(R):5'- CTATCCCTAAAGTTTTGGCTGC -3'
Sequencing Primer
(F):5'- CGATAGATTTTATGCCATCTGTCAC -3'
(R):5'- CAATTACGCGAGCGTGT -3'
|
Posted On |
2022-11-14 |