Incidental Mutation 'R7388:Vmn2r11'
| ID |
573250 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r11
|
| Ensembl Gene |
ENSMUSG00000091450 |
| Gene Name |
vomeronasal 2, receptor 11 |
| Synonyms |
EG384219 |
| MMRRC Submission |
045470-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R7388 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109202742 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 112
(W112R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
| AlphaFold |
E9Q4X4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164875
AA Change: W112R
PolyPhen 2
Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: W112R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
|
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
|
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (63/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afg3l2 |
T |
C |
18: 67,556,023 (GRCm39) |
E436G |
probably damaging |
Het |
| Agbl5 |
T |
A |
5: 31,060,583 (GRCm39) |
L759* |
probably null |
Het |
| Ankrd13b |
T |
C |
11: 77,363,583 (GRCm39) |
D460G |
probably benign |
Het |
| Apol10a |
A |
G |
15: 77,373,225 (GRCm39) |
D287G |
possibly damaging |
Het |
| Arhgap44 |
A |
T |
11: 64,915,094 (GRCm39) |
Y391* |
probably null |
Het |
| Asz1 |
G |
T |
6: 18,074,900 (GRCm39) |
S271R |
probably benign |
Het |
| AW554918 |
A |
G |
18: 25,473,170 (GRCm39) |
N325D |
probably benign |
Het |
| Brinp2 |
A |
T |
1: 158,082,579 (GRCm39) |
L247Q |
probably damaging |
Het |
| Casz1 |
A |
G |
4: 149,036,850 (GRCm39) |
D1704G |
unknown |
Het |
| Cdk5rap1 |
G |
A |
2: 154,202,595 (GRCm39) |
R212W |
probably damaging |
Het |
| Cdkl2 |
T |
A |
5: 92,167,318 (GRCm39) |
T444S |
probably benign |
Het |
| Cers2 |
T |
G |
3: 95,228,656 (GRCm39) |
F160V |
probably benign |
Het |
| Cfap276 |
T |
C |
3: 108,450,815 (GRCm39) |
F86L |
possibly damaging |
Het |
| Cga |
T |
A |
4: 34,907,076 (GRCm39) |
M99K |
probably benign |
Het |
| Cspp1 |
C |
T |
1: 10,135,572 (GRCm39) |
R138* |
probably null |
Het |
| Dao |
T |
G |
5: 114,153,273 (GRCm39) |
*133E |
probably null |
Het |
| Ddx1 |
A |
T |
12: 13,275,456 (GRCm39) |
C544S |
probably null |
Het |
| Dgkq |
A |
T |
5: 108,806,112 (GRCm39) |
V98E |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,169,300 (GRCm39) |
T434S |
possibly damaging |
Het |
| Dntt |
A |
G |
19: 41,027,418 (GRCm39) |
N162D |
probably benign |
Het |
| Dpysl5 |
T |
C |
5: 30,902,805 (GRCm39) |
V79A |
probably benign |
Het |
| Efcab3 |
T |
C |
11: 104,611,871 (GRCm39) |
L571P |
probably damaging |
Het |
| Ep300 |
T |
C |
15: 81,532,567 (GRCm39) |
C1602R |
unknown |
Het |
| Flrt3 |
C |
T |
2: 140,503,672 (GRCm39) |
|
probably null |
Het |
| Gk2 |
A |
G |
5: 97,604,757 (GRCm39) |
V27A |
probably damaging |
Het |
| Gnpat |
T |
G |
8: 125,614,553 (GRCm39) |
M663R |
probably benign |
Het |
| Hc |
A |
T |
2: 34,874,859 (GRCm39) |
|
probably null |
Het |
| Il12rb1 |
A |
G |
8: 71,263,271 (GRCm39) |
Y67C |
probably damaging |
Het |
| Ints15 |
G |
A |
5: 143,297,600 (GRCm39) |
A149V |
probably benign |
Het |
| Kmt2b |
C |
T |
7: 30,281,385 (GRCm39) |
D1229N |
probably damaging |
Het |
| Lamc1 |
T |
C |
1: 153,124,822 (GRCm39) |
T650A |
probably damaging |
Het |
| Lrp1 |
G |
A |
10: 127,419,766 (GRCm39) |
R948* |
probably null |
Het |
| Map3k21 |
T |
C |
8: 126,654,336 (GRCm39) |
I385T |
probably damaging |
Het |
| Mmrn1 |
T |
A |
6: 60,953,236 (GRCm39) |
S506T |
probably benign |
Het |
| Nlrp1a |
A |
G |
11: 71,014,023 (GRCm39) |
F409S |
probably damaging |
Het |
| Nlrp3 |
T |
A |
11: 59,455,892 (GRCm39) |
I896N |
probably benign |
Het |
| Noxred1 |
C |
A |
12: 87,273,799 (GRCm39) |
V81L |
probably damaging |
Het |
| Nrcam |
A |
T |
12: 44,645,272 (GRCm39) |
I1225F |
probably damaging |
Het |
| Or2z2 |
C |
T |
11: 58,346,481 (GRCm39) |
C98Y |
probably damaging |
Het |
| Otos |
T |
A |
1: 92,572,241 (GRCm39) |
|
probably null |
Het |
| Pcdh20 |
A |
G |
14: 88,706,103 (GRCm39) |
I399T |
probably benign |
Het |
| Pkhd1 |
C |
T |
1: 20,309,528 (GRCm39) |
V2807I |
not run |
Het |
| Prrx2 |
A |
G |
2: 30,770,902 (GRCm39) |
E235G |
probably damaging |
Het |
| Rab13 |
T |
C |
3: 90,128,327 (GRCm39) |
I41T |
probably damaging |
Het |
| Rai1 |
A |
C |
11: 60,080,201 (GRCm39) |
T1422P |
possibly damaging |
Het |
| Rcn1 |
C |
T |
2: 105,222,336 (GRCm39) |
V217M |
probably damaging |
Het |
| Scn2a |
T |
A |
2: 65,518,998 (GRCm39) |
V408E |
probably damaging |
Het |
| Sec16a |
C |
T |
2: 26,318,376 (GRCm39) |
A121T |
|
Het |
| Slc35d1 |
A |
G |
4: 103,046,982 (GRCm39) |
|
probably null |
Het |
| Slc39a6 |
A |
T |
18: 24,717,106 (GRCm39) |
V642E |
probably damaging |
Het |
| Slc6a19 |
G |
A |
13: 73,841,203 (GRCm39) |
A69V |
probably benign |
Het |
| Spink6 |
A |
T |
18: 44,215,386 (GRCm39) |
T79S |
probably damaging |
Het |
| Spire1 |
T |
C |
18: 67,652,950 (GRCm39) |
D170G |
probably damaging |
Het |
| Sugp1 |
T |
C |
8: 70,505,269 (GRCm39) |
S79P |
probably damaging |
Het |
| Syne3 |
A |
G |
12: 104,934,167 (GRCm39) |
Y201H |
probably damaging |
Het |
| Tbc1d10a |
T |
C |
11: 4,155,858 (GRCm39) |
|
probably null |
Het |
| Tmem14a |
C |
T |
1: 21,299,735 (GRCm39) |
Q122* |
probably null |
Het |
| Tmem161b |
C |
A |
13: 84,370,537 (GRCm39) |
|
probably benign |
Het |
| Trmt61a |
A |
G |
12: 111,645,321 (GRCm39) |
I86V |
possibly damaging |
Het |
| Tubgcp4 |
G |
A |
2: 121,020,447 (GRCm39) |
|
probably null |
Het |
| Vmn1r79 |
T |
A |
7: 11,910,668 (GRCm39) |
Y183* |
probably null |
Het |
| Vpreb1a |
T |
C |
16: 16,686,516 (GRCm39) |
K125E |
probably benign |
Het |
| Wdr6 |
A |
T |
9: 108,451,971 (GRCm39) |
F637L |
probably damaging |
Het |
|
| Other mutations in Vmn2r11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCATCCAGTGTCATAAATTCTTACC -3'
(R):5'- TCACATGTCAACACTCTGGATC -3'
Sequencing Primer
(F):5'- CCTTTGGTGTCCTAGACTGAATTGAC -3'
(R):5'- GTACCTATGGAATTACAACTCCAAG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation