Incidental Mutation 'R9038:Brd10'
| ID |
687577 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brd10
|
| Ensembl Gene |
ENSMUSG00000046138 |
| Gene Name |
bromodomain containing 10 |
| Synonyms |
9930021J03Rik, Gm9832 |
| MMRRC Submission |
068866-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.138)
|
| Stock # |
R9038 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
29691802-29783389 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 29731900 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 371
(Y371N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135473
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177155]
|
| AlphaFold |
H3BKP8 |
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176773
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177155
AA Change: Y371N
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: Y371N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
66 |
N/A |
INTRINSIC |
|
BROMO
|
75 |
198 |
1.22e-3 |
SMART |
|
low complexity region
|
205 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
298 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
441 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
689 |
N/A |
INTRINSIC |
|
coiled coil region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1097 |
1226 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1228 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1319 |
1348 |
N/A |
INTRINSIC |
|
low complexity region
|
1401 |
1416 |
N/A |
INTRINSIC |
|
low complexity region
|
1535 |
1557 |
N/A |
INTRINSIC |
|
low complexity region
|
1580 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1665 |
1678 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1699 |
1843 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1920 |
1926 |
N/A |
INTRINSIC |
|
low complexity region
|
1946 |
1960 |
N/A |
INTRINSIC |
|
low complexity region
|
1986 |
2004 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 98.9%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb5 |
A |
T |
12: 118,895,651 (GRCm39) |
C382S |
probably benign |
Het |
| Abcf2 |
A |
G |
5: 24,776,191 (GRCm39) |
V296A |
possibly damaging |
Het |
| Aco2 |
C |
G |
15: 81,756,620 (GRCm39) |
|
probably benign |
Het |
| Acvrl1 |
A |
G |
15: 101,039,011 (GRCm39) |
D436G |
possibly damaging |
Het |
| Adamts7 |
A |
G |
9: 90,056,692 (GRCm39) |
I254V |
|
Het |
| Arhgef18 |
A |
G |
8: 3,503,257 (GRCm39) |
I888V |
probably benign |
Het |
| Arhgef40 |
C |
A |
14: 52,235,072 (GRCm39) |
A1083D |
probably damaging |
Het |
| Arnt2 |
C |
A |
7: 83,954,059 (GRCm39) |
A275S |
probably benign |
Het |
| Brip1 |
C |
T |
11: 86,080,599 (GRCm39) |
V156I |
probably benign |
Het |
| Camk4 |
C |
A |
18: 33,291,953 (GRCm39) |
C204* |
probably null |
Het |
| Cenpe |
A |
G |
3: 134,923,797 (GRCm39) |
T161A |
probably benign |
Het |
| Chd2 |
G |
A |
7: 73,105,358 (GRCm39) |
H1256Y |
probably damaging |
Het |
| Chd9 |
G |
A |
8: 91,716,233 (GRCm39) |
V936I |
unknown |
Het |
| D6Ertd527e |
A |
G |
6: 87,089,233 (GRCm39) |
*465W |
probably null |
Het |
| Dcaf11 |
T |
A |
14: 55,803,114 (GRCm39) |
D309E |
probably damaging |
Het |
| Dtna |
A |
G |
18: 23,743,553 (GRCm39) |
N373S |
probably benign |
Het |
| Eif2b2 |
A |
G |
12: 85,266,897 (GRCm39) |
D104G |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,874,742 (GRCm39) |
T2302S |
probably benign |
Het |
| Gga1 |
A |
G |
15: 78,768,321 (GRCm39) |
K114E |
probably damaging |
Het |
| Gm12887 |
A |
G |
4: 121,473,616 (GRCm39) |
|
probably null |
Het |
| Gss |
A |
T |
2: 155,406,794 (GRCm39) |
I396N |
|
Het |
| H2-M5 |
T |
C |
17: 37,299,422 (GRCm39) |
I199M |
possibly damaging |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Ift172 |
G |
T |
5: 31,441,399 (GRCm39) |
T245K |
possibly damaging |
Het |
| Ift70a2 |
G |
A |
2: 75,808,215 (GRCm39) |
T99I |
probably benign |
Het |
| Iqck |
A |
G |
7: 118,498,881 (GRCm39) |
D173G |
probably damaging |
Het |
| Itga11 |
A |
G |
9: 62,675,039 (GRCm39) |
N857S |
possibly damaging |
Het |
| Kdm1b |
C |
A |
13: 47,202,770 (GRCm39) |
S68R |
probably benign |
Het |
| Ly6c1 |
C |
A |
15: 74,917,300 (GRCm39) |
G116V |
probably damaging |
Het |
| Myo6 |
G |
T |
9: 80,162,285 (GRCm39) |
V341L |
unknown |
Het |
| Nfkbie |
C |
A |
17: 45,870,183 (GRCm39) |
A176E |
probably damaging |
Het |
| Nlrp2 |
C |
T |
7: 5,330,478 (GRCm39) |
M639I |
probably benign |
Het |
| Or10g3 |
T |
A |
14: 52,609,716 (GRCm39) |
S265C |
probably damaging |
Het |
| Or10j2 |
T |
A |
1: 173,098,147 (GRCm39) |
I135N |
possibly damaging |
Het |
| Or56a41 |
T |
C |
7: 104,740,433 (GRCm39) |
I138V |
probably benign |
Het |
| Or5w16 |
A |
G |
2: 87,577,125 (GRCm39) |
N195S |
probably damaging |
Het |
| Or6c215 |
T |
C |
10: 129,637,564 (GRCm39) |
T277A |
probably damaging |
Het |
| Or8k40 |
A |
T |
2: 86,584,354 (GRCm39) |
S243T |
probably damaging |
Het |
| Pak4 |
G |
A |
7: 28,264,263 (GRCm39) |
T213M |
probably damaging |
Het |
| Pan2 |
C |
T |
10: 128,153,810 (GRCm39) |
Q1003* |
probably null |
Het |
| Pde4c |
G |
C |
8: 71,179,550 (GRCm39) |
V34L |
probably benign |
Het |
| Pi4k2a |
G |
A |
19: 42,089,235 (GRCm39) |
V199M |
probably damaging |
Het |
| Platr25 |
T |
C |
13: 62,848,007 (GRCm39) |
E285G |
probably damaging |
Het |
| Polr3e |
T |
C |
7: 120,536,906 (GRCm39) |
V356A |
possibly damaging |
Het |
| Prcp |
A |
G |
7: 92,567,017 (GRCm39) |
D243G |
probably benign |
Het |
| Qsox2 |
T |
C |
2: 26,115,246 (GRCm39) |
T161A |
probably damaging |
Het |
| Rhoj |
A |
G |
12: 75,355,700 (GRCm39) |
T35A |
|
Het |
| Scn9a |
T |
A |
2: 66,325,147 (GRCm39) |
M1336L |
probably damaging |
Het |
| Sel1l2 |
G |
T |
2: 140,117,384 (GRCm39) |
N162K |
probably damaging |
Het |
| Slc15a3 |
T |
C |
19: 10,820,866 (GRCm39) |
L161P |
probably damaging |
Het |
| Slc4a11 |
G |
A |
2: 130,533,663 (GRCm39) |
A100V |
probably damaging |
Het |
| Sp1 |
A |
G |
15: 102,316,320 (GRCm39) |
S41G |
probably benign |
Het |
| Tbx15 |
A |
G |
3: 99,222,085 (GRCm39) |
M183V |
probably benign |
Het |
| Tfip11 |
A |
G |
5: 112,481,214 (GRCm39) |
T397A |
possibly damaging |
Het |
| Themis |
T |
C |
10: 28,657,749 (GRCm39) |
S259P |
probably damaging |
Het |
| Tm7sf2 |
T |
C |
19: 6,117,172 (GRCm39) |
Y77C |
probably damaging |
Het |
| Tnnt2 |
C |
A |
1: 135,774,484 (GRCm39) |
P81H |
possibly damaging |
Het |
| Trpc7 |
T |
C |
13: 57,035,886 (GRCm39) |
T16A |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,745,056 (GRCm39) |
Y5331F |
possibly damaging |
Het |
| Virma |
A |
G |
4: 11,526,922 (GRCm39) |
Q1057R |
possibly damaging |
Het |
| Vmn2r118 |
A |
T |
17: 55,918,649 (GRCm39) |
F81Y |
probably damaging |
Het |
| Vmn2r88 |
T |
C |
14: 51,651,490 (GRCm39) |
V268A |
|
Het |
| Vmn2r93 |
T |
A |
17: 18,524,471 (GRCm39) |
M155K |
probably benign |
Het |
| Vps13b |
G |
T |
15: 35,875,931 (GRCm39) |
C2772F |
possibly damaging |
Het |
| Wdr90 |
T |
C |
17: 26,076,200 (GRCm39) |
N86D |
|
Het |
| Zbtb34 |
T |
C |
2: 33,301,248 (GRCm39) |
D431G |
probably damaging |
Het |
| Zc3h3 |
G |
A |
15: 75,711,237 (GRCm39) |
P408L |
probably benign |
Het |
| Zfp345 |
A |
G |
2: 150,313,864 (GRCm39) |
Y558H |
probably benign |
Het |
| Zfp583 |
G |
A |
7: 6,319,543 (GRCm39) |
P490S |
probably damaging |
Het |
|
| Other mutations in Brd10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Brd10
|
APN |
19 |
29,731,420 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01535:Brd10
|
APN |
19 |
29,731,212 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02019:Brd10
|
APN |
19 |
29,694,463 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02034:Brd10
|
APN |
19 |
29,694,259 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03114:Brd10
|
APN |
19 |
29,694,532 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03382:Brd10
|
APN |
19 |
29,694,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0142:Brd10
|
UTSW |
19 |
29,695,654 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0178:Brd10
|
UTSW |
19 |
29,732,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Brd10
|
UTSW |
19 |
29,731,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Brd10
|
UTSW |
19 |
29,695,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0735:Brd10
|
UTSW |
19 |
29,695,038 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0891:Brd10
|
UTSW |
19 |
29,695,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Brd10
|
UTSW |
19 |
29,697,974 (GRCm39) |
splice site |
probably benign |
|
|
R1289:Brd10
|
UTSW |
19 |
29,700,852 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1368:Brd10
|
UTSW |
19 |
29,693,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1387:Brd10
|
UTSW |
19 |
29,700,853 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1483:Brd10
|
UTSW |
19 |
29,696,745 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1526:Brd10
|
UTSW |
19 |
29,712,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Brd10
|
UTSW |
19 |
29,695,245 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1721:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1764:Brd10
|
UTSW |
19 |
29,696,560 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1822:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1824:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1859:Brd10
|
UTSW |
19 |
29,732,323 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1868:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1880:Brd10
|
UTSW |
19 |
29,695,523 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1898:Brd10
|
UTSW |
19 |
29,712,532 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1936:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1939:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1969:Brd10
|
UTSW |
19 |
29,694,075 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2153:Brd10
|
UTSW |
19 |
29,694,229 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2366:Brd10
|
UTSW |
19 |
29,731,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2379:Brd10
|
UTSW |
19 |
29,696,275 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3107:Brd10
|
UTSW |
19 |
29,700,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Brd10
|
UTSW |
19 |
29,720,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Brd10
|
UTSW |
19 |
29,696,149 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4328:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4329:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4387:Brd10
|
UTSW |
19 |
29,782,715 (GRCm39) |
unclassified |
probably benign |
|
|
R4688:Brd10
|
UTSW |
19 |
29,694,501 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4796:Brd10
|
UTSW |
19 |
29,731,018 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4820:Brd10
|
UTSW |
19 |
29,695,809 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4832:Brd10
|
UTSW |
19 |
29,694,616 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5056:Brd10
|
UTSW |
19 |
29,694,759 (GRCm39) |
missense |
probably benign |
|
|
R5150:Brd10
|
UTSW |
19 |
29,782,950 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5224:Brd10
|
UTSW |
19 |
29,696,450 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5306:Brd10
|
UTSW |
19 |
29,707,230 (GRCm39) |
intron |
probably benign |
|
|
R5460:Brd10
|
UTSW |
19 |
29,732,250 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5477:Brd10
|
UTSW |
19 |
29,731,518 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5531:Brd10
|
UTSW |
19 |
29,731,072 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5559:Brd10
|
UTSW |
19 |
29,694,363 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5647:Brd10
|
UTSW |
19 |
29,731,210 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5886:Brd10
|
UTSW |
19 |
29,696,677 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6029:Brd10
|
UTSW |
19 |
29,732,367 (GRCm39) |
unclassified |
probably benign |
|
|
R6240:Brd10
|
UTSW |
19 |
29,694,640 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6331:Brd10
|
UTSW |
19 |
29,695,147 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6456:Brd10
|
UTSW |
19 |
29,693,914 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6584:Brd10
|
UTSW |
19 |
29,696,128 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6661:Brd10
|
UTSW |
19 |
29,700,864 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6991:Brd10
|
UTSW |
19 |
29,696,508 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7059:Brd10
|
UTSW |
19 |
29,696,945 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7128:Brd10
|
UTSW |
19 |
29,693,881 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7211:Brd10
|
UTSW |
19 |
29,763,712 (GRCm39) |
missense |
|
|
|
R7471:Brd10
|
UTSW |
19 |
29,707,139 (GRCm39) |
splice site |
probably null |
|
|
R7686:Brd10
|
UTSW |
19 |
29,694,870 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8012:Brd10
|
UTSW |
19 |
29,695,534 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8203:Brd10
|
UTSW |
19 |
29,693,443 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8353:Brd10
|
UTSW |
19 |
29,731,242 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8672:Brd10
|
UTSW |
19 |
29,731,564 (GRCm39) |
missense |
probably benign |
|
|
R8755:Brd10
|
UTSW |
19 |
29,693,890 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8918:Brd10
|
UTSW |
19 |
29,696,841 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8954:Brd10
|
UTSW |
19 |
29,696,126 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9195:Brd10
|
UTSW |
19 |
29,763,703 (GRCm39) |
missense |
|
|
|
R9204:Brd10
|
UTSW |
19 |
29,696,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9518:Brd10
|
UTSW |
19 |
29,731,541 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9743:Brd10
|
UTSW |
19 |
29,694,261 (GRCm39) |
missense |
probably benign |
|
|
R9747:Brd10
|
UTSW |
19 |
29,731,911 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
RF011:Brd10
|
UTSW |
19 |
29,721,009 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0027:Brd10
|
UTSW |
19 |
29,712,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATTCTGGGGCCTGAAAGGG -3'
(R):5'- GACCTACTTTGCCTTACAGGAC -3'
Sequencing Primer
(F):5'- GGGTCTTTGTTTATAAATCCGCAC -3'
(R):5'- TGCCTTACAGGACTTGGGAAGC -3'
|
| Posted On |
2021-11-19 |
Incidental Mutation