Incidental Mutation 'R1892:Ptpn13'
| ID |
211583 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptpn13
|
| Ensembl Gene |
ENSMUSG00000034573 |
| Gene Name |
protein tyrosine phosphatase, non-receptor type 13 |
| Synonyms |
PTPL1, PTP-BL, Ptpri |
| MMRRC Submission |
039912-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.247)
|
| Stock # |
R1892 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
103573058-103746169 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 103649545 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 316
(Y316C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048119
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048957]
[ENSMUST00000196014]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000048957
AA Change: Y316C
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000048119
Gene: ENSMUSG00000034573
AA Change: Y316C
| Domain | Start | End | E-Value | Type |
|---|
|
KIND
|
3 |
190 |
2.3e-80 |
SMART |
|
Blast:B41
|
340 |
447 |
6e-34 |
BLAST |
|
coiled coil region
|
460 |
487 |
N/A |
INTRINSIC |
|
B41
|
561 |
774 |
3.3e-68 |
SMART |
|
FERM_C
|
780 |
869 |
3.2e-35 |
SMART |
|
low complexity region
|
1049 |
1058 |
N/A |
INTRINSIC |
|
PDZ
|
1093 |
1170 |
7.6e-25 |
SMART |
|
low complexity region
|
1224 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1309 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1331 |
1341 |
N/A |
INTRINSIC |
|
PDZ
|
1365 |
1442 |
1.7e-24 |
SMART |
|
low complexity region
|
1450 |
1468 |
N/A |
INTRINSIC |
|
PDZ
|
1499 |
1579 |
3.5e-19 |
SMART |
|
PDZ
|
1773 |
1845 |
1.2e-21 |
SMART |
|
PDZ
|
1867 |
1942 |
1.6e-16 |
SMART |
|
low complexity region
|
2123 |
2134 |
N/A |
INTRINSIC |
|
PTPc
|
2179 |
2436 |
6.9e-113 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196014
|
| SMART Domains |
Protein: ENSMUSP00000143571
Gene: ENSMUSG00000034573
| Domain | Start | End | E-Value | Type |
|---|
|
KIND
|
3 |
190 |
2.3e-80 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196800
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199412
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal T-helper cell differentiation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
G |
A |
7: 119,815,561 (GRCm39) |
A270T |
probably benign |
Het |
| Abcb7 |
A |
T |
X: 103,386,142 (GRCm39) |
H97Q |
probably damaging |
Het |
| Adat3 |
T |
C |
10: 80,442,249 (GRCm39) |
L29P |
probably damaging |
Het |
| AI987944 |
A |
T |
7: 41,024,020 (GRCm39) |
C320S |
probably damaging |
Het |
| Asic4 |
C |
T |
1: 75,446,126 (GRCm39) |
R285W |
probably damaging |
Het |
| Asic5 |
A |
T |
3: 81,928,293 (GRCm39) |
I419L |
probably damaging |
Het |
| Batf |
A |
G |
12: 85,736,102 (GRCm39) |
K42E |
probably damaging |
Het |
| Bcar3 |
A |
G |
3: 122,301,785 (GRCm39) |
N160S |
probably benign |
Het |
| Bco2 |
C |
A |
9: 50,461,863 (GRCm39) |
G47V |
probably damaging |
Het |
| Bicc1 |
T |
G |
10: 70,794,614 (GRCm39) |
K181T |
probably damaging |
Het |
| Brinp2 |
A |
G |
1: 158,082,542 (GRCm39) |
|
probably null |
Het |
| Cacng8 |
A |
G |
7: 3,463,568 (GRCm39) |
D240G |
possibly damaging |
Het |
| Calca |
A |
G |
7: 114,232,962 (GRCm39) |
Y96H |
probably damaging |
Het |
| Cdh1 |
A |
T |
8: 107,390,882 (GRCm39) |
K666I |
possibly damaging |
Het |
| Cdh16 |
A |
T |
8: 105,344,631 (GRCm39) |
I500N |
possibly damaging |
Het |
| Chst14 |
A |
G |
2: 118,757,830 (GRCm39) |
Y208C |
probably damaging |
Het |
| Chst9 |
T |
C |
18: 15,586,017 (GRCm39) |
H182R |
probably damaging |
Het |
| Clk2 |
A |
G |
3: 89,082,502 (GRCm39) |
I367M |
possibly damaging |
Het |
| Cobl |
G |
C |
11: 12,203,258 (GRCm39) |
S1066W |
probably damaging |
Het |
| Ctcfl |
A |
G |
2: 172,960,478 (GRCm39) |
V35A |
probably benign |
Het |
| Dchs1 |
G |
T |
7: 105,413,363 (GRCm39) |
H1151N |
probably benign |
Het |
| Dennd1c |
T |
C |
17: 57,374,083 (GRCm39) |
T529A |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 118,070,209 (GRCm39) |
V1532D |
possibly damaging |
Het |
| Dync1h1 |
A |
G |
12: 110,612,738 (GRCm39) |
Y2871C |
probably damaging |
Het |
| Dytn |
