Incidental Mutation 'R5944:Dcaf13'
ID 460496
Institutional Source Beutler Lab
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene Name DDB1 and CUL4 associated factor 13
Synonyms Wdsof1, LOC223499
MMRRC Submission 044136-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.955) question?
Stock # R5944 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 38976300-39010251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 39010072 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 419 (M419L)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
AlphaFold Q6PAC3
Predicted Effect probably benign
Transcript: ENSMUST00000022909
AA Change: M419L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: M419L

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227219
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.8%
Validation Efficiency 86% (51/59)
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb G T 5: 114,384,041 (GRCm39) R2190L probably damaging Het
Ankrd17 C T 5: 90,433,702 (GRCm39) R689H probably damaging Het
Apol7b A T 15: 77,307,967 (GRCm39) V176E probably damaging Het
Arsg T C 11: 109,426,137 (GRCm39) F319S probably damaging Het
Bcar3 T A 3: 122,316,932 (GRCm39) D634E probably benign Het
Bend7 T C 2: 4,749,167 (GRCm39) W95R probably damaging Het
Cenpj A G 14: 56,791,115 (GRCm39) probably null Het
Cfap91 G T 16: 38,148,672 (GRCm39) T252N probably damaging Het
Clasrp A T 7: 19,328,431 (GRCm39) Y116N probably damaging Het
Cldn17 T C 16: 88,303,597 (GRCm39) E44G probably damaging Het
Cyfip1 G A 7: 55,521,878 (GRCm39) E61K probably damaging Het
Eml4 A G 17: 83,753,472 (GRCm39) D269G possibly damaging Het
Fap T C 2: 62,372,605 (GRCm39) Y258C probably damaging Het
Fdxr T A 11: 115,160,672 (GRCm39) T288S probably benign Het
Frs3 T C 17: 48,003,233 (GRCm39) probably benign Het
Gm5581 T A 6: 131,145,363 (GRCm39) noncoding transcript Het
Gm7964 A G 7: 83,405,743 (GRCm39) D187G probably benign Het
Gpc5 T C 14: 115,607,250 (GRCm39) V284A probably benign Het
Hspa9 T C 18: 35,082,076 (GRCm39) T177A possibly damaging Het
Ifi202b T A 1: 173,791,365 (GRCm39) M438L probably benign Het
Ighv1-3 T C 12: 114,445,239 (GRCm39) probably benign Het
Krt36 G T 11: 99,996,139 (GRCm39) A95E probably benign Het
Krt9 C T 11: 100,079,265 (GRCm39) S709N unknown Het
Lmntd1 A T 6: 145,373,042 (GRCm39) S164T probably damaging Het
Or14c41 T A 7: 86,234,486 (GRCm39) M1K probably null Het
Or2ag1b A T 7: 106,288,853 (GRCm39) C28* probably null Het
Or52n4b G A 7: 108,144,484 (GRCm39) A249T possibly damaging Het
Or5b94 C T 19: 12,652,283 (GRCm39) T238I probably damaging Het
Or7a41 A T 10: 78,871,223 (GRCm39) M198L probably benign Het
Papola T A 12: 105,778,644 (GRCm39) F341I possibly damaging Het
Phf3 A G 1: 30,859,785 (GRCm39) L914P probably damaging Het
Sec24d T C 3: 123,087,230 (GRCm39) V132A probably benign Het
Serpini1 G A 3: 75,547,606 (GRCm39) D373N probably damaging Het
Sigirr T C 7: 140,671,300 (GRCm39) Y394C probably damaging Het
Slc29a4 G A 5: 142,704,573 (GRCm39) E372K probably damaging Het
Slc7a4 C T 16: 17,392,220 (GRCm39) V405I possibly damaging Het
Spatc1 T C 15: 76,168,138 (GRCm39) L199P probably damaging Het
Srgap3 T C 6: 112,772,775 (GRCm39) M149V possibly damaging Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Het
Stat3 C T 11: 100,785,931 (GRCm39) A449T probably damaging Het
Stat4 A G 1: 52,113,898 (GRCm39) N203D probably damaging Het
Tanc1 T C 2: 59,667,564 (GRCm39) probably null Het
Trav3-1 T C 14: 52,818,449 (GRCm39) I41T probably benign Het
Usp34 T A 11: 23,313,089 (GRCm39) D525E probably damaging Het
Vars1 T C 17: 35,232,620 (GRCm39) V848A probably damaging Het
Vmn2r101 A T 17: 19,809,769 (GRCm39) D185V probably benign Het
Wiz A G 17: 32,576,671 (GRCm39) S628P probably benign Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39,007,027 (GRCm39) nonsense probably null
IGL01081:Dcaf13 APN 15 38,982,201 (GRCm39) missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 38,982,145 (GRCm39) missense probably benign 0.00
IGL02174:Dcaf13 APN 15 39,001,544 (GRCm39) missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 38,982,102 (GRCm39) splice site probably benign
IGL02740:Dcaf13 APN 15 39,008,495 (GRCm39) nonsense probably null
IGL03092:Dcaf13 APN 15 38,991,371 (GRCm39) splice site probably benign
IGL03374:Dcaf13 APN 15 39,008,543 (GRCm39) nonsense probably null
R0590:Dcaf13 UTSW 15 39,008,480 (GRCm39) splice site probably benign
R0594:Dcaf13 UTSW 15 38,986,663 (GRCm39) missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39,001,484 (GRCm39) missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39,007,113 (GRCm39) missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 38,993,633 (GRCm39) missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 38,982,294 (GRCm39) missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39,001,483 (GRCm39) missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39,008,547 (GRCm39) missense probably benign
R4113:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 38,982,288 (GRCm39) missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39,001,637 (GRCm39) missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 38,986,619 (GRCm39) missense probably benign 0.16
R5454:Dcaf13 UTSW 15 38,987,759 (GRCm39) missense probably benign
R5834:Dcaf13 UTSW 15 39,007,037 (GRCm39) nonsense probably null
R5929:Dcaf13 UTSW 15 39,007,048 (GRCm39) missense possibly damaging 0.89
R6319:Dcaf13 UTSW 15 39,007,067 (GRCm39) missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39,007,132 (GRCm39) missense probably benign 0.04
R6664:Dcaf13 UTSW 15 38,982,283 (GRCm39) missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 38,986,635 (GRCm39) missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R8750:Dcaf13 UTSW 15 38,982,836 (GRCm39) missense probably damaging 1.00
R8944:Dcaf13 UTSW 15 39,001,612 (GRCm39) missense possibly damaging 0.79
R9294:Dcaf13 UTSW 15 38,993,687 (GRCm39) missense possibly damaging 0.92
R9300:Dcaf13 UTSW 15 39,010,102 (GRCm39) missense probably damaging 1.00
R9663:Dcaf13 UTSW 15 38,982,178 (GRCm39) missense possibly damaging 0.88
R9696:Dcaf13 UTSW 15 39,001,496 (GRCm39) missense possibly damaging 0.80
R9778:Dcaf13 UTSW 15 39,008,586 (GRCm39) missense probably damaging 0.99
Z1088:Dcaf13 UTSW 15 39,008,642 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTAAACTTAGTAAGGGATGCTGGG -3'
(R):5'- AGCTGGCTCTTAGATCAGTGC -3'

Sequencing Primer
(F):5'- GCATGCAGCACTAAGGTGTATTCC -3'
(R):5'- CTGGCTCTTAGATCAGTGCAAGTAG -3'
Posted On 2017-02-28