Incidental Mutation 'R0389:Fasn'
| ID |
31512 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
038595-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0389 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 120707008 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 881
(D881E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: D881E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: D881E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206589
AA Change: D881E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 91.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432M17Rik |
G |
A |
3: 121,465,053 (GRCm39) |
E30K |
unknown |
Het |
| Abi3bp |
A |
T |
16: 56,491,670 (GRCm39) |
T1319S |
possibly damaging |
Het |
| Adam18 |
T |
C |
8: 25,119,653 (GRCm39) |
|
probably null |
Het |
| Adgre1 |
G |
A |
17: 57,713,839 (GRCm39) |
D175N |
possibly damaging |
Het |
| Adgrf1 |
T |
C |
17: 43,614,679 (GRCm39) |
|
probably null |
Het |
| Ankhd1 |
A |
G |
18: 36,777,652 (GRCm39) |
S1612G |
possibly damaging |
Het |
| Anks1 |
A |
G |
17: 28,214,926 (GRCm39) |
R458G |
possibly damaging |
Het |
| Cacna1g |
C |
T |
11: 94,350,523 (GRCm39) |
V441M |
probably damaging |
Het |
| Cadps2 |
A |
T |
6: 23,321,781 (GRCm39) |
V1037E |
possibly damaging |
Het |
| Casz1 |
T |
C |
4: 149,033,368 (GRCm39) |
V1380A |
possibly damaging |
Het |
| Cenpq |
T |
C |
17: 41,244,085 (GRCm39) |
|
probably benign |
Het |
| Chrac1 |
T |
C |
15: 72,965,376 (GRCm39) |
I93T |
possibly damaging |
Het |
| Cntnap2 |
T |
A |
6: 45,986,571 (GRCm39) |
S359T |
probably benign |
Het |
| Col6a6 |
C |
A |
9: 105,661,403 (GRCm39) |
M235I |
probably benign |
Het |
| Crat |
T |
C |
2: 30,293,640 (GRCm39) |
|
probably benign |
Het |
| Cyp1a2 |
T |
C |
9: 57,589,308 (GRCm39) |
N169D |
probably benign |
Het |
| Dennd1c |
T |
A |
17: 57,374,649 (GRCm39) |
T499S |
probably benign |
Het |
| Dst |
A |
G |
1: 34,333,631 (GRCm39) |
|
probably null |
Het |
| Dync2h1 |
G |
T |
9: 7,167,244 (GRCm39) |
|
probably null |
Het |
| Eif3h |
C |
A |
15: 51,662,660 (GRCm39) |
V129F |
probably damaging |
Het |
| Eno2 |
A |
G |
6: 124,739,654 (GRCm39) |
F380L |
probably damaging |
Het |
| Ergic2 |
T |
A |
6: 148,084,700 (GRCm39) |
I34F |
probably benign |
Het |
| Ergic3 |
G |
A |
2: 155,858,707 (GRCm39) |
V278M |
probably benign |
Het |
| Fam185a |
C |
T |
5: 21,664,283 (GRCm39) |
T339M |
probably damaging |
Het |
| Fam20b |
A |
T |
1: 156,509,023 (GRCm39) |
D396E |
probably benign |
Het |
| Fat1 |
C |
A |
8: 45,403,385 (GRCm39) |
H45Q |
probably benign |
Het |
| Fbxw16 |
A |
T |
9: 109,261,550 (GRCm39) |
C439S |
probably benign |
Het |
| Garin1a |
T |
A |
6: 29,281,391 (GRCm39) |
V43E |
possibly damaging |
Het |
| Gba2 |
A |
T |
4: 43,570,832 (GRCm39) |
F280Y |
probably damaging |
Het |
| Gfm1 |
A |
G |
3: 67,365,251 (GRCm39) |
I517V |
probably benign |
Het |
| Gng13 |
C |
T |
17: 25,937,696 (GRCm39) |
Q8* |
probably null |
Het |
| Golga1 |
A |
T |
2: 38,908,453 (GRCm39) |
S749T |
probably damaging |
Het |
| Gphn |
A |
T |
12: 78,637,433 (GRCm39) |
I381F |
probably damaging |
Het |
| Grm3 |
T |
C |
5: 9,554,794 (GRCm39) |
N833D |
probably damaging |
Het |
| Gstt2 |
G |
T |
10: 75,668,266 (GRCm39) |
T163K |
probably damaging |
Het |
| Gusb |
A |
T |
5: 130,026,927 (GRCm39) |
V388E |
probably damaging |
Het |
| Hcrtr2 |
A |
T |
9: 76,153,662 (GRCm39) |
Y243* |
probably null |
Het |
| Hspg2 |
A |
G |
4: 137,242,734 (GRCm39) |
T650A |
possibly damaging |
Het |
| Ints2 |
C |
T |
11: 86,139,677 (GRCm39) |
V306I |
probably damaging |
Het |
| Itga1 |
T |
A |
13: 115,128,996 (GRCm39) |
D554V |
probably benign |
Het |
| Itgam |
C |
T |
7: 127,680,806 (GRCm39) |
A245V |
probably damaging |
Het |
| Kcnk15 |
A |
G |
2: 163,700,243 (GRCm39) |
T161A |
probably benign |
Het |
| Klhl18 |
A |
T |
9: 110,257,749 (GRCm39) |
C564S |
probably benign |
Het |
| Krt40 |
T |
A |
11: 99,432,540 (GRCm39) |
R159* |
probably null |
Het |
| L3mbtl4 |
G |
A |
17: 68,762,775 (GRCm39) |
V103M |
probably damaging |
Het |
| Lnx2 |
C |
A |
5: 146,955,850 (GRCm39) |
V649L |
possibly damaging |
Het |
| Lpp |
A |
T |
16: 24,426,991 (GRCm39) |
Q39H |
probably damaging |
Het |
| Lrpprc |
A |
T |
17: 85,060,540 (GRCm39) |
|
probably null |
Het |
| Map3k19 |
A |
T |
1: 127,750,152 (GRCm39) |
N1066K |
probably benign |
Het |
| Mbtps2 |
G |
T |
X: 156,351,364 (GRCm39) |
T134K |
probably benign |
Het |
| Mfng |
C |
T |
15: 78,648,637 (GRCm39) |
V147M |
possibly damaging |
Het |
| Mks1 |
T |
C |
11: 87,748,754 (GRCm39) |
S273P |
probably benign |
Het |
| Myh2 |
T |
C |
11: 67,071,647 (GRCm39) |
L488P |
probably damaging |
Het |
| Myo15a |
A |
G |
11: 60,369,364 (GRCm39) |
N708S |
probably benign |
Het |
| Myo6 |
A |
T |
9: 80,199,748 (GRCm39) |
N1019I |
probably damaging |
Het |
| Myrf |
G |
C |
19: 10,195,526 (GRCm39) |
T428S |
probably benign |
Het |
| Ncoa1 |
T |
G |
12: 4,345,976 (GRCm39) |
N457T |
probably benign |
Het |
| Neb |
T |
C |
2: 52,051,489 (GRCm39) |
|
probably null |
Het |
| Nlrp4e |
C |
A |
7: 23,054,628 (GRCm39) |
N927K |
probably damaging |
Het |
| Npffr2 |
T |
C |
5: 89,730,613 (GRCm39) |
M181T |
probably benign |
Het |
| Nxf7 |
A |
T |
X: 134,485,132 (GRCm39) |
C495S |
possibly damaging |
Het |
| Oas1g |
T |
C |
5: 121,025,592 (GRCm39) |
T12A |
probably benign |
Het |
| Or11g2 |
T |
A |
14: 50,856,036 (GRCm39) |
L119Q |
probably damaging |
Het |
| Or1e17 |
T |
A |
11: 73,831,879 (GRCm39) |
V269E |
probably benign |
Het |
| Or2g7 |
C |
G |
17: 38,378,562 (GRCm39) |
R167G |
possibly damaging |
Het |
| Or52s1b |
A |
T |
7: 102,822,490 (GRCm39) |
V118E |
possibly damaging |
Het |
| Or5p60 |
A |
G |
7: 107,724,023 (GRCm39) |
V149A |
probably benign |
Het |
| Papln |
C |
T |
12: 83,830,153 (GRCm39) |
Q1008* |
probably null |
Het |
| Pcdhb10 |
A |
C |
18: 37,545,485 (GRCm39) |
D187A |
probably damaging |
Het |
| Phf2 |
T |
A |
13: 48,957,965 (GRCm39) |
E1016D |
unknown |
Het |
| Phf8 |
T |
A |
X: 150,335,618 (GRCm39) |
D197E |
probably benign |
Het |
| Pikfyve |
A |
G |
1: 65,235,865 (GRCm39) |
H179R |
probably damaging |
Het |
| Prkcz |
T |
A |
4: 155,353,597 (GRCm39) |
D250V |
probably damaging |
Het |
| Prpf4 |
A |
G |
4: 62,340,842 (GRCm39) |
Y419C |
probably damaging |
Het |
| Prr15l |
C |
A |
11: 96,825,440 (GRCm39) |
Y23* |
probably null |
Het |
| Prr5 |
T |
A |
15: 84,587,152 (GRCm39) |
S301T |
probably benign |
Het |
| Psg16 |
T |
A |
7: 16,829,088 (GRCm39) |
I224N |
probably benign |
Het |
| Radil |
A |
G |
5: 142,529,226 (GRCm39) |
F186L |
probably damaging |
Het |
| Reg3g |
A |
T |
6: 78,445,544 (GRCm39) |
M1K |
probably null |
Het |
| Rps6ka3 |
A |
G |
X: 158,100,963 (GRCm39) |
Y76C |
probably damaging |
Het |
| Rtl1 |
C |
T |
12: 109,556,797 (GRCm39) |
V1681I |
possibly damaging |
Het |
| Sfmbt1 |
C |
T |
14: 30,533,464 (GRCm39) |
R614C |
probably damaging |
Het |
| Slc12a4 |
A |
G |
8: 106,678,599 (GRCm39) |
S244P |
probably benign |
Het |
| Sp140l2 |
T |
A |
1: 85,247,773 (GRCm39) |
N5Y |
probably benign |
Het |
| Sptbn1 |
T |
C |
11: 30,089,250 (GRCm39) |
T671A |
possibly damaging |
Het |
| Supt16 |
A |
T |
14: 52,411,570 (GRCm39) |
N604K |
probably damaging |
Het |
| Synj2 |
G |
A |
17: 6,080,058 (GRCm39) |
V1096I |
probably benign |
Het |
| Tas2r129 |
G |
T |
6: 132,928,159 (GRCm39) |
C32F |
probably benign |
Het |
| Tbc1d25 |
T |
C |
X: 8,039,108 (GRCm39) |
Y140C |
probably damaging |
Het |
| Tdrd7 |
A |
G |
4: 46,016,987 (GRCm39) |
D709G |
probably benign |
Het |
| Tfap2d |
C |
T |
1: 19,174,591 (GRCm39) |
R15C |
possibly damaging |
Het |
| Tgfbi |
C |
A |
13: 56,777,515 (GRCm39) |
T333N |
probably benign |
Het |
| Tnk1 |
T |
C |
11: 69,746,508 (GRCm39) |
Y235C |
probably damaging |
Het |
| Ttc17 |
A |
G |
2: 94,208,439 (GRCm39) |
F144S |
probably benign |
Het |
| Twnk |
G |
T |
19: 44,996,578 (GRCm39) |
G337V |
possibly damaging |
Het |
| Unc13a |
A |
G |
8: 72,110,676 (GRCm39) |
F464L |
probably benign |
Het |
| Usp17le |
C |
A |
7: 104,417,667 (GRCm39) |
A492S |
probably damaging |
Het |
| Vmn1r213 |
A |
T |
13: 23,195,932 (GRCm39) |
M172L |
probably benign |
Het |
| Vmn1r71 |
G |
A |
7: 10,482,238 (GRCm39) |
T84I |
probably benign |
Het |
| Vmn2r109 |
C |
T |
17: 20,761,336 (GRCm39) |
V674M |
probably damaging |
Het |
| Vmn2r19 |
A |
T |
6: 123,312,945 (GRCm39) |
I672F |
possibly damaging |
Het |
| Vmn2r77 |
T |
C |
7: 86,450,702 (GRCm39) |
V196A |
probably benign |
Het |
| Xdh |
T |
A |
17: 74,205,357 (GRCm39) |
H1036L |
probably damaging |
Het |
| Zfp930 |
T |
A |
8: 69,680,948 (GRCm39) |
Y214* |
probably null |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCATGACAATCAATCTCCGCAG -3'
(R):5'- CACATCAAGTGGGACCACAGTCAG -3'
Sequencing Primer
(F):5'- CAATCTCCGCAGCCCCC -3'
(R):5'- CCACAGTCAGACTTGGGATG -3'
|
| Posted On |
2013-04-24 |
Incidental Mutation