Incidental Mutation 'IGL01909:Or8d1'
ID 179748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8d1
Ensembl Gene ENSMUSG00000047667
Gene Name olfactory receptor family 8 subfamily D member 1
Synonyms GA_x6K02T2PVTD-32550930-32551856, MOR171-9, MTPCR09, Olfr26
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL01909
Quality Score
Chromosome 9
Chromosomal Location 38766356-38767286 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 38767013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 218 (Y218*)
Ref Sequence ENSEMBL: ENSMUSP00000100467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104874] [ENSMUST00000217350]
AlphaFold Q7TRB7
Predicted Effect probably null
Transcript: ENSMUST00000104874
AA Change: Y218*
SMART Domains Protein: ENSMUSP00000100467
Gene: ENSMUSG00000047667
AA Change: Y218*

Pfam:7tm_4 31 308 3.8e-49 PFAM
Pfam:7tm_1 41 290 2.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217350
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700111E14Rik A T 6: 36,914,152 (GRCm39) probably benign Het
Actn2 A T 13: 12,324,479 (GRCm39) probably null Het
Apom C T 17: 35,350,208 (GRCm39) A78T probably benign Het
Bambi A G 18: 3,508,229 (GRCm39) Y7C possibly damaging Het
Cdc42bpb T C 12: 111,289,576 (GRCm39) M418V probably benign Het
Clptm1 T C 7: 19,389,701 (GRCm39) N43D probably benign Het
Cspp1 T C 1: 10,136,886 (GRCm39) V241A probably benign Het
Ctnna3 T A 10: 63,339,910 (GRCm39) I32N probably benign Het
Elp2 A G 18: 24,752,576 (GRCm39) probably benign Het
Frmd4a A G 2: 4,608,844 (GRCm39) D893G probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
H2-M10.1 C A 17: 36,635,971 (GRCm39) G154* probably null Het
Igdcc3 C T 9: 65,051,819 (GRCm39) R141W probably damaging Het
Igkv14-130 A G 6: 67,768,323 (GRCm39) K60E possibly damaging Het
Kcnmb2 A G 3: 32,252,512 (GRCm39) probably benign Het
Lrp4 T C 2: 91,324,529 (GRCm39) L1288P possibly damaging Het
Mavs T A 2: 131,087,441 (GRCm39) M313K probably benign Het
Mia2 A G 12: 59,154,731 (GRCm39) E148G possibly damaging Het
Or6c76b A T 10: 129,692,950 (GRCm39) T188S probably damaging Het
Or8b12b T A 9: 37,684,159 (GRCm39) I68K possibly damaging Het
Plekha3 C T 2: 76,517,047 (GRCm39) T133M probably damaging Het
Plxna1 A T 6: 89,309,066 (GRCm39) probably null Het
Septin2 A G 1: 93,426,823 (GRCm39) N144S probably damaging Het
Slc9a4 T C 1: 40,651,451 (GRCm39) probably benign Het
Slco1b2 T A 6: 141,594,312 (GRCm39) I59K probably damaging Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Tnrc6b A G 15: 80,786,184 (GRCm39) S1243G possibly damaging Het
Unc13a T A 8: 72,091,854 (GRCm39) probably benign Het
Vmn2r105 T C 17: 20,444,918 (GRCm39) R525G probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r37 T A 7: 9,219,032 (GRCm39) K451* probably null Het
Vmn2r71 C T 7: 85,270,001 (GRCm39) T504I probably benign Het
Zfp668 A T 7: 127,465,994 (GRCm39) C397S probably damaging Het
Other mutations in Or8d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Or8d1 APN 9 38,767,095 (GRCm39) missense probably benign 0.00
IGL02146:Or8d1 APN 9 38,766,654 (GRCm39) missense probably benign 0.01
IGL02229:Or8d1 APN 9 38,766,712 (GRCm39) missense possibly damaging 0.62
IGL02382:Or8d1 APN 9 38,766,364 (GRCm39) missense probably benign
IGL03007:Or8d1 APN 9 38,766,592 (GRCm39) missense probably damaging 1.00
IGL03118:Or8d1 APN 9 38,766,526 (GRCm39) missense probably damaging 1.00
PIT4403001:Or8d1 UTSW 9 38,766,676 (GRCm39) missense probably benign 0.39
R0590:Or8d1 UTSW 9 38,766,766 (GRCm39) missense probably damaging 0.99
R0862:Or8d1 UTSW 9 38,766,478 (GRCm39) missense possibly damaging 0.89
R1779:Or8d1 UTSW 9 38,766,846 (GRCm39) missense possibly damaging 0.55
R1796:Or8d1 UTSW 9 38,766,820 (GRCm39) missense probably benign 0.01
R2083:Or8d1 UTSW 9 38,766,637 (GRCm39) missense probably benign 0.10
R3420:Or8d1 UTSW 9 38,766,621 (GRCm39) missense possibly damaging 0.92
R3421:Or8d1 UTSW 9 38,766,621 (GRCm39) missense possibly damaging 0.92
R4328:Or8d1 UTSW 9 38,767,132 (GRCm39) missense possibly damaging 0.62
R4470:Or8d1 UTSW 9 38,766,927 (GRCm39) missense probably damaging 1.00
R4471:Or8d1 UTSW 9 38,766,927 (GRCm39) missense probably damaging 1.00
R5047:Or8d1 UTSW 9 38,766,585 (GRCm39) missense probably benign 0.36
R5267:Or8d1 UTSW 9 38,767,101 (GRCm39) missense probably damaging 1.00
R5318:Or8d1 UTSW 9 38,766,744 (GRCm39) missense probably damaging 1.00
R6502:Or8d1 UTSW 9 38,766,933 (GRCm39) missense probably damaging 0.99
R7221:Or8d1 UTSW 9 38,766,538 (GRCm39) missense probably damaging 1.00
R7297:Or8d1 UTSW 9 38,767,245 (GRCm39) missense probably damaging 1.00
R7448:Or8d1 UTSW 9 38,766,412 (GRCm39) missense probably damaging 1.00
R7525:Or8d1 UTSW 9 38,766,534 (GRCm39) missense possibly damaging 0.89
R8040:Or8d1 UTSW 9 38,766,460 (GRCm39) missense probably damaging 0.99
R8303:Or8d1 UTSW 9 38,766,837 (GRCm39) missense probably damaging 1.00
R8972:Or8d1 UTSW 9 38,767,254 (GRCm39) missense probably damaging 1.00
Z1177:Or8d1 UTSW 9 38,766,531 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07