Incidental Mutation 'R0843:Zfp277'
ID |
77261 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp277
|
Ensembl Gene |
ENSMUSG00000055917 |
Gene Name |
zinc finger protein 277 |
Synonyms |
NIRF4, 2410017E24Rik |
MMRRC Submission |
039022-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.061)
|
Stock # |
R0843 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
12 |
Chromosomal Location |
40365045-40495789 bp(-) (GRCm39) |
Type of Mutation |
critical splice donor site (2 bp from exon) |
DNA Base Change (assembly) |
A to C
at 40370599 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000064226
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069637]
[ENSMUST00000069692]
|
AlphaFold |
E9Q6D6 |
Predicted Effect |
probably null
Transcript: ENSMUST00000069637
|
SMART Domains |
Protein: ENSMUSP00000068032 Gene: ENSMUSG00000055917
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
59 |
84 |
4.27e1 |
SMART |
coiled coil region
|
143 |
171 |
N/A |
INTRINSIC |
ZnF_C2H2
|
174 |
198 |
3.85e1 |
SMART |
ZnF_C2H2
|
225 |
249 |
2.24e-3 |
SMART |
low complexity region
|
280 |
292 |
N/A |
INTRINSIC |
ZnF_C2H2
|
303 |
326 |
1.91e1 |
SMART |
ZnF_C2H2
|
356 |
382 |
4.94e0 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000069692
|
SMART Domains |
Protein: ENSMUSP00000064226 Gene: ENSMUSG00000055917
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
185 |
210 |
4.27e1 |
SMART |
coiled coil region
|
269 |
297 |
N/A |
INTRINSIC |
ZnF_C2H2
|
300 |
324 |
3.85e1 |
SMART |
ZnF_C2H2
|
351 |
375 |
2.24e-3 |
SMART |
low complexity region
|
406 |
418 |
N/A |
INTRINSIC |
ZnF_C2H2
|
429 |
452 |
1.91e1 |
SMART |
ZnF_C2H2
|
482 |
508 |
4.94e0 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221604
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222394
|
Meta Mutation Damage Score |
0.9495 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.5%
- 10x: 96.5%
- 20x: 92.6%
|
Validation Efficiency |
98% (40/41) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adrb2 |
T |
C |
18: 62,312,142 (GRCm39) |
R228G |
probably benign |
Het |
Arrdc3 |
T |
C |
13: 81,038,922 (GRCm39) |
|
probably benign |
Het |
Cacna1d |
T |
C |
14: 29,846,828 (GRCm39) |
Y526C |
probably damaging |
Het |
Cenpn |
T |
C |
8: 117,660,045 (GRCm39) |
V125A |
probably benign |
Het |
Cyfip1 |
A |
T |
7: 55,572,568 (GRCm39) |
H963L |
probably benign |
Het |
Dnah8 |
T |
C |
17: 31,032,069 (GRCm39) |
Y4130H |
probably damaging |
Het |
Dnmt3a |
T |
C |
12: 3,922,886 (GRCm39) |
|
probably benign |
Het |
Dync1h1 |
C |
T |
12: 110,631,647 (GRCm39) |
T4448M |
possibly damaging |
Het |
Efr3a |
T |
A |
15: 65,709,272 (GRCm39) |
|
probably benign |
Het |
Fgf11 |
T |
G |
11: 69,689,602 (GRCm39) |
|
probably benign |
Het |
Gabrr1 |
T |
A |
4: 33,161,717 (GRCm39) |
I347N |
possibly damaging |
Het |
Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
Hspa1b |
T |
A |
17: 35,176,524 (GRCm39) |
N487I |
possibly damaging |
Het |
Ifi207 |
A |
T |
1: 173,555,143 (GRCm39) |
N853K |
probably damaging |
Het |
Iqgap3 |
A |
G |
3: 88,015,738 (GRCm39) |
D40G |
possibly damaging |
Het |
Iyd |
T |
C |
10: 3,495,663 (GRCm39) |
V107A |
possibly damaging |
Het |
Kctd3 |
A |
T |
1: 188,729,170 (GRCm39) |
L129* |
probably null |
Het |
Myo7b |
A |
G |
18: 32,107,137 (GRCm39) |
F1286S |
possibly damaging |
Het |
Or4a47 |
C |
T |
2: 89,665,960 (GRCm39) |
V110I |
probably benign |
Het |
Or52s1b |
T |
A |
7: 102,822,326 (GRCm39) |
T173S |
possibly damaging |
Het |
Or8c15 |
T |
A |
9: 38,120,579 (GRCm39) |
F77I |
possibly damaging |
Het |
Pcsk5 |
T |
A |
19: 17,632,182 (GRCm39) |
Y328F |
probably damaging |
Het |
Plxnb1 |
T |
C |
9: 108,942,769 (GRCm39) |
L1810P |
probably benign |
Het |
Polr2h |
T |
A |
16: 20,537,649 (GRCm39) |
V50E |
probably damaging |
Het |
Ppm1g |
T |
C |
5: 31,364,895 (GRCm39) |
|
probably benign |
Het |
Ptpru |
T |
A |
4: 131,525,259 (GRCm39) |
R741S |
probably benign |
Het |
Pyroxd2 |
T |
C |
19: 42,735,986 (GRCm39) |
E64G |
probably damaging |
Het |
Rad54b |
T |
C |
4: 11,609,471 (GRCm39) |
|
probably null |
Het |
Rangap1 |
A |
T |
15: 81,594,703 (GRCm39) |
D375E |
probably benign |
Het |
Rhbdf1 |
G |
A |
11: 32,165,053 (GRCm39) |
R107C |
probably damaging |
Het |
Scaf11 |
T |
C |
15: 96,329,706 (GRCm39) |
E140G |
probably damaging |
Het |
Slitrk6 |
G |
T |
14: 110,987,530 (GRCm39) |
H726N |
probably benign |
Het |
Spry2 |
A |
G |
14: 106,130,524 (GRCm39) |
C221R |
probably damaging |
Het |
Stx2 |
C |
T |
5: 129,076,612 (GRCm39) |
V24M |
probably damaging |
Het |
Tent5b |
T |
C |
4: 133,213,842 (GRCm39) |
S238P |
probably damaging |
Het |
Tll2 |
T |
A |
19: 41,116,902 (GRCm39) |
|
probably null |
Het |
Ttyh3 |
C |
A |
5: 140,612,201 (GRCm39) |
|
probably null |
Het |
Vmn2r116 |
T |
C |
17: 23,619,934 (GRCm39) |
V556A |
probably benign |
Het |
Xpo5 |
T |
C |
17: 46,533,576 (GRCm39) |
|
probably benign |
Het |
Zc3h3 |
A |
G |
15: 75,709,328 (GRCm39) |
S514P |
probably benign |
Het |
|
Other mutations in Zfp277 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01466:Zfp277
|
APN |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.24 |
IGL01477:Zfp277
|
APN |
12 |
40,370,675 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02081:Zfp277
|
APN |
12 |
40,378,795 (GRCm39) |
nonsense |
probably null |
|
IGL02165:Zfp277
|
APN |
12 |
40,365,802 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL02613:Zfp277
|
APN |
12 |
40,379,514 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02688:Zfp277
|
APN |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02825:Zfp277
|
APN |
12 |
40,367,175 (GRCm39) |
missense |
probably benign |
0.06 |
R0194:Zfp277
|
UTSW |
12 |
40,428,876 (GRCm39) |
splice site |
probably benign |
|
R0226:Zfp277
|
UTSW |
12 |
40,414,161 (GRCm39) |
missense |
possibly damaging |
0.67 |
R1263:Zfp277
|
UTSW |
12 |
40,414,164 (GRCm39) |
missense |
probably damaging |
0.99 |
R1584:Zfp277
|
UTSW |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.12 |
R1609:Zfp277
|
UTSW |
12 |
40,378,719 (GRCm39) |
missense |
probably damaging |
0.99 |
R1644:Zfp277
|
UTSW |
12 |
40,379,609 (GRCm39) |
splice site |
probably null |
|
R1789:Zfp277
|
UTSW |
12 |
40,414,084 (GRCm39) |
missense |
probably benign |
0.00 |
R1882:Zfp277
|
UTSW |
12 |
40,495,745 (GRCm39) |
missense |
probably benign |
0.03 |
R2011:Zfp277
|
UTSW |
12 |
40,367,217 (GRCm39) |
nonsense |
probably null |
|
R4884:Zfp277
|
UTSW |
12 |
40,413,152 (GRCm39) |
missense |
probably damaging |
0.97 |
R4976:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5119:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5532:Zfp277
|
UTSW |
12 |
40,385,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R6340:Zfp277
|
UTSW |
12 |
40,368,548 (GRCm39) |
missense |
possibly damaging |
0.57 |
R7191:Zfp277
|
UTSW |
12 |
40,379,561 (GRCm39) |
missense |
probably damaging |
1.00 |
R7378:Zfp277
|
UTSW |
12 |
40,365,852 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7446:Zfp277
|
UTSW |
12 |
40,378,729 (GRCm39) |
missense |
probably damaging |
1.00 |
R7564:Zfp277
|
UTSW |
12 |
40,379,594 (GRCm39) |
missense |
probably damaging |
0.99 |
R7861:Zfp277
|
UTSW |
12 |
40,365,880 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8428:Zfp277
|
UTSW |
12 |
40,379,577 (GRCm39) |
missense |
probably damaging |
1.00 |
R9673:Zfp277
|
UTSW |
12 |
40,370,611 (GRCm39) |
missense |
probably benign |
0.15 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGGTCAGTCAATCGTCCTCTACAC -3'
(R):5'- ACCTCCAGTGAGAAGATGACCATGC -3'
Sequencing Primer
(F):5'- agtcacccacctaaatgaacc -3'
(R):5'- GAGAAGATGACCATGCTTTCTGTC -3'
|
Posted On |
2013-10-16 |