Mutagenetix > Incidental Mutation

Incidental Mutation 'R9038:Or10g3'

687559

Institutional Source

Beutler Lab

Gene Symbol

Or10g3

Ensembl Gene

ENSMUSG00000094140

Gene Name

olfactory receptor family 10 subfamily G member 3

Synonyms

GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512

MMRRC Submission

068866-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R9038 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

52609567-52610508 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 52609716 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Cysteine at position 265 (S265C)

Ref Sequence

ENSEMBL: ENSMUSP00000149717 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]

AlphaFold

Q8VF72

Predicted Effect

probably damaging
Transcript: ENSMUST00000071221
AA Change: S265C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: S265C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.1e-48	PFAM
Pfam:7tm_1	41	290	2.9e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214980
AA Change: S265C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 99.8%
10x: 98.9%
20x: 95.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	T	12: 118,895,651 (GRCm39)	C382S	probably benign	Het
Abcf2	A	G	5: 24,776,191 (GRCm39)	V296A	possibly damaging	Het
Aco2	C	G	15: 81,756,620 (GRCm39)		probably benign	Het
Acvrl1	A	G	15: 101,039,011 (GRCm39)	D436G	possibly damaging	Het
Adamts7	A	G	9: 90,056,692 (GRCm39)	I254V		Het
Arhgef18	A	G	8: 3,503,257 (GRCm39)	I888V	probably benign	Het
Arhgef40	C	A	14: 52,235,072 (GRCm39)	A1083D	probably damaging	Het
Arnt2	C	A	7: 83,954,059 (GRCm39)	A275S	probably benign	Het
Brd10	A	T	19: 29,731,900 (GRCm39)	Y371N	possibly damaging	Het
Brip1	C	T	11: 86,080,599 (GRCm39)	V156I	probably benign	Het
Camk4	C	A	18: 33,291,953 (GRCm39)	C204*	probably null	Het
Cenpe	A	G	3: 134,923,797 (GRCm39)	T161A	probably benign	Het
Chd2	G	A	7: 73,105,358 (GRCm39)	H1256Y	probably damaging	Het
Chd9	G	A	8: 91,716,233 (GRCm39)	V936I	unknown	Het
D6Ertd527e	A	G	6: 87,089,233 (GRCm39)	*465W	probably null	Het
Dcaf11	T	A	14: 55,803,114 (GRCm39)	D309E	probably damaging	Het
Dtna	A	G	18: 23,743,553 (GRCm39)	N373S	probably benign	Het
Eif2b2	A	G	12: 85,266,897 (GRCm39)	D104G	probably benign	Het
Fras1	A	T	5: 96,874,742 (GRCm39)	T2302S	probably benign	Het
Gga1	A	G	15: 78,768,321 (GRCm39)	K114E	probably damaging	Het
Gm12887	A	G	4: 121,473,616 (GRCm39)		probably null	Het
Gss	A	T	2: 155,406,794 (GRCm39)	I396N		Het
H2-M5	T	C	17: 37,299,422 (GRCm39)	I199M	possibly damaging	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Ift172	G	T	5: 31,441,399 (GRCm39)	T245K	possibly damaging	Het
Ift70a2	G	A	2: 75,808,215 (GRCm39)	T99I	probably benign	Het
Iqck	A	G	7: 118,498,881 (GRCm39)	D173G	probably damaging	Het
Itga11	A	G	9: 62,675,039 (GRCm39)	N857S	possibly damaging	Het
Kdm1b	C	A	13: 47,202,770 (GRCm39)	S68R	probably benign	Het
Ly6c1	C	A	15: 74,917,300 (GRCm39)	G116V	probably damaging	Het
Myo6	G	T	9: 80,162,285 (GRCm39)	V341L	unknown	Het
Nfkbie	C	A	17: 45,870,183 (GRCm39)	A176E	probably damaging	Het
Nlrp2	C	T	7: 5,330,478 (GRCm39)	M639I	probably benign	Het
Or10j2	T	A	1: 173,098,147 (GRCm39)	I135N	possibly damaging	Het
Or56a41	T	C	7: 104,740,433 (GRCm39)	I138V	probably benign	Het
Or5w16	A	G	2: 87,577,125 (GRCm39)	N195S	probably damaging	Het
Or6c215	T	C	10: 129,637,564 (GRCm39)	T277A	probably damaging	Het
Or8k40	A	T	2: 86,584,354 (GRCm39)	S243T	probably damaging	Het
Pak4	G	A	7: 28,264,263 (GRCm39)	T213M	probably damaging	Het
Pan2	C	T	10: 128,153,810 (GRCm39)	Q1003*	probably null	Het
Pde4c	G	C	8: 71,179,550 (GRCm39)	V34L	probably benign	Het
Pi4k2a	G	A	19: 42,089,235 (GRCm39)	V199M	probably damaging	Het
Platr25	T	C	13: 62,848,007 (GRCm39)	E285G	probably damaging	Het
Polr3e	T	C	7: 120,536,906 (GRCm39)	V356A	possibly damaging	Het
Prcp	A	G	7: 92,567,017 (GRCm39)	D243G	probably benign	Het
Qsox2	T	C	2: 26,115,246 (GRCm39)	T161A	probably damaging	Het
Rhoj	A	G	12: 75,355,700 (GRCm39)	T35A		Het
Scn9a	T	A	2: 66,325,147 (GRCm39)	M1336L	probably damaging	Het
Sel1l2	G	T	2: 140,117,384 (GRCm39)	N162K	probably damaging	Het
Slc15a3	T	C	19: 10,820,866 (GRCm39)	L161P	probably damaging	Het
Slc4a11	G	A	2: 130,533,663 (GRCm39)	A100V	probably damaging	Het
Sp1	A	G	15: 102,316,320 (GRCm39)	S41G	probably benign	Het
Tbx15	A	G	3: 99,222,085 (GRCm39)	M183V	probably benign	Het
Tfip11	A	G	5: 112,481,214 (GRCm39)	T397A	possibly damaging	Het
Themis	T	C	10: 28,657,749 (GRCm39)	S259P	probably damaging	Het
Tm7sf2	T	C	19: 6,117,172 (GRCm39)	Y77C	probably damaging	Het
Tnnt2	C	A	1: 135,774,484 (GRCm39)	P81H	possibly damaging	Het
Trpc7	T	C	13: 57,035,886 (GRCm39)	T16A	probably benign	Het
Ttn	T	A	2: 76,745,056 (GRCm39)	Y5331F	possibly damaging	Het
Virma	A	G	4: 11,526,922 (GRCm39)	Q1057R	possibly damaging	Het
Vmn2r118	A	T	17: 55,918,649 (GRCm39)	F81Y	probably damaging	Het
Vmn2r88	T	C	14: 51,651,490 (GRCm39)	V268A		Het
Vmn2r93	T	A	17: 18,524,471 (GRCm39)	M155K	probably benign	Het
Vps13b	G	T	15: 35,875,931 (GRCm39)	C2772F	possibly damaging	Het
Wdr90	T	C	17: 26,076,200 (GRCm39)	N86D		Het
Zbtb34	T	C	2: 33,301,248 (GRCm39)	D431G	probably damaging	Het
Zc3h3	G	A	15: 75,711,237 (GRCm39)	P408L	probably benign	Het
Zfp345	A	G	2: 150,313,864 (GRCm39)	Y558H	probably benign	Het
Zfp583	G	A	7: 6,319,543 (GRCm39)	P490S	probably damaging	Het

Other mutations in Or10g3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01328:Or10g3	APN	14	52,609,967 (GRCm39)	missense	probably damaging	1.00
IGL01375:Or10g3	APN	14	52,609,865 (GRCm39)	missense	probably damaging	0.99
IGL02343:Or10g3	APN	14	52,609,934 (GRCm39)	missense	probably damaging	1.00
R1443:Or10g3	UTSW	14	52,610,408 (GRCm39)	missense	probably damaging	1.00
R1902:Or10g3	UTSW	14	52,610,174 (GRCm39)	missense	possibly damaging	0.81
R1903:Or10g3	UTSW	14	52,610,174 (GRCm39)	missense	possibly damaging	0.81
R3115:Or10g3	UTSW	14	52,610,397 (GRCm39)	missense	probably damaging	1.00
R4752:Or10g3	UTSW	14	52,609,764 (GRCm39)	missense	probably damaging	1.00
R5345:Or10g3	UTSW	14	52,609,725 (GRCm39)	nonsense	probably null
R5689:Or10g3	UTSW	14	52,610,214 (GRCm39)	missense	possibly damaging	0.83
R6185:Or10g3	UTSW	14	52,610,019 (GRCm39)	missense	possibly damaging	0.91
R6287:Or10g3	UTSW	14	52,609,748 (GRCm39)	missense	probably damaging	1.00
R6757:Or10g3	UTSW	14	52,610,172 (GRCm39)	missense	probably damaging	1.00
R8751:Or10g3	UTSW	14	52,610,420 (GRCm39)	missense	probably benign	0.03
R8855:Or10g3	UTSW	14	52,610,196 (GRCm39)	missense	probably damaging	1.00
R8866:Or10g3	UTSW	14	52,610,196 (GRCm39)	missense	probably damaging	1.00
R9450:Or10g3	UTSW	14	52,610,110 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AGTGGAAACCTGGGTGTCTC -3'
(R):5'- ACAGTCAATGAGTTGGTGACC -3'

Sequencing Primer
(F):5'- AAACCTGGGTGTCTCCTCAGAAG -3'
(R):5'- CAATGAGTTGGTGACCTTTGTGGAC -3'

Posted On

2021-11-19