Incidental Mutation 'R1727:Slit3'
| ID |
198252 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slit3
|
| Ensembl Gene |
ENSMUSG00000056427 |
| Gene Name |
slit guidance ligand 3 |
| Synonyms |
Slit1, b2b2362.1Clo |
| MMRRC Submission |
039759-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.871)
|
| Stock # |
R1727 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
35012283-35599334 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 35520659 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 599
(R599C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066857
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069837]
|
| AlphaFold |
Q9WVB4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069837
AA Change: R599C
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000066857
Gene: ENSMUSG00000056427
AA Change: R599C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
23 |
N/A |
INTRINSIC |
|
LRRNT
|
33 |
65 |
2.12e-8 |
SMART |
|
LRR
|
59 |
83 |
1.37e2 |
SMART |
|
LRR_TYP
|
84 |
107 |
1.12e-3 |
SMART |
|
LRR_TYP
|
108 |
131 |
7.78e-3 |
SMART |
|
LRR_TYP
|
132 |
155 |
5.42e-2 |
SMART |
|
LRR
|
156 |
179 |
5.88e0 |
SMART |
|
LRR
|
180 |
203 |
7.55e-1 |
SMART |
|
LRRCT
|
215 |
264 |
1.33e-6 |
SMART |
|
LRRNT
|
279 |
311 |
6.79e-7 |
SMART |
|
LRR
|
305 |
329 |
1.16e2 |
SMART |
|
LRR
|
330 |
353 |
1.26e1 |
SMART |
|
LRR_TYP
|
354 |
377 |
2.79e-4 |
SMART |
|
LRR
|
378 |
401 |
4.05e-1 |
SMART |
|
LRR
|
402 |
425 |
4.05e-1 |
SMART |
|
LRRCT
|
437 |
486 |
7.75e-8 |
SMART |
|
LRRNT
|
504 |
536 |
1.95e-7 |
SMART |
|
LRR_TYP
|
556 |
579 |
7.49e-5 |
SMART |
|
LRR
|
581 |
603 |
6.41e1 |
SMART |
|
LRR_TYP
|
604 |
627 |
2.53e-2 |
SMART |
|
LRR
|
628 |
651 |
1.76e-1 |
SMART |
|
LRRCT
|
663 |
712 |
2.52e-7 |
SMART |
|
LRRNT
|
724 |
756 |
3e-8 |
SMART |
|
LRR
|
774 |
797 |
2.14e0 |
SMART |
|
LRR_TYP
|
798 |
821 |
2.95e-3 |
SMART |
|
LRR_TYP
|
822 |
845 |
2.43e-4 |
SMART |
|
LRRCT
|
857 |
906 |
1.12e-13 |
SMART |
|
EGF
|
919 |
953 |
6.86e-4 |
SMART |
|
EGF
|
958 |
994 |
8.84e-7 |
SMART |
|
EGF
|
999 |
1032 |
1.13e-4 |
SMART |
|
EGF
|
1037 |
1072 |
2.3e-5 |
SMART |
|
EGF_CA
|
1074 |
1110 |
5.92e-8 |
SMART |
|
EGF
|
1122 |
1155 |
3.79e-6 |
SMART |
|
LamG
|
1178 |
1314 |
3.16e-34 |
SMART |
|
EGF
|
1331 |
1365 |
2.19e-2 |
SMART |
|
EGF
|
1371 |
1403 |
1.13e-4 |
SMART |
|
EGF
|
1411 |
1444 |
5.57e-4 |
SMART |
|
CT
|
1455 |
1523 |
4.56e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.3654 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.3%
|
| Validation Efficiency |
96% (98/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts6 |
T |
C |
13: 104,565,472 (GRCm39) |
|
probably benign |
Het |
| Ak2 |
C |
T |
4: 128,901,556 (GRCm39) |
P159L |
probably damaging |
Het |
| Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
| Akr1a1 |
A |
G |
4: 116,498,248 (GRCm39) |
L99P |
probably damaging |
Het |
| Anxa8 |
T |
A |
14: 33,811,547 (GRCm39) |
M34K |
probably damaging |
Het |
| Axl |
T |
G |
7: 25,460,191 (GRCm39) |
D767A |
possibly damaging |
Het |
| B430305J03Rik |
A |
G |
3: 61,271,299 (GRCm39) |
|
probably benign |
Het |
| Cdh24 |
A |
T |
14: 54,876,095 (GRCm39) |
Y182* |
probably null |
Het |
| Cdk5rap2 |
T |
C |
4: 70,190,916 (GRCm39) |
D1043G |
probably benign |
Het |
| Cdk5rap2 |
A |
T |
4: 70,208,209 (GRCm39) |
S746T |
possibly damaging |
Het |
| Cep120 |
T |
C |
18: 53,860,801 (GRCm39) |
M210V |
probably benign |
