Incidental Mutation 'R8422:Or10g7'
ID 653259
Institutional Source Beutler Lab
Gene Symbol Or10g7
Ensembl Gene ENSMUSG00000044292
Gene Name olfactory receptor family 10 subfamily G member 7
Synonyms GA_x6K02T2PVTD-33692287-33693222, MOR223-3, Olfr978
MMRRC Submission 067817-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R8422 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39905108-39906043 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39905850 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 248 (L248P)
Ref Sequence ENSEMBL: ENSMUSP00000151115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057161] [ENSMUST00000215523] [ENSMUST00000217600]
AlphaFold E9Q985
Predicted Effect probably damaging
Transcript: ENSMUST00000057161
AA Change: L248P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000060106
Gene: ENSMUSG00000044292
AA Change: L248P

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-56 PFAM
Pfam:7tm_1 39 287 1.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215523
Predicted Effect probably damaging
Transcript: ENSMUST00000217600
AA Change: L248P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik G T 14: 32,384,254 (GRCm39) S570R possibly damaging Het
4921517D22Rik T C 13: 59,839,443 (GRCm39) M1V probably null Het
4921524J17Rik T G 8: 86,138,918 (GRCm39) K57T possibly damaging Het
4930596D02Rik G T 14: 35,532,009 (GRCm39) Q189K probably benign Het
Anapc1 T C 2: 128,517,757 (GRCm39) T296A probably benign Het
Aqp7 T A 4: 41,035,622 (GRCm39) M78L probably benign Het
C1qtnf5 C A 9: 44,019,961 (GRCm39) A195E possibly damaging Het
Calhm2 T C 19: 47,121,579 (GRCm39) I197V probably benign Het
Ccdc186 G A 19: 56,801,617 (GRCm39) L167F probably benign Het
Ccr3 T C 9: 123,828,799 (GRCm39) Y45H probably damaging Het
Cct3 G C 3: 88,208,126 (GRCm39) R38P probably damaging Het
Clstn2 T C 9: 97,340,239 (GRCm39) D711G probably benign Het
Dab2ip T A 2: 35,597,767 (GRCm39) I157N probably damaging Het
Dchs2 T C 3: 83,232,570 (GRCm39) V2185A probably benign Het
Dis3l2 A G 1: 86,782,099 (GRCm39) T219A probably benign Het
F2rl3 G T 8: 73,489,813 (GRCm39) V347L probably benign Het
Fastkd1 A G 2: 69,532,778 (GRCm39) S530P probably damaging Het
Fgfr3 T A 5: 33,892,249 (GRCm39) Y689* probably null Het
Gm10521 A G 1: 171,724,026 (GRCm39) I112M unknown Het
Gm9736 C A 10: 77,586,714 (GRCm39) V159F unknown Het
Hba-x A T 11: 32,227,736 (GRCm39) H88L probably benign Het
Il12rb2 A T 6: 67,337,800 (GRCm39) V27E probably benign Het
Imp4 G T 1: 34,482,997 (GRCm39) G196V probably damaging Het
Itga11 A C 9: 62,674,960 (GRCm39) I831L probably benign Het
Macf1 C T 4: 123,303,279 (GRCm39) V408I possibly damaging Het
Nedd4 T A 9: 72,649,964 (GRCm39) D771E probably damaging Het
Noc3l T C 19: 38,795,547 (GRCm39) Y413C probably benign Het
Npas3 C A 12: 54,115,292 (GRCm39) T738K probably benign Het
Ntrk2 A T 13: 59,133,715 (GRCm39) D498V probably damaging Het
Nyap1 T C 5: 137,734,083 (GRCm39) T317A probably benign Het
Or14a256 T A 7: 86,265,466 (GRCm39) H129L probably benign Het
Or4c107 T C 2: 88,789,341 (GRCm39) M177T probably benign Het
Or5d47 T A 2: 87,804,143 (GRCm39) I289L probably benign Het
Pcdhb20 A T 18: 37,637,849 (GRCm39) D125V probably damaging Het
Phc3 G A 3: 30,984,039 (GRCm39) Q692* probably null Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Ppp1r12a T A 10: 108,077,042 (GRCm39) H339Q probably benign Het
Ppp1r3a G A 6: 14,718,434 (GRCm39) Q827* probably null Het
Ptpra T A 2: 130,374,091 (GRCm39) I265N possibly damaging Het
Rabggta G T 14: 55,955,915 (GRCm39) H447Q probably benign Het
Ralgps1 T C 2: 33,062,442 (GRCm39) D277G possibly damaging Het
Riok3 A T 18: 12,269,869 (GRCm39) E100V probably null Het
Rtcb C T 10: 85,779,168 (GRCm39) V362M probably benign Het
Scd2 G T 19: 44,289,743 (GRCm39) C246F probably benign Het
Slco6c1 T C 1: 97,053,508 (GRCm39) E131G probably damaging Het
Tanc2 A G 11: 105,726,014 (GRCm39) M393V probably benign Het
Tas2r136 A T 6: 132,754,290 (GRCm39) I279N probably damaging Het
Tbx3 G T 5: 119,818,581 (GRCm39) K405N possibly damaging Het
Thumpd2 A T 17: 81,334,373 (GRCm39) V405D probably damaging Het
Tlr12 A G 4: 128,510,427 (GRCm39) S608P probably damaging Het
Wfs1 T C 5: 37,131,219 (GRCm39) K165E probably benign Het
Zfp810 C A 9: 22,194,518 (GRCm39) E57* probably null Het
Other mutations in Or10g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or10g7 APN 9 39,905,625 (GRCm39) missense probably damaging 0.99
IGL02429:Or10g7 APN 9 39,905,138 (GRCm39) missense probably benign
IGL02887:Or10g7 APN 9 39,905,109 (GRCm39) start codon destroyed probably null 0.99
R0190:Or10g7 UTSW 9 39,905,840 (GRCm39) missense probably benign 0.01
R0355:Or10g7 UTSW 9 39,905,459 (GRCm39) missense possibly damaging 0.72
R1348:Or10g7 UTSW 9 39,905,124 (GRCm39) missense probably benign
R1856:Or10g7 UTSW 9 39,905,655 (GRCm39) missense probably benign 0.29
R3853:Or10g7 UTSW 9 39,905,450 (GRCm39) missense probably damaging 0.99
R3886:Or10g7 UTSW 9 39,905,835 (GRCm39) missense probably damaging 1.00
R5678:Or10g7 UTSW 9 39,905,199 (GRCm39) missense probably benign 0.00
R5994:Or10g7 UTSW 9 39,905,519 (GRCm39) nonsense probably null
R6185:Or10g7 UTSW 9 39,905,420 (GRCm39) missense probably benign 0.19
R6721:Or10g7 UTSW 9 39,905,603 (GRCm39) missense possibly damaging 0.55
R7414:Or10g7 UTSW 9 39,905,349 (GRCm39) missense possibly damaging 0.53
R7556:Or10g7 UTSW 9 39,905,978 (GRCm39) missense probably damaging 1.00
R8192:Or10g7 UTSW 9 39,905,467 (GRCm39) missense probably damaging 1.00
R9323:Or10g7 UTSW 9 39,905,360 (GRCm39) missense possibly damaging 0.88
X0025:Or10g7 UTSW 9 39,905,240 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- TGCAGACACCTCAGCCAATG -3'
(R):5'- GATGTTAAGAGTATTCATCCTCACG -3'

Sequencing Primer
(F):5'- TCAGCCAATGAGATGGTCATC -3'
(R):5'- TTTATCCTGAGGAAGCACAGAC -3'
Posted On 2020-10-20