Incidental Mutation 'R6277:Or13p10'
ID 507699
Institutional Source Beutler Lab
Gene Symbol Or13p10
Ensembl Gene ENSMUSG00000043698
Gene Name olfactory receptor family 13 subfamily P member 10
Synonyms MOR258-5, Olfr62, IH12, GA_x6K02T2QD9B-18877756-18876809
MMRRC Submission 044447-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R6277 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118522716-118523663 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 118523520 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 269 (S269T)
Ref Sequence ENSEMBL: ENSMUSP00000149687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102666] [ENSMUST00000213189] [ENSMUST00000217013]
AlphaFold L7MU75
Predicted Effect probably benign
Transcript: ENSMUST00000102666
AA Change: S269T

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000099727
Gene: ENSMUSG00000043698
AA Change: S269T

Pfam:7tm_4 34 311 2.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1e-8 PFAM
Pfam:7tm_1 44 293 2.2e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213189
AA Change: S269T

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000217013
AA Change: S269T

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.2%
Validation Efficiency 96% (70/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A G 14: 32,385,651 (GRCm39) Y105H possibly damaging Het
4921539E11Rik A T 4: 103,088,668 (GRCm39) Y179* probably null Het
Abca7 G C 10: 79,841,992 (GRCm39) V1042L probably benign Het
Adck5 C A 15: 76,477,463 (GRCm39) T99K possibly damaging Het
Adcy5 A G 16: 35,109,896 (GRCm39) T823A probably benign Het
Adra1d G T 2: 131,403,083 (GRCm39) R336S probably damaging Het
Arhgap39 A T 15: 76,619,337 (GRCm39) M749K probably damaging Het
Arid4a A G 12: 71,086,665 (GRCm39) R168G possibly damaging Het
Atxn10 A G 15: 85,275,893 (GRCm39) T317A probably benign Het
Bicc1 T C 10: 70,863,731 (GRCm39) K22E possibly damaging Het
Cacna1b T G 2: 24,620,808 (GRCm39) T281P probably damaging Het
Ccdc174 A T 6: 91,857,272 (GRCm39) Q26L probably damaging Het
Celf3 T C 3: 94,392,672 (GRCm39) C124R probably damaging Het
Cfap44 A G 16: 44,257,669 (GRCm39) E1068G probably benign Het
Crybg1 T A 10: 43,873,255 (GRCm39) E1284D probably benign Het
Dcbld2 T A 16: 58,272,119 (GRCm39) Y392N probably damaging Het
Dcbld2 C T 16: 58,285,866 (GRCm39) P675L probably damaging Het
Dnah12 A T 14: 26,492,439 (GRCm39) H1193L probably damaging Het
Efcab3 G C 11: 104,901,148 (GRCm39) E4422D possibly damaging Het
Ern2 A G 7: 121,785,330 (GRCm39) F16L probably benign Het
Fam163b G T 2: 27,002,763 (GRCm39) T78N probably benign Het
Fbxw21 A T 9: 108,974,623 (GRCm39) I299K possibly damaging Het
Foxg1 A G 12: 49,432,299 (GRCm39) N344S probably benign Het
Git2 A G 5: 114,871,308 (GRCm39) I202T probably damaging Het
Gm11595 G T 11: 99,663,510 (GRCm39) P57T unknown Het
Gm12258 G A 11: 58,745,113 (GRCm39) V15M probably damaging Het
Gm15056 C T 8: 21,390,914 (GRCm39) G40S probably damaging Het
Gnal C A 18: 67,346,143 (GRCm39) H274Q probably damaging Het
Hormad2 A T 11: 4,371,583 (GRCm39) probably null Het
Ighv7-2 A G 12: 113,876,087 (GRCm39) I6T probably benign Het
Irf9 A G 14: 55,845,109 (GRCm39) D323G probably benign Het
Klhl23 G T 2: 69,664,096 (GRCm39) D482Y probably damaging Het
Lama4 A G 10: 38,982,006 (GRCm39) N1745S probably damaging Het
Lct T A 1: 128,231,974 (GRCm39) Y625F probably benign Het
Lrrc26 T C 2: 25,180,116 (GRCm39) V39A probably benign Het
Mllt6 G A 11: 97,564,774 (GRCm39) A527T probably damaging Het
Mrgprb4 T A 7: 47,848,649 (GRCm39) D93V probably benign Het
Nlrp5 A G 7: 23,120,880 (GRCm39) D698G probably damaging Het
Pacsin1 T A 17: 27,924,969 (GRCm39) probably null Het
Padi3 A T 4: 140,518,472 (GRCm39) probably null Het
Pcdha8 T C 18: 37,127,411 (GRCm39) I631T probably damaging Het
Pkn3 G A 2: 29,972,957 (GRCm39) G315D possibly damaging Het
Ppfibp1 T A 6: 146,907,422 (GRCm39) D228E probably benign Het
Prag1 G T 8: 36,613,745 (GRCm39) R1099L probably damaging Het
Pramel31 A G 4: 144,090,223 (GRCm39) E421G probably damaging Het
Prr36 A G 8: 4,264,746 (GRCm39) probably benign Het
Prrc2c A G 1: 162,541,883 (GRCm39) S369P probably benign Het
Ptprn2 A G 12: 116,839,800 (GRCm39) D441G probably benign Het
Slc9c1 G A 16: 45,427,204 (GRCm39) probably benign Het
Slit1 G A 19: 41,588,948 (GRCm39) T1513I possibly damaging Het
Smcr8 C T 11: 60,669,635 (GRCm39) T261M probably benign Het
Spata17 G A 1: 186,926,151 (GRCm39) R60* probably null Het
Speer4f1 A G 5: 17,681,241 (GRCm39) R40G probably damaging Het
Spns3 A G 11: 72,420,466 (GRCm39) V340A possibly damaging Het
Srgap3 T C 6: 112,716,344 (GRCm39) I595V probably benign Het
Srms G A 2: 180,848,038 (GRCm39) A489V possibly damaging Het
St3gal4 T C 9: 34,964,558 (GRCm39) N169S probably damaging Het
Taar5 T A 10: 23,847,169 (GRCm39) V189E probably damaging Het
Tbc1d32 G A 10: 56,071,525 (GRCm39) P333L probably benign Het
Tet3 G T 6: 83,345,066 (GRCm39) Y1790* probably null Het
Ticrr T A 7: 79,344,444 (GRCm39) H1436Q probably benign Het
Top6bl G T 19: 4,677,250 (GRCm39) S466* probably null Het
Ubl7 C T 9: 57,830,555 (GRCm39) L334F possibly damaging Het
Unc13a A G 8: 72,119,283 (GRCm39) probably null Het
Unc13c T C 9: 73,606,451 (GRCm39) D1303G probably damaging Het
Vmn2r114 A G 17: 23,509,954 (GRCm39) L842P possibly damaging Het
Vps35 G T 8: 85,987,857 (GRCm39) Q765K possibly damaging Het
Zfp87 G T 13: 74,520,643 (GRCm39) S145* probably null Het
Zgrf1 C T 3: 127,392,461 (GRCm39) A1327V possibly damaging Het
Zkscan6 T A 11: 65,718,983 (GRCm39) S334R probably benign Het
Other mutations in Or13p10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Or13p10 APN 4 118,523,475 (GRCm39) missense probably damaging 1.00
IGL02203:Or13p10 APN 4 118,523,379 (GRCm39) missense probably benign 0.00
IGL02259:Or13p10 APN 4 118,523,634 (GRCm39) missense probably benign 0.00
IGL02523:Or13p10 APN 4 118,523,238 (GRCm39) missense probably benign 0.03
IGL03324:Or13p10 APN 4 118,523,069 (GRCm39) missense probably benign 0.00
R1215:Or13p10 UTSW 4 118,523,496 (GRCm39) missense possibly damaging 0.69
R1656:Or13p10 UTSW 4 118,523,385 (GRCm39) missense probably damaging 0.99
R2085:Or13p10 UTSW 4 118,523,301 (GRCm39) missense probably damaging 0.98
R2441:Or13p10 UTSW 4 118,523,332 (GRCm39) missense possibly damaging 0.94
R6306:Or13p10 UTSW 4 118,523,490 (GRCm39) missense probably benign 0.00
R6418:Or13p10 UTSW 4 118,522,808 (GRCm39) missense possibly damaging 0.77
R6700:Or13p10 UTSW 4 118,523,609 (GRCm39) missense probably benign 0.42
R7410:Or13p10 UTSW 4 118,523,629 (GRCm39) missense probably benign 0.31
R7723:Or13p10 UTSW 4 118,522,914 (GRCm39) missense probably benign 0.01
R7991:Or13p10 UTSW 4 118,523,489 (GRCm39) nonsense probably null
R8222:Or13p10 UTSW 4 118,523,113 (GRCm39) missense probably damaging 1.00
R8329:Or13p10 UTSW 4 118,523,604 (GRCm39) missense probably damaging 1.00
R8896:Or13p10 UTSW 4 118,523,502 (GRCm39) missense probably benign 0.05
Z1176:Or13p10 UTSW 4 118,523,023 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-03-15