Incidental Mutation 'R9008:Obsl1'
| ID |
685396 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Obsl1
|
| Ensembl Gene |
ENSMUSG00000026211 |
| Gene Name |
obscurin-like 1 |
| Synonyms |
|
| MMRRC Submission |
068838-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.269)
|
| Stock # |
R9008 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
75462469-75483134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 75482027 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Tryptophan
at position 281
(L281W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109197
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037330]
[ENSMUST00000113565]
[ENSMUST00000113567]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037330
|
| SMART Domains |
Protein: ENSMUSP00000040310
Gene: ENSMUSG00000032968
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
199 |
N/A |
INTRINSIC |
|
TGFB
|
263 |
366 |
1.58e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113565
AA Change: L281W
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000109195
Gene: ENSMUSG00000026211
AA Change: L281W
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
24 |
91 |
1.23e-12 |
SMART |
|
IGc2
|
140 |
216 |
2.33e-13 |
SMART |
|
IGc2
|
258 |
326 |
1.48e-6 |
SMART |
|
IG
|
347 |
427 |
9.49e-5 |
SMART |
|
IG
|
435 |
511 |
1.04e-1 |
SMART |
|
FN3
|
518 |
601 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
608 |
714 |
5e-57 |
PDB |
|
Blast:IG_like
|
622 |
711 |
2e-50 |
BLAST |
|
IG
|
723 |
804 |
3.79e-4 |
SMART |
|
IG
|
814 |
893 |
2.58e-6 |
SMART |
|
IGc2
|
911 |
977 |
1.12e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113567
AA Change: L281W
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000109197
Gene: ENSMUSG00000026211
AA Change: L281W
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
24 |
91 |
1.23e-12 |
SMART |
|
IGc2
|
140 |
216 |
2.33e-13 |
SMART |
|
IGc2
|
258 |
326 |
1.48e-6 |
SMART |
|
IG
|
347 |
427 |
9.49e-5 |
SMART |
|
IG
|
435 |
511 |
1.04e-1 |
SMART |
|
FN3
|
518 |
601 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
608 |
714 |
8e-57 |
PDB |
|
Blast:IG_like
|
622 |
711 |
3e-50 |
BLAST |
|
IG
|
723 |
804 |
3.79e-4 |
SMART |
|
IG
|
814 |
893 |
2.58e-6 |
SMART |
|
IGc2
|
911 |
977 |
1.12e-6 |
SMART |
|
IG
|
996 |
1075 |
1.27e-5 |
SMART |
|
IGc2
|
1094 |
1160 |
4.07e-4 |
SMART |
|
IGc2
|
1186 |
1252 |
9.49e-5 |
SMART |
|
IG
|
1274 |
1353 |
7.41e-7 |
SMART |
|
IG
|
1363 |
1444 |
1.15e-3 |
SMART |
|
IG
|
1454 |
1533 |
8.33e-1 |
SMART |
|
IGc2
|
1549 |
1615 |
8.72e-4 |
SMART |
|
IG
|
1633 |
1712 |
1e-3 |
SMART |
|
IG
|
1723 |
1802 |
3.82e-9 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114553
Gene: ENSMUSG00000026211
AA Change: L86W
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1g1ca_
|
2 |
32 |
1e-3 |
SMART |
|
IGc2
|
64 |
132 |
1.48e-6 |
SMART |
|
IG
|
153 |
233 |
9.49e-5 |
SMART |
|
IG
|
241 |
317 |
1.04e-1 |
SMART |
|
FN3
|
324 |
407 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
414 |
520 |
4e-57 |
PDB |
|
Blast:IG_like
|
428 |
517 |
2e-50 |
BLAST |
|
IG
|
529 |
610 |
3.79e-4 |
SMART |
|
IG
|
620 |
699 |
2.58e-6 |
SMART |
|
IGc2
|
717 |
783 |
1.12e-6 |
SMART |
|
IG
|
802 |
881 |
1.27e-5 |
SMART |
|
IGc2
|
900 |
966 |
4.07e-4 |
SMART |
|
IGc2
|
992 |
1058 |
9.49e-5 |
SMART |
|
IG
|
1080 |
1159 |
7.41e-7 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.5%
|
| Validation Efficiency |
98% (78/80) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
A |
T |
14: 118,849,162 (GRCm39) |
S536R |
probably damaging |
Het |
| Acacb |
G |
A |
5: 114,386,815 (GRCm39) |
|
silent |
Het |
| Acsm1 |
T |
C |
7: 119,258,325 (GRCm39) |
Y473H |
probably benign |
Het |
| Adam30 |
T |
A |
3: 98,070,034 (GRCm39) |
C622* |
probably null |
Het |
| Adprs |
C |
T |
4: 126,210,632 (GRCm39) |
V283M |
probably damaging |
Het |
| AI606181 |
G |
T |
19: 41,582,032 (GRCm39) |
R67S |
unknown |
Het |
| Btbd3 |
A |
G |
2: 138,125,453 (GRCm39) |
I212M |
probably benign |
Het |
| C1s1 |
C |
T |
6: 124,509,499 (GRCm39) |
|
probably null |
Het |
| C7 |
T |
A |
15: 5,040,409 (GRCm39) |
T539S |
|
Het |
| Cd5l |
A |
C |
3: 87,275,972 (GRCm39) |
D314A |
probably damaging |
Het |
| Celsr3 |
T |
A |
9: 108,706,151 (GRCm39) |
V878E |
possibly damaging |
Het |
| Cfap74 |
T |
C |
4: 155,503,121 (GRCm39) |
S38P |
|
Het |
| Chst2 |
C |
T |
9: 95,288,347 (GRCm39) |
|
probably benign |
Het |
| Deaf1 |
T |
C |
7: 140,904,078 (GRCm39) |
T103A |
probably damaging |
Het |
| Deup1 |
T |
A |
9: 15,511,140 (GRCm39) |
D213V |
probably damaging |
Het |
| Dhrs1 |
A |
G |
14: 55,978,638 (GRCm39) |
|
probably null |
Het |
| Dnah7a |
A |
G |
1: 53,701,501 (GRCm39) |
V218A |
possibly damaging |
Het |
| Dock7 |
G |
A |
4: 98,833,448 (GRCm39) |
Q1950* |
probably null |
Het |
| Ehf |
G |
A |
2: 103,097,173 (GRCm39) |
R283W |
|
Het |
| Elovl3 |
A |
T |
19: 46,123,087 (GRCm39) |
N221I |
possibly damaging |
Het |
| Gm11938 |
A |
T |
11: 99,493,966 (GRCm39) |
V43E |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,630,795 (GRCm39) |
|
probably benign |
Het |
| Hnf4g |
A |
G |
3: 3,708,096 (GRCm39) |
N115S |
probably benign |
Het |
| Hnrnpr |
A |
T |
4: 136,056,737 (GRCm39) |
N246Y |
probably damaging |
Het |
| Itpka |
A |
G |
2: 119,579,894 (GRCm39) |
E211G |
probably damaging |
Het |
| Krt78 |
TAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCACATTCTCCTCTAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCAGATTCTCTTCCAGGCATGGTCACCTGGCCTCCATATTCTCTTCCAGGCACGGTCACCTGGCCTCCA |
TAGGCACGGTCACCTGGCCTCCACATTCTCCTCTAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCAGATTCTCTTCCAGGCATGGTCACCTGGCCTCCATATTCTCTTCCAGGCACGGTCACCTGGCCTCCA |
15: 101,855,211 (GRCm39) |
|
probably benign |
Het |
| Lcorl |
A |
T |
5: 45,931,516 (GRCm39) |
|
probably benign |
Het |
| Lypd9 |
T |
A |
11: 58,338,209 (GRCm39) |
E61V |
probably benign |
Het |
| Mgat5 |
T |
C |
1: 127,407,308 (GRCm39) |
I658T |
probably damaging |
Het |
| Mier2 |
G |
A |
10: 79,384,274 (GRCm39) |
R166W |
probably damaging |
Het |
| Mov10 |
A |
G |
3: 104,707,332 (GRCm39) |
Y606H |
probably benign |
Het |
| Naa38 |
T |
G |
11: 69,287,148 (GRCm39) |
V76G |
probably damaging |
Het |
| Nelfe |
C |
A |
17: 35,073,334 (GRCm39) |
P290T |
possibly damaging |
Het |
| Nfil3 |
A |
T |
13: 53,121,609 (GRCm39) |
Y432N |
probably damaging |
Het |
| Nipbl |
T |
C |
15: 8,356,608 (GRCm39) |
K1593E |
probably damaging |
Het |
| Nlrc3 |
G |
C |
16: 3,776,807 (GRCm39) |
L56V |
possibly damaging |
Het |
| Nlrp1a |
A |
T |
11: 71,014,735 (GRCm39) |
F172I |
possibly damaging |
Het |
| Ntn4 |
T |
A |
10: 93,569,466 (GRCm39) |
|
probably benign |
Het |
| Nudt2 |
G |
A |
4: 41,480,288 (GRCm39) |
R57Q |
probably damaging |
Het |
| Olfm4 |
A |
T |
14: 80,255,607 (GRCm39) |
N250I |
unknown |
Het |
| Or10aa3 |
T |
A |
1: 173,878,413 (GRCm39) |
V158E |
probably damaging |
Het |
| Or1x6 |
G |
A |
11: 50,938,938 (GRCm39) |
M1I |
probably null |
Het |
| Or2m13 |
T |
A |
16: 19,226,173 (GRCm39) |
I198F |
probably benign |
Het |
| Or2r2 |
T |
C |
6: 42,463,903 (GRCm39) |
S75G |
probably damaging |
Het |
| Or5p50 |
A |
G |
7: 107,422,628 (GRCm39) |
I16T |
possibly damaging |
Het |
| Pappa |
A |
T |
4: 65,074,426 (GRCm39) |
T327S |
probably damaging |
Het |
| Pcdhb4 |
T |
G |
18: 37,440,714 (GRCm39) |
M8R |
probably benign |
Het |
| Phf21b |
T |
A |
15: 84,671,563 (GRCm39) |
I444F |
probably damaging |
Het |
| Pkd1l2 |
A |
C |
8: 117,769,037 (GRCm39) |
V1205G |
probably benign |
Het |
| Plec |
T |
C |
15: 76,060,232 (GRCm39) |
Y3235C |
probably damaging |
Het |
| Pnmt |
C |
T |
11: 98,278,832 (GRCm39) |
T266I |
possibly damaging |
Het |
| Ppfia2 |
T |
A |
10: 106,655,220 (GRCm39) |
D262E |
probably benign |
Het |
| Rabggta |
A |
T |
14: 55,955,913 (GRCm39) |
L448Q |
probably damaging |
Het |
| Rap1gds1 |
C |
T |
3: 138,661,177 (GRCm39) |
R449H |
probably benign |
Het |
| Rictor |
T |
A |
15: 6,801,610 (GRCm39) |
|
probably benign |
Het |
| Rttn |
T |
C |
18: 89,027,556 (GRCm39) |
F557S |
probably damaging |
Het |
| Ryr3 |
A |
G |
2: 112,465,748 (GRCm39) |
C4809R |
probably damaging |
Het |
| Sacs |
A |
C |
14: 61,441,992 (GRCm39) |
D1346A |
probably benign |
Het |
| Slain1 |
T |
A |
14: 103,923,191 (GRCm39) |
S261T |
probably damaging |
Het |
| Slc22a4 |
C |
T |
11: 53,881,664 (GRCm39) |
W351* |
probably null |
Het |
| Smpd3 |
C |
T |
8: 106,984,058 (GRCm39) |
G554S |
probably benign |
Het |
| Spag17 |
C |
T |
3: 99,934,942 (GRCm39) |
S716F |
possibly damaging |
Het |
| Spata31f1e |
C |
T |
4: 42,792,546 (GRCm39) |
G529S |
probably benign |
Het |
| Spg11 |
C |
T |
2: 121,900,413 (GRCm39) |
M1546I |
probably benign |
Het |
| Spmip11 |
T |
G |
15: 98,486,493 (GRCm39) |
S88A |
possibly damaging |
Het |
| Stac3 |
C |
T |
10: 127,339,454 (GRCm39) |
L117F |
probably damaging |
Het |
| Surf6 |
A |
G |
2: 26,782,536 (GRCm39) |
W264R |
probably damaging |
Het |
| Taar7e |
T |
C |
10: 23,913,810 (GRCm39) |
V100A |
probably damaging |
Het |
| Tenm3 |
T |
C |
8: 48,795,688 (GRCm39) |
H534R |
probably damaging |
Het |
| Tinagl1 |
C |
A |
4: 130,067,823 (GRCm39) |
R57L |
probably damaging |
Het |
| Tnfrsf11a |
G |
A |
1: 105,754,854 (GRCm39) |
A309T |
possibly damaging |
Het |
| Traf6 |
A |
G |
2: 101,527,333 (GRCm39) |
Y361C |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,777,334 (GRCm39) |
|
probably benign |
Het |
| Ufl1 |
A |
T |
4: 25,254,778 (GRCm39) |
Y559* |
probably null |
Het |
| Upk1b |
A |
T |
16: 38,607,570 (GRCm39) |
N52K |
probably damaging |
Het |
| Uqcrb |
A |
G |
13: 67,053,363 (GRCm39) |
S5P |
probably benign |
Het |
| Use1 |
A |
G |
8: 71,819,688 (GRCm39) |
Y3C |
unknown |
Het |
| Usp9y |
T |
A |
Y: 1,434,993 (GRCm39) |
I279L |
possibly damaging |
Het |
| Vmn1r142 |
A |
G |
7: 21,862,796 (GRCm39) |
L222P |
probably damaging |
Het |
| Vmn1r184 |
A |
C |
7: 25,967,177 (GRCm39) |
N308H |
probably benign |
Het |
| Vmn2r14 |
C |
A |
5: 109,367,893 (GRCm39) |
M366I |
probably benign |
Het |
| Vmn2r73 |
G |
T |
7: 85,521,904 (GRCm39) |
S145Y |
probably damaging |
Het |
| Wdfy1 |
A |
T |
1: 79,692,697 (GRCm39) |
W207R |
probably damaging |
Het |
| Zbtb38 |
A |
T |
9: 96,569,100 (GRCm39) |
N661K |
probably benign |
Het |
| Zkscan3 |
G |
T |
13: 21,572,383 (GRCm39) |
H416Q |
possibly damaging |
Het |
|
| Other mutations in Obsl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Obsl1
|
APN |
1 |
75,467,518 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01111:Obsl1
|
APN |
1 |
75,473,789 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01140:Obsl1
|
APN |
1 |
75,466,400 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02149:Obsl1
|
APN |
1 |
75,480,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Obsl1
|
APN |
1 |
75,480,442 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02269:Obsl1
|
APN |
1 |
75,464,357 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02296:Obsl1
|
APN |
1 |
75,474,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02386:Obsl1
|
APN |
1 |
75,469,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Obsl1
|
APN |
1 |
75,481,890 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02601:Obsl1
|
APN |
1 |
75,466,264 (GRCm39) |
missense |
probably benign |
|
|
IGL03053:Obsl1
|
APN |
1 |
75,469,723 (GRCm39) |
missense |
probably benign |
|
|
IGL03181:Obsl1
|
APN |
1 |
75,469,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03402:Obsl1
|
APN |
1 |
75,463,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
Jude
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Obsl1
|
UTSW |
1 |
75,482,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4382001:Obsl1
|
UTSW |
1 |
75,464,607 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0281:Obsl1
|
UTSW |
1 |
75,469,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Obsl1
|
UTSW |
1 |
75,469,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1394:Obsl1
|
UTSW |
1 |
75,469,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1395:Obsl1
|
UTSW |
1 |
75,469,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1439:Obsl1
|
UTSW |
1 |
75,463,428 (GRCm39) |
nonsense |
probably null |
|
|
R1456:Obsl1
|
UTSW |
1 |
75,464,300 (GRCm39) |
nonsense |
probably null |
|
|
R1728:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1729:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1730:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1739:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1757:Obsl1
|
UTSW |
1 |
75,470,527 (GRCm39) |
missense |
probably benign |
|
|
R1762:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1783:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1784:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1785:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1851:Obsl1
|
UTSW |
1 |
75,469,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Obsl1
|
UTSW |
1 |
75,469,753 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1873:Obsl1
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1875:Obsl1
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Obsl1
|
UTSW |
1 |
75,482,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Obsl1
|
UTSW |
1 |
75,482,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2069:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2122:Obsl1
|
UTSW |
1 |
75,470,527 (GRCm39) |
missense |
probably benign |
|
|
R2141:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2142:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2184:Obsl1
|
UTSW |
1 |
75,478,861 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2267:Obsl1
|
UTSW |
1 |
75,482,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2883:Obsl1
|
UTSW |
1 |
75,473,155 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3079:Obsl1
|
UTSW |
1 |
75,467,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Obsl1
|
UTSW |
1 |
75,474,890 (GRCm39) |
missense |
probably benign |
|
|
R4002:Obsl1
|
UTSW |
1 |
75,476,743 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4365:Obsl1
|
UTSW |
1 |
75,464,693 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4366:Obsl1
|
UTSW |
1 |
75,464,693 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4414:Obsl1
|
UTSW |
1 |
75,467,546 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4700:Obsl1
|
UTSW |
1 |
75,480,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4799:Obsl1
|
UTSW |
1 |
75,466,145 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5081:Obsl1
|
UTSW |
1 |
75,464,607 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5389:Obsl1
|
UTSW |
1 |
75,479,905 (GRCm39) |
intron |
probably benign |
|
|
R5757:Obsl1
|
UTSW |
1 |
75,469,699 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5890:Obsl1
|
UTSW |
1 |
75,470,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5946:Obsl1
|
UTSW |
1 |
75,467,851 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6005:Obsl1
|
UTSW |
1 |
75,468,859 (GRCm39) |
splice site |
probably null |
|
|
R6118:Obsl1
|
UTSW |
1 |
75,468,722 (GRCm39) |
intron |
probably benign |
|
|
R6154:Obsl1
|
UTSW |
1 |
75,476,788 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6317:Obsl1
|
UTSW |
1 |
75,466,273 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6379:Obsl1
|
UTSW |
1 |
75,479,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6387:Obsl1
|
UTSW |
1 |
75,468,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7084:Obsl1
|
UTSW |
1 |
75,464,394 (GRCm39) |
missense |
probably benign |
|
|
R7123:Obsl1
|
UTSW |
1 |
75,466,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7202:Obsl1
|
UTSW |
1 |
75,466,360 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7291:Obsl1
|
UTSW |
1 |
75,466,161 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7305:Obsl1
|
UTSW |
1 |
75,470,590 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Obsl1
|
UTSW |
1 |
75,479,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7402:Obsl1
|
UTSW |
1 |
75,464,348 (GRCm39) |
missense |
probably benign |
|
|
R7474:Obsl1
|
UTSW |
1 |
75,474,828 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7611:Obsl1
|
UTSW |
1 |
75,482,024 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7672:Obsl1
|
UTSW |
1 |
75,469,365 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7715:Obsl1
|
UTSW |
1 |
75,478,680 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7762:Obsl1
|
UTSW |
1 |
75,480,167 (GRCm39) |
missense |
probably benign |
|
|
R8005:Obsl1
|
UTSW |
1 |
75,482,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8012:Obsl1
|
UTSW |
1 |
75,469,317 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8379:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8381:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8383:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8396:Obsl1
|
UTSW |
1 |
75,480,350 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8465:Obsl1
|
UTSW |
1 |
75,480,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8506:Obsl1
|
UTSW |
1 |
75,482,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8710:Obsl1
|
UTSW |
1 |
75,469,326 (GRCm39) |
missense |
probably benign |
|
|
R8877:Obsl1
|
UTSW |
1 |
75,473,167 (GRCm39) |
nonsense |
probably null |
|
|
R8903:Obsl1
|
UTSW |
1 |
75,463,917 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8913:Obsl1
|
UTSW |
1 |
75,467,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8924:Obsl1
|
UTSW |
1 |
75,482,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8955:Obsl1
|
UTSW |
1 |
75,480,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9121:Obsl1
|
UTSW |
1 |
75,482,636 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9295:Obsl1
|
UTSW |
1 |
75,476,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9362:Obsl1
|
UTSW |
1 |
75,482,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9367:Obsl1
|
UTSW |
1 |
75,466,177 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9459:Obsl1
|
UTSW |
1 |
75,474,884 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9496:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9497:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9498:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9502:Obsl1
|
UTSW |
1 |
75,466,267 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9546:Obsl1
|
UTSW |
1 |
75,482,030 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9550:Obsl1
|
UTSW |
1 |
75,474,910 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9561:Obsl1
|
UTSW |
1 |
75,480,157 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9687:Obsl1
|
UTSW |
1 |
75,479,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V8831:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
X0061:Obsl1
|
UTSW |
1 |
75,463,412 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Obsl1
|
UTSW |
1 |
75,467,656 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Obsl1
|
UTSW |
1 |
75,480,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCTTTCACGTGCAGCTGG -3'
(R):5'- AGCCACTTCAAGCTGGAGC -3'
Sequencing Primer
(F):5'- AGCTGGACCGCGCTTAG -3'
(R):5'- TGACGTTGCGCATCCTG -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation