Incidental Mutation 'IGL02262:Dcaf13'
| ID |
286805 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dcaf13
|
| Ensembl Gene |
ENSMUSG00000022300 |
| Gene Name |
DDB1 and CUL4 associated factor 13 |
| Synonyms |
Wdsof1, LOC223499 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.955)
|
| Stock # |
IGL02262
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
38976300-39010251 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 38982102 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000022909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022909]
|
| AlphaFold |
Q6PAC3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022909
|
| SMART Domains |
Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
55 |
95 |
5.77e-5 |
SMART |
|
WD40
|
98 |
137 |
4.38e-5 |
SMART |
|
WD40
|
185 |
225 |
5.97e-1 |
SMART |
|
Blast:WD40
|
228 |
267 |
1e-18 |
BLAST |
|
WD40
|
271 |
310 |
2.69e-5 |
SMART |
|
WD40
|
312 |
353 |
2.96e-2 |
SMART |
|
Pfam:Sof1
|
354 |
440 |
7.2e-38 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(9) : Targeted, other(2) Gene trapped(7) |
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrg6 |
G |
T |
10: 14,317,140 (GRCm39) |
A560E |
probably benign |
Het |
| Apol7c |
A |
T |
15: 77,410,013 (GRCm39) |
M311K |
probably benign |
Het |
| Arap2 |
A |
C |
5: 62,800,184 (GRCm39) |
V1281G |
probably damaging |
Het |
| Cacna1s |
C |
T |
1: 136,035,867 (GRCm39) |
T1388I |
probably damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,656,414 (GRCm39) |
G1585S |
probably benign |
Het |
| Dscaml1 |
G |
A |
9: 45,643,378 (GRCm39) |
V1266I |
probably benign |
Het |
| Epc1 |
A |
G |
18: 6,437,278 (GRCm39) |
L750P |
probably damaging |
Het |
| Fgd6 |
T |
A |
10: 93,961,490 (GRCm39) |
M1108K |
probably damaging |
Het |
| Gm14496 |
T |
C |
2: 181,637,805 (GRCm39) |
I293T |
probably damaging |
Het |
| Gm21759 |
T |
C |
5: 8,230,747 (GRCm39) |
|
probably benign |
Het |
| Igkv3-10 |
A |
T |
6: 70,550,154 (GRCm39) |
D100V |
possibly damaging |
Het |
| Ipo13 |
A |
C |
4: 117,761,010 (GRCm39) |
I569M |
probably damaging |
Het |
| Itgb4 |
G |
A |
11: 115,879,752 (GRCm39) |
V635I |
probably damaging |
Het |
| Kif26b |
A |
G |
1: 178,743,633 (GRCm39) |
Y1243C |
probably benign |
Het |
| Map3k12 |
T |
C |
15: 102,410,510 (GRCm39) |
E489G |
probably damaging |
Het |
| Mtcl2 |
A |
T |
2: 156,872,826 (GRCm39) |
V895E |
probably damaging |
Het |
| Nrxn1 |
A |
G |
17: 91,011,636 (GRCm39) |
V331A |
probably damaging |
Het |
| Ntrk1 |
G |
A |
3: 87,689,104 (GRCm39) |
L529F |
probably damaging |
Het |
| Obscn |
A |
T |
11: 58,919,359 (GRCm39) |
C6882S |
possibly damaging |
Het |
| Or14j5 |
A |
C |
17: 38,162,154 (GRCm39) |
T224P |
probably damaging |
Het |
| Or8b48 |
C |
T |
9: 38,492,809 (GRCm39) |
P79S |
probably damaging |
Het |
| Ppp1r13b |
C |
A |
12: 111,801,645 (GRCm39) |
L346F |
possibly damaging |
Het |
| Psg22 |
T |
C |
7: 18,458,496 (GRCm39) |
S396P |
probably damaging |
Het |
| Rbm19 |
A |
G |
5: 120,281,470 (GRCm39) |
E797G |
probably damaging |
Het |
| Ros1 |
T |
G |
10: 52,055,065 (GRCm39) |
D79A |
probably damaging |
Het |
| Scn10a |
C |
T |
9: 119,487,499 (GRCm39) |
V612I |
possibly damaging |
Het |
| Sema4c |
A |
G |
1: 36,589,422 (GRCm39) |
V568A |
probably damaging |
Het |
| Traf5 |
A |
G |
1: 191,729,636 (GRCm39) |
F472L |
probably damaging |
Het |
| Trim30b |
C |
T |
7: 104,015,107 (GRCm39) |
