Incidental Mutation 'IGL00434:Lrrn3'
ID 28684
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrn3
Ensembl Gene ENSMUSG00000036295
Gene Name leucine rich repeat protein 3, neuronal
Synonyms NLRR-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # IGL00434
Quality Score
Status
Chromosome 12
Chromosomal Location 41501667-41536056 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 41502191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043884] [ENSMUST00000132121] [ENSMUST00000134965]
AlphaFold Q8CBC6
Predicted Effect probably benign
Transcript: ENSMUST00000043884
SMART Domains Protein: ENSMUSP00000043818
Gene: ENSMUSG00000036295

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
LRRNT 28 73 9.17e-4 SMART
LRR 115 138 2.63e0 SMART
LRR_TYP 139 162 1.5e-4 SMART
LRR 163 186 7.55e-1 SMART
LRR 187 210 1.76e1 SMART
LRR 211 234 1.62e1 SMART
LRR 235 258 5.11e0 SMART
LRR 260 282 3.18e1 SMART
LRR 333 356 4.44e0 SMART
LRRCT 368 420 3.7e-5 SMART
IGc2 435 503 5.04e-9 SMART
FN3 521 602 3.49e0 SMART
transmembrane domain 626 648 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132121
SMART Domains Protein: ENSMUSP00000118779
Gene: ENSMUSG00000056899

DomainStartEndE-ValueType
Pfam:Peptidase_S24 38 115 7.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134965
SMART Domains Protein: ENSMUSP00000116441
Gene: ENSMUSG00000056899

