Incidental Mutation 'IGL01766:Dcaf13'
ID 153664
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene Name DDB1 and CUL4 associated factor 13
Synonyms LOC223499, Wdsof1
Accession Numbers

Genbank: NM_198606; MGI: 2684929

Is this an essential gene? Probably essential (E-score: 0.955) question?
Stock # IGL01766
Quality Score
Status
Chromosome 15
Chromosomal Location 39112865-39146856 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39118750 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 37 (V37A)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
AlphaFold Q6PAC3
Predicted Effect probably benign
Transcript: ENSMUST00000022909
AA Change: V37A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: V37A

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,224,561 D310G probably benign Het
Ahnak A G 19: 9,000,118 T7A unknown Het
Arhgap21 T A 2: 20,849,637 D1648V possibly damaging Het
Cd274 T C 19: 29,385,410 *291Q probably null Het
Ceacam1 G A 7: 25,471,995 S348L probably damaging Het
Degs1 A T 1: 182,279,095 F200I probably damaging Het
Dock4 G T 12: 40,446,379 E8* probably null Het
Dsc2 G A 18: 20,046,342 P223L possibly damaging Het
Exo1 A G 1: 175,892,021 T171A possibly damaging Het
Gen1 C T 12: 11,256,894 D92N probably damaging Het
Gm572 A T 4: 148,654,895 H60L possibly damaging Het
Gucy2c T C 6: 136,715,973 T719A probably benign Het
Heatr5a T C 12: 51,889,664 S1575G probably benign Het
Hspa12a T C 19: 58,799,467 E641G probably damaging Het
Itgb4 G A 11: 115,988,926 V635I probably damaging Het
Luzp1 T C 4: 136,542,773 I769T possibly damaging Het
Map2k5 C T 9: 63,377,227 A11T probably benign Het
Myo9b A G 8: 71,290,517 E74G probably damaging Het
Myom1 T C 17: 71,077,288 V666A probably damaging Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Olfr389 T A 11: 73,777,075 N84I probably benign Het
Olfr816 A G 10: 129,911,780 F166S probably damaging Het
Olfr987 A G 2: 85,331,601 L99S probably benign Het
Plekhg1 A G 10: 3,873,400 T123A probably damaging Het
Polrmt T C 10: 79,736,568 E1077G possibly damaging Het
Ptprh A G 7: 4,580,916 W226R probably benign Het
Robo1 A G 16: 73,004,665 H1059R probably benign Het
Sesn1 A G 10: 41,898,369 T306A probably benign Het
Sox14 T A 9: 99,875,116 H190L probably damaging Het
Spag8 G T 4: 43,653,209 probably benign Het
Tomm40 T C 7: 19,703,082 H20R possibly damaging Het
Znhit3 G T 11: 84,916,133 probably benign Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39143632 nonsense probably null
IGL01081:Dcaf13 APN 15 39118806 missense probably damaging 1.00
IGL02174:Dcaf13 APN 15 39138149 missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 39118707 splice site probably benign
IGL02740:Dcaf13 APN 15 39145100 nonsense probably null
IGL03092:Dcaf13 APN 15 39127976 splice site probably benign
IGL03374:Dcaf13 APN 15 39145148 nonsense probably null
R0590:Dcaf13 UTSW 15 39145085 splice site probably benign
R0594:Dcaf13 UTSW 15 39123268 missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39138089 missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39143718 missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 39130238 missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 39118899 missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39138088 missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39145152 missense probably benign
R4113:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 39118893 missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39138242 missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 39123224 missense probably benign 0.16
R5454:Dcaf13 UTSW 15 39124364 missense probably benign
R5834:Dcaf13 UTSW 15 39143642 nonsense probably null
R5929:Dcaf13 UTSW 15 39143653 missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39146677 missense probably benign
R6319:Dcaf13 UTSW 15 39143672 missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39143737 missense probably benign 0.04
R6664:Dcaf13 UTSW 15 39118888 missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 39123240 missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
R8750:Dcaf13 UTSW 15 39119441 missense probably damaging 1.00
R8944:Dcaf13 UTSW 15 39138217 missense possibly damaging 0.79
R9294:Dcaf13 UTSW 15 39130292 missense possibly damaging 0.92
R9300:Dcaf13 UTSW 15 39146707 missense probably damaging 1.00
Z1088:Dcaf13 UTSW 15 39145247 missense probably damaging 1.00
Posted On 2014-02-04