Mutagenetix > Incidental Mutation

Incidental Mutation 'R9677:Vmn2r11'

728373

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R9677 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109201332 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 391 (T391A)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: T391A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actc1	T	C	2: 113,878,636 (GRCm39)	T320A	probably benign	Het
Btnl2	T	A	17: 34,580,007 (GRCm39)	I180N	possibly damaging	Het
Chmp6	C	T	11: 119,806,459 (GRCm39)	R59*	probably null	Het
Cisd2	T	A	3: 135,129,044 (GRCm39)	I27F	possibly damaging	Het
Col3a1	C	T	1: 45,369,727 (GRCm39)	P336S	unknown	Het
Ctps1	G	T	4: 120,410,092 (GRCm39)	H330Q	probably benign	Het
Ddx52	A	G	11: 83,836,946 (GRCm39)	N146D	probably benign	Het
Dnah1	T	C	14: 31,029,821 (GRCm39)	I495V	probably benign	Het
Dop1a	T	A	9: 86,425,098 (GRCm39)	D2139E		Het
Fam169b	A	G	7: 67,954,388 (GRCm39)	D79G	probably benign	Het
Hspa1b	C	A	17: 35,177,860 (GRCm39)	V42L	probably benign	Het
Ift122	T	A	6: 115,897,357 (GRCm39)	S919T	probably benign	Het
Lrrc9	T	C	12: 72,497,539 (GRCm39)	L119S	probably damaging	Het
Map3k6	G	T	4: 132,968,427 (GRCm39)	V10F	probably benign	Het
Med26	A	T	8: 73,249,930 (GRCm39)	Y390N	probably damaging	Het
Nup50	A	G	15: 84,819,479 (GRCm39)	E251G	possibly damaging	Het
Or4a81	A	T	2: 89,619,161 (GRCm39)	D178E	possibly damaging	Het
Or5b105	T	A	19: 13,080,518 (GRCm39)	D50V	probably damaging	Het
Rab30	G	A	7: 92,469,245 (GRCm39)	G16D	probably damaging	Het
Rbis	A	G	3: 14,674,674 (GRCm39)	V56A	probably damaging	Het
Slc12a5	A	G	2: 164,834,246 (GRCm39)	M756V	possibly damaging	Het
Syne1	T	C	10: 5,215,125 (GRCm39)	D3193G	probably damaging	Het
Tfrc	A	G	16: 32,434,179 (GRCm39)	K136R	probably benign	Het
Tmem220	G	T	11: 66,925,011 (GRCm39)	V173L	probably benign	Het
Tnxb	C	T	17: 34,917,878 (GRCm39)	P2264S	possibly damaging	Het
Uba6	G	A	5: 86,265,910 (GRCm39)	P999L	probably damaging	Het
Vmn2r80	T	C	10: 78,984,672 (GRCm39)	F8S	probably benign	Het
Zdhhc2	T	A	8: 40,909,712 (GRCm39)	L150*	probably null	Het
Zmym2	T	C	14: 57,187,115 (GRCm39)	V1093A	probably benign	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109,201,823 (GRCm39)	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109,201,692 (GRCm39)	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109,201,560 (GRCm39)	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109,196,800 (GRCm39)	missense	possibly damaging	0.95
R6804:Vmn2r11	UTSW	5	109,201,350 (GRCm39)	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67

Predicted Primers

PCR Primer
(F):5'- GGGTCCATTTAAAAGATCCCATTC -3'
(R):5'- ACTTTTGAACACCACCACAGTG -3'

Sequencing Primer
(F):5'- GTACTGCCATTTGCTGAG -3'
(R):5'- ACCACAGTGAGATTGCTAAATTTAAG -3'

Posted On

2022-10-06