Het |
| Chga |
C |
T |
12: 102,527,696 (GRCm39) |
H117Y |
possibly damaging |
Het |
| Cnga4 |
T |
C |
7: 105,054,961 (GRCm39) |
W79R |
probably damaging |
Het |
| Cntnap5b |
C |
T |
1: 100,141,469 (GRCm39) |
T575I |
possibly damaging |
Het |
| Col6a3 |
T |
A |
1: 90,724,296 (GRCm39) |
|
probably null |
Het |
| Copz2 |
T |
C |
11: 96,744,301 (GRCm39) |
V71A |
probably benign |
Het |
| Dennd3 |
G |
T |
15: 73,436,977 (GRCm39) |
R1068L |
possibly damaging |
Het |
| Dhrs7 |
T |
C |
12: 72,706,238 (GRCm39) |
T56A |
probably damaging |
Het |
| Dnah17 |
G |
A |
11: 117,961,315 (GRCm39) |
T2557I |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 117,987,362 (GRCm39) |
L1320* |
probably null |
Het |
| Dynlt2b |
T |
A |
16: 32,241,751 (GRCm39) |
M78K |
probably benign |
Het |
| Eif3b |
T |
C |
5: 140,411,077 (GRCm39) |
I176T |
probably damaging |
Het |
| Eif4b |
T |
A |
15: 101,998,497 (GRCm39) |
D392E |
possibly damaging |
Het |
| Eif4h |
T |
C |
5: 134,668,134 (GRCm39) |
Y7C |
probably damaging |
Het |
| Enam |
A |
T |
5: 88,651,853 (GRCm39) |
S1046C |
probably damaging |
Het |
| Epg5 |
T |
A |
18: 78,059,030 (GRCm39) |
V1928E |
possibly damaging |
Het |
| Erbin |
T |
A |
13: 103,964,476 (GRCm39) |
E1222V |
probably benign |
Het |
| Fhdc1 |
T |
A |
3: 84,353,483 (GRCm39) |
I581F |
possibly damaging |
Het |
| Fhip2b |
C |
A |
14: 70,831,438 (GRCm39) |
G32V |
probably damaging |
Het |
| Fstl4 |
A |
C |
11: 52,959,478 (GRCm39) |
Q173P |
probably damaging |
Het |
| Gm266 |
A |
G |
12: 111,451,913 (GRCm39) |
F98L |
possibly damaging |
Het |
| Gsdmc2 |
T |
C |
15: 63,721,628 (GRCm39) |
|
probably benign |
Het |
| Gtf2h3 |
A |
G |
5: 124,728,419 (GRCm39) |
Q156R |
probably benign |
Het |
| H2-T23 |
T |
C |
17: 36,342,545 (GRCm39) |
T198A |
possibly damaging |
Het |
| Il1r1 |
C |
A |
1: 40,332,424 (GRCm39) |
A68E |
probably benign |
Het |
| Kcna7 |
A |
T |
7: 45,058,930 (GRCm39) |
I406F |
possibly damaging |
Het |
| Lbr |
A |
G |
1: 181,647,481 (GRCm39) |
I432T |
probably benign |
Het |
| Lnx1 |
A |
T |
5: 74,768,577 (GRCm39) |
|
probably null |
Het |
| Lrrcc1 |
T |
A |
3: 14,602,423 (GRCm39) |
I50N |
probably damaging |
Het |
| Lss |
T |
C |
10: 76,375,678 (GRCm39) |
V237A |
possibly damaging |
Het |
| Mcm10 |
A |
G |
2: 5,011,336 (GRCm39) |
F212L |
probably benign |
Het |
| Methig1 |
A |
C |
15: 100,251,130 (GRCm39) |
I14L |
probably benign |
Het |
| Mrpl41 |
A |
T |
2: 24,864,636 (GRCm39) |
V55E |
probably damaging |
Het |
| Mtfp1 |
C |
A |
11: 4,043,982 (GRCm39) |
D83Y |
probably damaging |
Het |
| Myh1 |
T |
A |
11: 67,101,292 (GRCm39) |
|
probably benign |
Het |
| Myo1e |
T |
C |
9: 70,283,806 (GRCm39) |
F834S |
possibly damaging |
Het |
| Ndufs7 |
A |
T |
10: 80,091,853 (GRCm39) |
|
probably benign |
Het |
| Nlrp4e |
T |
A |
7: 23,020,420 (GRCm39) |
N302K |
probably benign |
Het |
| Nt5e |
T |
A |
9: 88,210,082 (GRCm39) |
M115K |
possibly damaging |
Het |
| Nup153 |
A |
T |
13: 46,847,261 (GRCm39) |
C723S |
probably damaging |
Het |
| Obox6 |
G |
A |
7: 15,568,502 (GRCm39) |
P125S |
probably benign |
Het |
| Or1n2 |
G |
A |
2: 36,797,405 (GRCm39) |
C149Y |
probably benign |
Het |
| Or2t48 |
A |
T |
11: 58,420,342 (GRCm39) |
S157T |
possibly damaging |
Het |
| Or52n3 |
C |
T |
7: 104,530,721 (GRCm39) |
T269I |
probably benign |
Het |
| Or5an11 |
T |
G |
19: 12,246,365 (GRCm39) |
I257S |
possibly damaging |
Het |
| Or8i2 |
A |