T |
C |
1: 63,716,420 (GRCm39) |
E51G |
probably benign |
Het |
| Esd |
C |
T |
14: 74,987,113 (GRCm39) |
A266V |
probably damaging |
Het |
| Gli1 |
T |
C |
10: 127,165,975 (GRCm39) |
M1093V |
possibly damaging |
Het |
| Gm15446 |
A |
G |
5: 110,091,253 (GRCm39) |
K502E |
probably damaging |
Het |
| Gm4076 |
T |
A |
13: 85,275,447 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9830 |
A |
G |
9: 44,375,825 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9938 |
G |
A |
19: 23,701,955 (GRCm39) |
|
probably benign |
Het |
| Grhl1 |
G |
A |
12: 24,634,909 (GRCm39) |
R245H |
probably damaging |
Het |
| Hnrnpul1 |
A |
T |
7: 25,426,191 (GRCm39) |
D553E |
probably benign |
Het |
| Hpn |
G |
A |
7: 30,798,468 (GRCm39) |
Q415* |
probably null |
Het |
| Hsd11b1 |
T |
G |
1: 192,906,068 (GRCm39) |
M175L |
probably benign |
Het |
| Htra1 |
G |
A |
7: 130,586,799 (GRCm39) |
V461I |
possibly damaging |
Het |
| Il1rl2 |
A |
G |
1: 40,366,694 (GRCm39) |
H76R |
probably damaging |
Het |
| Insrr |
G |
A |
3: 87,721,184 (GRCm39) |
V1112M |
probably damaging |
Het |
| Ints9 |
T |
C |
14: 65,257,872 (GRCm39) |
S351P |
probably benign |
Het |
| Itgav |
T |
A |
2: 83,601,680 (GRCm39) |
N350K |
probably damaging |
Het |
| Kdm4d |
C |
A |
9: 14,375,613 (GRCm39) |
V82L |
probably benign |
Het |
| Klc1 |
T |
C |
12: 111,748,261 (GRCm39) |
|
probably null |
Het |
| Kmt5c |
T |
A |
7: 4,745,714 (GRCm39) |
C69* |
probably null |
Het |
| Lgals3 |
T |
G |
14: 47,622,164 (GRCm39) |
N193K |
possibly damaging |
Het |
| Morc2b |
T |
A |
17: 33,354,748 (GRCm39) |
D1008V |
probably damaging |
Het |
| Mpg |
C |
T |
11: 32,181,720 (GRCm39) |
Q243* |
probably null |
Het |
| Muc15 |
C |
T |
2: 110,567,697 (GRCm39) |
R281* |
probably null |
Het |
| Ncstn |
CAGCTCCACGAAG |
CAG |
1: 171,899,038 (GRCm39) |
|
probably null |
Het |
| Nek5 |
A |
G |
8: 22,597,745 (GRCm39) |
M278T |
probably benign |
Het |
| Npas2 |
A |
G |
1: 39,384,503 (GRCm39) |
T599A |
probably benign |
Het |
| Nrf1 |
A |
G |
6: 30,144,787 (GRCm39) |
D519G |
probably null |
Het |
| Nup43 |
A |
G |
10: 7,549,373 (GRCm39) |
H176R |
probably damaging |
Het |
| Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
| Or10j3 |
T |
C |
1: 173,031,795 (GRCm39) |
Y291H |
probably damaging |
Het |
| Or5p72 |
A |
T |
7: 108,022,147 (GRCm39) |
Y123F |
possibly damaging |
Het |
| Or6c75 |
A |
C |
10: 129,336,902 (GRCm39) |
I50L |
probably benign |
Het |
| Perm1 |
C |
T |
4: 156,302,340 (GRCm39) |
R295C |
probably benign |
Het |
| Pik3ip1 |
G |
T |
11: 3,283,304 (GRCm39) |
A135S |
probably damaging |
Het |
| Pira13 |
A |
C |
7: 3,827,573 (GRCm39) |
C195G |
probably benign |
Het |
| Ppp4c |
A |
G |
7: 126,385,452 (GRCm39) |
V119A |
probably damaging |
Het |
| Prepl |
A |
G |
17: 85,395,878 (GRCm39) |
Y35H |
possibly damaging |
Het |
| Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
| Ranbp2 |
T |
C |
10: 58,299,921 (GRCm39) |
V491A |
probably benign |
Het |
| Ranbp9 |
C |
A |
13: 43,569,933 (GRCm39) |
C495F |
possibly damaging |
Het |
| Rfx8 |
A |
T |
1: 39,709,746 (GRCm39) |
|
probably null |
Het |
| Rnf111 |
T |
A |
9: 70,383,656 (GRCm39) |
K92N |
probably damaging |
Het |
| Rtn1 |
A |
G |
12: 72,259,337 (GRCm39) |
I772T |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,673,844 (GRCm39) |
K72* |
probably null |
Het |
| Sergef |
A |
T |
7: 46,264,040 (GRCm39) |
|
probably null |
Het |
| Sez6l |
T |
C |
5: 112,620,665 (GRCm39) |
N305S |
probably damaging |
Het |
| Slc40a1 |
A |
T |
1: 45,950,302 (GRCm39) |
C383* |
probably null |
Het |
| Stab2 |
C |
T |
10: 86,773,913 (GRCm39) |
C806Y |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,524,189 (GRCm39) |
T795A |
probably benign |
Het |
| Stk31 |
T |
C |
6: 49,415,408 (GRCm39) |
I536T |
probably damaging |
Het |
| Stox1 |
T |
A |
10: 62,501,178 (GRCm39) |
T461S |
possibly damaging |
Het |
| Suv39h2 |
T |
C |
2: 3,460,805 (GRCm39) |
Y219C |
probably damaging |
Het |
| Tap1 |
T |
G |
17: 34,413,915 (GRCm39) |
D643E |
probably damaging |
Het |
| Tbc1d2b |
T |
A |
9: 90,100,996 (GRCm39) |
I665F |
probably damaging |
Het |
| Tdrd6 |
T |
C |
17: 43,935,696 (GRCm39) |
N1784S |
probably benign |
Het |
| Tmem14c |
T |
C |
13: 41,174,633 (GRCm39) |
F81L |
possibly damaging |
Het |
| Tnrc6c |
A |
G |
11: 117,605,188 (GRCm39) |
N108D |
probably benign |
Het |
| Tox3 |
A |
T |
8: 90,996,869 (GRCm39) |
N131K |
probably benign |
Het |
| Tspear |
T |
A |
10: 77,706,308 (GRCm39) |
D359E |
probably benign |
Het |
| Ttc9 |
A |
G |
12: 81,678,551 (GRCm39) |
I125V |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,728,531 (GRCm39) |
|
probably benign |
Het |
| Ubn2 |
C |
T |
6: 38,468,226 (GRCm39) |
S980F |
probably damaging |
Het |
| Vcf1 |
G |
T |
11: 113,554,212 (GRCm39) |
P161H |
probably damaging |
Het |
| Zfp362 |
T |
A |
4: 128,684,057 (GRCm39) |
T30S |
probably benign |
Het |
| Zfp385c |
A |
C |
11: 100,528,630 (GRCm39) |
H32Q |
probably damaging |
Het |
| Zfp870 |
A |
T |
17: 33,102,863 (GRCm39) |
H156Q |
possibly damaging |
Het |
| Zfp873 |
T |
C |
10: 81,897,080 (GRCm39) |
C641R |
probably damaging |
Het |
| Zfp950 |
A |
T |
19: 61,107,549 (GRCm39) |
H511Q |
probably benign |
Het |
|
| Other mutations in Ptpn13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Ptpn13
|
APN |
5 |
103,698,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00569:Ptpn13
|
APN |
5 |
103,738,872 (GRCm39) |
splice site |
probably benign |
|
|
IGL00764:Ptpn13
|
APN |
5 |
103,745,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00805:Ptpn13
|
APN |
5 |
103,702,595 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL00922:Ptpn13
|
APN |
5 |
103,735,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00959:Ptpn13
|
APN |
5 |
103,665,437 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01090:Ptpn13
|
APN |
5 |
103,689,180 (GRCm39) |
missense |
probably null |
0.80 |
|
IGL01352:Ptpn13
|
APN |
5 |
103,634,641 (GRCm39) |
splice site |
probably null |
|
|
IGL01510:Ptpn13
|
APN |
5 |
103,710,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01515:Ptpn13
|
APN |
5 |
103,703,979 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01896:Ptpn13
|
APN |
5 |
103,649,389 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02094:Ptpn13
|
APN |
5 |
103,742,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02561:Ptpn13
|
APN |
5 |
103,710,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02562:Ptpn13
|
APN |
5 |
103,710,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02567:Ptpn13
|
APN |
5 |
103,710,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Ptpn13
|
APN |
5 |
103,649,769 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02679:Ptpn13
|
APN |
5 |
103,717,320 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02981:Ptpn13
|
APN |
5 |
103,676,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03131:Ptpn13
|
APN |
5 |
103,665,425 (GRCm39) |
missense |
probably benign |
|
|
IGL03136:Ptpn13
|
APN |
5 |
103,691,329 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL03163:Ptpn13
|
APN |
5 |
103,739,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03271:Ptpn13
|
APN |
5 |
103,610,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Ptpn13
|
APN |
5 |
103,688,943 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03328:Ptpn13
|
APN |
5 |
103,664,214 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03343:Ptpn13
|
APN |
5 |
103,702,816 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02835:Ptpn13
|
UTSW |
5 |
103,707,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0021:Ptpn13
|
UTSW |
5 |
103,676,686 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0017:Ptpn13
|
UTSW |
5 |
103,634,638 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0090:Ptpn13
|
UTSW |
5 |
103,717,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0111:Ptpn13
|
UTSW |
5 |
103,728,629 (GRCm39) |
splice site |
probably benign |
|
|
R0183:Ptpn13
|
UTSW |
5 |
103,664,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0230:Ptpn13
|
UTSW |
5 |
103,674,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0302:Ptpn13
|
UTSW |
5 |
103,713,091 (GRCm39) |
missense |
probably benign |
|
|
R0360:Ptpn13
|
UTSW |
5 |
103,681,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0364:Ptpn13
|
UTSW |
5 |
103,681,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0388:Ptpn13
|
UTSW |
5 |
103,702,928 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0504:Ptpn13
|
UTSW |
5 |
103,649,362 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0558:Ptpn13
|
UTSW |
5 |
103,677,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0562:Ptpn13
|
UTSW |
5 |
103,664,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0568:Ptpn13
|
UTSW |
5 |
103,637,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0609:Ptpn13
|
UTSW |
5 |
103,704,011 (GRCm39) |
missense |
probably benign |
|
|
R0669:Ptpn13
|
UTSW |
5 |
103,703,975 (GRCm39) |
missense |
probably benign |
|
|
R0739:Ptpn13
|
UTSW |
5 |
103,722,998 (GRCm39) |
missense |
probably benign |
|
|
R1006:Ptpn13
|
UTSW |
5 |
103,734,655 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1164:Ptpn13
|
UTSW |
5 |
103,637,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1274:Ptpn13
|
UTSW |
5 |
103,698,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1501:Ptpn13
|
UTSW |
5 |
103,664,230 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1529:Ptpn13
|
UTSW |
5 |
103,711,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1533:Ptpn13
|
UTSW |
5 |
103,704,044 (GRCm39) |
nonsense |
probably null |
|
|
R1613:Ptpn13
|
UTSW |
5 |
103,684,737 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1616:Ptpn13
|
UTSW |
5 |
103,713,103 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1830:Ptpn13
|
UTSW |
5 |
103,691,325 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1907:Ptpn13
|
UTSW |
5 |
103,728,575 (GRCm39) |
missense |
probably null |
0.45 |
|
R2143:Ptpn13
|
UTSW |
5 |
103,703,999 (GRCm39) |
missense |
probably benign |
|
|
R2145:Ptpn13
|
UTSW |
5 |
103,703,999 (GRCm39) |
missense |
probably benign |
|
|
R2151:Ptpn13
|
UTSW |
5 |
103,673,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2180:Ptpn13
|
UTSW |
5 |
103,717,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Ptpn13
|
UTSW |
5 |
103,637,527 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2313:Ptpn13
|
UTSW |
5 |
103,712,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3522:Ptpn13
|
UTSW |
5 |
103,737,720 (GRCm39) |
splice site |
probably benign |
|
|
R3773:Ptpn13
|
UTSW |
5 |
103,624,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3924:Ptpn13
|
UTSW |
5 |
103,698,607 (GRCm39) |
splice site |
probably benign |
|
|
R4289:Ptpn13
|
UTSW |
5 |
103,681,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4348:Ptpn13
|
UTSW |
5 |
103,717,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Ptpn13
|
UTSW |
5 |
103,681,273 (GRCm39) |
splice site |
probably null |
|
|
R4526:Ptpn13
|
UTSW |
5 |
103,649,335 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4557:Ptpn13
|
UTSW |
5 |
103,688,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4596:Ptpn13
|
UTSW |
5 |
103,671,558 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4632:Ptpn13
|
UTSW |
5 |
103,717,726 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4727:Ptpn13
|
UTSW |
5 |
103,717,721 (GRCm39) |
missense |
probably benign |
|
|
R4780:Ptpn13
|
UTSW |
5 |
103,734,639 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4793:Ptpn13
|
UTSW |
5 |
103,730,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4812:Ptpn13
|
UTSW |
5 |
103,671,481 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4939:Ptpn13
|
UTSW |
5 |
103,665,335 (GRCm39) |
splice site |
probably null |
|
|
R4951:Ptpn13
|
UTSW |
5 |
103,735,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5052:Ptpn13
|
UTSW |
5 |
103,709,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5148:Ptpn13
|
UTSW |
5 |
103,640,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5309:Ptpn13
|
UTSW |
5 |
103,688,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5521:Ptpn13
|
UTSW |
5 |
103,649,294 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5545:Ptpn13
|
UTSW |
5 |
103,709,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5696:Ptpn13
|
UTSW |
5 |
103,702,625 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5735:Ptpn13
|
UTSW |
5 |
103,702,686 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5815:Ptpn13
|
UTSW |
5 |
103,745,556 (GRCm39) |
splice site |
probably null |
|
|
R5876:Ptpn13
|
UTSW |
5 |
103,624,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5878:Ptpn13
|
UTSW |
5 |
103,624,984 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6366:Ptpn13
|
UTSW |
5 |
103,698,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6455:Ptpn13
|
UTSW |
5 |
103,689,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6492:Ptpn13
|
UTSW |
5 |
103,649,478 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6709:Ptpn13
|
UTSW |
5 |
103,734,622 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6759:Ptpn13
|
UTSW |
5 |
103,713,121 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6944:Ptpn13
|
UTSW |
5 |
103,624,857 (GRCm39) |
missense |
probably null |
1.00 |
|
R7079:Ptpn13
|
UTSW |
5 |
103,649,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7253:Ptpn13
|
UTSW |
5 |
103,713,150 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7254:Ptpn13
|
UTSW |
5 |
103,742,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7391:Ptpn13
|
UTSW |
5 |
103,688,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7451:Ptpn13
|
UTSW |
5 |
103,674,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7614:Ptpn13
|
UTSW |
5 |
103,649,331 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7652:Ptpn13
|
UTSW |
5 |
103,677,578 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7655:Ptpn13
|
UTSW |
5 |
103,688,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7656:Ptpn13
|
UTSW |
5 |
103,688,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7683:Ptpn13
|
UTSW |
5 |
103,713,018 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7734:Ptpn13
|
UTSW |
5 |
103,709,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7794:Ptpn13
|
UTSW |
5 |
103,640,090 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7834:Ptpn13
|
UTSW |
5 |
103,610,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7911:Ptpn13
|
UTSW |
5 |
103,688,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8010:Ptpn13
|
UTSW |
5 |
103,707,803 (GRCm39) |
nonsense |
probably null |
|
|
R8308:Ptpn13
|
UTSW |
5 |
103,688,838 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8493:Ptpn13
|
UTSW |
5 |
103,717,671 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8493:Ptpn13
|
UTSW |
5 |
103,712,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Ptpn13
|
UTSW |
5 |
103,705,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8556:Ptpn13
|
UTSW |
5 |
103,707,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8924:Ptpn13
|
UTSW |
5 |
103,739,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8933:Ptpn13
|
UTSW |
5 |
103,727,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8958:Ptpn13
|
UTSW |
5 |
103,698,973 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8975:Ptpn13
|
UTSW |
5 |
103,649,266 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9080:Ptpn13
|
UTSW |
5 |
103,637,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9091:Ptpn13
|
UTSW |
5 |
103,649,735 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9219:Ptpn13
|
UTSW |
5 |
103,745,632 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9270:Ptpn13
|
UTSW |
5 |
103,649,735 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9577:Ptpn13
|
UTSW |
5 |
103,676,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9593:Ptpn13
|
UTSW |
5 |
103,674,998 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9705:Ptpn13
|
UTSW |
5 |
103,681,221 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
RF017:Ptpn13
|
UTSW |
5 |
103,741,446 (GRCm39) |
missense |
probably benign |
0.45 |
|
Z1177:Ptpn13
|
UTSW |
5 |
103,717,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCCATCAGAGACACACGAG -3'
(R):5'- TCGAATTCGGTCCAAAGCGC -3'
Sequencing Primer
(F):5'- CACACGAGATGAGGAAGACTATCTC -3'
(R):5'- GAATTCGGTCCAAAGCGCTTGATAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation