Incidental Mutation 'IGL01909:Olfr26'
ID179748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr26
Ensembl Gene ENSMUSG00000047667
Gene Nameolfactory receptor 26
SynonymsMTPCR09, MOR171-9, GA_x6K02T2PVTD-32550930-32551856
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #IGL01909
Quality Score
Status
Chromosome9
Chromosomal Location38855060-38855990 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 38855717 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 218 (Y218*)
Ref Sequence ENSEMBL: ENSMUSP00000100467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104874] [ENSMUST00000217350]
Predicted Effect probably null
Transcript: ENSMUST00000104874
AA Change: Y218*
SMART Domains Protein: ENSMUSP00000100467
Gene: ENSMUSG00000047667
AA Change: Y218*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.8e-49 PFAM
Pfam:7tm_1 41 290 2.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217350
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700111E14Rik A T 6: 36,937,217 probably benign Het
Actn2 A T 13: 12,309,593 probably null Het
Apom C T 17: 35,131,232 A78T probably benign Het
Bambi A G 18: 3,508,229 Y7C possibly damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cdc42bpb T C 12: 111,323,142 M418V probably benign Het
Clptm1 T C 7: 19,655,776 N43D probably benign Het
Cspp1 T C 1: 10,066,661 V241A probably benign Het
Ctnna3 T A 10: 63,504,131 I32N probably benign Het
Elp2 A G 18: 24,619,519 probably benign Het
Frmd4a A G 2: 4,604,033 D893G probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
H2-M10.1 C A 17: 36,325,079 G154* probably null Het
Igdcc3 C T 9: 65,144,537 R141W probably damaging Het
Igkv14-130 A G 6: 67,791,339 K60E possibly damaging Het
Kcnmb2 A G 3: 32,198,363 probably benign Het
Lrp4 T C 2: 91,494,184 L1288P possibly damaging Het
Mavs T A 2: 131,245,521 M313K probably benign Het
Mia2 A G 12: 59,107,945 E148G possibly damaging Het
Olfr813 A T 10: 129,857,081 T188S probably damaging Het
Olfr875 T A 9: 37,772,863 I68K possibly damaging Het
Plekha3 C T 2: 76,686,703 T133M probably damaging Het
Plxna1 A T 6: 89,332,084 probably null Het
Sept2 A G 1: 93,499,101 N144S probably damaging Het
Slc9a4 T C 1: 40,612,291 probably benign Het
Slco1b2 T A 6: 141,648,586 I59K probably damaging Het
Tnrc6b A G 15: 80,901,983 S1243G possibly damaging Het
Unc13a T A 8: 71,639,210 probably benign Het
Vmn2r105 T C 17: 20,224,656 R525G probably damaging Het
Vmn2r37 T A 7: 9,216,033 K451* probably null Het
Vmn2r71 C T 7: 85,620,793 T504I probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp668 A T 7: 127,866,822 C397S probably damaging Het
Other mutations in Olfr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Olfr26 APN 9 38855799 missense probably benign 0.00
IGL02146:Olfr26 APN 9 38855358 missense probably benign 0.01
IGL02229:Olfr26 APN 9 38855416 missense possibly damaging 0.62
IGL02382:Olfr26 APN 9 38855068 missense probably benign
IGL03007:Olfr26 APN 9 38855296 missense probably damaging 1.00
IGL03118:Olfr26 APN 9 38855230 missense probably damaging 1.00
PIT4403001:Olfr26 UTSW 9 38855380 missense probably benign 0.39
R0590:Olfr26 UTSW 9 38855470 missense probably damaging 0.99
R0862:Olfr26 UTSW 9 38855182 missense possibly damaging 0.89
R1779:Olfr26 UTSW 9 38855550 missense possibly damaging 0.55
R1796:Olfr26 UTSW 9 38855524 missense probably benign 0.01
R2083:Olfr26 UTSW 9 38855341 missense probably benign 0.10
R3420:Olfr26 UTSW 9 38855325 missense possibly damaging 0.92
R3421:Olfr26 UTSW 9 38855325 missense possibly damaging 0.92
R4328:Olfr26 UTSW 9 38855836 missense possibly damaging 0.62
R4470:Olfr26 UTSW 9 38855631 missense probably damaging 1.00
R4471:Olfr26 UTSW 9 38855631 missense probably damaging 1.00
R5047:Olfr26 UTSW 9 38855289 missense probably benign 0.36
R5267:Olfr26 UTSW 9 38855805 missense probably damaging 1.00
R5318:Olfr26 UTSW 9 38855448 missense probably damaging 1.00
R6502:Olfr26 UTSW 9 38855637 missense probably damaging 0.99
R7221:Olfr26 UTSW 9 38855242 missense probably damaging 1.00
R7297:Olfr26 UTSW 9 38855949 missense probably damaging 1.00
R7448:Olfr26 UTSW 9 38855116 missense probably damaging 1.00
R7525:Olfr26 UTSW 9 38855238 missense possibly damaging 0.89
R8040:Olfr26 UTSW 9 38855164 missense probably damaging 0.99
R8303:Olfr26 UTSW 9 38855541 missense probably damaging 1.00
Z1177:Olfr26 UTSW 9 38855235 missense probably damaging 1.00
Posted On2014-05-07