Incidental Mutation 'R7864:Or10q1'
ID 607752
Institutional Source Beutler Lab
Gene Symbol Or10q1
Ensembl Gene ENSMUSG00000050865
Gene Name olfactory receptor family 10 subfamily Q member 1
Synonyms MOR266-1, Olfr1494, GA_x6K02T2RE5P-4082427-4083374
MMRRC Submission 045917-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R7864 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13726472-13727419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13726710 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 80 (D80G)
Ref Sequence ENSEMBL: ENSMUSP00000146563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051768] [ENSMUST00000207836]
AlphaFold Q8VGP8
Predicted Effect probably benign
Transcript: ENSMUST00000051768
AA Change: D80G

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000056291
Gene: ENSMUSG00000050865
AA Change: D80G

DomainStartEndE-ValueType
low complexity region 13 27 N/A INTRINSIC
Pfam:7tm_4 35 313 3.2e-53 PFAM
Pfam:7tm_1 45 295 7.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207836
AA Change: D80G

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot2 C T 12: 84,034,796 (GRCm39) R41W probably benign Het
Adam32 T A 8: 25,412,292 (GRCm39) H88L probably benign Het
Ank1 A G 8: 23,577,976 (GRCm39) T238A probably damaging Het
Arid1b T C 17: 5,392,530 (GRCm39) L1967P probably damaging Het
Bbx G T 16: 50,082,797 (GRCm39) H216Q probably damaging Het
C030005K15Rik G A 10: 97,561,614 (GRCm39) T39M probably damaging Het
C1s2 A G 6: 124,602,246 (GRCm39) V655A probably benign Het
Carmil2 A G 8: 106,414,906 (GRCm39) Y184C probably damaging Het
Ces1f G A 8: 94,000,769 (GRCm39) A125V possibly damaging Het
Chaf1a C T 17: 56,354,339 (GRCm39) T203I unknown Het
Cntn5 A G 9: 9,984,182 (GRCm39) S144P probably damaging Het
Cpa5 A T 6: 30,631,394 (GRCm39) Y436F probably damaging Het
Dbf4 A T 5: 8,460,010 (GRCm39) H150Q possibly damaging Het
Dlg5 G A 14: 24,295,280 (GRCm39) P80L probably damaging Het
Dock8 A T 19: 25,140,864 (GRCm39) D1360V possibly damaging Het
Ecm1 A T 3: 95,641,689 (GRCm39) I515N probably benign Het
Fancc A T 13: 63,548,073 (GRCm39) C75* probably null Het
Foxa1 A T 12: 57,589,533 (GRCm39) V229D probably damaging Het
Gga1 T C 15: 78,772,444 (GRCm39) M248T probably damaging Het
Gm1527 A G 3: 28,980,619 (GRCm39) Q573R probably benign Het
Hivep1 A C 13: 42,312,290 (GRCm39) H1510P probably benign Het
Htr1f A C 16: 64,747,157 (GRCm39) I45S probably damaging Het
Itsn1 T C 16: 91,598,454 (GRCm39) V129A possibly damaging Het
Klrg2 G T 6: 38,605,024 (GRCm39) Q347K possibly damaging Het
Lama2 G A 10: 26,932,611 (GRCm39) T1996I probably benign Het
Man1a C A 10: 53,906,843 (GRCm39) L219F possibly damaging Het
Mcub A G 3: 129,712,272 (GRCm39) I201T probably damaging Het
Otogl A G 10: 107,705,428 (GRCm39) L633P probably damaging Het
Pate9 A T 9: 36,445,747 (GRCm39) F68Y probably benign Het
Pik3ca T A 3: 32,497,762 (GRCm39) L429* probably null Het
