Incidental Mutation 'R1976:Dazap1'
ID 221734
Institutional Source Beutler Lab
Gene Symbol Dazap1
Ensembl Gene ENSMUSG00000069565
Gene Name DAZ associated protein 1
Synonyms 2410042M16Rik, mPrrp
MMRRC Submission 039989-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.473) question?
Stock # R1976 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 80097320-80124242 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to A at 80110454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092305] [ENSMUST00000105361] [ENSMUST00000105362] [ENSMUST00000156935] [ENSMUST00000156935]
AlphaFold Q9JII5
Predicted Effect probably null
Transcript: ENSMUST00000092305
SMART Domains Protein: ENSMUSP00000089958
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 114 186 6.25e-25 SMART
low complexity region 238 261 N/A INTRINSIC
low complexity region 270 332 N/A INTRINSIC
low complexity region 363 394 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105361
SMART Domains Protein: ENSMUSP00000101000
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 113 185 6.25e-25 SMART
low complexity region 237 260 N/A INTRINSIC
low complexity region 269 331 N/A INTRINSIC
low complexity region 363 394 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105362
SMART Domains Protein: ENSMUSP00000101001
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 113 185 6.25e-25 SMART
low complexity region 237 260 N/A INTRINSIC
low complexity region 269 331 N/A INTRINSIC
low complexity region 362 393 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150328
Predicted Effect probably null
Transcript: ENSMUST00000156935
SMART Domains Protein: ENSMUSP00000117497
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 3 75 1.89e-24 SMART
RRM 105 171 6.71e-16 SMART
Predicted Effect probably null
Transcript: ENSMUST00000156935
SMART Domains Protein: ENSMUSP00000117497
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 3 75 1.89e-24 SMART
RRM 105 171 6.71e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184241
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 98% (65/66)
MGI Phenotype PHENOTYPE: Homozygotes for a null allele show partial lethality during fetal growth through weaning, growth retardation, spermatogenic arrest, and premature death. Homozygotes for a hypomorphic allele live longer but are small and sterile and display small gonads, spermatogenic arrest, and abnormal pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,347,815 (GRCm39) V3556A probably damaging Het
Abcb5 T C 12: 118,854,417 (GRCm39) I833V probably benign Het
Adgrd1 A T 5: 129,217,861 (GRCm39) H432L probably benign Het
Alppl2 T A 1: 87,016,463 (GRCm39) I204F probably damaging Het
Ascc3 T A 10: 50,525,262 (GRCm39) F486I probably damaging Het
Bcl9l T A 9: 44,417,449 (GRCm39) L429Q possibly damaging Het
Ccdc33 A T 9: 58,024,445 (GRCm39) Y227* probably null Het
Cd101 A G 3: 100,915,377 (GRCm39) V730A probably damaging Het
Cdadc1 A T 14: 59,811,217 (GRCm39) V431E probably damaging Het
Dbpht2 T A 12: 74,342,635 (GRCm39) noncoding transcript Het
Dennd4b A T 3: 90,180,362 (GRCm39) T742S probably damaging Het
Dhtkd1 T C 2: 5,907,202 (GRCm39) E838G possibly damaging Het
Dync2h1 A T 9: 7,129,045 (GRCm39) D1823E probably benign Het
Enox1 T A 14: 77,906,233 (GRCm39) N556K probably benign Het
Fam227a T C 15: 79,510,477 (GRCm39) I392M possibly damaging Het
Fnip2 A T 3: 79,388,238 (GRCm39) M831K probably benign Het
Foxn1 T C 11: 78,256,763 (GRCm39) probably benign Het
Garre1 A C 7: 33,956,805 (GRCm39) N353K probably damaging Het
Glis3 T C 19: 28,240,077 (GRCm39) 936 probably benign Het
Gm4953 T A 1: 158,995,923 (GRCm39) noncoding transcript Het
Gsr T G 8: 34,170,288 (GRCm39) probably null Het
Habp4 G T 13: 64,332,420 (GRCm39) V344F probably benign Het
Hdac7 G A 15: 97,704,386 (GRCm39) Q495* probably null Het
Helb T C 10: 119,930,168 (GRCm39) D737G possibly damaging Het
Hltf A G 3: 20,160,610 (GRCm39) D759G probably damaging Het
Hlx G T 1: 184,464,184 (GRCm39) A52D probably damaging Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Itsn2 A G 12: 4,722,733 (GRCm39) probably benign Het
Kank2 A T 9: 21,705,857 (GRCm39) V387E probably damaging Het
Lefty1 T C 1: 180,765,389 (GRCm39) V319A probably benign Het
Lonp1 T C 17: 56,922,068 (GRCm39) T771A possibly damaging Het
Lpcat2b A T 5: 107,581,716 (GRCm39) K348N possibly damaging Het
Lsamp T C 16: 41,709,430 (GRCm39) V103A probably damaging Het
Ltbp4 A T 7: 27,026,195 (GRCm39) C538S probably damaging Het
Micu1 T C 10: 59,604,035 (GRCm39) S174P probably damaging Het
Mta1 A G 12: 113,099,926 (GRCm39) N607S probably damaging Het
Muc5b C T 7: 141,416,891 (GRCm39) S3279L probably benign Het
Naalad2 T C 9: 18,289,995 (GRCm39) E211G probably damaging Het
Nup155 T A 15: 8,165,311 (GRCm39) M649K probably benign Het
Pan2 T C 10: 128,156,282 (GRCm39) V1171A probably damaging Het
Pisd A G 5: 32,896,209 (GRCm39) V372A probably damaging Het
Prim1 T A 10: 127,859,668 (GRCm39) C288S probably benign Het
Rab23 T A 1: 33,763,019 (GRCm39) C30S probably damaging Het
Sacs A G 14: 61,440,344 (GRCm39) T797A probably benign Het
Sall3 T C 18: 81,015,108 (GRCm39) D940G probably benign Het
Scn1a T C 2: 66,161,615 (GRCm39) E311G probably benign Het
Sdk1 T A 5: 142,129,573 (GRCm39) I1598N probably damaging Het
Slc22a17 A T 14: 55,145,957 (GRCm39) probably null Het
Slc36a4 T A 9: 15,645,506 (GRCm39) V311D probably damaging Het
Sprr3 T A 3: 92,364,253 (GRCm39) Q197L possibly damaging Het
Stab2 A C 10: 86,732,360 (GRCm39) probably null Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Tas2r123 T A 6: 132,824,295 (GRCm39) V64D probably damaging Het
Trhde T G 10: 114,424,336 (GRCm39) N483T possibly damaging Het
Trp53 C T 11: 69,479,323 (GRCm39) T167M probably damaging Het
Tspan8 A G 10: 115,680,035 (GRCm39) I217V probably benign Het
Tut4 T C 4: 108,336,720 (GRCm39) L148P probably benign Het
Usp17la A G 7: 104,509,527 (GRCm39) E44G possibly damaging Het
Usp40 T G 1: 87,906,258 (GRCm39) Q659P probably benign Het
Vmn1r4 T C 6: 56,933,723 (GRCm39) C76R probably damaging Het
Vmn2r118 C T 17: 55,899,925 (GRCm39) G660R probably damaging Het
Zfp786 T A 6: 47,796,691 (GRCm39) H749L probably damaging Het
Other mutations in Dazap1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03151:Dazap1 APN 10 80,116,754 (GRCm39) splice site probably benign
R0058:Dazap1 UTSW 10 80,097,415 (GRCm39) splice site probably benign
R0058:Dazap1 UTSW 10 80,097,415 (GRCm39) splice site probably benign
R0131:Dazap1 UTSW 10 80,114,060 (GRCm39) splice site probably null
R0132:Dazap1 UTSW 10 80,114,060 (GRCm39) splice site probably null
R0938:Dazap1 UTSW 10 80,116,795 (GRCm39) missense possibly damaging 0.82
R2233:Dazap1 UTSW 10 80,113,433 (GRCm39) missense possibly damaging 0.69
R2234:Dazap1 UTSW 10 80,113,433 (GRCm39) missense possibly damaging 0.69
R2326:Dazap1 UTSW 10 80,120,067 (GRCm39) missense possibly damaging 0.90
R3619:Dazap1 UTSW 10 80,121,194 (GRCm39) unclassified probably benign
R3747:Dazap1 UTSW 10 80,123,498 (GRCm39) missense possibly damaging 0.94
R6009:Dazap1 UTSW 10 80,121,138 (GRCm39) unclassified probably benign
R6324:Dazap1 UTSW 10 80,113,494 (GRCm39) missense probably benign 0.17
R6484:Dazap1 UTSW 10 80,113,481 (GRCm39) missense probably benign 0.11
R9628:Dazap1 UTSW 10 80,118,999 (GRCm39) missense unknown
R9758:Dazap1 UTSW 10 80,113,440 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTGTGCTAGGACATGTATGCC -3'
(R):5'- CGATCTATGGGAAACGTGAAGC -3'

Sequencing Primer
(F):5'- TCTCCGAGCAGAGACTCTACG -3'
(R):5'- TCTATGGGAAACGTGAAGCCAGAG -3'
Posted On 2014-08-25