G |
2: 86,852,607 (GRCm39) |
F94L |
probably damaging |
Het |
| Pcdh1 |
A |
C |
18: 38,336,085 (GRCm39) |
Y44* |
probably null |
Het |
| Pcdhb6 |
A |
T |
18: 37,467,640 (GRCm39) |
D187V |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,727,001 (GRCm39) |
|
probably benign |
Het |
| Pdcl3 |
T |
A |
1: 39,034,836 (GRCm39) |
I80K |
possibly damaging |
Het |
| Pde12 |
A |
T |
14: 26,390,022 (GRCm39) |
V229E |
probably benign |
Het |
| Plcg1 |
A |
G |
2: 160,590,008 (GRCm39) |
E142G |
probably benign |
Het |
| Plxnb1 |
A |
G |
9: 108,930,125 (GRCm39) |
|
probably null |
Het |
| Pnpla1 |
A |
G |
17: 29,097,508 (GRCm39) |
I225V |
probably benign |
Het |
| Polr2f |
A |
G |
15: 79,028,805 (GRCm39) |
|
probably benign |
Het |
| Prob1 |
A |
G |
18: 35,787,364 (GRCm39) |
S297P |
possibly damaging |
Het |
| Qsox2 |
A |
C |
2: 26,110,970 (GRCm39) |
S132A |
probably benign |
Het |
| Rab19 |
T |
A |
6: 39,365,095 (GRCm39) |
Y118* |
probably null |
Het |
| Rfwd3 |
C |
T |
8: 112,014,874 (GRCm39) |
R326Q |
probably damaging |
Het |
| Rptn |
T |
C |
3: 93,304,445 (GRCm39) |
S593P |
possibly damaging |
Het |
| Septin11 |
T |
C |
5: 93,304,783 (GRCm39) |
I200T |
probably damaging |
Het |
| Slc10a4 |
T |
A |
5: 73,173,491 (GRCm39) |
|
probably benign |
Het |
| Slc9c1 |
A |
T |
16: 45,422,324 (GRCm39) |
I1130F |
probably benign |
Het |
| Snx19 |
C |
T |
9: 30,344,662 (GRCm39) |
P622L |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,471,782 (GRCm39) |
L50P |
probably damaging |
Het |
| St8sia1 |
A |
T |
6: 142,822,453 (GRCm39) |
C137S |
probably damaging |
Het |
| Syt11 |
G |
C |
3: 88,669,259 (GRCm39) |
T211S |
possibly damaging |
Het |
| Tanc1 |
A |
C |
2: 59,621,153 (GRCm39) |
Y324S |
probably damaging |
Het |
| Tas2r136 |
T |
C |
6: 132,754,753 (GRCm39) |
I125V |
possibly damaging |
Het |
| Tbc1d15 |
A |
T |
10: 115,046,130 (GRCm39) |
W458R |
probably damaging |
Het |
| Tecta |
G |
T |
9: 42,270,597 (GRCm39) |
T1237N |
probably damaging |
Het |
| Tet2 |
T |
A |
3: 133,193,051 (GRCm39) |
D461V |
probably damaging |
Het |
| Tmco3 |
G |
A |
8: 13,368,866 (GRCm39) |
V573M |
possibly damaging |
Het |
| Tmem212 |
A |
T |
3: 27,938,961 (GRCm39) |
M175K |
probably benign |
Het |
| Traf6 |
A |
G |
2: 101,527,084 (GRCm39) |
H278R |
probably benign |
Het |
| Trerf1 |
T |
A |
17: 47,652,092 (GRCm39) |
|
noncoding transcript |
Het |
| Ttn |
A |
C |
2: 76,576,988 (GRCm39) |
V24635G |
probably damaging |
Het |
| Ush1c |
A |
T |
7: 45,858,655 (GRCm39) |
D544E |
probably damaging |
Het |
| Usp47 |
C |
T |
7: 111,685,307 (GRCm39) |
T586M |
probably damaging |
Het |
| Vmn2r1 |
T |
A |
3: 63,989,163 (GRCm39) |
M34K |
probably benign |
Het |
| Vmn2r102 |
T |
A |
17: 19,897,770 (GRCm39) |
W262R |
probably damaging |
Het |
| Wasf3 |
C |
T |
5: 146,403,769 (GRCm39) |
A293V |
probably benign |
Het |
| Xrn2 |
A |
G |
2: 146,903,436 (GRCm39) |
Q812R |
probably benign |
Het |
| Zc3h7b |
T |
C |
15: 81,652,230 (GRCm39) |
I10T |
probably damaging |
Het |
| Zfp747 |
A |
T |
7: 126,973,249 (GRCm39) |
L307Q |
probably damaging |
Het |
| Zfp777 |
A |
T |
6: 48,020,824 (GRCm39) |
F266Y |
probably damaging |
Het |
|
| Other mutations in Slit3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00731:Slit3
|
APN |
11 |
35,512,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Slit3
|
APN |
11 |
35,501,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01612:Slit3
|
