Mutagenetix > Incidental Mutation

Incidental Mutation 'R7817:Or9m1b'

601579

Institutional Source

Beutler Lab

Gene Symbol

Or9m1b

Ensembl Gene

ENSMUSG00000075141

Gene Name

olfactory receptor family 9 subfamily M member 1B

Synonyms

Olfr1160, MOR173-1, GA_x6K02T2Q125-49498697-49497765

MMRRC Submission

045871-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

R7817 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87836161-87837120 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 87836355 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 247 (I247V)

Ref Sequence

ENSEMBL: ENSMUSP00000148857 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]

AlphaFold

A2AVT0

Predicted Effect

probably benign
Transcript: ENSMUST00000099839
AA Change: I256V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: I256V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	40	316	1.2e-46	PFAM
Pfam:7tm_1	50	298	2e-17	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215457
AA Change: I247V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

96% (45/47)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts17	T	C	7: 66,559,224 (GRCm39)	V338A	probably damaging	Het
Akap13	G	A	7: 75,380,213 (GRCm39)	R462H	probably damaging	Het
BC005537	C	T	13: 24,987,382 (GRCm39)	R7W	possibly damaging	Het
Bivm	G	T	1: 44,165,561 (GRCm39)	A4S	probably benign	Het
Cacng3	G	A	7: 122,367,822 (GRCm39)	R234Q	probably damaging	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,128,173 (GRCm39)		probably benign	Het
Cftr	A	G	6: 18,267,967 (GRCm39)	D642G	probably damaging	Het
Cltc	A	G	11: 86,615,949 (GRCm39)	V443A	probably damaging	Het
Csmd3	C	T	15: 47,721,356 (GRCm39)	R1425H	probably damaging	Het
Cttnbp2	G	C	6: 18,426,092 (GRCm39)	A762G	possibly damaging	Het
Dscam	T	C	16: 96,442,064 (GRCm39)	T1588A	probably benign	Het
Gabra4	A	G	5: 71,798,206 (GRCm39)	M207T	probably damaging	Het
Galnt3	A	G	2: 65,926,243 (GRCm39)	Y322H	probably damaging	Het
Glud1	A	T	14: 34,051,244 (GRCm39)		probably null	Het
Gm47189	A	G	14: 41,492,011 (GRCm39)	Y89H	probably damaging	Het
Klhl1	A	T	14: 96,374,186 (GRCm39)	M620K	possibly damaging	Het
Krt9	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	11: 100,079,903 (GRCm39)		probably benign	Het
Mocs2	A	G	13: 114,957,382 (GRCm39)	E62G	probably damaging	Het
Myh7	C	G	14: 55,226,258 (GRCm39)	D461H	probably damaging	Het
Nek10	C	T	14: 15,001,017 (GRCm38)	P1066S	probably benign	Het
Nfxl1	T	C	5: 72,671,632 (GRCm39)	K876E	possibly damaging	Het
Nipsnap3a	T	A	4: 52,997,279 (GRCm39)	F182I	probably damaging	Het
Nlrc3	C	T	16: 3,783,327 (GRCm39)	G60S	possibly damaging	Het
Notch2	T	C	3: 98,014,443 (GRCm39)	Y666H	probably damaging	Het
Pars2	T	A	4: 106,511,276 (GRCm39)	Y353N	probably damaging	Het
Pcdhb11	A	G	18: 37,556,962 (GRCm39)	E764G	probably damaging	Het
Pcdhb3	T	A	18: 37,435,982 (GRCm39)	D649E	probably benign	Het
Pde7b	T	G	10: 20,319,051 (GRCm39)	R90S	probably damaging	Het
Pik3r5	T	C	11: 68,384,483 (GRCm39)	V625A	probably damaging	Het
Prdm9	G	A	17: 15,779,311 (GRCm39)	R113W	probably damaging	Het
Psg26	A	G	7: 18,216,572 (GRCm39)	V89A	not run	Het
Rad1	T	C	15: 10,493,404 (GRCm39)	V277A	probably benign	Het
Rb1	A	T	14: 73,435,983 (GRCm39)	L894Q	probably damaging	Het
Rorb	A	T	19: 18,965,460 (GRCm39)	C10S	probably damaging	Het
Ryk	C	T	9: 102,768,432 (GRCm39)	Q361*	probably null	Het
Serpina3b	A	G	12: 104,099,223 (GRCm39)	N246S	probably benign	Het
Srr	A	G	11: 74,799,524 (GRCm39)	V317A	possibly damaging	Het
Timd2	A	T	11: 46,561,781 (GRCm39)	C288S	probably benign	Het
Tomm70a	C	T	16: 56,965,136 (GRCm39)	A440V	probably damaging	Het
Trim62	T	C	4: 128,794,478 (GRCm39)	V215A	probably benign	Het
Trio	C	G	15: 27,749,952 (GRCm39)	V2250L	probably benign	Het
Ubr5	G	A	15: 37,980,076 (GRCm39)	A2434V	probably null	Het
Unc13d	A	T	11: 115,967,109 (GRCm39)	V91D	probably damaging	Het
Vmn1r159	T	A	7: 22,542,487 (GRCm39)	I182F	possibly damaging	Het
Vmn1r230	T	A	17: 21,066,823 (GRCm39)	V4D	probably benign	Het
Zfp27	T	C	7: 29,595,815 (GRCm39)	Y50C	possibly damaging	Het
Zfp354c	TCACACTCGGCACA	TCACA	11: 50,706,067 (GRCm39)		probably benign	Het
Zfp518b	T	C	5: 38,829,741 (GRCm39)	I755V	not run	Het