DomainStartEndE-ValueType
Pfam:Peptidase_S24 38 114 6.4e-11 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibited increased mean percent body fat and male homozygous mutant mice exhibited enhanced glucose tolerance when compared with controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid2 T C 15: 96,269,181 (GRCm39) V1098A probably damaging Het
Bltp1 T C 3: 37,041,448 (GRCm39) F2609L probably damaging Het
Ccdc126 C T 6: 49,311,239 (GRCm39) probably benign Het
Cds2 T C 2: 132,135,271 (GRCm39) L54P probably damaging Het
Cdsn A T 17: 35,865,740 (GRCm39) S90C unknown Het
Clcn6 G T 4: 148,098,195 (GRCm39) D581E probably damaging Het
Clec4f T A 6: 83,630,198 (GRCm39) H120L possibly damaging Het
Col12a1 T C 9: 79,560,614 (GRCm39) T1838A probably benign Het
Col22a1 T C 15: 71,878,524 (GRCm39) D211G possibly damaging Het
Cpne8 T C 15: 90,381,261 (GRCm39) probably benign Het
Dgkk T A X: 6,772,697 (GRCm39) M462K probably benign Het
Dhx29 T A 13: 113,091,759 (GRCm39) H834Q probably benign Het
Esyt1 A G 10: 128,353,504 (GRCm39) Y578H possibly damaging Het
Fnip2 C A 3: 79,419,796 (GRCm39) probably benign Het
Fut1 T G 7: 45,268,855 (GRCm39) C270G probably damaging Het
Ganab T A 19: 8,884,707 (GRCm39) V170D probably damaging Het
Gys1 T A 7: 45,094,256 (GRCm39) M364K possibly damaging Het
Ighv1-85 A C 12: 115,963,654 (GRCm39) C115W probably damaging Het
Igkv4-74 T G 6: 69,162,044 (GRCm39) T42P probably damaging Het
Jmjd4 A G 11: 59,341,321 (GRCm39) Y84C probably damaging Het
Kif11 A C 19: 37,399,857 (GRCm39) E781D possibly damaging Het
Kif14 G A 1: 136,396,756 (GRCm39) S354N probably benign Het
Klf1 C T 8: 85,628,628 (GRCm39) P9S possibly damaging Het
Ltbp4 C A 7: 27,028,230 (GRCm39) R309L probably damaging Het
Marchf10 T C 11: 105,293,014 (GRCm39) E131G possibly damaging Het
Men1 G A 19: 6,387,237 (GRCm39) probably null Het
Mgme1 T A 2: 144,121,056 (GRCm39) probably benign Het
Nkiras2 G A 11: 100,515,808 (GRCm39) G45D probably damaging Het
Orc2 A T 1: 58,532,875 (GRCm39) D16E possibly damaging Het
Pcyox1l T C 18: 61,830,613 (GRCm39) T420A probably benign Het
Pira13 C A 7: 3,826,088 (GRCm39) G302C probably damaging Het
Pm20d1 A G 1: 131,741,738 (GRCm39) probably benign Het
Ppp1r3c T C 19: 36,711,503 (GRCm39) D89G probably damaging Het
Ppp2ca G A 11: 52,012,776 (GRCm39) R302H probably benign Het
Riok3 T C 18: 12,281,904 (GRCm39) V291A probably damaging Het
Rragd A G 4: 33,007,219 (GRCm39) probably benign Het
Scai C A 2: 38,998,406 (GRCm39) L174F probably damaging Het
Slc25a44 T C 3: 88,323,369 (GRCm39) I227V probably benign Het
Slc35f1 T C 10: 52,938,548 (GRCm39) L160P probably damaging Het
Slc38a1 A G 15: 96,483,504 (GRCm39) Y275H possibly damaging Het
Slco6b1 A G 1: 96,916,375 (GRCm39) noncoding transcript Het
Spag8 G T 4: 43,652,890 (GRCm39) C190* probably null Het
Tbr1 T C 2: 61,635,625 (GRCm39) F192L probably benign Het
Tti1 C T 2: 157,850,886 (GRCm39) E118K probably damaging Het
Tti1 T A 2: 157,850,885 (GRCm39) E118V probably damaging Het
Vcan G T 13: 89,852,821 (GRCm39) P713Q probably damaging Het
Vcf2 A T X: 149,181,395 (GRCm39) V132E possibly damaging Het
Wt1 G T 2: 104,974,486 (GRCm39) probably null Het
Xylt1 T A 7: 117,249,912 (GRCm39) I694N probably damaging Het
Zfp516 T A 18: 82,975,233 (GRCm39) M477K probably benign Het
Other mutations in Lrrn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Lrrn3 APN 12 41,502,592 (GRCm39) missense probably damaging 1.00
IGL02927:Lrrn3 APN 12 41,503,343 (GRCm39) missense probably damaging 1.00
IGL02970:Lrrn3 APN 12 41,502,359 (GRCm39) missense probably benign
IGL02995:Lrrn3 APN 12 41,502,216 (GRCm39) missense probably damaging 1.00
IGL02999:Lrrn3 APN 12 41,502,750 (GRCm39) missense probably benign 0.01
IGL03182:Lrrn3 APN 12 41,504,020 (GRCm39) missense probably damaging 1.00
IGL03280:Lrrn3 APN 12 41,504,146 (GRCm39) missense probably damaging 0.97
PIT4469001:Lrrn3 UTSW 12 41,503,017 (GRCm39) missense probably benign 0.03
R0167:Lrrn3 UTSW 12 41,504,014 (GRCm39) missense probably damaging 1.00
R0414:Lrrn3 UTSW 12 41,503,939 (GRCm39) missense probably damaging 1.00
R0787:Lrrn3 UTSW 12 41,504,230 (GRCm39) missense probably damaging 1.00
R0894:Lrrn3 UTSW 12 41,504,033 (GRCm39) missense probably damaging 1.00
R1433:Lrrn3 UTSW 12 41,502,583 (GRCm39) missense possibly damaging 0.74
R1610:Lrrn3 UTSW 12 41,502,992 (GRCm39) missense possibly damaging 0.89
R1834:Lrrn3 UTSW 12 41,503,517 (GRCm39) missense probably damaging 1.00
R2068:Lrrn3 UTSW 12 41,502,995 (GRCm39) missense probably damaging 1.00
R2871:Lrrn3 UTSW 12 41,502,722 (GRCm39) missense probably benign 0.00
R2871:Lrrn3 UTSW 12 41,502,722 (GRCm39) missense probably benign 0.00
R3771:Lrrn3 UTSW 12 41,502,869 (GRCm39) missense probably damaging 1.00
R4408:Lrrn3 UTSW 12 41,504,041 (GRCm39) missense probably benign 0.04
R4410:Lrrn3 UTSW 12 41,502,583 (GRCm39) missense possibly damaging 0.74
R4684:Lrrn3 UTSW 12 41,504,243 (GRCm39) missense possibly damaging 0.75
R4770:Lrrn3 UTSW 12 41,502,442 (GRCm39) missense probably benign 0.08
R4927:Lrrn3 UTSW 12 41,503,124 (GRCm39) missense probably damaging 1.00
R5037:Lrrn3 UTSW 12 41,503,594 (GRCm39) missense probably damaging 1.00
R5482:Lrrn3 UTSW 12 41,502,387 (GRCm39) missense probably damaging 0.96
R5482:Lrrn3 UTSW 12 41,502,386 (GRCm39) missense probably benign 0.01
R5667:Lrrn3 UTSW 12 41,502,297 (GRCm39) missense possibly damaging 0.77
R6022:Lrrn3 UTSW 12 41,503,429 (GRCm39) missense probably damaging 0.96
R6087:Lrrn3 UTSW 12 41,503,534 (GRCm39) missense possibly damaging 0.84
R6129:Lrrn3 UTSW 12 41,503,787 (GRCm39) nonsense probably null
R6309:Lrrn3 UTSW 12 41,503,205 (GRCm39) missense probably damaging 1.00
R7449:Lrrn3 UTSW 12 41,503,487 (GRCm39) missense probably damaging 1.00
R7555:Lrrn3 UTSW 12 41,502,910 (GRCm39) missense probably benign 0.01
R7560:Lrrn3 UTSW 12 41,502,712 (GRCm39) missense possibly damaging 0.93
R8059:Lrrn3 UTSW 12 41,504,216 (GRCm39) missense probably benign 0.22
R8134:Lrrn3 UTSW 12 41,503,047 (GRCm39) missense probably damaging 1.00
R8798:Lrrn3 UTSW 12 41,503,174 (GRCm39) missense possibly damaging 0.61
R9308:Lrrn3 UTSW 12 41,503,945 (GRCm39) missense probably damaging 1.00
R9318:Lrrn3 UTSW 12 41,503,243 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17