Incidental Mutation 'R4032:Olfr722'
ID313552
Institutional Source Beutler Lab
Gene Symbol Olfr722
Ensembl Gene ENSMUSG00000048933
Gene Nameolfactory receptor 722
SynonymsGA_x6K02T2PMLR-5566715-5565789, MOR241-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #R4032 (G1)
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location49894258-49901999 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 49894976 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 275 (H275Q)
Ref Sequence ENSEMBL: ENSMUSP00000059721 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053290]
Predicted Effect probably benign
Transcript: ENSMUST00000053290
AA Change: H275Q

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000059721
Gene: ENSMUSG00000048933
AA Change: H275Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 4.3e-44 PFAM
Pfam:7tm_1 41 288 2.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213271
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh2 C T 5: 114,124,226 E148K probably damaging Het
Arhgap17 G T 7: 123,280,066 probably benign Het
Atp13a4 T A 16: 29,418,571 M846L probably damaging Het
Capn5 G T 7: 98,129,246 Q389K probably damaging Het
Cdkl3 T A 11: 52,011,291 I109N probably damaging Het
Cry2 T C 2: 92,413,827 I334V probably benign Het
Cs T C 10: 128,361,044 L436P probably damaging Het
D17H6S53E T C 17: 35,127,379 S89P probably benign Het
Dync1h1 C T 12: 110,618,049 Q629* probably null Het
Fam122a C T 19: 24,476,742 M205I probably benign Het
Hist1h4k T C 13: 21,750,418 I30V possibly damaging Het
Itpka C T 2: 119,742,601 P75S probably benign Het
Lyst C T 13: 13,616,665 H38Y probably damaging Het
Mansc4 T C 6: 147,075,180 K313E probably benign Het
Megf6 T A 4: 154,177,093 C58* probably null Het
Mtor T C 4: 148,536,752 V1869A probably benign Het
Mybpc1 T C 10: 88,529,564 D899G probably benign Het
Nek10 C A 14: 14,853,877 probably null Het
Nfkb1 T C 3: 135,594,349 S657G possibly damaging Het
Olfr447 A T 6: 42,911,625 Y34F probably benign Het
Olfr564 A G 7: 102,804,189 K237R probably benign Het
Olfr734 T A 14: 50,320,310 D175V possibly damaging Het
Olfr976 T C 9: 39,956,333 T213A probably benign Het
Pde1b A G 15: 103,521,326 D82G probably damaging Het
Pdzrn4 C T 15: 92,769,533 T522M probably damaging Het
Ptpro C A 6: 137,461,742 N373K probably damaging Het
Ptprs T C 17: 56,413,386 Y1478C probably damaging Het
Sdc2 A T 15: 33,017,177 I46F probably damaging Het
Sergef C A 7: 46,443,302 E428* probably null Het
Stk36 A G 1: 74,626,048 S651G probably benign Het
Ubr5 A G 15: 38,024,837 V559A probably benign Het
Ugt8a C A 3: 125,874,158 D345Y probably damaging Het
Usp44 A G 10: 93,847,265 probably benign Het
Vps13a A T 19: 16,616,899 L3156Q probably damaging Het
Zfp655 A G 5: 145,244,048 T239A possibly damaging Het
Zfp72 T C 13: 74,372,330 T210A possibly damaging Het
Other mutations in Olfr722
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1229:Olfr722 UTSW 14 49895254 nonsense probably null
R1400:Olfr722 UTSW 14 49895691 missense possibly damaging 0.49
R1417:Olfr722 UTSW 14 49895563 nonsense probably null
R2126:Olfr722 UTSW 14 49895067 missense probably benign 0.01
R3968:Olfr722 UTSW 14 49895526 missense probably damaging 1.00
R4008:Olfr722 UTSW 14 49895007 missense probably benign 0.00
R4409:Olfr722 UTSW 14 49895773 missense probably benign 0.01
R4934:Olfr722 UTSW 14 49895749 missense probably benign 0.00
R5110:Olfr722 UTSW 14 49895575 missense possibly damaging 0.49
R5232:Olfr722 UTSW 14 49895698 missense probably damaging 1.00
R7019:Olfr722 UTSW 14 49895667 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAAGTACCTAACACAGCATTTGC -3'
(R):5'- TTGGGACTTCTGGCCTCCTATG -3'

Sequencing Primer
(F):5'- GCTAAAGAACTGATTCAATGCATG -3'
(R):5'- GCTGTCATTCTCTACCACGTAAAAGG -3'
Posted On2015-04-30