Incidental Mutation 'R2178:Or7c70'
| ID |
237009 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or7c70
|
| Ensembl Gene |
ENSMUSG00000051190 |
| Gene Name |
olfactory receptor family 7 subfamily C member 70 |
| Synonyms |
MOR142-2_p, Olfr1356, MOR142-1, GA_x6K02T2QGN0-2962025-2962987 |
| MMRRC Submission |
040180-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.236)
|
| Stock # |
R2178 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
78682785-78683747 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 78683612 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 46
(I46F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144815
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061289]
[ENSMUST00000205100]
|
| AlphaFold |
Q7TQU8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000061289
AA Change: I46F
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000054345
Gene: ENSMUSG00000051190
AA Change: I46F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
308 |
3.6e-58 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
35 |
305 |
1.4e-5 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
6.5e-22 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000205100
AA Change: I46F
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000144815
Gene: ENSMUSG00000051190
AA Change: I46F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
308 |
3.6e-58 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
35 |
305 |
1.4e-5 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
6.5e-22 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.6%
- 20x: 95.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy6 |
A |
T |
15: 98,492,236 (GRCm39) |
N1007K |
probably damaging |
Het |
| Apon |
C |
A |
10: 128,090,634 (GRCm39) |
A104E |
probably benign |
Het |
| Cdh15 |
T |
A |
8: 123,591,715 (GRCm39) |
|
probably null |
Het |
| Cep135 |
T |
C |
5: 76,779,297 (GRCm39) |
V769A |
probably benign |
Het |
| Cep152 |
A |
T |
2: 125,421,954 (GRCm39) |
|
probably null |
Het |
| Clca3a1 |
T |
C |
3: 144,711,863 (GRCm39) |
N711D |
probably damaging |
Het |
| Col1a2 |
T |
C |
6: 4,531,143 (GRCm39) |
F731L |
unknown |
Het |
| Cpt1b |
T |
C |
15: 89,303,246 (GRCm39) |
E603G |
probably damaging |
Het |
| Cspp1 |
T |
G |
1: 10,174,471 (GRCm39) |
D641E |
possibly damaging |
Het |
| Ddr2 |
C |
T |
1: 169,822,251 (GRCm39) |
R399Q |
probably benign |
Het |
| Dzip1 |
T |
C |
14: 119,126,816 (GRCm39) |
|
probably null |
Het |
| Greb1 |
A |
G |
12: 16,746,388 (GRCm39) |
V1294A |
probably damaging |
Het |
| Hmgb4 |
A |
G |
4: 128,154,275 (GRCm39) |
S98P |
probably damaging |
Het |
| Kif12 |
G |
A |
4: 63,085,196 (GRCm39) |
P515L |
probably benign |
Het |
| Kmt5b |
A |
C |
19: 3,865,372 (GRCm39) |
E789A |
possibly damaging |
Het |
| Lama1 |
G |
T |
17: 68,076,510 (GRCm39) |
V1095F |
probably benign |
Het |
| Leprot |
T |
C |
4: 101,513,308 (GRCm39) |
V32A |
probably benign |
Het |
| Mcoln1 |
A |
G |
8: 3,558,766 (GRCm39) |
T255A |
probably damaging |
Het |
| Mertk |
G |
A |
2: 128,634,984 (GRCm39) |
E765K |
probably damaging |
Het |
| Muc5b |
A |
G |
7: 141,417,853 (GRCm39) |
T3600A |
possibly damaging |
Het |
| Ncapd3 |
A |
T |
9: 26,999,845 (GRCm39) |
E1395V |
probably benign |
Het |
| Ntrk2 |
T |
C |
13: 58,956,616 (GRCm39) |
F25S |
probably benign |
Het |
| Or2a5 |
A |
G |
6: 42,873,732 (GRCm39) |
M116V |
probably benign |
Het |
| Or6z1 |
G |
T |
7: 6,504,487 (GRCm39) |
A246D |
probably damaging |
Het |
| Pappa |
C |
A |
4: 65,269,924 (GRCm39) |
H1613N |
probably benign |
Het |
| Polq |
T |
C |
16: 36,883,191 (GRCm39) |
V1785A |
probably damaging |
Het |
| Pramel23 |
A |
T |
4: 143,424,612 (GRCm39) |
I277K |
possibly damaging |
Het |
| Prkar2a |
T |
C |
9: 108,617,737 (GRCm39) |
|
probably null |
Het |
| Qrich2 |
T |
C |
11: 116,334,603 (GRCm39) |
D2194G |
probably damaging |
Het |
| Rnf183 |
T |
C |
4: 62,346,333 (GRCm39) |
N155S |
probably benign |
Het |
| S1pr5 |
T |
C |
9: 21,155,760 (GRCm39) |
N222S |
probably benign |
Het |
| Scnn1a |
C |
T |
6: 125,307,965 (GRCm39) |
R170C |
probably damaging |
Het |
| Slc25a2 |
T |
C |
18: 37,771,311 (GRCm39) |
T73A |
probably benign |
Het |
| Tgfb1 |
A |
G |
7: 25,404,234 (GRCm39) |
N347S |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,315,433 (GRCm39) |
V229A |
probably benign |
Het |
| Tjp3 |
T |
C |
10: 81,115,941 (GRCm39) |
E313G |
probably benign |
Het |
| Tnfsf11 |
A |
G |
14: 78,521,682 (GRCm39) |
S176P |
probably benign |
Het |
| Vmn2r68 |
TCC |
TC |
7: 84,870,758 (GRCm39) |
|
probably null |
Het |
| Vps39 |
C |
A |
2: 120,154,160 (GRCm39) |
E612* |
probably null |
Het |
| Vwf |
T |
A |
6: 125,619,095 (GRCm39) |
Y1258N |
possibly damaging |
Het |
|
| Other mutations in Or7c70 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00904:Or7c70
|
APN |
10 |
78,683,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01343:Or7c70
|
APN |
10 |
78,683,431 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01576:Or7c70
|
APN |
10 |
78,683,207 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02314:Or7c70
|
APN |
10 |
78,683,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02474:Or7c70
|
APN |
10 |
78,682,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Or7c70
|
APN |
10 |
78,683,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03049:Or7c70
|
APN |
10 |
78,683,356 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03328:Or7c70
|
APN |
10 |
78,683,201 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1602:Or7c70
|
UTSW |
10 |
78,682,802 (GRCm39) |
missense |
probably benign |
|
|
R1722:Or7c70
|
UTSW |
10 |
78,682,805 (GRCm39) |
missense |
probably benign |
|
|
R3903:Or7c70
|
UTSW |
10 |
78,683,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3904:Or7c70
|
UTSW |
10 |
78,683,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4241:Or7c70
|
UTSW |
10 |
78,683,739 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4833:Or7c70
|
UTSW |
10 |
78,683,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5465:Or7c70
|
UTSW |
10 |
78,682,852 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5527:Or7c70
|
UTSW |
10 |
78,683,609 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5606:Or7c70
|
UTSW |
10 |
78,683,395 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5977:Or7c70
|
UTSW |
10 |
78,683,572 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6219:Or7c70
|
UTSW |
10 |
78,683,093 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6996:Or7c70
|
UTSW |
10 |
78,683,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7136:Or7c70
|
UTSW |
10 |
78,683,615 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7782:Or7c70
|
UTSW |
10 |
78,683,447 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7996:Or7c70
|
UTSW |
10 |
78,683,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Or7c70
|
UTSW |
10 |
78,683,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9330:Or7c70
|
UTSW |
10 |
78,683,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9427:Or7c70
|
UTSW |
10 |
78,682,906 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9474:Or7c70
|
UTSW |
10 |
78,682,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Or7c70
|
UTSW |
10 |
78,682,855 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
Z1177:Or7c70
|
UTSW |
10 |
78,683,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGTCCAGGCATCCAAACAC -3'
(R):5'- GGATCCACTTGAGATGAATTTGTGC -3'
Sequencing Primer
(F):5'- AGAACCTTGGGGATAGTGG -3'
(R):5'- AGATGAATTTGTGCTGTTTTTCTCTC -3'
|
| Posted On |
2014-10-02 |
Incidental Mutation