Mutagenetix > Incidental Mutation

Incidental Mutation 'R7984:Or9m1b'

651354

Institutional Source

Beutler Lab

Gene Symbol

Or9m1b

Ensembl Gene

ENSMUSG00000075141

Gene Name

olfactory receptor family 9 subfamily M member 1B

Synonyms

Olfr1160, MOR173-1, GA_x6K02T2Q125-49498697-49497765

MMRRC Submission

046025-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

R7984 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87836161-87837120 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 87836969 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 42 (N42I)

Ref Sequence

ENSEMBL: ENSMUSP00000148857 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]

AlphaFold

A2AVT0

Predicted Effect

probably damaging
Transcript: ENSMUST00000099839
AA Change: N51I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: N51I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	40	316	1.2e-46	PFAM
Pfam:7tm_1	50	298	2e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215457
AA Change: N42I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (58/58)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1e1	G	T	13: 4,645,679 (GRCm39)	H226N	probably damaging	Het
Aldh1a7	T	C	19: 20,686,764 (GRCm39)	D283G	probably damaging	Het
Angel1	T	C	12: 86,767,068 (GRCm39)	D436G	probably benign	Het
Ank1	G	A	8: 23,578,982 (GRCm39)	R314Q	probably damaging	Het
Apbb2	T	C	5: 66,465,035 (GRCm39)	E629G	probably damaging	Het
Card9	T	G	2: 26,246,784 (GRCm39)	I355L	probably benign	Het
Cdon	C	T	9: 35,414,598 (GRCm39)	P1158S	probably benign	Het
Cpne7	T	G	8: 123,846,461 (GRCm39)	V91G	possibly damaging	Het
Dlc1	T	A	8: 37,405,472 (GRCm39)	T106S	possibly damaging	Het
Dnah1	A	T	14: 30,989,772 (GRCm39)	F3248Y	probably damaging	Het
Dnah7a	A	T	1: 53,543,377 (GRCm39)	D2264E	probably benign	Het
Dock7	A	T	4: 98,877,303 (GRCm39)	N1078K	unknown	Het
Emc1	T	A	4: 139,102,760 (GRCm39)	L973H	probably damaging	Het
Fer1l5	T	A	1: 36,447,702 (GRCm39)	L955Q	possibly damaging	Het
Fpr-rs7	T	C	17: 20,333,671 (GRCm39)	N273S	probably benign	Het
Gle1	T	A	2: 29,828,588 (GRCm39)	Y137N	probably damaging	Het
Grik4	G	A	9: 42,582,557 (GRCm39)	Q130*	probably null	Het
Hcn1	C	T	13: 118,112,609 (GRCm39)	Q858*	probably null	Het
Heg1	A	C	16: 33,583,945 (GRCm39)	S76R	possibly damaging	Het
Ikbke	T	A	1: 131,203,523 (GRCm39)	E50V	probably null	Het
Itga5	G	A	15: 103,264,379 (GRCm39)	P297S	probably damaging	Het
Kcng1	C	A	2: 168,104,406 (GRCm39)	R480L	possibly damaging	Het
Kdm3b	G	T	18: 34,956,752 (GRCm39)	E1236*	probably null	Het
Ldlrad4	G	T	18: 68,368,740 (GRCm39)	A66S	possibly damaging	Het
Lrp5	A	G	19: 3,662,342 (GRCm39)	F894L	probably damaging	Het
Lrrk1	T	C	7: 65,950,477 (GRCm39)		probably null	Het
Man2a2	T	G	7: 80,003,056 (GRCm39)	T1018P	probably damaging	Het
Mctp2	T	C	7: 71,752,937 (GRCm39)	Q772R	possibly damaging	Het
Meioc	T	A	11: 102,565,432 (GRCm39)	N293K	possibly damaging	Het
Mrps24	A	T	11: 5,657,495 (GRCm39)	C34S	possibly damaging	Het
Nek1	G	T	8: 61,574,087 (GRCm39)	E1112*	probably null	Het
Nt5dc2	A	G	14: 30,860,775 (GRCm39)	S317G	probably damaging	Het
Obscn	G	T	11: 58,997,151 (GRCm39)	Q1492K	possibly damaging	Het
Or2a57	T	G	6: 43,212,730 (GRCm39)	S63A	probably damaging	Het
Or52e4	T	C	7: 104,705,639 (GRCm39)	F62S	probably damaging	Het
Or6c69	A	G	10: 129,747,941 (GRCm39)	F69L	probably benign	Het
Or8b36	A	G	9: 37,937,155 (GRCm39)	T18A	probably damaging	Het
Or9s23	A	G	1: 92,501,144 (GRCm39)	I84V	probably benign	Het
P2ry12	T	A	3: 59,125,022 (GRCm39)	I218F	probably damaging	Het
Paip1	C	T	13: 119,566,698 (GRCm39)	Q11*	probably null	Het
Pcdhga3	C	A	18: 37,809,549 (GRCm39)	D667E	probably benign	Het
Pcnx2	T	G	8: 126,485,865 (GRCm39)	E1911A	probably benign	Het
Pibf1	T	C	14: 99,459,063 (GRCm39)	L678P	probably damaging	Het
Pira2	A	T	7: 3,844,696 (GRCm39)	F445Y	probably benign	Het
Prickle2	T	C	6: 92,387,855 (GRCm39)	T516A	probably benign	Het
Prl2c1	G	A	13: 28,039,310 (GRCm39)		probably null	Het
Rnf112	A	G	11: 61,340,306 (GRCm39)	V656A	possibly damaging	Het
Siglecf	A	C	7: 43,004,655 (GRCm39)		probably null	Het
Slc24a1	A	T	9: 64,856,811 (GRCm39)	L32*	probably null	Het
Slc7a1	A	G	5: 148,278,920 (GRCm39)	V284A	possibly damaging	Het
Slco5a1	T	A	1: 12,951,608 (GRCm39)	H565L	probably damaging	Het
Slit2	A	G	5: 48,333,465 (GRCm39)		probably benign	Het
Sulf1	A	G	1: 12,929,497 (GRCm39)	T255A	probably benign	Het
Tmem130	C	T	5: 144,692,237 (GRCm39)	G56R	possibly damaging	Het
Trmt1l	A	C	1: 151,311,489 (GRCm39)	Q116H	probably benign	Het
Ttn	A	T	2: 76,554,094 (GRCm39)	W30870R	probably damaging	Het
Unc13b	A	T	4: 43,173,973 (GRCm39)	L1600F	unknown	Het
Vmn1r233	C	T	17: 21,214,417 (GRCm39)	V178M	probably damaging	Het
Vmn2r18	G	A	5: 151,485,526 (GRCm39)	P656L	probably damaging	Het
Vmn2r33	A	T	7: 7,566,862 (GRCm39)	D83E	probably benign	Het
Vps13b	G	A	15: 35,880,059 (GRCm39)	V3045I	probably benign	Het
Wdr25	A	T	12: 108,976,983 (GRCm39)		probably null	Het
Xpo6	A	G	7: 125,719,616 (GRCm39)	V591A	probably benign	Het

Other mutations in Or9m1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Or9m1b	APN	2	87,836,988 (GRCm39)	missense	probably damaging	1.00
IGL01321:Or9m1b	APN	2	87,836,589 (GRCm39)	missense	probably damaging	0.97
IGL02009:Or9m1b	APN	2	87,837,117 (GRCm39)	missense	probably benign
IGL03409:Or9m1b	APN	2	87,836,239 (GRCm39)	missense	probably damaging	1.00
R0089:Or9m1b	UTSW	2	87,836,331 (GRCm39)	missense	probably damaging	1.00
R0685:Or9m1b	UTSW	2	87,836,762 (GRCm39)	missense	probably damaging	1.00
R1416:Or9m1b	UTSW	2	87,836,915 (GRCm39)	missense	probably damaging	1.00
R1852:Or9m1b	UTSW	2	87,836,865 (GRCm39)	missense	probably damaging	1.00
R1965:Or9m1b	UTSW	2	87,836,648 (GRCm39)	missense	probably damaging	1.00
R2206:Or9m1b	UTSW	2	87,836,579 (GRCm39)	missense	probably benign	0.00
R4853:Or9m1b	UTSW	2	87,836,448 (GRCm39)	missense	probably damaging	1.00
R5599:Or9m1b	UTSW	2	87,836,349 (GRCm39)	missense	probably benign	0.44
R6851:Or9m1b	UTSW	2	87,836,300 (GRCm39)	missense	probably damaging	0.98
R6995:Or9m1b	UTSW	2	87,836,529 (GRCm39)	missense	probably benign	0.00
R7817:Or9m1b	UTSW	2	87,836,355 (GRCm39)	missense	probably benign
R7970:Or9m1b	UTSW	2	87,836,169 (GRCm39)	missense	probably benign	0.02
R8325:Or9m1b	UTSW	2	87,836,537 (GRCm39)	missense	probably damaging	1.00
R8912:Or9m1b	UTSW	2	87,836,661 (GRCm39)	missense	possibly damaging	0.93
Z1176:Or9m1b	UTSW	2	87,836,781 (GRCm39)	missense	probably damaging	0.98
Z31818:Or9m1b	UTSW	2	87,836,234 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GAAAGATTCTGTATCAACCAGAGAG -3'
(R):5'- CTGTCATCTATATTCAGAGCACAAC -3'

Sequencing Primer
(F):5'- CACAAGTAATTTGGGGGC -3'
(R):5'- TGTGATGGTGAATATGAAGCATG -3'

Posted On

2020-09-15