Pkhd1l1 T C 15: 44,389,449 (GRCm39) probably null Het
Pld4 C A 12: 112,731,557 (GRCm39) Q237K probably damaging Het
Plekhm2 T C 4: 141,355,357 (GRCm39) E897G probably damaging Het
Pomt2 A G 12: 87,169,656 (GRCm39) F475L probably benign Het
Popdc3 G A 10: 45,191,278 (GRCm39) A130T probably benign Het
Prss54 T C 8: 96,286,297 (GRCm39) K259E probably benign Het
Psg23 T G 7: 18,344,435 (GRCm39) N340T possibly damaging Het
Rab1a G T 11: 20,165,673 (GRCm39) G23* probably null Het
Rgs9 A T 11: 109,166,446 (GRCm39) F108Y probably damaging Het
Scn9a T A 2: 66,314,904 (GRCm39) T1605S possibly damaging Het
Sh2d4b G A 14: 40,562,208 (GRCm39) T319I probably damaging Het
Slc28a3 A T 13: 58,726,217 (GRCm39) probably null Het
Syngap1 A T 17: 27,189,502 (GRCm39) Q1286L Het
Tmem132d G A 5: 127,860,980 (GRCm39) T1047I probably damaging Het
Togaram2 G A 17: 72,007,935 (GRCm39) R420H probably damaging Het
Uimc1 G A 13: 55,241,080 (GRCm39) R3* probably null Het
Vmn2r7 C T 3: 64,598,947 (GRCm39) V537I probably benign Het
Wwp1 T A 4: 19,635,328 (GRCm39) K584N probably damaging Het
Zc3h12d A T 10: 7,715,723 (GRCm39) Q42L possibly damaging Het
Zfp729a A T 13: 67,769,569 (GRCm39) V220E probably benign Het
Zfp91 A G 19: 12,748,403 (GRCm39) V391A probably damaging Het
Other mutations in Or10q1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or10q1 APN 19 13,727,165 (GRCm39) missense probably benign 0.04
IGL02335:Or10q1 APN 19 13,727,298 (GRCm39) missense probably benign 0.01
IGL02388:Or10q1 APN 19 13,726,994 (GRCm39) missense possibly damaging 0.91
IGL03231:Or10q1 APN 19 13,726,749 (GRCm39) missense probably benign 0.35
R0133:Or10q1 UTSW 19 13,727,352 (GRCm39) missense probably damaging 1.00
R0142:Or10q1 UTSW 19 13,726,619 (GRCm39) missense probably benign 0.00
R0561:Or10q1 UTSW 19 13,726,662 (GRCm39) missense probably damaging 1.00
R0783:Or10q1 UTSW 19 13,727,040 (GRCm39) missense probably damaging 0.99
R1826:Or10q1 UTSW 19 13,726,711 (GRCm39) missense probably benign 0.05
R1967:Or10q1 UTSW 19 13,727,417 (GRCm39) makesense probably null
R3706:Or10q1 UTSW 19 13,726,476 (GRCm39) missense probably benign 0.42
R5417:Or10q1 UTSW 19 13,727,217 (GRCm39) missense probably benign 0.18
R6508:Or10q1 UTSW 19 13,726,718 (GRCm39) missense probably damaging 1.00
R7126:Or10q1 UTSW 19 13,726,887 (GRCm39) missense possibly damaging 0.90
R7262:Or10q1 UTSW 19 13,726,535 (GRCm39) missense probably benign 0.02
R7395:Or10q1 UTSW 19 13,726,502 (GRCm39) missense probably damaging 0.98
R7740:Or10q1 UTSW 19 13,727,328 (GRCm39) missense probably benign 0.00
R7744:Or10q1 UTSW 19 13,727,419 (GRCm39) makesense probably null
R8495:Or10q1 UTSW 19 13,726,593 (GRCm39) missense possibly damaging 0.95
R9372:Or10q1 UTSW 19 13,727,069 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- GACCACTGAGTTTGTGTTCCG -3'
(R):5'- GACACACAGCTTCTTGGTCATG -3'

Sequencing Primer
(F):5'- GAGTTTGTGTTCCGTGTCTTCACC -3'
(R):5'- CACACAGCTTCTTGGTCATGATGAG -3'
Posted On 2019-12-20