Mutagenetix > Incidental Mutation

Incidental Mutation 'R9627:Tasor'

725242

Institutional Source

Beutler Lab

Gene Symbol

Tasor

Ensembl Gene

ENSMUSG00000040651

Gene Name

transcription activation suppressor

Synonyms

D14Abb1e, Fam208a, 4933409E02Rik, MommeD6

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9627 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

27150791-27205512 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27194123 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1108 (S1108P)

Ref Sequence

ENSEMBL: ENSMUSP00000022450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022450]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000022450
AA Change: S1108P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000022450
Gene: ENSMUSG00000040651
AA Change: S1108P

Domain	Start	End	E-Value	Type
low complexity region	20	27	N/A	INTRINSIC
low complexity region	42	61	N/A	INTRINSIC
low complexity region	74	88	N/A	INTRINSIC
Pfam:DUF3715	153	314	1.5e-55	PFAM
low complexity region	442	457	N/A	INTRINSIC
low complexity region	1087	1102	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for ENU mutations are not viable past gastrulation. [provided by MGI curators]

Allele List at MGI

All alleles(26) : Gene trapped(26)

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	T	2: 68,487,834 (GRCm39)		probably benign	Het
Abca14	T	C	7: 119,854,530 (GRCm39)	V898A	probably benign	Het
Adamtsl1	A	T	4: 86,306,762 (GRCm39)	D1400V	possibly damaging	Het
Akap6	T	A	12: 53,151,413 (GRCm39)	M1159K		Het
Atg13	C	A	2: 91,509,098 (GRCm39)	G446*	probably null	Het
Atp6v1g2	G	T	17: 35,454,956 (GRCm39)		probably null	Het
Bmp2k	C	T	5: 97,201,028 (GRCm39)	A316V	possibly damaging	Het
Ccdc34	AAGA	AA	2: 109,871,010 (GRCm39)		probably null	Het
Cfap251	A	G	5: 123,460,557 (GRCm39)	D1173G	probably benign	Het
Cln6	T	A	9: 62,754,303 (GRCm39)	I115N	probably damaging	Het
Cma1	T	C	14: 56,181,289 (GRCm39)	T39A	probably benign	Het
Cpsf1	A	T	15: 76,484,088 (GRCm39)	M744K	probably damaging	Het
Csf1r	A	G	18: 61,260,972 (GRCm39)	Y721C	probably damaging	Het
Dcaf12	A	G	4: 41,293,976 (GRCm39)	L387P	probably benign	Het
Ephb1	T	C	9: 101,918,468 (GRCm39)	E347G	possibly damaging	Het
Fig4	T	A	10: 41,108,178 (GRCm39)	H674L	probably benign	Het
Foxa3	T	A	7: 18,748,458 (GRCm39)	K223*	probably null	Het
Gimap7	T	C	6: 48,700,600 (GRCm39)	V62A	probably damaging	Het
Glrx3	T	A	7: 137,046,755 (GRCm39)	V49E	probably benign	Het
Greb1	T	C	12: 16,756,167 (GRCm39)	Y823C	probably damaging	Het
H3c7	G	T	13: 23,728,793 (GRCm39)	V47L	possibly damaging	Het
Hapln4	C	A	8: 70,539,520 (GRCm39)	R184S	possibly damaging	Het
Hmcn1	C	T	1: 150,506,054 (GRCm39)	C3824Y	probably damaging	Het
Hrnr	T	C	3: 93,233,235 (GRCm39)	S1158P	unknown	Het
Itln1	A	G	1: 171,360,985 (GRCm39)	S36P	probably benign	Het
Kcnh5	A	C	12: 75,160,990 (GRCm39)	I306S	probably damaging	Het
Kctd19	T	A	8: 106,113,997 (GRCm39)	M559L	probably benign	Het
Kif2a	A	G	13: 107,158,558 (GRCm39)	I9T	possibly damaging	Het
Klra5	G	A	6: 129,883,701 (GRCm39)	T142I	probably benign	Het
Ldlrad3	A	G	2: 101,785,423 (GRCm39)	V184A	probably damaging	Het
Lrrc27	T	C	7: 138,808,582 (GRCm39)		probably benign	Het
Mark1	A	G	1: 184,646,817 (GRCm39)	V340A	probably benign	Het
Mrps31	T	C	8: 22,901,558 (GRCm39)	V26A	probably benign	Het
Mtrr	G	A	13: 68,725,756 (GRCm39)	L118F	probably damaging	Het
Naip5	T	A	13: 100,356,338 (GRCm39)	E1092D	probably benign	Het
Nbas	G	T	12: 13,350,203 (GRCm39)	V285F	possibly damaging	Het
Nfrkb	T	C	9: 31,321,189 (GRCm39)	L675P	possibly damaging	Het
Or10v9	T	A	19: 11,832,910 (GRCm39)	I136F	possibly damaging	Het
Or1q1	T	A	2: 36,887,665 (GRCm39)	V281E		Het
Or5k15	T	A	16: 58,709,771 (GRCm39)	I271L	probably benign	Het
Phkg1	C	T	5: 129,893,376 (GRCm39)	W358*	probably null	Het
Plekhj1	A	C	10: 80,633,494 (GRCm39)	I51S	possibly damaging	Het
Plxnd1	C	T	6: 115,940,274 (GRCm39)	R1370Q	possibly damaging	Het
Prkg2	T	C	5: 99,079,869 (GRCm39)	*763W	probably null	Het
Rhobtb2	A	G	14: 70,034,349 (GRCm39)	F292S	probably damaging	Het
Rlf	A	T	4: 121,007,002 (GRCm39)	C769*	probably null	Het
Rmi1	C	A	13: 58,557,366 (GRCm39)	D538E	possibly damaging	Het
Scn4a	C	T	11: 106,212,839 (GRCm39)	V1389I	probably benign	Het
Serpinc1	A	T	1: 160,821,101 (GRCm39)	K183*	probably null	Het
Setd4	A	T	16: 93,380,562 (GRCm39)	M399K	possibly damaging	Het
Setx	T	C	2: 29,034,661 (GRCm39)	M382T	probably damaging	Het
Slc6a9	A	G	4: 117,721,210 (GRCm39)	Y208C	probably damaging	Het
Slfn2	A	T	11: 82,960,367 (GRCm39)	K115N		Het
Snrk	A	T	9: 121,966,427 (GRCm39)	K117*	probably null	Het
Spata31	A	G	13: 65,065,409 (GRCm39)	Y38C	possibly damaging	Het
Stab2	T	C	10: 86,793,704 (GRCm39)	T464A	probably damaging	Het
Tagap1	C	T	17: 7,224,327 (GRCm39)	G123D	probably benign	Het
Tas2r136	T	C	6: 132,754,948 (GRCm39)	K60E	possibly damaging	Het
Tmem200b	A	C	4: 131,649,437 (GRCm39)	Y119S	probably damaging	Het
Usp48	G	A	4: 137,340,996 (GRCm39)	G332E	probably benign	Het
Wwp2	T	G	8: 108,278,959 (GRCm39)	L578W	probably damaging	Het
Zfp53	T	A	17: 21,728,745 (GRCm39)	C259*	probably null	Het

Other mutations in Tasor

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00093:Tasor	APN	14	27,170,163 (GRCm39)	missense	probably damaging	1.00
IGL00467:Tasor	APN	14	27,170,121 (GRCm39)	missense	probably benign	0.02
IGL01071:Tasor	APN	14	27,164,579 (GRCm39)	critical splice donor site	probably null
IGL01351:Tasor	APN	14	27,186,258 (GRCm39)	missense	probably benign	0.02
IGL01375:Tasor	APN	14	27,162,120 (GRCm39)	missense	probably damaging	1.00
IGL01509:Tasor	APN	14	27,181,731 (GRCm39)	splice site	probably benign
IGL02342:Tasor	APN	14	27,198,624 (GRCm39)	missense	possibly damaging	0.83
IGL03105:Tasor	APN	14	27,164,509 (GRCm39)	missense	probably damaging	0.98
IGL03131:Tasor	APN	14	27,183,136 (GRCm39)	nonsense	probably null
IGL03248:Tasor	APN	14	27,198,649 (GRCm39)	missense	probably damaging	1.00
IGL03383:Tasor	APN	14	27,163,918 (GRCm39)	missense	possibly damaging	0.93
balsam	UTSW	14	27,183,107 (GRCm39)	missense	probably benign	0.01
santa_rosa	UTSW	14	27,198,658 (GRCm39)	splice site	probably null
D4043:Tasor	UTSW	14	27,193,949 (GRCm39)	missense	probably benign	0.07
R0147:Tasor	UTSW	14	27,193,725 (GRCm39)	missense	probably benign	0.23
R0512:Tasor	UTSW	14	27,168,363 (GRCm39)	missense	probably damaging	1.00
R0589:Tasor	UTSW	14	27,183,107 (GRCm39)	missense	probably benign	0.01
R0609:Tasor	UTSW	14	27,183,707 (GRCm39)	missense	probably benign	0.09
R0798:Tasor	UTSW	14	27,198,593 (GRCm39)	missense	probably damaging	1.00
R1107:Tasor	UTSW	14	27,201,680 (GRCm39)	nonsense	probably null
R1205:Tasor	UTSW	14	27,183,275 (GRCm39)	missense	probably damaging	1.00
R1376:Tasor	UTSW	14	27,151,338 (GRCm39)	missense	probably benign	0.00
R1376:Tasor	UTSW	14	27,151,338 (GRCm39)	missense	probably benign	0.00
R1441:Tasor	UTSW	14	27,186,217 (GRCm39)	nonsense	probably null
R1493:Tasor	UTSW	14	27,171,926 (GRCm39)	missense	probably damaging	1.00
R1527:Tasor	UTSW	14	27,202,050 (GRCm39)	critical splice donor site	probably null
R1729:Tasor	UTSW	14	27,201,590 (GRCm39)	missense	probably damaging	1.00
R1752:Tasor	UTSW	14	27,193,885 (GRCm39)	nonsense	probably null
R1960:Tasor	UTSW	14	27,201,746 (GRCm39)	missense	possibly damaging	0.95
R1960:Tasor	UTSW	14	27,160,621 (GRCm39)	missense	probably damaging	1.00
R1965:Tasor	UTSW	14	27,164,511 (GRCm39)	missense	probably damaging	1.00
R2074:Tasor	UTSW	14	27,183,170 (GRCm39)	missense	probably benign	0.03
R2107:Tasor	UTSW	14	27,183,744 (GRCm39)	critical splice donor site	probably null
R2130:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2130:Tasor	UTSW	14	27,168,345 (GRCm39)	missense	probably damaging	1.00
R2131:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2133:Tasor	UTSW	14	27,198,571 (GRCm39)	missense	possibly damaging	0.74
R2140:Tasor	UTSW	14	27,201,992 (GRCm39)	missense	probably damaging	1.00
R2184:Tasor	UTSW	14	27,188,141 (GRCm39)	missense	possibly damaging	0.83
R2279:Tasor	UTSW	14	27,164,452 (GRCm39)	missense	probably damaging	1.00
R3979:Tasor	UTSW	14	27,199,087 (GRCm39)	missense	possibly damaging	0.95
R4113:Tasor	UTSW	14	27,181,918 (GRCm39)	nonsense	probably null
R4434:Tasor	UTSW	14	27,171,818 (GRCm39)	critical splice donor site	probably null
R4562:Tasor	UTSW	14	27,188,265 (GRCm39)	missense	possibly damaging	0.67
R4568:Tasor	UTSW	14	27,198,658 (GRCm39)	splice site	probably null
R4754:Tasor	UTSW	14	27,183,052 (GRCm39)	missense	probably benign
R4980:Tasor	UTSW	14	27,183,382 (GRCm39)	missense	probably benign	0.39
R4993:Tasor	UTSW	14	27,151,071 (GRCm39)	missense	possibly damaging	0.88
R5200:Tasor	UTSW	14	27,151,183 (GRCm39)	missense	probably benign	0.41
R5316:Tasor	UTSW	14	27,193,992 (GRCm39)	missense	possibly damaging	0.52
R5599:Tasor	UTSW	14	27,201,886 (GRCm39)	missense	probably benign	0.01
R5678:Tasor	UTSW	14	27,151,080 (GRCm39)	small insertion	probably benign
R5680:Tasor	UTSW	14	27,151,080 (GRCm39)	small insertion	probably benign
R5887:Tasor	UTSW	14	27,188,254 (GRCm39)	nonsense	probably null
R6181:Tasor	UTSW	14	27,194,235 (GRCm39)	missense	probably benign	0.01
R6556:Tasor	UTSW	14	27,151,215 (GRCm39)	missense	probably benign
R6603:Tasor	UTSW	14	27,168,343 (GRCm39)	missense	probably damaging	1.00
R6829:Tasor	UTSW	14	27,164,438 (GRCm39)	missense	possibly damaging	0.90
R6864:Tasor	UTSW	14	27,183,115 (GRCm39)	missense	probably damaging	0.96
R6919:Tasor	UTSW	14	27,171,758 (GRCm39)	nonsense	probably null
R7046:Tasor	UTSW	14	27,194,392 (GRCm39)	missense	probably damaging	1.00
R7057:Tasor	UTSW	14	27,183,608 (GRCm39)	missense	probably damaging	0.97
R7064:Tasor	UTSW	14	27,194,288 (GRCm39)	missense	probably benign	0.09
R7290:Tasor	UTSW	14	27,160,610 (GRCm39)	missense	probably damaging	1.00
R7303:Tasor	UTSW	14	27,193,809 (GRCm39)	missense	probably damaging	1.00
R7439:Tasor	UTSW	14	27,193,602 (GRCm39)	missense	probably damaging	1.00
R7524:Tasor	UTSW	14	27,188,160 (GRCm39)	missense	probably damaging	0.99
R7580:Tasor	UTSW	14	27,188,243 (GRCm39)	missense	probably benign	0.29
R7726:Tasor	UTSW	14	27,169,454 (GRCm39)	missense	probably damaging	0.99
R7771:Tasor	UTSW	14	27,189,516 (GRCm39)	missense	probably damaging	1.00
R7782:Tasor	UTSW	14	27,193,901 (GRCm39)	missense	probably benign	0.07
R7795:Tasor	UTSW	14	27,203,340 (GRCm39)	missense
R7835:Tasor	UTSW	14	27,198,600 (GRCm39)	missense	probably damaging	1.00
R7954:Tasor	UTSW	14	27,169,481 (GRCm39)	critical splice donor site	probably null
R7981:Tasor	UTSW	14	27,168,373 (GRCm39)	missense	possibly damaging	0.49
R8101:Tasor	UTSW	14	27,164,438 (GRCm39)	missense	possibly damaging	0.90
R8160:Tasor	UTSW	14	27,171,913 (GRCm39)	missense	probably damaging	1.00
R8307:Tasor	UTSW	14	27,193,622 (GRCm39)	missense	probably damaging	1.00
R8913:Tasor	UTSW	14	27,188,145 (GRCm39)	missense	probably damaging	1.00
R9070:Tasor	UTSW	14	27,194,484 (GRCm39)	missense	probably benign	0.14
R9219:Tasor	UTSW	14	27,186,344 (GRCm39)	missense	possibly damaging	0.50
R9420:Tasor	UTSW	14	27,163,927 (GRCm39)	missense	probably damaging	0.99
R9513:Tasor	UTSW	14	27,186,271 (GRCm39)	nonsense	probably null
R9562:Tasor	UTSW	14	27,201,766 (GRCm39)	critical splice donor site	probably null
R9565:Tasor	UTSW	14	27,201,766 (GRCm39)	critical splice donor site	probably null
X0002:Tasor	UTSW	14	27,194,063 (GRCm39)	missense	possibly damaging	0.90
Z1176:Tasor	UTSW	14	27,199,105 (GRCm39)	missense	probably damaging	1.00
Z1176:Tasor	UTSW	14	27,151,165 (GRCm39)	missense	probably damaging	0.97
Z1177:Tasor	UTSW	14	27,170,207 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACACCTATCTTTTCAGCACAAGAG -3'
(R):5'- GGACTGTATCACCAGGTACAGTG -3'

Sequencing Primer
(F):5'- GAAGATGAATCGCCTTTCTGAG -3'
(R):5'- CTGTATCACCAGGTACAGTGTGATC -3'

Posted On

2022-09-12