Incidental Mutation 'R5279:Triobp'
| ID |
404139 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
042839-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5279 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 78878591 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 398
(V398F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122988
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109687]
[ENSMUST00000109688]
[ENSMUST00000109689]
[ENSMUST00000109690]
[ENSMUST00000130663]
[ENSMUST00000144151]
[ENSMUST00000229270]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109687
|
| SMART Domains |
Protein: ENSMUSP00000105309
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
coiled coil region
|
339 |
377 |
N/A |
INTRINSIC |
|
coiled coil region
|
401 |
463 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000109688
|
| SMART Domains |
Protein: ENSMUSP00000105310
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
30 |
47 |
N/A |
INTRINSIC |
|
PH
|
54 |
151 |
6.2e-19 |
SMART |
|
coiled coil region
|
324 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
386 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
448 |
510 |
N/A |
INTRINSIC |
|
coiled coil region
|
544 |
623 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109689
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109690
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000130663
AA Change: V398F
PolyPhen 2
Score 0.664 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000122988
Gene: ENSMUSG00000033088
AA Change: V398F
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144151
|
| SMART Domains |
Protein: ENSMUSP00000116765
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
1 |
92 |
1.04e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229270
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230425
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
99% (73/74) |
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
C |
A |
17: 24,508,388 (GRCm39) |
G1049V |
probably damaging |
Het |
| Afdn |
G |
A |
17: 14,109,214 (GRCm39) |
R1579H |
probably damaging |
Het |
| Ankrd28 |
T |
A |
14: 31,456,963 (GRCm39) |
N386Y |
probably damaging |
Het |
| Atf7ip |
T |
A |
6: 136,580,377 (GRCm39) |
Y1100* |
probably null |
Het |
| Atp9b |
T |
A |
18: 80,956,073 (GRCm39) |
E3V |
probably damaging |
Het |
| AW554918 |
T |
G |
18: 25,308,488 (GRCm39) |
D60E |
possibly damaging |
Het |
| Baz2b |
G |
T |
2: 59,762,496 (GRCm39) |
Q927K |
probably damaging |
Het |
| Birc6 |
A |
G |
17: 74,957,042 (GRCm39) |
R3659G |
probably damaging |
Het |
| C8a |
T |
G |
4: 104,703,185 (GRCm39) |
N291H |
probably damaging |
Het |
| Calcoco1 |
G |
A |
15: 102,619,420 (GRCm39) |
L390F |
probably damaging |
Het |
| Carmil3 |
A |
G |
14: 55,739,028 (GRCm39) |
D894G |
probably damaging |
Het |
| Cdc20 |
A |
G |
4: 118,290,711 (GRCm39) |
Y430H |
probably damaging |
Het |
| Cdc6 |
A |
T |
11: 98,803,088 (GRCm39) |
I316F |
probably damaging |
Het |
| Ceacam23 |
T |
A |
7: 17,607,214 (GRCm39) |
|
noncoding transcript |
Het |
| Cenpu |
T |
A |
8: 47,031,945 (GRCm39) |
|
probably null |
Het |
| Csmd2 |
T |
A |
4: 128,350,707 (GRCm39) |
V1592D |
probably benign |
Het |
| Csmd3 |
G |
T |
15: 48,655,340 (GRCm39) |
|
probably null |
Het |
| Dnah7c |
T |
C |
1: 46,558,429 (GRCm39) |
F512L |
probably benign |
Het |
| Fam136a |
T |
A |
6: 86,343,686 (GRCm39) |
L61Q |
probably damaging |
Het |
| Fpgs |
A |
C |
2: 32,582,779 (GRCm39) |
|
probably benign |
Het |
| Fzd4 |
G |
A |
7: 89,056,881 (GRCm39) |
M309I |
probably benign |
Het |
| Gad2 |
A |
G |
2: 22,563,969 (GRCm39) |
T391A |
probably benign |
Het |
| Gm11563 |
A |
T |
11: 99,549,539 (GRCm39) |
S72T |
unknown |
Het |
| Gon4l |
A |
G |
3: 88,794,944 (GRCm39) |
I716V |
probably benign |
Het |
| Itga9 |
T |
C |
9: 118,457,273 (GRCm39) |
V128A |
probably damaging |
Het |
| Kat6a |
CGCAGCAGCAGCAGCAGCA |
CGCAGCAGCAGCA |
8: 23,429,664 (GRCm39) |
|
probably benign |
Het |
| Lrrc9 |
T |
A |
12: 72,542,368 (GRCm39) |
D1063E |
possibly damaging |
Het |
| Lyst |
T |
A |
13: 13,823,387 (GRCm39) |
L1453* |
probably null |
Het |
| Mcm3ap |
T |
C |
10: 76,343,373 (GRCm39) |
V1755A |
probably damaging |
Het |
| Mrc1 |
T |
C |
2: 14,314,869 (GRCm39) |
S985P |
probably damaging |
Het |
| Mst1 |
A |
C |
9: 107,959,414 (GRCm39) |
K233N |
probably damaging |
Het |
| Nr2c2ap |
G |
A |
8: 70,584,653 (GRCm39) |
D42N |
probably damaging |
Het |
| Ntn1 |
A |
G |
11: 68,276,538 (GRCm39) |
S137P |
probably benign |
Het |
| Pard3 |
T |
C |
8: 128,186,867 (GRCm39) |
|
probably null |
Het |
| Pcdh15 |
T |
A |
10: 74,430,015 (GRCm39) |
D1210E |
probably damaging |
Het |
| Pcdhga5 |
T |
C |
18: 37,827,774 (GRCm39) |
L74P |
probably benign |
Het |
| Pcsk5 |
T |
C |
19: 17,573,022 (GRCm39) |
|
probably null |
Het |
| Pdia3 |
T |
C |
2: 121,244,484 (GRCm39) |
|
probably benign |
Het |
| Pikfyve |
A |
T |
1: 65,235,858 (GRCm39) |
R177* |
probably null |
Het |
| Pklr |
A |
G |
3: 89,050,566 (GRCm39) |
E409G |
probably damaging |
Het |
| Plod2 |
T |
C |
9: 92,463,376 (GRCm39) |
Y154H |
probably damaging |
Het |
| Psmc3 |
T |
A |
2: 90,884,667 (GRCm39) |
D6E |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,547,334 (GRCm39) |
N205I |
possibly damaging |
Het |
| Rbm6 |
T |
C |
9: 107,655,213 (GRCm39) |
E1006G |
probably benign |
Het |
| Rgl2 |
T |
C |
17: 34,154,922 (GRCm39) |
V642A |
probably benign |
Het |
| Rnf8 |
T |
A |
17: 29,845,680 (GRCm39) |
H104Q |
possibly damaging |
Het |
| Robo4 |
CGG |
CG |
9: 37,322,786 (GRCm39) |
|
probably null |
Het |
| Rpa1 |
T |
C |
11: 75,204,170 (GRCm39) |
N269S |
probably damaging |
Het |
| Sdk2 |
A |
G |
11: 113,757,857 (GRCm39) |
M519T |
probably benign |
Het |
| Snx30 |
A |
G |
4: 59,885,070 (GRCm39) |
S237G |
probably benign |
Het |
| Spx |
A |
G |
6: 142,359,766 (GRCm39) |
N36S |
probably damaging |
Het |
| Stard7 |
T |
C |
2: 127,137,416 (GRCm39) |
Y289H |
probably damaging |
Het |
| Sugp2 |
T |
C |
8: 70,709,757 (GRCm39) |
|
probably benign |
Het |
| Susd4 |
C |
T |
1: 182,715,043 (GRCm39) |
T288I |
probably damaging |
Het |
| Tceanc2 |
T |
A |
4: 107,034,826 (GRCm39) |
|
probably null |
Het |
| Tm4sf4 |
T |
G |
3: 57,341,159 (GRCm39) |
V97G |
probably benign |
Het |
| Tmtc1 |
C |
T |
6: 148,256,629 (GRCm39) |
|
probably benign |
Het |
| Trappc11 |
C |
T |
8: 47,958,339 (GRCm39) |
|
probably benign |
Het |
| Ttll9 |
T |
A |
2: 152,804,464 (GRCm39) |
S2T |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,731,320 (GRCm39) |
|
probably benign |
Het |
| Tyw3 |
A |
G |
3: 154,300,108 (GRCm39) |
C80R |
probably damaging |
Het |
| Usp24 |
T |
C |
4: 106,242,621 (GRCm39) |
V1177A |
possibly damaging |
Het |
| Vmn1r65 |
A |
G |
7: 6,011,754 (GRCm39) |
V160A |
probably damaging |
Het |
| Vmn2r104 |
T |
A |
17: 20,262,146 (GRCm39) |
H328L |
probably benign |
Het |
| Vmn2r65 |
A |
C |
7: 84,589,849 (GRCm39) |
I689S |
probably damaging |
Het |
| Wrn |
A |
G |
8: 33,731,129 (GRCm39) |
Y1068H |
probably damaging |
Het |
| Xpo4 |
C |
A |
14: 57,850,866 (GRCm39) |
S346I |
probably benign |
Het |
| Zc3h3 |
T |
A |
15: 75,711,439 (GRCm39) |
T341S |
probably benign |
Het |
| Zxdc |
T |
C |
6: 90,347,419 (GRCm39) |
M260T |
possibly damaging |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0276:Triobp
|
UTSW |
15 |
78,857,876 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1510:Triobp
|
UTSW |
15 |
78,887,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2051:Triobp
|
UTSW |
15 |
78,888,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2351:Triobp
|
UTSW |
15 |
78,888,780 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9514:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCAAAGAGCACCCATGTTTGG -3'
(R):5'- AACTCCTGAGGGCAAACTGG -3'
Sequencing Primer
(F):5'- CATGTTTGGGGAGCCCTCTC -3'
(R):5'- AACTGGAGGCCCCCAAGTC -3'
|
| Posted On |
2016-07-22 |
Incidental Mutation