Other mutations in Or9m1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Or9m1b	APN	2	87,836,988 (GRCm39)	missense	probably damaging	1.00
IGL01321:Or9m1b	APN	2	87,836,589 (GRCm39)	missense	probably damaging	0.97
IGL02009:Or9m1b	APN	2	87,837,117 (GRCm39)	missense	probably benign
IGL03409:Or9m1b	APN	2	87,836,239 (GRCm39)	missense	probably damaging	1.00
R0089:Or9m1b	UTSW	2	87,836,331 (GRCm39)	missense	probably damaging	1.00
R0685:Or9m1b	UTSW	2	87,836,762 (GRCm39)	missense	probably damaging	1.00
R1416:Or9m1b	UTSW	2	87,836,915 (GRCm39)	missense	probably damaging	1.00
R1852:Or9m1b	UTSW	2	87,836,865 (GRCm39)	missense	probably damaging	1.00
R1965:Or9m1b	UTSW	2	87,836,648 (GRCm39)	missense	probably damaging	1.00
R2206:Or9m1b	UTSW	2	87,836,579 (GRCm39)	missense	probably benign	0.00
R4853:Or9m1b	UTSW	2	87,836,448 (GRCm39)	missense	probably damaging	1.00
R5599:Or9m1b	UTSW	2	87,836,349 (GRCm39)	missense	probably benign	0.44
R6851:Or9m1b	UTSW	2	87,836,300 (GRCm39)	missense	probably damaging	0.98
R6995:Or9m1b	UTSW	2	87,836,529 (GRCm39)	missense	probably benign	0.00
R7970:Or9m1b	UTSW	2	87,836,169 (GRCm39)	missense	probably benign	0.02
R7984:Or9m1b	UTSW	2	87,836,969 (GRCm39)	missense	probably damaging	1.00
R8325:Or9m1b	UTSW	2	87,836,537 (GRCm39)	missense	probably damaging	1.00
R8912:Or9m1b	UTSW	2	87,836,661 (GRCm39)	missense	possibly damaging	0.93
Z1176:Or9m1b	UTSW	2	87,836,781 (GRCm39)	missense	probably damaging	0.98
Z31818:Or9m1b	UTSW	2	87,836,234 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GCTAATGCTGTAAAGCCCATC -3'
(R):5'- TGCTTTGATACCTACACACATGAC -3'

Sequencing Primer
(F):5'- GCTGTAAAGCCCATCGTTAAATAGC -3'
(R):5'- CACACATGACATAATATTGGTGGTG -3'

Posted On

2019-12-03