Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00434:Lrrn3'

28684

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrn3

Ensembl Gene

ENSMUSG00000036295

Gene Name

leucine rich repeat protein 3, neuronal

Synonyms

NLRR-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.203) question?

Stock #

IGL00434

Quality Score

Status

Chromosome

Chromosomal Location

41451668-41486431 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 41452192 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000116441 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043884] [ENSMUST00000132121] [ENSMUST00000134965]

AlphaFold

Q8CBC6

Predicted Effect

probably benign
Transcript: ENSMUST00000043884

SMART Domains

Protein: ENSMUSP00000043818
Gene: ENSMUSG00000036295

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
LRRNT	28	73	9.17e-4	SMART
LRR	115	138	2.63e0	SMART
LRR_TYP	139	162	1.5e-4	SMART
LRR	163	186	7.55e-1	SMART
LRR	187	210	1.76e1	SMART
LRR	211	234	1.62e1	SMART
LRR	235	258	5.11e0	SMART
LRR	260	282	3.18e1	SMART
LRR	333	356	4.44e0	SMART
LRRCT	368	420	3.7e-5	SMART
IGc2	435	503	5.04e-9	SMART
FN3	521	602	3.49e0	SMART
transmembrane domain	626	648	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000132121

SMART Domains

Protein: ENSMUSP00000118779
Gene: ENSMUSG00000056899

Domain	Start	End	E-Value	Type
Pfam:Peptidase_S24	38	115	7.7e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000134965

SMART Domains

Protein: ENSMUSP00000116441
Gene: ENSMUSG00000056899

Domain	Start	End	E-Value	Type
Pfam:Peptidase_S24	38	114	6.4e-11	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mutant mice exhibited increased mean percent body fat and male homozygous mutant mice exhibited enhanced glucose tolerance when compared with controls. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 36,987,299	F2609L	probably damaging	Het
Arid2	T	C	15: 96,371,300	V1098A	probably damaging	Het
Ccdc126	C	T	6: 49,334,305		probably benign	Het
Cds2	T	C	2: 132,293,351	L54P	probably damaging	Het
Cdsn	A	T	17: 35,554,843	S90C	unknown	Het
Clcn6	G	T	4: 148,013,738	D581E	probably damaging	Het
Clec4f	T	A	6: 83,653,216	H120L	possibly damaging	Het
Col12a1	T	C	9: 79,653,332	T1838A	probably benign	Het
Col22a1	T	C	15: 72,006,675	D211G	possibly damaging	Het
Cpne8	T	C	15: 90,497,058		probably benign	Het
Dgkk	T	A	X: 6,906,458	M462K	probably benign	Het
Dhx29	T	A	13: 112,955,225	H834Q	probably benign	Het
Esyt1	A	G	10: 128,517,635	Y578H	possibly damaging	Het
Fnip2	C	A	3: 79,512,489		probably benign	Het
Fut1	T	G	7: 45,619,431	C270G	probably damaging	Het
Ganab	T	A	19: 8,907,343	V170D	probably damaging	Het
Gm15448	C	A	7: 3,823,089	G302C	probably damaging	Het
Gys1	T	A	7: 45,444,832	M364K	possibly damaging	Het
Ighv1-85	A	C	12: 116,000,034	C115W	probably damaging	Het
Igkv4-74	T	G	6: 69,185,060	T42P	probably damaging	Het
Jmjd4	A	G	11: 59,450,495	Y84C	probably damaging	Het
Kif11	A	C	19: 37,411,409	E781D	possibly damaging	Het
Kif14	G	A	1: 136,469,018	S354N	probably benign	Het
Klf1	C	T	8: 84,901,999	P9S	possibly damaging	Het
Ltbp4	C	A	7: 27,328,805	R309L	probably damaging	Het
March10	T	C	11: 105,402,188	E131G	possibly damaging	Het
Men1	G	A	19: 6,337,207		probably null	Het
Mgme1	T	A	2: 144,279,136		probably benign	Het
Nkiras2	G	A	11: 100,624,982	G45D	probably damaging	Het
Orc2	A	T	1: 58,493,716	D16E	possibly damaging	Het
Pcyox1l	T	C	18: 61,697,542	T420A	probably benign	Het
Pm20d1	A	G	1: 131,814,000		probably benign	Het
Ppp1r3c	T	C	19: 36,734,103	D89G	probably damaging	Het
Ppp2ca	G	A	11: 52,121,949	R302H	probably benign	Het
Riok3	T	C	18: 12,148,847	V291A	probably damaging	Het
Rragd	A	G	4: 33,007,219		probably benign	Het
Scai	C	A	2: 39,108,394	L174F	probably damaging	Het
Slc25a44	T	C	3: 88,416,062	I227V	probably benign	Het
Slc35f1	T	C	10: 53,062,452	L160P	probably damaging	Het
Slc38a1	A	G	15: 96,585,623	Y275H	possibly damaging	Het
Slco6b1	A	G	1: 96,988,650		noncoding transcript	Het
Spag8	G	T	4: 43,652,890	C190*	probably null	Het
Tbr1	T	C	2: 61,805,281	F192L	probably benign	Het
Tmem29	A	T	X: 150,398,399	V132E	possibly damaging	Het
Tti1	C	T	2: 158,008,966	E118K	probably damaging	Het
Tti1	T	A	2: 158,008,965	E118V	probably damaging	Het
Vcan	G	T	13: 89,704,702	P713Q	probably damaging	Het
Wt1	G	T	2: 105,144,141		probably null	Het
Xylt1	T	A	7: 117,650,685	I694N	probably damaging	Het
Zfp516	T	A	18: 82,957,108	M477K	probably benign	Het

Other mutations in Lrrn3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02825:Lrrn3	APN	12	41452593	missense	probably damaging	1.00
IGL02927:Lrrn3	APN	12	41453344	missense	probably damaging	1.00
IGL02970:Lrrn3	APN	12	41452360	missense	probably benign
IGL02995:Lrrn3	APN	12	41452217	missense	probably damaging	1.00
IGL02999:Lrrn3	APN	12	41452751	missense	probably benign	0.01
IGL03182:Lrrn3	APN	12	41454021	missense	probably damaging	1.00
IGL03280:Lrrn3	APN	12	41454147	missense	probably damaging	0.97
PIT4469001:Lrrn3	UTSW	12	41453018	missense	probably benign	0.03
R0167:Lrrn3	UTSW	12	41454015	missense	probably damaging	1.00
R0414:Lrrn3	UTSW	12	41453940	missense	probably damaging	1.00
R0787:Lrrn3	UTSW	12	41454231	missense	probably damaging	1.00
R0894:Lrrn3	UTSW	12	41454034	missense	probably damaging	1.00
R1433:Lrrn3	UTSW	12	41452584	missense	possibly damaging	0.74
R1610:Lrrn3	UTSW	12	41452993	missense	possibly damaging	0.89
R1834:Lrrn3	UTSW	12	41453518	missense	probably damaging	1.00
R2068:Lrrn3	UTSW	12	41452996	missense	probably damaging	1.00
R2871:Lrrn3	UTSW	12	41452723	missense	probably benign	0.00
R2871:Lrrn3	UTSW	12	41452723	missense	probably benign	0.00
R3771:Lrrn3	UTSW	12	41452870	missense	probably damaging	1.00
R4408:Lrrn3	UTSW	12	41454042	missense	probably benign	0.04
R4410:Lrrn3	UTSW	12	41452584	missense	possibly damaging	0.74
R4684:Lrrn3	UTSW	12	41454244	missense	possibly damaging	0.75
R4770:Lrrn3	UTSW	12	41452443	missense	probably benign	0.08
R4927:Lrrn3	UTSW	12	41453125	missense	probably damaging	1.00
R5037:Lrrn3	UTSW	12	41453595	missense	probably damaging	1.00
R5482:Lrrn3	UTSW	12	41452387	missense	probably benign	0.01
R5482:Lrrn3	UTSW	12	41452388	missense	probably damaging	0.96
R5667:Lrrn3	UTSW	12	41452298	missense	possibly damaging	0.77
R6022:Lrrn3	UTSW	12	41453430	missense	probably damaging	0.96
R6087:Lrrn3	UTSW	12	41453535	missense	possibly damaging	0.84
R6129:Lrrn3	UTSW	12	41453788	nonsense	probably null
R6309:Lrrn3	UTSW	12	41453206	missense	probably damaging	1.00
R7449:Lrrn3	UTSW	12	41453488	missense	probably damaging	1.00
R7555:Lrrn3	UTSW	12	41452911	missense	probably benign	0.01
R7560:Lrrn3	UTSW	12	41452713	missense	possibly damaging	0.93
R8059:Lrrn3	UTSW	12	41454217	missense	probably benign	0.22
R8134:Lrrn3	UTSW	12	41453048	missense	probably damaging	1.00
R8798:Lrrn3	UTSW	12	41453175	missense	possibly damaging	0.61
R9308:Lrrn3	UTSW	12	41453946	missense	probably damaging	1.00
R9318:Lrrn3	UTSW	12	41453244	missense	probably damaging	1.00

Posted On

2013-04-17