APN |
11 |
35,591,211 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02145:Slit3
|
APN |
11 |
35,520,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02146:Slit3
|
APN |
11 |
35,125,675 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02430:Slit3
|
APN |
11 |
35,068,601 (GRCm39) |
splice site |
probably null |
|
|
IGL02528:Slit3
|
APN |
11 |
35,469,801 (GRCm39) |
missense |
probably benign |
|
|
IGL02530:Slit3
|
APN |
11 |
35,598,969 (GRCm39) |
makesense |
probably null |
|
|
IGL02640:Slit3
|
APN |
11 |
35,591,172 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02819:Slit3
|
APN |
11 |
35,062,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Slit3
|
APN |
11 |
35,539,874 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03150:Slit3
|
APN |
11 |
35,399,084 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03161:Slit3
|
APN |
11 |
35,591,241 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03336:Slit3
|
APN |
11 |
35,560,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Bloated
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
Quellung
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02988:Slit3
|
UTSW |
11 |
35,598,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4791001:Slit3
|
UTSW |
11 |
35,552,072 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0334:Slit3
|
UTSW |
11 |
35,469,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0385:Slit3
|
UTSW |
11 |
35,591,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0840:Slit3
|
UTSW |
11 |
35,514,263 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Slit3
|
UTSW |
11 |
35,012,462 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1364:Slit3
|
UTSW |
11 |
35,560,934 (GRCm39) |
missense |
probably benign |
|
|
R1476:Slit3
|
UTSW |
11 |
35,577,126 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1508:Slit3
|
UTSW |
11 |
35,461,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Slit3
|
UTSW |
11 |
35,125,733 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1692:Slit3
|
UTSW |
11 |
35,550,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1696:Slit3
|
UTSW |
11 |
35,566,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1752:Slit3
|
UTSW |
11 |
35,455,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1970:Slit3
|
UTSW |
11 |
35,521,668 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2077:Slit3
|
UTSW |
11 |
35,435,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2126:Slit3
|
UTSW |
11 |
35,579,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Slit3
|
UTSW |
11 |
35,503,088 (GRCm39) |
splice site |
probably null |
|
|
R2162:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R2873:Slit3
|
UTSW |
11 |
35,435,620 (GRCm39) |
nonsense |
probably null |
|
|
R3813:Slit3
|
UTSW |
11 |
35,566,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3831:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3832:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3833:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3839:Slit3
|
UTSW |
11 |
35,399,064 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4152:Slit3
|
UTSW |
11 |
35,589,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4387:Slit3
|
UTSW |
11 |
35,574,875 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4795:Slit3
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4910:Slit3
|
UTSW |
11 |
35,523,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Slit3
|
UTSW |
11 |
35,579,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5106:Slit3
|
UTSW |
11 |
35,503,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5218:Slit3
|
UTSW |
11 |
35,575,002 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Slit3
|
UTSW |
11 |
35,512,975 (GRCm39) |
missense |
probably benign |
|
|
R5354:Slit3
|
UTSW |
11 |
35,566,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Slit3
|
UTSW |
11 |
35,598,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5896:Slit3
|
UTSW |
11 |
35,598,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5933:Slit3
|
UTSW |
11 |
35,520,578 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5963:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Slit3
|
UTSW |
11 |
35,461,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6153:Slit3
|
UTSW |
11 |
35,591,310 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6484:Slit3
|
UTSW |
11 |
35,552,125 (GRCm39) |
missense |
probably benign |
|
|
R6526:Slit3
|
UTSW |
11 |
35,552,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6797:Slit3
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6887:Slit3
|
UTSW |
11 |
35,435,633 (GRCm39) |
splice site |
probably null |
|
|
R7067:Slit3
|
UTSW |
11 |
35,399,057 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7150:Slit3
|
UTSW |
11 |
35,461,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Slit3
|
UTSW |
11 |
35,490,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Slit3
|
UTSW |
11 |
35,501,516 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7418:Slit3
|
UTSW |
11 |
35,577,255 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7545:Slit3
|
UTSW |
11 |
35,591,139 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7727:Slit3
|
UTSW |
11 |
35,574,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Slit3
|
UTSW |
11 |
35,591,235 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8177:Slit3
|
UTSW |
11 |
35,469,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Slit3
|
UTSW |
11 |
35,554,903 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8416:Slit3
|
UTSW |
11 |
35,399,062 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8417:Slit3
|
UTSW |
11 |
35,501,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8476:Slit3
|
UTSW |
11 |
35,520,596 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8785:Slit3
|
UTSW |
11 |
35,560,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8955:Slit3
|
UTSW |
11 |
35,589,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9040:Slit3
|
UTSW |
11 |
35,594,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9068:Slit3
|
UTSW |
11 |
35,574,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Slit3
|
UTSW |
11 |
35,012,463 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9266:Slit3
|
UTSW |
11 |
35,598,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9539:Slit3
|
UTSW |
11 |
35,589,155 (GRCm39) |
nonsense |
probably null |
|
|
R9636:Slit3
|
UTSW |
11 |
35,594,088 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0028:Slit3
|
UTSW |
11 |
35,455,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Slit3
|
UTSW |
11 |
35,598,751 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACCTGCTGTGAGAAGTGACCTTG -3'
(R):5'- TGCTTGAACGTAGATGCTCGCC -3'
Sequencing Primer
(F):5'- CAAGCTGAGACTCCAGTGTC -3'
(R):5'- AACGTAGATGCTCGCCTTCAG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation