Incidental Mutation 'R4855:Oprm1'
| ID |
373896 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oprm1
|
| Ensembl Gene |
ENSMUSG00000000766 |
| Gene Name |
opioid receptor, mu 1 |
| Synonyms |
MOP-R, MOR-1, MOP receptor, mor, Oprm, muOR |
| MMRRC Submission |
042466-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R4855 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
6708593-6988209 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 6788468 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 408
(C408S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000783
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000783]
[ENSMUST00000052751]
[ENSMUST00000056385]
[ENSMUST00000063036]
[ENSMUST00000092729]
[ENSMUST00000092731]
[ENSMUST00000092734]
[ENSMUST00000147171]
[ENSMUST00000105607]
[ENSMUST00000105615]
[ENSMUST00000123861]
[ENSMUST00000129954]
[ENSMUST00000105597]
[ENSMUST00000105605]
[ENSMUST00000129221]
[ENSMUST00000105601]
[ENSMUST00000105604]
[ENSMUST00000144264]
[ENSMUST00000105611]
[ENSMUST00000135502]
[ENSMUST00000150374]
[ENSMUST00000152674]
[ENSMUST00000154906]
[ENSMUST00000154941]
|
| AlphaFold |
P42866 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000000783
AA Change: C408S
PolyPhen 2
Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000000783
Gene: ENSMUSG00000000766
AA Change: C408S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
339 |
1.6e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.3e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052751
|
| SMART Domains |
Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000056385
|
| SMART Domains |
Protein: ENSMUSP00000060590
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063036
|
| SMART Domains |
Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
8.7e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092729
|
| SMART Domains |
Protein: ENSMUSP00000090405
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.6e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.1e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092731
|
| SMART Domains |
Protein: ENSMUSP00000090407
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.9e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092734
|
| SMART Domains |
Protein: ENSMUSP00000090410
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141897
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147171
|
| SMART Domains |
Protein: ENSMUSP00000117950
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
9.2e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105607
|
| SMART Domains |
Protein: ENSMUSP00000101232
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105615
|
| SMART Domains |
Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
1.3e-63 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123861
|
| SMART Domains |
Protein: ENSMUSP00000120187
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
100 |
3e-9 |
SMART |
|
PDB:4DKL|A
|
52 |
100 |
3e-21 |
PDB |
|
low complexity region
|
119 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
184 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129954
|
| SMART Domains |
Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
6.9e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.5e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
5.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105597
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105605
|
| SMART Domains |
Protein: ENSMUSP00000101230
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.8e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129221
|
| SMART Domains |
Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
7.3e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2.4e-67 |
PFAM |
|