V94M |
probably damaging |
Het |
| Wasl |
A |
T |
6: 24,619,186 (GRCm39) |
S445T |
unknown |
Het |
| Zfp541 |
A |
G |
7: 15,813,620 (GRCm39) |
K758E |
probably damaging |
Het |
|
| Other mutations in Dcaf13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00787:Dcaf13
|
APN |
15 |
39,007,027 (GRCm39) |
nonsense |
probably null |
|
|
IGL01081:Dcaf13
|
APN |
15 |
38,982,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01766:Dcaf13
|
APN |
15 |
38,982,145 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02174:Dcaf13
|
APN |
15 |
39,001,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02740:Dcaf13
|
APN |
15 |
39,008,495 (GRCm39) |
nonsense |
probably null |
|
|
IGL03092:Dcaf13
|
APN |
15 |
38,991,371 (GRCm39) |
splice site |
probably benign |
|
|
IGL03374:Dcaf13
|
APN |
15 |
39,008,543 (GRCm39) |
nonsense |
probably null |
|
|
R0590:Dcaf13
|
UTSW |
15 |
39,008,480 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Dcaf13
|
UTSW |
15 |
38,986,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0711:Dcaf13
|
UTSW |
15 |
39,001,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1036:Dcaf13
|
UTSW |
15 |
39,007,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Dcaf13
|
UTSW |
15 |
38,993,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Dcaf13
|
UTSW |
15 |
38,982,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1933:Dcaf13
|
UTSW |
15 |
39,001,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2508:Dcaf13
|
UTSW |
15 |
39,008,547 (GRCm39) |
missense |
probably benign |
|
|
R4113:Dcaf13
|
UTSW |
15 |
38,993,615 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4595:Dcaf13
|
UTSW |
15 |
38,982,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Dcaf13
|
UTSW |
15 |
39,001,637 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R5431:Dcaf13
|
UTSW |
15 |
38,986,619 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5454:Dcaf13
|
UTSW |
15 |
38,987,759 (GRCm39) |
missense |
probably benign |
|
|
R5834:Dcaf13
|
UTSW |
15 |
39,007,037 (GRCm39) |
nonsense |
probably null |
|
|
R5929:Dcaf13
|
UTSW |
15 |
39,007,048 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5944:Dcaf13
|
UTSW |
15 |
39,010,072 (GRCm39) |
missense |
probably benign |
|
|
R6319:Dcaf13
|
UTSW |
15 |
39,007,067 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6394:Dcaf13
|
UTSW |
15 |
39,007,132 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6664:Dcaf13
|
UTSW |
15 |
38,982,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6884:Dcaf13
|
UTSW |
15 |
38,986,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7419:Dcaf13
|
UTSW |
15 |
38,993,615 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8750:Dcaf13
|
UTSW |
15 |
38,982,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8944:Dcaf13
|
UTSW |
15 |
39,001,612 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9294:Dcaf13
|
UTSW |
15 |
38,993,687 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9300:Dcaf13
|
UTSW |
15 |
39,010,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9663:Dcaf13
|
UTSW |
15 |
38,982,178 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9696:Dcaf13
|
UTSW |
15 |
39,001,496 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9778:Dcaf13
|
UTSW |
15 |
39,008,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Dcaf13
|
UTSW |
15 |
39,008,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation