Incidental Mutation 'R3787:Vmn1r63'
ID272309
Institutional Source Beutler Lab
Gene Symbol Vmn1r63
Ensembl Gene ENSMUSG00000058631
Gene Namevomeronasal 1 receptor 63
SynonymsV1R1, V1rd1
MMRRC Submission 040754-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #R3787 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location5802345-5805445 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 5802752 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 294 (M294L)
Ref Sequence ENSEMBL: ENSMUSP00000074593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075085]
Predicted Effect probably benign
Transcript: ENSMUST00000075085
AA Change: M294L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074593
Gene: ENSMUSG00000058631
AA Change: M294L

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 3.1e-10 PFAM
Pfam:V1R 31 297 2.2e-17 PFAM
Predicted Effect
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207420
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik G T 5: 139,455,442 P35Q probably damaging Het
Aoc1 T C 6: 48,905,655 L177P probably damaging Het
Aprt T C 8: 122,575,529 D65G probably benign Het
Auh C A 13: 52,929,457 R62L possibly damaging Het
Bmp4 C T 14: 46,385,714 probably null Het
Bptf C A 11: 107,073,827 D1514Y probably damaging Het
Carmil3 T C 14: 55,496,976 F418S probably damaging Het
Ccdc112 C T 18: 46,299,298 R72H probably benign Het
Ccdc138 T C 10: 58,538,270 Y371H probably damaging Het
Chsy3 T C 18: 59,408,998 Y403H probably damaging Het
Cul4a T C 8: 13,133,668 V352A probably damaging Het
D5Ertd577e T A 5: 95,482,897 L211Q probably damaging Het
Dennd3 T C 15: 73,547,577 V739A possibly damaging Het
Dmxl1 G A 18: 49,865,122 S763N probably damaging Het
Dmxl2 T C 9: 54,369,878 D2893G probably damaging Het
Dnah8 A G 17: 30,755,041 D2800G probably damaging Het
Dnaja2 C T 8: 85,540,386 G281R probably damaging Het
Exo1 A G 1: 175,899,469 T449A probably benign Het
Fancd2 T G 6: 113,565,204 S770A probably damaging Het
Fmo1 A T 1: 162,830,014 S519R possibly damaging Het
Fryl T C 5: 73,101,476 Y655C probably benign Het
Gpt2 G T 8: 85,525,573 V506L probably benign Het
Heatr1 G T 13: 12,434,460 L1946F probably damaging Het
Inpp5k T C 11: 75,647,686 L461P probably damaging Het
Magi2 C T 5: 20,465,909 T580M probably damaging Het
Mcm9 A G 10: 53,615,980 V415A possibly damaging Het
Mki67 A T 7: 135,700,283 N1007K possibly damaging Het
Mpped1 A T 15: 83,796,583 probably benign Het
Mtpap T C 18: 4,380,670 V116A probably damaging Het
Myo15 A T 11: 60,477,572 Y386F probably damaging Het
Neurod1 T A 2: 79,454,595 N148I probably damaging Het
Nfs1 A G 2: 156,128,583 I270T possibly damaging Het
Nr1i3 A G 1: 171,214,425 D26G probably damaging Het
Nsa2 G T 13: 97,135,534 Q60K possibly damaging Het
Olfr61 G A 7: 140,637,835 V45I probably benign Het
Olfr951 T C 9: 39,394,382 V197A probably benign Het
Pde4dip G T 3: 97,715,552 P1447Q possibly damaging Het
Plxna2 A G 1: 194,643,934 T59A probably benign Het
Pmepa1 G A 2: 173,228,133 R210W probably damaging Het
Ppp1r12c G A 7: 4,486,584 A193V probably damaging Het
Prdm15 G T 16: 97,797,745 H904Q probably benign Het
Rala T A 13: 17,882,446 E185V probably benign Het
Reep1 T A 6: 71,795,215 D162E probably damaging Het
Rev3l T A 10: 39,846,210 L2528Q probably damaging Het
Rfc1 A T 5: 65,296,014 S264T probably benign Het
Sall4 A G 2: 168,756,123 S266P probably damaging Het
Sipa1l2 C T 8: 125,423,205 A1602T probably benign Het
Sipa1l2 C A 8: 125,450,383 C1164F possibly damaging Het
Slc4a1ap T A 5: 31,528,139 L254I possibly damaging Het
Slc5a3 A G 16: 92,077,928 N291S possibly damaging Het
Stab2 T A 10: 86,969,277 D279V possibly damaging Het
Synrg T C 11: 84,001,920 F613S probably damaging Het
Tekt1 A G 11: 72,344,894 I376T probably damaging Het
Thbs4 T C 13: 92,773,164 N375S probably benign Het
Tro G A X: 150,655,052 T203I possibly damaging Het
Txnl4b C T 8: 109,572,777 A123V probably damaging Het
Vmn2r58 C T 7: 41,864,074 D382N probably benign Het
Wap G A 11: 6,638,550 Q25* probably null Het
Other mutations in Vmn1r63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02465:Vmn1r63 APN 7 5803039 missense probably damaging 1.00
IGL02897:Vmn1r63 APN 7 5802745 missense possibly damaging 0.51
IGL03032:Vmn1r63 APN 7 5803351 missense probably benign 0.18
IGL03190:Vmn1r63 APN 7 5803111 missense probably benign 0.00
R0118:Vmn1r63 UTSW 7 5802839 missense probably benign 0.00
R0227:Vmn1r63 UTSW 7 5802742 nonsense probably null
R0323:Vmn1r63 UTSW 7 5803336 missense probably benign 0.03
R0610:Vmn1r63 UTSW 7 5803064 missense possibly damaging 0.89
R0630:Vmn1r63 UTSW 7 5803264 missense probably damaging 1.00
R0689:Vmn1r63 UTSW 7 5803610 missense probably benign 0.24
R1916:Vmn1r63 UTSW 7 5803226 missense probably damaging 0.96
R1993:Vmn1r63 UTSW 7 5803255 missense probably benign 0.12
R1994:Vmn1r63 UTSW 7 5803255 missense probably benign 0.12
R2209:Vmn1r63 UTSW 7 5803213 missense probably damaging 0.99
R4156:Vmn1r63 UTSW 7 5803532 missense possibly damaging 0.89
R4702:Vmn1r63 UTSW 7 5803517 missense possibly damaging 0.68
R4728:Vmn1r63 UTSW 7 5803363 missense probably damaging 0.99
R5410:Vmn1r63 UTSW 7 5803190 missense possibly damaging 0.55
R5796:Vmn1r63 UTSW 7 5803141 missense probably benign
R6580:Vmn1r63 UTSW 7 5802914 missense probably benign 0.02
R6723:Vmn1r63 UTSW 7 5802949 missense probably damaging 0.96
R7418:Vmn1r63 UTSW 7 5803555 missense possibly damaging 0.94
R7476:Vmn1r63 UTSW 7 5803001 missense probably benign 0.13
R7769:Vmn1r63 UTSW 7 5803370 missense probably damaging 1.00
X0027:Vmn1r63 UTSW 7 5802931 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCCAGTAGGTTACATGACTATC -3'
(R):5'- ACACCATCCTGATGCTGGTG -3'

Sequencing Primer
(F):5'- TTACATGACTATCACAGGGTGGC -3'
(R):5'- CATCCTGATGCTGGTGGTCAC -3'
Posted On2015-03-25