Mutagenetix > Incidental Mutation

Incidental Mutation 'R8406:Or13a24'

652420

Institutional Source

Beutler Lab

Gene Symbol

Or13a24

Ensembl Gene

ENSMUSG00000095901

Gene Name

olfactory receptor family 13 subfamily A member 24

Synonyms

Olfr538, MOR253-13P, MOR253-13P, MOR253-12P, GA_x6K02T2PBJ9-42723314-42724246, MOR253-10P, Olfr1523-ps1, Olfr1553-ps1, MOR253-12P

MMRRC Submission

067765-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R8406 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

140154068-140155000 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to T at 140154044 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084457] [ENSMUST00000210973]

AlphaFold

Q7TRT5

Predicted Effect

probably benign
Transcript: ENSMUST00000084457

SMART Domains

Protein: ENSMUSP00000081495
Gene: ENSMUSG00000095901

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	5e-50	PFAM
Pfam:7TM_GPCR_Srsx	35	304	2.8e-6	PFAM
Pfam:7tm_1	41	290	2.5e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000210973

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	A	G	11: 109,977,343 (GRCm39)	F139L	probably damaging	Het
Adgrg6	A	T	10: 14,343,082 (GRCm39)	D288E	probably benign	Het
Agbl1	A	G	7: 76,068,415 (GRCm39)	E327G		Het
Aipl1	T	A	11: 71,922,332 (GRCm39)	M126L	possibly damaging	Het
Alkal2	G	T	12: 30,934,850 (GRCm39)	G23V	probably damaging	Het
Arl3	A	T	19: 46,530,823 (GRCm39)	S157T	probably benign	Het
Armc3	A	T	2: 19,240,365 (GRCm39)	I41F	probably damaging	Het
Atg9a	A	C	1: 75,167,028 (GRCm39)	Y8D	probably damaging	Het
Atp10b	T	G	11: 43,093,984 (GRCm39)	H509Q	probably benign	Het
Cabyr	C	A	18: 12,883,804 (GRCm39)	T97K	probably benign	Het
Ccdc91	T	C	6: 147,438,920 (GRCm39)	F174S	possibly damaging	Het
Cep350	A	T	1: 155,798,164 (GRCm39)	H1207Q	probably benign	Het
Clstn3	A	T	6: 124,439,136 (GRCm39)	N40K	probably damaging	Het
Col4a4	G	A	1: 82,501,611 (GRCm39)	P381S	unknown	Het
Cpne5	A	T	17: 29,428,455 (GRCm39)	F116Y	probably benign	Het
Csf2rb2	T	C	15: 78,171,216 (GRCm39)	T457A	probably benign	Het
Cyb5d2	T	C	11: 72,679,959 (GRCm39)	E112G	probably benign	Het
Cyp2b13	T	C	7: 25,781,223 (GRCm39)	F212L	probably benign	Het
Dlx6	T	G	6: 6,863,779 (GRCm39)	S134A	probably benign	Het
Egln1	A	G	8: 125,638,489 (GRCm39)	Y380H	probably benign	Het
Fbxl13	A	T	5: 21,728,652 (GRCm39)	I479N	probably damaging	Het
Fhip1a	G	T	3: 85,580,027 (GRCm39)	P726Q	probably benign	Het
Fis1	A	G	5: 136,991,865 (GRCm39)	K20E	probably benign	Het
Foxk1	G	T	5: 142,387,528 (GRCm39)	V84L	unknown	Het
Gdf5	C	A	2: 155,784,272 (GRCm39)	G227W	probably damaging	Het
Ghrh	T	A	2: 157,175,656 (GRCm39)	T13S	probably benign	Het
Gnb2	A	G	5: 137,526,865 (GRCm39)	L308P	probably damaging	Het
Grik2	A	T	10: 49,148,863 (GRCm39)	V574D	probably damaging	Het
Hydin	A	T	8: 111,336,543 (GRCm39)	I5107F	possibly damaging	Het
Kl	A	T	5: 150,906,229 (GRCm39)	Y533F	probably benign	Het
Man2b1	G	T	8: 85,822,907 (GRCm39)	R816L	probably damaging	Het
Myo5c	T	C	9: 75,182,823 (GRCm39)	Y821H	probably damaging	Het
Myo7b	A	T	18: 32,092,866 (GRCm39)	C2076S	probably damaging	Het
Naip6	C	T	13: 100,436,784 (GRCm39)	A580T	possibly damaging	Het
Nectin2	A	T	7: 19,472,275 (GRCm39)	V38E	probably damaging	Het
Osbpl9	T	C	4: 108,921,770 (GRCm39)	Y536C	possibly damaging	Het
Pcdh18	T	G	3: 49,710,998 (GRCm39)	I106L	probably damaging	Het
Pde4dip	T	C	3: 97,606,428 (GRCm39)	K2149E	probably benign	Het
Pds5a	A	T	5: 65,803,681 (GRCm39)	C588S	probably benign	Het
Phf8-ps	C	A	17: 33,286,038 (GRCm39)	A255S	probably benign	Het
Pop1	T	C	15: 34,529,316 (GRCm39)	M812T	probably benign	Het
Pou2f3	T	C	9: 43,051,153 (GRCm39)	T178A	probably damaging	Het
Rab44	C	T	17: 29,359,294 (GRCm39)	A494V	unknown	Het
Ros1	G	C	10: 51,977,941 (GRCm39)	T1456S	possibly damaging	Het
Rubcnl	T	G	14: 75,289,425 (GRCm39)	F644L	probably damaging	Het
Saraf	C	T	8: 34,632,602 (GRCm39)	P227L	probably benign	Het
Sh3glb1	T	G	3: 144,397,198 (GRCm39)	E383D	probably damaging	Het
Sh3rf3	T	C	10: 58,919,407 (GRCm39)	V508A	probably damaging	Het
Sirt6	A	T	10: 81,458,328 (GRCm39)	H308Q	probably benign	Het
Slc29a1	T	A	17: 45,900,706 (GRCm39)	I119F	probably damaging	Het
Smtnl1	C	T	2: 84,648,742 (GRCm39)	E171K	probably benign	Het
Spg11	T	A	2: 121,923,923 (GRCm39)	E799D	probably damaging	Het
Tecpr1	A	T	5: 144,137,658 (GRCm39)	W894R	probably damaging	Het
Tiam2	A	C	17: 3,558,065 (GRCm39)	I1230L	possibly damaging	Het
Tnfrsf8	A	G	4: 145,019,265 (GRCm39)	L190P	probably damaging	Het
Trim35	C	T	14: 66,534,724 (GRCm39)	T69M	possibly damaging	Het
Ttll7	T	C	3: 146,645,779 (GRCm39)	Y546H	probably benign	Het
Ubash3b	C	T	9: 40,940,971 (GRCm39)	G389R	probably damaging	Het
Vma21-ps	C	T	4: 52,497,034 (GRCm39)	V71I	probably damaging	Het
Vmn1r43	T	A	6: 89,847,414 (GRCm39)	H24L	possibly damaging	Het
Vps37c	T	A	19: 10,687,719 (GRCm39)	L60Q	probably damaging	Het
Ythdf2	A	G	4: 131,931,946 (GRCm39)	W405R	probably damaging	Het
Zfp775	T	C	6: 48,597,637 (GRCm39)	C504R	probably damaging	Het
Zfp82	A	G	7: 29,761,652 (GRCm39)		probably null	Het
Zpr1	T	A	9: 46,185,400 (GRCm39)	I127N	probably damaging	Het

Other mutations in Or13a24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01894:Or13a24	APN	7	140,154,683 (GRCm39)	missense	possibly damaging	0.93
IGL02066:Or13a24	APN	7	140,154,413 (GRCm39)	missense	possibly damaging	0.55
IGL02214:Or13a24	APN	7	140,154,470 (GRCm39)	nonsense	probably null
IGL02466:Or13a24	APN	7	140,154,684 (GRCm39)	missense	probably benign	0.01
IGL02534:Or13a24	APN	7	140,154,554 (GRCm39)	missense	probably benign	0.00
R0631:Or13a24	UTSW	7	140,154,420 (GRCm39)	missense	probably damaging	1.00
R0989:Or13a24	UTSW	7	140,154,200 (GRCm39)	missense	probably damaging	0.99
R1470:Or13a24	UTSW	7	140,154,662 (GRCm39)	missense	probably benign	0.02
R1470:Or13a24	UTSW	7	140,154,662 (GRCm39)	missense	probably benign	0.02
R1533:Or13a24	UTSW	7	140,155,034 (GRCm39)	splice site	probably null
R1764:Or13a24	UTSW	7	140,154,383 (GRCm39)	missense	probably damaging	0.97
R2184:Or13a24	UTSW	7	140,154,315 (GRCm39)	missense	probably benign
R2513:Or13a24	UTSW	7	140,154,069 (GRCm39)	start codon destroyed	probably null	0.97
R4445:Or13a24	UTSW	7	140,154,302 (GRCm39)	missense	probably damaging	1.00
R4476:Or13a24	UTSW	7	140,154,842 (GRCm39)	missense	probably damaging	1.00
R4607:Or13a24	UTSW	7	140,154,554 (GRCm39)	missense	probably benign	0.02
R4608:Or13a24	UTSW	7	140,154,554 (GRCm39)	missense	probably benign	0.02
R4752:Or13a24	UTSW	7	140,154,515 (GRCm39)	missense	possibly damaging	0.57
R6934:Or13a24	UTSW	7	140,154,564 (GRCm39)	missense	probably damaging	1.00
R6978:Or13a24	UTSW	7	140,154,200 (GRCm39)	missense	probably damaging	0.99
R7559:Or13a24	UTSW	7	140,154,356 (GRCm39)	missense	probably damaging	1.00
R7583:Or13a24	UTSW	7	140,154,123 (GRCm39)	missense	probably benign	0.01
R7685:Or13a24	UTSW	7	140,154,159 (GRCm39)	missense	probably damaging	1.00
R8884:Or13a24	UTSW	7	140,154,224 (GRCm39)	missense	probably benign	0.00
Z1177:Or13a24	UTSW	7	140,154,869 (GRCm39)	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- TCCAAACCTACAGGGAGAGATTC -3'
(R):5'- CAGTGCTGGAGGTGATCAAAGC -3'

Sequencing Primer
(F):5'- CCTACAGGGAGAGATTCCTAGCTG -3'
(R):5'- GCAATGATCACCATGTTACCC -3'

Posted On

2020-10-20