Mutagenetix > Incidental Mutation

Incidental Mutation 'R7744:Or10q1'

596763

Institutional Source

Beutler Lab

Gene Symbol

Or10q1

Ensembl Gene

ENSMUSG00000050865

Gene Name

olfactory receptor family 10 subfamily Q member 1

Synonyms

MOR266-1, Olfr1494, GA_x6K02T2RE5P-4082427-4083374

MMRRC Submission

045800-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R7744 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13726472-13727419 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 13727419 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Tryptophan at position 316 (*316W)

Ref Sequence

ENSEMBL: ENSMUSP00000146563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051768] [ENSMUST00000207836]

AlphaFold

Q8VGP8

Predicted Effect

probably null
Transcript: ENSMUST00000051768
AA Change: *316W

SMART Domains

Protein: ENSMUSP00000056291
Gene: ENSMUSG00000050865
AA Change: *316W

Domain	Start	End	E-Value	Type
low complexity region	13	27	N/A	INTRINSIC
Pfam:7tm_4	35	313	3.2e-53	PFAM
Pfam:7tm_1	45	295	7.5e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000207836
AA Change: *316W

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,240,421 (GRCm39)	N761K	possibly damaging	Het
Abi2	A	G	1: 60,476,362 (GRCm39)	I145V	probably benign	Het
Ampd2	C	A	3: 107,987,432 (GRCm39)	V134L	probably benign	Het
Atf7ip2	T	A	16: 10,059,522 (GRCm39)	V354E	possibly damaging	Het
Bglap	T	C	3: 88,290,958 (GRCm39)	Y91C	probably damaging	Het
Cacna1e	A	T	1: 154,341,538 (GRCm39)	S1219T	probably damaging	Het
Ccng2	C	G	5: 93,421,202 (GRCm39)	S237R	probably benign	Het
Cd177	A	G	7: 24,449,800 (GRCm39)	C562R	probably damaging	Het
Cfap57	C	T	4: 118,472,128 (GRCm39)	V84I	probably benign	Het
Chd7	T	A	4: 8,862,485 (GRCm39)		probably null	Het
Dyrk3	A	G	1: 131,057,543 (GRCm39)	V210A	probably damaging	Het
Eif3c	C	A	7: 126,158,066 (GRCm39)	G297W	probably damaging	Het
Eml1	A	G	12: 108,482,863 (GRCm39)	H494R	probably benign	Het
Enpp2	A	T	15: 54,764,629 (GRCm39)		probably null	Het
Fbxw21	C	A	9: 108,986,720 (GRCm39)	C53F	possibly damaging	Het
Fndc3a	C	A	14: 72,799,156 (GRCm39)	G609V	possibly damaging	Het
Grid1	A	G	14: 35,172,036 (GRCm39)	D514G	probably damaging	Het
Gxylt2	T	C	6: 100,760,278 (GRCm39)	V271A	probably damaging	Het
Hes1	A	G	16: 29,884,997 (GRCm39)	K74R	probably damaging	Het
Igsf9	A	G	1: 172,319,752 (GRCm39)	N349S	probably benign	Het
Isx	T	A	8: 75,600,285 (GRCm39)	I6N	possibly damaging	Het
Kcnb1	A	T	2: 167,030,251 (GRCm39)	F98Y	probably damaging	Het
Kif1b	G	C	4: 149,321,532 (GRCm39)	T1129R	possibly damaging	Het
Klra10	T	A	6: 130,249,724 (GRCm39)		probably null	Het
Mcm10	A	T	2: 4,996,253 (GRCm39)	L870Q	probably damaging	Het
Mettl16	T	A	11: 74,693,829 (GRCm39)	I280K	probably benign	Het
Mre11a	G	A	9: 14,721,128 (GRCm39)	R349Q	possibly damaging	Het
Mrpl10	C	T	11: 96,935,402 (GRCm39)	T34I	probably damaging	Het
Muc16	T	A	9: 18,496,392 (GRCm39)		probably null	Het
Myt1l	T	C	12: 29,877,548 (GRCm39)	C400R	unknown	Het
Nbr1	C	T	11: 101,460,210 (GRCm39)	T402M	probably damaging	Het
Ndufs1	A	G	1: 63,200,099 (GRCm39)	M271T	possibly damaging	Het
Or4c29	C	T	2: 88,740,003 (GRCm39)	V245I	possibly damaging	Het
Or51f23c-ps1	G	T	7: 102,431,597 (GRCm39)	V305L	probably benign	Het
Pakap	T	C	4: 57,709,519 (GRCm39)	S155P	probably damaging	Het
Pced1a	C	T	2: 130,263,972 (GRCm39)	D227N	probably damaging	Het
Phf21b	A	G	15: 84,689,070 (GRCm39)	I152T	probably damaging	Het
Pla2g4a	A	G	1: 149,736,853 (GRCm39)	V430A	probably benign	Het
Plbd1	T	C	6: 136,594,244 (GRCm39)	E335G	probably benign	Het
Plce1	G	A	19: 38,608,899 (GRCm39)	V403M	possibly damaging	Het
Pnpla6	T	A	8: 3,581,677 (GRCm39)	N642K	probably benign	Het
Ptprb	T	C	10: 116,113,389 (GRCm39)	I123T	probably benign	Het
Rab3il1	T	A	19: 10,005,641 (GRCm39)		probably null	Het
Ranbp3	C	T	17: 57,015,219 (GRCm39)	T307M	possibly damaging	Het
Rasgrp2	T	C	19: 6,455,031 (GRCm39)	S254P	probably damaging	Het
Rgl3	T	C	9: 21,898,866 (GRCm39)	K191R	probably benign	Het
Rnf223	G	A	4: 156,216,982 (GRCm39)	R119H	probably benign	Het
Sapcd2	C	T	2: 25,263,508 (GRCm39)	P217S	unknown	Het
Setd7	C	T	3: 51,434,261 (GRCm39)		probably null	Het
Sh3bp1	A	C	15: 78,794,209 (GRCm39)	T526P	possibly damaging	Het
Slc17a4	C	A	13: 24,085,767 (GRCm39)	W382L	probably benign	Het
Slc26a3	A	T	12: 31,513,464 (GRCm39)		probably null	Het
Tmem129	A	G	5: 33,811,732 (GRCm39)	L356P	probably damaging	Het
Trib1	T	A	15: 59,526,512 (GRCm39)	Y361N	probably benign	Het
Xirp1	T	A	9: 119,845,912 (GRCm39)	R990S	possibly damaging	Het
Zfp950	A	C	19: 61,116,010 (GRCm39)		probably null	Het

Other mutations in Or10q1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02134:Or10q1	APN	19	13,727,165 (GRCm39)	missense	probably benign	0.04
IGL02335:Or10q1	APN	19	13,727,298 (GRCm39)	missense	probably benign	0.01
IGL02388:Or10q1	APN	19	13,726,994 (GRCm39)	missense	possibly damaging	0.91
IGL03231:Or10q1	APN	19	13,726,749 (GRCm39)	missense	probably benign	0.35
R0133:Or10q1	UTSW	19	13,727,352 (GRCm39)	missense	probably damaging	1.00
R0142:Or10q1	UTSW	19	13,726,619 (GRCm39)	missense	probably benign	0.00
R0561:Or10q1	UTSW	19	13,726,662 (GRCm39)	missense	probably damaging	1.00
R0783:Or10q1	UTSW	19	13,727,040 (GRCm39)	missense	probably damaging	0.99
R1826:Or10q1	UTSW	19	13,726,711 (GRCm39)	missense	probably benign	0.05
R1967:Or10q1	UTSW	19	13,727,417 (GRCm39)	makesense	probably null
R3706:Or10q1	UTSW	19	13,726,476 (GRCm39)	missense	probably benign	0.42
R5417:Or10q1	UTSW	19	13,727,217 (GRCm39)	missense	probably benign	0.18
R6508:Or10q1	UTSW	19	13,726,718 (GRCm39)	missense	probably damaging	1.00
R7126:Or10q1	UTSW	19	13,726,887 (GRCm39)	missense	possibly damaging	0.90
R7262:Or10q1	UTSW	19	13,726,535 (GRCm39)	missense	probably benign	0.02
R7395:Or10q1	UTSW	19	13,726,502 (GRCm39)	missense	probably damaging	0.98
R7740:Or10q1	UTSW	19	13,727,328 (GRCm39)	missense	probably benign	0.00
R7864:Or10q1	UTSW	19	13,726,710 (GRCm39)	missense	probably benign	0.03
R8495:Or10q1	UTSW	19	13,726,593 (GRCm39)	missense	possibly damaging	0.95
R9372:Or10q1	UTSW	19	13,727,069 (GRCm39)	missense	probably benign	0.14

Predicted Primers

PCR Primer
(F):5'- ACCTCACTGTGGTCTTGCTG -3'
(R):5'- GCTCCCATATTGGAAGCTATATTC -3'

Sequencing Primer
(F):5'- CAGTATGGTTGCTGCAGCC -3'
(R):5'- GTCCTTTTCAGTTGAATGGT -3'

Posted On

2019-11-26