low complexity region
|
340 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105601
|
| SMART Domains |
Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
100 |
3e-9 |
SMART |
|
PDB:4DKL|A
|
52 |
100 |
3e-21 |
PDB |
|
low complexity region
|
119 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
184 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105604
|
| SMART Domains |
Protein: ENSMUSP00000101229
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
332 |
5.1e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.9e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.8e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144264
|
| SMART Domains |
Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105611
|
| SMART Domains |
Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.4e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
4.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135502
|
| SMART Domains |
Protein: ENSMUSP00000135143
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
339 |
2.2e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.9e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
7.5e-67 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148625
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150374
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152674
|
| SMART Domains |
Protein: ENSMUSP00000115552
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
94 |
8e-8 |
SMART |
|
PDB:4DKL|A
|
52 |
94 |
7e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154906
|
| SMART Domains |
Protein: ENSMUSP00000114342
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
332 |
1.5e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.6e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154941
|
| SMART Domains |
Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
9.6e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
6.1e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2e-67 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.5%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Ablim2 |
C |
T |
5: 35,959,766 (GRCm39) |
R73C |
possibly damaging |
Het |
| Adad1 |
G |
T |
3: 37,139,260 (GRCm39) |
L443F |
probably damaging |
Het |
| Amph |
T |
A |
13: 19,268,378 (GRCm39) |
M70K |
probably damaging |
Het |
| Ankra2 |
T |
A |
13: 98,409,919 (GRCm39) |
L306H |
probably damaging |
Het |
| Arc |
A |
C |
15: 74,543,592 (GRCm39) |
D210E |
probably benign |
Het |
| Arhgap10 |
A |
G |
8: 78,159,367 (GRCm39) |
|
probably null |
Het |
| Atp8b5 |
T |
A |
4: 43,344,449 (GRCm39) |
N445K |
probably benign |
Het |
| C1qc |
G |
T |
4: 136,617,746 (GRCm39) |
Q117K |
probably benign |
Het |
| Cadps |
T |
A |
14: 12,822,449 (GRCm38) |
E97V |
unknown |
Het |
| Capn13 |
GCA |
G |
17: 73,658,501 (GRCm39) |
|
probably null |
Het |
| Cdk13 |
A |
T |
13: 17,895,868 (GRCm39) |
W1014R |
probably damaging |
Het |
| Cltb |
C |
T |
13: 54,746,908 (GRCm39) |
E23K |
probably damaging |
Het |
| Clvs2 |
A |
T |
10: 33,498,642 (GRCm39) |
I96N |
probably damaging |
Het |
| Cwf19l1 |
A |
G |
19: 44,103,006 (GRCm39) |
V403A |
probably damaging |
Het |
| Ddr2 |
A |
T |
1: 169,816,066 (GRCm39) |
L547Q |
possibly damaging |
Het |
| Ebf1 |
A |
T |
11: 44,863,735 (GRCm39) |
K354* |
probably null |
Het |
| Fat4 |
A |
G |
3: 38,942,466 (GRCm39) |
Q453R |
probably benign |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gata6 |
A |
G |
18: 11,054,497 (GRCm39) |
E142G |
possibly damaging |
Het |
| Gm14221 |
T |
C |
2: 160,416,600 (GRCm39) |
|
noncoding transcript |
Het |
| Gm42791 |
C |
A |
5: 148,896,247 (GRCm39) |
|
probably benign |
Het |
| Gm6370 |
G |
T |
5: 146,430,621 (GRCm39) |
V269L |
probably benign |
Het |
| Gphn |
G |
A |
12: 78,673,984 (GRCm39) |
V526M |
probably damaging |
Het |
| Gpt |
A |
T |
15: 76,583,485 (GRCm39) |
E206V |
probably damaging |
Het |
| Grm3 |
G |
A |
5: 9,620,047 (GRCm39) |
A399V |
probably damaging |
Het |
| Helq |
A |
T |
5: 100,931,025 (GRCm39) |
V575E |
possibly damaging |
Het |
| Herc4 |
A |
G |
10: 63,151,437 (GRCm39) |
|
probably null |
Het |
| Ifi207 |
A |
T |
1: 173,557,381 (GRCm39) |
N452K |
probably damaging |
Het |
| Ikbke |
A |
G |
1: 131,184,848 (GRCm39) |
|
probably null |
Het |
| Kbtbd2 |
A |
G |
6: 56,756,687 (GRCm39) |
F350L |
probably benign |
Het |
| Kmt2c |
A |
G |
5: 25,519,555 (GRCm39) |
V2185A |
probably benign |
Het |
| Lgi2 |
T |
C |
5: 52,695,849 (GRCm39) |
Q362R |
probably damaging |
Het |
| Lrit1 |
G |
A |
14: 36,783,773 (GRCm39) |
G367E |
possibly damaging |
Het |
| Lrp1 |
G |
A |
10: 127,446,311 (GRCm39) |
H78Y |
probably benign |
Het |
| Matk |
A |
G |
10: 81,098,720 (GRCm39) |
|
probably benign |
Het |
| Med21 |
G |
A |
6: 146,549,690 (GRCm39) |
G24S |
probably damaging |
Het |
| Met |
G |
T |
6: 17,558,796 (GRCm39) |
L1141F |
probably damaging |
Het |
| Mroh3 |
A |
T |
1: 136,128,677 (GRCm39) |
|
probably null |
Het |
| Mrpl15 |
T |
C |
1: 4,844,683 (GRCm39) |
I203V |
probably benign |
Het |
| Naip1 |
T |
C |
13: 100,559,728 (GRCm39) |
|
probably null |
Het |
| Ndufa9 |
A |
C |
6: 126,804,505 (GRCm39) |
Y298* |
probably null |
Het |
| Neb |
T |
C |
2: 52,188,906 (GRCm39) |
E808G |
probably damaging |
Het |
| Nol4l |
C |
T |
2: 153,253,726 (GRCm39) |
G616S |
probably benign |
Het |
| Or2ag18 |
T |
C |
7: 106,405,463 (GRCm39) |
M69V |
probably benign |
Het |
| Or4f14 |
A |
G |
2: 111,742,444 (GRCm39) |
V277A |
probably benign |
Het |
| Or4k42 |
T |
G |
2: 111,320,293 (GRCm39) |
D70A |
probably damaging |
Het |
| Or52e7 |
T |
A |
7: 104,684,858 (GRCm39) |
I151N |
probably damaging |
Het |
| Or5ak20 |
T |
C |
2: 85,183,793 (GRCm39) |
N159S |
possibly damaging |
Het |
| Paqr3 |
A |
G |
5: 97,256,053 (GRCm39) |
I107T |
possibly damaging |
Het |
| Pex5l |
G |
A |
3: 33,196,989 (GRCm39) |
|
probably benign |
Het |
| Phf8-ps |
C |
T |
17: 33,285,713 (GRCm39) |
S363N |
probably benign |
Het |
| Pik3ap1 |
T |
C |
19: 41,316,284 (GRCm39) |
D326G |
probably benign |
Het |
| Plaa |
G |
T |
4: 94,474,645 (GRCm39) |
D252E |
probably damaging |
Het |
| Plxna2 |
G |
A |
1: 194,480,040 (GRCm39) |
V1404I |
probably benign |
Het |
| Ppargc1a |
G |
A |
5: 51,631,564 (GRCm39) |
A355V |
possibly damaging |
Het |
| Primpol |
A |
G |
8: 47,039,726 (GRCm39) |
S350P |
probably benign |
Het |
| Prlr |
T |
C |
15: 10,328,883 (GRCm39) |
S453P |
probably benign |
Het |
| Psmd5 |
T |
C |
2: 34,742,564 (GRCm39) |
|
probably benign |
Het |
| Robo2 |
A |
T |
16: 73,768,079 (GRCm39) |
V571E |
probably damaging |
Het |
| Sbspon |
A |
T |
1: 15,929,264 (GRCm39) |
S176T |
possibly damaging |
Het |
| Scyl2 |
G |
A |
10: 89,476,325 (GRCm39) |
|
probably benign |
Het |
| Sema3e |
T |
A |
5: 14,280,144 (GRCm39) |
V341E |
probably damaging |
Het |
| Serpinb3b |
A |
T |
1: 107,082,270 (GRCm39) |
F331L |
possibly damaging |
Het |
| Setd2 |
A |
G |
9: 110,401,022 (GRCm39) |
H1736R |
probably benign |
Het |
| Sidt2 |
A |
T |
9: 45,863,327 (GRCm39) |
D180E |
probably benign |
Het |
| Skint9 |
A |
T |
4: 112,248,208 (GRCm39) |
Y179N |
probably benign |
Het |
| Slc27a5 |
T |
C |
7: 12,722,560 (GRCm39) |
N638S |
probably benign |
Het |
| Slc6a4 |
T |
A |
11: 76,904,135 (GRCm39) |
W197R |
probably damaging |
Het |
| Spag17 |
A |
T |
3: 99,970,649 (GRCm39) |
M1278L |
probably benign |
Het |
| Sptbn1 |
T |
A |
11: 30,092,353 (GRCm39) |
I471F |
probably damaging |
Het |
| Tasor2 |
A |
T |
13: 3,616,680 (GRCm39) |
|
probably null |
Het |
| Teddm1a |
A |
G |
1: 153,768,382 (GRCm39) |
Q282R |
probably benign |
Het |
| Tex35 |
A |
G |
1: 156,927,295 (GRCm39) |
L160P |
probably damaging |
Het |
| Tfap2c |
T |
C |
2: 172,393,438 (GRCm39) |
Y118H |
probably damaging |
Het |
| Tpp1 |
T |
C |
7: 105,395,930 (GRCm39) |
Q533R |
probably benign |
Het |
| Ttc13 |
C |
T |
8: 125,401,174 (GRCm39) |
D730N |
probably damaging |
Het |
| Ufc1 |
A |
G |
1: 171,122,375 (GRCm39) |
|
probably benign |
Het |
| Vcpip1 |
A |
G |
1: 9,817,589 (GRCm39) |
W265R |
probably damaging |
Het |
| Wdr11 |
C |
G |
7: 129,202,158 (GRCm39) |
|
probably null |
Het |
| Xirp2 |
A |
G |
2: 67,341,408 (GRCm39) |
I1216M |
possibly damaging |
Het |
| Zswim2 |
A |
G |
2: 83,747,187 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Oprm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01018:Oprm1
|
APN |
10 |
6,987,170 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01768:Oprm1
|
APN |
10 |
6,779,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Oprm1
|
APN |
10 |
6,780,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03391:Oprm1
|
APN |
10 |
6,964,077 (GRCm39) |
intron |
probably benign |
|
|
IGL03410:Oprm1
|
APN |
10 |
6,780,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Oprm1
|
UTSW |
10 |
6,779,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0189:Oprm1
|
UTSW |
10 |
6,739,071 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0321:Oprm1
|
UTSW |
10 |
6,779,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Oprm1
|
UTSW |
10 |
6,782,604 (GRCm39) |
splice site |
probably null |
|
|
R0730:Oprm1
|
UTSW |
10 |
6,782,652 (GRCm39) |
intron |
probably benign |
|
|
R1542:Oprm1
|
UTSW |
10 |
6,738,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1743:Oprm1
|
UTSW |
10 |
6,780,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1874:Oprm1
|
UTSW |
10 |
6,739,035 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2864:Oprm1
|
UTSW |
10 |
6,744,226 (GRCm39) |
splice site |
probably null |
|
|
R2964:Oprm1
|
UTSW |
10 |
6,738,914 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3792:Oprm1
|
UTSW |
10 |
6,789,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4008:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R4049:Oprm1
|
UTSW |
10 |
6,779,087 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4088:Oprm1
|
UTSW |
10 |
6,780,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4724:Oprm1
|
UTSW |
10 |
6,708,656 (GRCm39) |
nonsense |
probably null |
|
|
R4812:Oprm1
|
UTSW |
10 |
6,782,698 (GRCm39) |
intron |
probably benign |
|
|
R4822:Oprm1
|
UTSW |
10 |
6,779,036 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5072:Oprm1
|
UTSW |
10 |
6,782,550 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5768:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R6327:Oprm1
|
UTSW |
10 |
6,780,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7135:Oprm1
|
UTSW |
10 |
6,780,203 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7413:Oprm1
|
UTSW |
10 |
6,778,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7455:Oprm1
|
UTSW |
10 |
6,780,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8192:Oprm1
|
UTSW |
10 |
6,788,417 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8210:Oprm1
|
UTSW |
10 |
6,780,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8945:Oprm1
|
UTSW |
10 |
6,782,644 (GRCm39) |
intron |
probably benign |
|
|
R9054:Oprm1
|
UTSW |
10 |
6,773,914 (GRCm39) |
intron |
probably benign |
|
|
R9723:Oprm1
|
UTSW |
10 |
6,788,514 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9726:Oprm1
|
UTSW |
10 |
6,929,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Oprm1
|
UTSW |
10 |
6,780,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCTTTGATCCTAGAATGAAAGC -3'
(R):5'- ACCCATTTCAGCACTATGAGAAG -3'
Sequencing Primer
(F):5'- TCATTTGTCTATAGGAAGGAAGGG -3'
(R):5'- CCATTTCAGCACTATGAGAAGTTATC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation