Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02020:Mphosph9'

183938

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mphosph9

Ensembl Gene

ENSMUSG00000038126

Gene Name

M-phase phosphoprotein 9

Synonyms

4930548D04Rik, MPP9, B930097C17Rik, 9630025B04Rik, MPP-9

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02020

Quality Score

Status

Chromosome

Chromosomal Location

124389022-124466001 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 124397013 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 1110 (N1110S)

Ref Sequence

ENSEMBL: ENSMUSP00000138982 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031344] [ENSMUST00000147737] [ENSMUST00000184951]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000031344
AA Change: N1080S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000031344
Gene: ENSMUSG00000038126
AA Change: N1080S

Domain	Start	End	E-Value	Type
low complexity region	102	119	N/A	INTRINSIC
low complexity region	128	140	N/A	INTRINSIC
low complexity region	414	428	N/A	INTRINSIC
coiled coil region	574	736	N/A	INTRINSIC
low complexity region	879	898	N/A	INTRINSIC
low complexity region	957	971	N/A	INTRINSIC
coiled coil region	1040	1105	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128027

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142498

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143476

Predicted Effect

probably benign
Transcript: ENSMUST00000147737

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156745

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157159

Predicted Effect

probably damaging
Transcript: ENSMUST00000184951
AA Change: N1110S

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000138982
Gene: ENSMUSG00000038126
AA Change: N1110S

Domain	Start	End	E-Value	Type
coiled coil region	102	130	N/A	INTRINSIC
low complexity region	132	149	N/A	INTRINSIC
low complexity region	158	170	N/A	INTRINSIC
low complexity region	444	458	N/A	INTRINSIC
coiled coil region	604	766	N/A	INTRINSIC
low complexity region	909	928	N/A	INTRINSIC
low complexity region	987	1001	N/A	INTRINSIC
coiled coil region	1070	1135	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl1	A	T	8: 84,659,577 (GRCm39)	Q711L	probably benign	Het
Atg9b	A	C	5: 24,596,056 (GRCm39)	N205K	possibly damaging	Het
Brinp3	T	C	1: 146,777,865 (GRCm39)		probably benign	Het
Cdh20	A	G	1: 110,066,078 (GRCm39)	Y784C	probably damaging	Het
Csmd2	T	A	4: 128,453,672 (GRCm39)	D142E	probably damaging	Het
Dscam	A	G	16: 96,517,269 (GRCm39)	L880P	probably damaging	Het
Gm14496	A	G	2: 181,637,882 (GRCm39)	T319A	possibly damaging	Het
Hr	A	G	14: 70,793,877 (GRCm39)	T46A	probably benign	Het
Ighv1-7	A	G	12: 114,502,345 (GRCm39)	C41R	probably damaging	Het
Itga3	C	T	11: 94,948,216 (GRCm39)	V539I	probably benign	Het
Kif13a	T	A	13: 46,947,495 (GRCm39)	I830F	probably benign	Het
Or5m11b	A	G	2: 85,805,579 (GRCm39)		probably benign	Het
Pdia3	G	A	2: 121,266,900 (GRCm39)		probably null	Het
Phpt1	T	C	2: 25,464,221 (GRCm39)	I87M	probably damaging	Het
Psd3	T	C	8: 68,426,822 (GRCm39)		probably benign	Het
Ranbp2	A	G	10: 58,315,769 (GRCm39)	E2163G	probably damaging	Het
Ranbp6	T	C	19: 29,787,176 (GRCm39)	I1059V	probably benign	Het
Runx2	C	T	17: 44,969,486 (GRCm39)	G253D	probably damaging	Het
S100a5	A	G	3: 90,517,121 (GRCm39)		probably benign	Het
Skint1	T	A	4: 111,882,724 (GRCm39)	M256K	probably benign	Het
Slc9a3	C	T	13: 74,306,967 (GRCm39)	A364V	probably damaging	Het
Srsf3-ps	C	A	11: 98,516,335 (GRCm39)	V13L	probably damaging	Het
Trip11	C	T	12: 101,850,572 (GRCm39)	R879Q	probably damaging	Het
Tubgcp3	T	C	8: 12,687,780 (GRCm39)	T588A	possibly damaging	Het
Vmn2r100	T	A	17: 19,725,200 (GRCm39)	V43E	possibly damaging	Het
Washc4	T	C	10: 83,400,336 (GRCm39)	S421P	probably damaging	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Wwp2	G	A	8: 108,283,127 (GRCm39)	R354Q	probably damaging	Het
Zfp804b	T	A	5: 6,819,118 (GRCm39)	Q1315L	probably damaging	Het

Other mutations in Mphosph9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01363:Mphosph9	APN	5	124,400,084 (GRCm39)	missense	probably damaging	1.00
IGL01527:Mphosph9	APN	5	124,421,687 (GRCm39)	splice site	probably benign
IGL01784:Mphosph9	APN	5	124,403,373 (GRCm39)	splice site	probably benign
IGL01958:Mphosph9	APN	5	124,463,053 (GRCm39)	utr 5 prime	probably benign
IGL02190:Mphosph9	APN	5	124,403,488 (GRCm39)	missense	possibly damaging	0.92
IGL02261:Mphosph9	APN	5	124,398,150 (GRCm39)	missense	probably damaging	1.00
IGL02569:Mphosph9	APN	5	124,435,634 (GRCm39)	nonsense	probably null
IGL02640:Mphosph9	APN	5	124,453,563 (GRCm39)	missense	possibly damaging	0.66
IGL02702:Mphosph9	APN	5	124,398,052 (GRCm39)	missense	probably damaging	1.00
IGL02793:Mphosph9	APN	5	124,421,800 (GRCm39)	critical splice acceptor site	probably null
IGL02813:Mphosph9	APN	5	124,453,691 (GRCm39)	missense	probably benign	0.37
IGL02875:Mphosph9	APN	5	124,421,800 (GRCm39)	critical splice acceptor site	probably null
IGL03149:Mphosph9	APN	5	124,401,074 (GRCm39)	missense	probably damaging	1.00
PIT4445001:Mphosph9	UTSW	5	124,436,853 (GRCm39)	missense	possibly damaging	0.82
R0304:Mphosph9	UTSW	5	124,436,892 (GRCm39)	missense	probably benign	0.01
R0437:Mphosph9	UTSW	5	124,453,631 (GRCm39)	missense	probably benign	0.27
R0483:Mphosph9	UTSW	5	124,445,033 (GRCm39)	nonsense	probably null
R0811:Mphosph9	UTSW	5	124,436,822 (GRCm39)	missense	probably damaging	1.00
R0812:Mphosph9	UTSW	5	124,436,822 (GRCm39)	missense	probably damaging	1.00
R0942:Mphosph9	UTSW	5	124,400,100 (GRCm39)	nonsense	probably null
R1175:Mphosph9	UTSW	5	124,453,739 (GRCm39)	missense	possibly damaging	0.94
R1372:Mphosph9	UTSW	5	124,421,808 (GRCm39)	splice site	probably null
R1442:Mphosph9	UTSW	5	124,403,461 (GRCm39)	missense	possibly damaging	0.62
R1533:Mphosph9	UTSW	5	124,405,204 (GRCm39)	missense	probably damaging	1.00
R1959:Mphosph9	UTSW	5	124,453,764 (GRCm39)	missense	possibly damaging	0.92
R2036:Mphosph9	UTSW	5	124,442,274 (GRCm39)	missense	probably damaging	0.97
R2256:Mphosph9	UTSW	5	124,421,722 (GRCm39)	missense	probably benign	0.00
R2919:Mphosph9	UTSW	5	124,399,069 (GRCm39)	missense	probably benign	0.22
R2920:Mphosph9	UTSW	5	124,399,069 (GRCm39)	missense	probably benign	0.22
R4064:Mphosph9	UTSW	5	124,428,980 (GRCm39)	missense	probably damaging	1.00
R4272:Mphosph9	UTSW	5	124,442,266 (GRCm39)	missense	probably damaging	0.96
R4430:Mphosph9	UTSW	5	124,403,509 (GRCm39)	missense	possibly damaging	0.83
R4883:Mphosph9	UTSW	5	124,437,108 (GRCm39)	missense	probably damaging	1.00
R4992:Mphosph9	UTSW	5	124,442,253 (GRCm39)	missense	probably damaging	1.00
R5815:Mphosph9	UTSW	5	124,453,481 (GRCm39)	missense	probably damaging	1.00
R5993:Mphosph9	UTSW	5	124,454,161 (GRCm39)	missense	probably benign	0.40
R6102:Mphosph9	UTSW	5	124,435,772 (GRCm39)	missense	possibly damaging	0.86
R6295:Mphosph9	UTSW	5	124,458,978 (GRCm39)	missense	possibly damaging	0.46
R6320:Mphosph9	UTSW	5	124,463,024 (GRCm39)	missense	probably damaging	0.99
R6628:Mphosph9	UTSW	5	124,436,825 (GRCm39)	missense	probably damaging	0.98
R6692:Mphosph9	UTSW	5	124,398,179 (GRCm39)	missense	probably damaging	1.00
R6705:Mphosph9	UTSW	5	124,429,027 (GRCm39)	missense	possibly damaging	0.83
R6747:Mphosph9	UTSW	5	124,435,762 (GRCm39)	missense	possibly damaging	0.93
R6787:Mphosph9	UTSW	5	124,399,090 (GRCm39)	missense	probably damaging	0.99
R6850:Mphosph9	UTSW	5	124,399,019 (GRCm39)	missense	probably damaging	1.00
R6956:Mphosph9	UTSW	5	124,435,621 (GRCm39)	missense	probably damaging	1.00
R7075:Mphosph9	UTSW	5	124,458,922 (GRCm39)	missense	probably damaging	0.99
R7604:Mphosph9	UTSW	5	124,454,180 (GRCm39)	missense	probably benign	0.01
R7789:Mphosph9	UTSW	5	124,453,650 (GRCm39)	missense	probably damaging	1.00
R7808:Mphosph9	UTSW	5	124,399,009 (GRCm39)	missense	probably damaging	0.99
R7823:Mphosph9	UTSW	5	124,442,319 (GRCm39)	missense	probably damaging	0.99
R7891:Mphosph9	UTSW	5	124,428,967 (GRCm39)	missense	probably damaging	1.00
R8210:Mphosph9	UTSW	5	124,405,174 (GRCm39)	missense	probably damaging	1.00
R8256:Mphosph9	UTSW	5	124,393,169 (GRCm39)	missense	probably damaging	1.00
R8385:Mphosph9	UTSW	5	124,450,785 (GRCm39)	missense	probably benign	0.19
R8438:Mphosph9	UTSW	5	124,430,455 (GRCm39)	missense	probably benign	0.19
R8692:Mphosph9	UTSW	5	124,450,875 (GRCm39)	missense	probably damaging	0.99
R8790:Mphosph9	UTSW	5	124,453,736 (GRCm39)	missense	probably damaging	1.00
R8818:Mphosph9	UTSW	5	124,463,027 (GRCm39)	nonsense	probably null
R8847:Mphosph9	UTSW	5	124,454,209 (GRCm39)	missense	possibly damaging	0.91
R9018:Mphosph9	UTSW	5	124,436,713 (GRCm39)	missense	probably benign	0.12
R9208:Mphosph9	UTSW	5	124,450,854 (GRCm39)	missense	probably damaging	0.97
R9221:Mphosph9	UTSW	5	124,403,427 (GRCm39)	missense	probably benign	0.10
R9603:Mphosph9	UTSW	5	124,463,015 (GRCm39)	nonsense	probably null
R9721:Mphosph9	UTSW	5	124,436,738 (GRCm39)	missense	possibly damaging	0.87

Posted On

2014-05-07