Incidental Mutation 'R3763:Zfp958'
| ID |
270594 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp958
|
| Ensembl Gene |
ENSMUSG00000058748 |
| Gene Name |
zinc finger protein 958 |
| Synonyms |
BC003267 |
| MMRRC Submission |
040873-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R3763 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
4663167-4680231 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 4676226 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073201]
[ENSMUST00000202692]
|
| AlphaFold |
Q99LG7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000073201
|
| SMART Domains |
Protein: ENSMUSP00000072937
Gene: ENSMUSG00000058748
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
65 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
102 |
124 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
130 |
152 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
158 |
180 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
186 |
208 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
214 |
236 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
242 |
264 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
354 |
376 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
382 |
404 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
410 |
432 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
438 |
460 |
6.88e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000202692
|
| SMART Domains |
Protein: ENSMUSP00000143842
Gene: ENSMUSG00000058748
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
6.88e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.5%
|
| Validation Efficiency |
100% (37/37) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acvr2a |
A |
G |
2: 48,760,331 (GRCm39) |
E29G |
possibly damaging |
Het |
| Aff3 |
A |
G |
1: 38,291,770 (GRCm39) |
|
probably benign |
Het |
| AW146154 |
A |
G |
7: 41,129,794 (GRCm39) |
C441R |
probably damaging |
Het |
| Cacna1a |
T |
C |
8: 85,310,271 (GRCm39) |
V1443A |
possibly damaging |
Het |
| Commd1 |
T |
A |
11: 22,924,102 (GRCm39) |
F292Y |
probably benign |
Het |
| Ct45a |
C |
T |
X: 55,590,568 (GRCm39) |
V78I |
probably benign |
Het |
| Ddx18 |
A |
G |
1: 121,489,106 (GRCm39) |
Y314H |
probably damaging |
Het |
| Dna2 |
C |
T |
10: 62,802,576 (GRCm39) |
T898I |
probably damaging |
Het |
| Epc1 |
C |
A |
18: 6,440,091 (GRCm39) |
V59L |
possibly damaging |
Het |
| Etv6 |
C |
A |
6: 134,239,975 (GRCm39) |
|
probably benign |
Het |
| Fam118a |
A |
G |
15: 84,937,998 (GRCm39) |
D293G |
possibly damaging |
Het |
| Gzmn |
A |
C |
14: 56,404,361 (GRCm39) |
S159A |
probably benign |
Het |
| Insc |
A |
G |
7: 114,390,207 (GRCm39) |
D26G |
probably damaging |
Het |
| L1td1 |
A |
G |
4: 98,626,072 (GRCm39) |
R756G |
probably damaging |
Het |
| Ltk |
A |
G |
2: 119,582,318 (GRCm39) |
L499P |
probably benign |
Het |
| Mast4 |
A |
T |
13: 102,923,927 (GRCm39) |
L291M |
probably damaging |
Het |
| Nefm |
G |
T |
14: 68,361,797 (GRCm39) |
R156S |
probably damaging |
Het |
| Nppc |
T |
A |
1: 86,597,580 (GRCm39) |
N63Y |
probably damaging |
Het |
| Or5p79 |
A |
T |
7: 108,221,924 (GRCm39) |
I302F |
probably damaging |
Het |
| Or6c69 |
A |
G |
10: 129,747,314 (GRCm39) |
S278P |
probably damaging |
Het |
| Pcdhb7 |
T |
C |
18: 37,474,936 (GRCm39) |
V24A |
probably benign |
Het |
| Pcm1 |
C |
A |
8: 41,733,114 (GRCm39) |
Q787K |
probably damaging |
Het |
| Prg3 |
A |
G |
2: 84,823,334 (GRCm39) |
K170E |
possibly damaging |
Het |
| Slc25a54 |
T |
C |
3: 109,019,370 (GRCm39) |
S325P |
probably damaging |
Het |
| Slc44a1 |
T |
C |
4: 53,563,286 (GRCm39) |
V671A |
probably benign |
Het |
| Spock3 |
T |
A |
8: 63,597,049 (GRCm39) |
|
probably null |
Het |
| Stk-ps2 |
G |
A |
1: 46,069,081 (GRCm39) |
|
noncoding transcript |
Het |
| Svep1 |
T |
G |
4: 58,084,833 (GRCm39) |
D1835A |
possibly damaging |
Het |
| Tmcc3 |
A |
G |
10: 94,415,179 (GRCm39) |
T294A |
probably benign |
Het |
| Tsen54 |
A |
G |
11: 115,711,237 (GRCm39) |
N62S |
probably benign |
Het |
| Ulk1 |
C |
T |
5: 110,937,223 (GRCm39) |
R691Q |
probably benign |
Het |
| Vmn2r18 |
G |
A |
5: 151,508,644 (GRCm39) |
A160V |
probably damaging |
Het |
| Wnk4 |
T |
C |
11: 101,160,114 (GRCm39) |
V661A |
probably benign |
Het |
| Zfhx4 |
A |
G |
3: 5,468,404 (GRCm39) |
Y2854C |
probably damaging |
Het |
| Zfp563 |
G |
T |
17: 33,323,902 (GRCm39) |
E166* |
probably null |
Het |
| Zfp687 |
T |
A |
3: 94,919,391 (GRCm39) |
N127I |
probably damaging |
Het |
|
| Other mutations in Zfp958 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01950:Zfp958
|
APN |
8 |
4,678,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Zfp958
|
APN |
8 |
4,678,990 (GRCm39) |
nonsense |
probably null |
|
|
IGL02716:Zfp958
|
APN |
8 |
4,675,967 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1118:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1119:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1478:Zfp958
|
UTSW |
8 |
4,679,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Zfp958
|
UTSW |
8 |
4,679,147 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1837:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5258:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5304:Zfp958
|
UTSW |
8 |
4,676,196 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5512:Zfp958
|
UTSW |
8 |
4,675,838 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5907:Zfp958
|
UTSW |
8 |
4,679,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6604:Zfp958
|
UTSW |
8 |
4,678,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6688:Zfp958
|
UTSW |
8 |
4,678,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6727:Zfp958
|
UTSW |
8 |
4,678,247 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6981:Zfp958
|
UTSW |
8 |
4,676,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7010:Zfp958
|
UTSW |
8 |
4,678,377 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7140:Zfp958
|
UTSW |
8 |
4,678,481 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8096:Zfp958
|
UTSW |
8 |
4,663,273 (GRCm39) |
start gained |
probably benign |
|
|
R8491:Zfp958
|
UTSW |
8 |
4,676,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8673:Zfp958
|
UTSW |
8 |
4,678,268 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8847:Zfp958
|
UTSW |
8 |
4,678,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9612:Zfp958
|
UTSW |
8 |
4,678,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGTGACCTTTGATGATGTGC -3'
(R):5'- CCTGTAAGCCAACCCCAATT -3'
Sequencing Primer
(F):5'- TACTGGAACCTCACTGCTATAGG -3'
(R):5'- AAGTTGTCCTTATAAGAGTTGCCTTG -3'
|
| Posted On |
2015-03-18 |
Incidental Mutation