Incidental Mutation 'IGL01788:Vmn1r28'
| ID |
155110 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r28
|
| Ensembl Gene |
ENSMUSG00000115705 |
| Gene Name |
vomeronasal 1 receptor 28 |
| Synonyms |
V1rc25 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
IGL01788
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
58239279-58243645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 58242522 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Asparagine
at position 122
(H122N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153785
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176874]
[ENSMUST00000226813]
[ENSMUST00000227805]
[ENSMUST00000228678]
|
| AlphaFold |
Q8R2C9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176874
AA Change: H122N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000135311
Gene: ENSMUSG00000094291
AA Change: H122N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
8.4e-59 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226813
AA Change: H122N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227805
AA Change: H122N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228678
AA Change: H122N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9230009I02Rik |
T |
G |
11: 50,982,542 (GRCm39) |
|
noncoding transcript |
Het |
| Acp6 |
A |
G |
3: 97,073,198 (GRCm39) |
T80A |
probably damaging |
Het |
| Adamtsl5 |
T |
C |
10: 80,180,757 (GRCm39) |
T102A |
probably benign |
Het |
| Adcy6 |
C |
A |
15: 98,494,400 (GRCm39) |
E812* |
probably null |
Het |
| Apol6 |
G |
A |
15: 76,935,216 (GRCm39) |
V162I |
possibly damaging |
Het |
| Atp6v1h |
T |
A |
1: 5,220,206 (GRCm39) |
M396K |
possibly damaging |
Het |
| B3gnt8 |
A |
G |
7: 25,328,613 (GRCm39) |
T348A |
probably damaging |
Het |
| Cgnl1 |
A |
G |
9: 71,562,672 (GRCm39) |
V869A |
probably benign |
Het |
| Dcaf5 |
A |
T |
12: 80,395,098 (GRCm39) |
I357N |
probably damaging |
Het |
| Dennd4a |
A |
G |
9: 64,749,903 (GRCm39) |
I165V |
probably benign |
Het |
| Dlgap2 |
T |
A |
8: 14,893,631 (GRCm39) |
I982K |
probably benign |
Het |
| Dop1a |
A |
T |
9: 86,413,772 (GRCm39) |
H1891L |
probably benign |
Het |
| Fhad1 |
A |
C |
4: 141,660,113 (GRCm39) |
S65R |
probably benign |
Het |
| Fn1 |
A |
G |
1: 71,652,996 (GRCm39) |
I1331T |
probably damaging |
Het |
| Fto |
A |
T |
8: 92,136,359 (GRCm39) |
Y211F |
probably benign |
Het |
| Gm3278 |
A |
C |
14: 16,080,370 (GRCm39) |
R60S |
probably benign |
Het |
| Ifna9 |
A |
G |
4: 88,510,097 (GRCm39) |
S176P |
probably damaging |
Het |
| Klk1 |
T |
C |
7: 43,878,407 (GRCm39) |
I189T |
probably benign |
Het |
| Mcph1 |
G |
A |
8: 18,682,419 (GRCm39) |
G519R |
probably damaging |
Het |
| Mcph1 |
G |
A |
8: 18,682,420 (GRCm39) |
G519E |
probably damaging |
Het |
| N4bp1 |
A |
T |
8: 87,587,624 (GRCm39) |
V438E |
probably benign |
Het |
| Ncapg |
T |
A |
5: 45,828,423 (GRCm39) |
V58E |
probably damaging |
Het |
| Nid2 |
T |
A |
14: 19,858,047 (GRCm39) |
S1054T |
probably damaging |
Het |
| Nlrp4a |
A |
T |
7: 26,153,492 (GRCm39) |
Y681F |
probably benign |
Het |
| Or4f57 |
T |
C |
2: 111,791,352 (GRCm39) |
D22G |
probably benign |
Het |
| Or4k15c |
A |
G |
14: 50,321,959 (GRCm39) |
Y60H |
probably damaging |
Het |
| Or52e19b |
C |
A |
7: 103,032,770 (GRCm39) |
M146I |
probably benign |
Het |
| Or5b94 |
G |
A |
19: 12,652,442 (GRCm39) |
R291K |
probably damaging |
Het |
| Papln |
A |
T |
12: 83,822,236 (GRCm39) |
T364S |
probably benign |
Het |
| Pcdh18 |
C |
A |
3: 49,710,371 (GRCm39) |
E315* |
probably null |
Het |
| Pmel |
G |
A |
10: 128,553,701 (GRCm39) |
R445Q |
probably damaging |
Het |
| Ppp1r12b |
C |
T |
1: 134,821,245 (GRCm39) |
V182I |
possibly damaging |
Het |
| Ptprn2 |
A |
G |
12: 116,864,607 (GRCm39) |
T541A |
probably damaging |
Het |
| Rbl1 |
A |
T |
2: 157,005,576 (GRCm39) |
N813K |
probably benign |
Het |
| Sash1 |
C |
A |
10: 8,609,410 (GRCm39) |
R713L |
probably benign |
Het |
| Slc13a1 |
T |
G |
6: 24,134,371 (GRCm39) |
T171P |
probably damaging |
Het |
| Slc18b1 |
G |
T |
10: 23,701,899 (GRCm39) |
E407D |
probably damaging |
Het |
| Slc2a6 |
G |
A |
2: 26,914,227 (GRCm39) |
Q297* |
probably null |
Het |
| Vmn1r209 |
T |
C |
13: 22,989,832 (GRCm39) |
H286R |
probably damaging |
Het |
| Wfs1 |
A |
G |
5: 37,125,980 (GRCm39) |
Y304H |
probably benign |
Het |
| Zfp512b |
A |
G |
2: 181,230,556 (GRCm39) |
S445P |
possibly damaging |
Het |
|
| Other mutations in Vmn1r28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Vmn1r28
|
APN |
6 |
58,242,176 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01712:Vmn1r28
|
APN |
6 |
58,242,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02629:Vmn1r28
|
APN |
6 |
58,242,801 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0001:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0009:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0040:Vmn1r28
|
UTSW |
6 |
58,242,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0078:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0079:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0081:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0165:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0166:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0167:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0172:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0173:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0288:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1143:Vmn1r28
|
UTSW |
6 |
58,242,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1225:Vmn1r28
|
UTSW |
6 |
58,242,951 (GRCm39) |
nonsense |
probably null |
|
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1836:Vmn1r28
|
UTSW |
6 |
58,242,237 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1882:Vmn1r28
|
UTSW |
6 |
58,242,963 (GRCm39) |
missense |
probably benign |
|
|
R1905:Vmn1r28
|
UTSW |
6 |
58,242,912 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4912:Vmn1r28
|
UTSW |
6 |
58,242,525 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5071:Vmn1r28
|
UTSW |
6 |
58,242,894 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5113:Vmn1r28
|
UTSW |
6 |
58,242,843 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5261:Vmn1r28
|
UTSW |
6 |
58,242,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5265:Vmn1r28
|
UTSW |
6 |
58,242,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5839:Vmn1r28
|
UTSW |
6 |
58,242,280 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6180:Vmn1r28
|
UTSW |
6 |
58,242,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6643:Vmn1r28
|
UTSW |
6 |
58,242,945 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6884:Vmn1r28
|
UTSW |
6 |
58,242,633 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7393:Vmn1r28
|
UTSW |
6 |
58,242,574 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7471:Vmn1r28
|
UTSW |
6 |
58,242,850 (GRCm39) |
nonsense |
probably null |
|
|
R7738:Vmn1r28
|
UTSW |
6 |
58,243,039 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7961:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8009:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
|
R8156:Vmn1r28
|
UTSW |
6 |
58,242,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8167:Vmn1r28
|
UTSW |
6 |
58,243,052 (GRCm39) |
missense |
noncoding transcript |
|
|
R8879:Vmn1r28
|
UTSW |
6 |
58,242,669 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9639:Vmn1r28
|
UTSW |
6 |
58,242,996 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2014-02-04 |
Incidental Mutation