Incidental Mutation 'R0846:Zfp773'
ID |
77372 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp773
|
Ensembl Gene |
ENSMUSG00000063535 |
Gene Name |
zinc finger protein 773 |
Synonyms |
2810409K11Rik |
MMRRC Submission |
039025-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.055)
|
Stock # |
R0846 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
7133677-7139754 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 7135691 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Serine
at position 302
(C302S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032622
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032622]
[ENSMUST00000211240]
|
AlphaFold |
Q9CZ29 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000032622
AA Change: C302S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000032622 Gene: ENSMUSG00000063535 AA Change: C302S
Domain | Start | End | E-Value | Type |
KRAB
|
75 |
134 |
6.82e-8 |
SMART |
ZnF_C2H2
|
241 |
263 |
1.31e0 |
SMART |
ZnF_C2H2
|
269 |
291 |
1.5e-4 |
SMART |
ZnF_C2H2
|
297 |
319 |
4.17e-3 |
SMART |
ZnF_C2H2
|
325 |
347 |
2.05e-2 |
SMART |
ZnF_C2H2
|
353 |
375 |
2.24e-3 |
SMART |
ZnF_C2H2
|
381 |
403 |
8.81e-2 |
SMART |
ZnF_C2H2
|
409 |
431 |
7.26e-3 |
SMART |
ZnF_C2H2
|
437 |
459 |
7.26e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000211240
|
Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.2%
- 20x: 90.2%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 37 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aak1 |
T |
C |
6: 86,936,071 (GRCm39) |
|
probably benign |
Het |
Adgrv1 |
G |
A |
13: 81,627,861 (GRCm39) |
R3667* |
probably null |
Het |
Adh5 |
T |
G |
3: 138,156,835 (GRCm39) |
C174G |
probably damaging |
Het |
Cap1 |
A |
C |
4: 122,756,692 (GRCm39) |
|
probably null |
Het |
Caps2 |
G |
A |
10: 112,051,490 (GRCm39) |
R587H |
probably damaging |
Het |
Ccn1 |
T |
A |
3: 145,353,525 (GRCm39) |
M346L |
possibly damaging |
Het |
Cdo1 |
A |
G |
18: 46,848,812 (GRCm39) |
V142A |
probably damaging |
Het |
Chuk |
T |
C |
19: 44,079,467 (GRCm39) |
T345A |
probably damaging |
Het |
Cobll1 |
T |
C |
2: 64,932,409 (GRCm39) |
|
probably null |
Het |
Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
Cop1 |
T |
C |
1: 159,147,386 (GRCm39) |
Y571H |
probably benign |
Het |
Cstpp1 |
T |
A |
2: 91,214,182 (GRCm39) |
T58S |
probably damaging |
Het |
Dcc |
A |
G |
18: 71,959,283 (GRCm39) |
V163A |
probably benign |
Het |
Dnah11 |
G |
T |
12: 117,897,585 (GRCm39) |
N3548K |
probably damaging |
Het |
Ehhadh |
G |
T |
16: 21,592,247 (GRCm39) |
S152* |
probably null |
Het |
Fitm2 |
T |
C |
2: 163,311,734 (GRCm39) |
T160A |
probably benign |
Het |
Fos |
C |
T |
12: 85,522,457 (GRCm39) |
T162I |
probably damaging |
Het |
Fsd2 |
T |
C |
7: 81,190,145 (GRCm39) |
I546V |
probably benign |
Het |
Gal3st2c |
T |
C |
1: 93,934,669 (GRCm39) |
V19A |
possibly damaging |
Het |
Gorasp2 |
T |
A |
2: 70,521,298 (GRCm39) |
S443T |
probably benign |
Het |
Klf4 |
G |
A |
4: 55,530,191 (GRCm39) |
H307Y |
probably damaging |
Het |
Ldc1 |
A |
C |
4: 130,115,417 (GRCm39) |
S44A |
probably benign |
Het |
Mark3 |
A |
G |
12: 111,593,658 (GRCm39) |
D230G |
possibly damaging |
Het |
Mnat1 |
T |
G |
12: 73,170,706 (GRCm39) |
|
probably null |
Het |
Or5m9b |
T |
C |
2: 85,905,510 (GRCm39) |
L142P |
possibly damaging |
Het |
Otogl |
T |
G |
10: 107,608,157 (GRCm39) |
T2073P |
probably benign |
Het |
Pdxdc1 |
A |
C |
16: 13,672,257 (GRCm39) |
|
probably null |
Het |
Pkhd1l1 |
T |
C |
15: 44,358,993 (GRCm39) |
S401P |
probably damaging |
Het |
Polr1a |
T |
C |
6: 71,901,627 (GRCm39) |
Y262H |
probably damaging |
Het |
Pramel19 |
A |
T |
4: 101,798,447 (GRCm39) |
K139N |
probably benign |
Het |
Scamp4 |
T |
C |
10: 80,450,537 (GRCm39) |
F205L |
probably benign |
Het |
Scn1a |
C |
T |
2: 66,155,099 (GRCm39) |
S620N |
probably benign |
Het |
Scn7a |
C |
T |
2: 66,527,944 (GRCm39) |
D849N |
possibly damaging |
Het |
Slc17a8 |
T |
C |
10: 89,442,596 (GRCm39) |
D79G |
possibly damaging |
Het |
Sync |
A |
G |
4: 129,187,897 (GRCm39) |
S310G |
probably benign |
Het |
Tbc1d9b |
A |
C |
11: 50,062,148 (GRCm39) |
I1219L |
probably benign |
Het |
Vmn1r47 |
T |
A |
6: 89,999,657 (GRCm39) |
M263K |
probably benign |
Het |
|
Other mutations in Zfp773 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00764:Zfp773
|
APN |
7 |
7,135,683 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00780:Zfp773
|
APN |
7 |
7,136,113 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01348:Zfp773
|
APN |
7 |
7,138,314 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02224:Zfp773
|
APN |
7 |
7,135,975 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02447:Zfp773
|
APN |
7 |
7,139,655 (GRCm39) |
utr 5 prime |
probably benign |
|
IGL02869:Zfp773
|
APN |
7 |
7,137,232 (GRCm39) |
missense |
probably benign |
0.22 |
R0505:Zfp773
|
UTSW |
7 |
7,136,023 (GRCm39) |
missense |
probably benign |
0.03 |
R0585:Zfp773
|
UTSW |
7 |
7,135,574 (GRCm39) |
missense |
probably benign |
0.21 |
R0804:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
R1179:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
R2847:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
R3841:Zfp773
|
UTSW |
7 |
7,135,390 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4116:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
R4638:Zfp773
|
UTSW |
7 |
7,138,335 (GRCm39) |
missense |
probably damaging |
1.00 |
R5126:Zfp773
|
UTSW |
7 |
7,139,623 (GRCm39) |
missense |
unknown |
|
R6142:Zfp773
|
UTSW |
7 |
7,135,481 (GRCm39) |
missense |
probably benign |
0.00 |
R7072:Zfp773
|
UTSW |
7 |
7,135,874 (GRCm39) |
missense |
probably benign |
0.15 |
R7232:Zfp773
|
UTSW |
7 |
7,135,984 (GRCm39) |
missense |
probably benign |
0.14 |
R7748:Zfp773
|
UTSW |
7 |
7,135,907 (GRCm39) |
missense |
probably benign |
0.04 |
R7888:Zfp773
|
UTSW |
7 |
7,135,978 (GRCm39) |
missense |
probably benign |
0.00 |
R8681:Zfp773
|
UTSW |
7 |
7,139,482 (GRCm39) |
missense |
possibly damaging |
0.70 |
R8784:Zfp773
|
UTSW |
7 |
7,135,570 (GRCm39) |
missense |
probably benign |
0.19 |
R8946:Zfp773
|
UTSW |
7 |
7,135,469 (GRCm39) |
missense |
possibly damaging |
0.82 |
R9056:Zfp773
|
UTSW |
7 |
7,135,989 (GRCm39) |
missense |
probably damaging |
0.99 |
R9154:Zfp773
|
UTSW |
7 |
7,138,302 (GRCm39) |
missense |
probably damaging |
0.98 |
R9295:Zfp773
|
UTSW |
7 |
7,135,694 (GRCm39) |
missense |
probably benign |
0.06 |
RF007:Zfp773
|
UTSW |
7 |
7,135,689 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TCCTACACTGGCTGCACTCAAAAG -3'
(R):5'- AGCTGAGCCATGCTGAGAAACC -3'
Sequencing Primer
(F):5'- cttaaataattttccacactcgcc -3'
(R):5'- GCAGAATGCAGAATTTCAGTTCC -3'
|
Posted On |
2013-10-16 |