Incidental Mutation 'R3800:Or10a4'
ID 272926
Institutional Source Beutler Lab
Gene Symbol Or10a4
Ensembl Gene ENSMUSG00000073897
Gene Name olfactory receptor family 10 subfamily A member 4
Synonyms MOR263-5, GA_x6K02T2PBJ9-9470146-9471093, Olfr17, P2
MMRRC Submission 040759-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R3800 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106696674-106697621 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 106696938 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 89 (Q89*)
Ref Sequence ENSEMBL: ENSMUSP00000147931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098138] [ENSMUST00000210568]
AlphaFold Q7TRM9
Predicted Effect probably null
Transcript: ENSMUST00000098138
AA Change: Q89*
SMART Domains Protein: ENSMUSP00000095741
Gene: ENSMUSG00000073897
AA Change: Q89*

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.6e-58 PFAM
Pfam:7tm_1 42 291 2.2e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000210568
AA Change: Q89*
Meta Mutation Damage Score 0.9585 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency 95% (52/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene possess olfactory neurons whose axons fail to project to the appropriate glomeruli in the olfactopry bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik G T 14: 32,385,025 (GRCm39) D313E possibly damaging Het
Abca12 C T 1: 71,305,046 (GRCm39) V2070I probably damaging Het
Adam23 C T 1: 63,590,933 (GRCm39) R467* probably null Het
Adgrf5 T C 17: 43,757,951 (GRCm39) probably benign Het
Aire A G 10: 77,877,889 (GRCm39) probably null Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Arhgap28 T C 17: 68,180,031 (GRCm39) D268G probably damaging Het
Btbd9 T C 17: 30,732,633 (GRCm39) I351V possibly damaging Het
Cacna1b C T 2: 24,548,971 (GRCm39) R1138Q probably benign Het
Caskin1 T G 17: 24,720,246 (GRCm39) V456G probably benign Het
Ccdc96 A G 5: 36,643,611 (GRCm39) D539G probably damaging Het
Cep290 T C 10: 100,408,803 (GRCm39) I2425T probably damaging Het
Cfap251 T C 5: 123,392,784 (GRCm39) probably benign Het
Col18a1 C A 10: 76,903,221 (GRCm39) G998* probably null Het
Cpe A G 8: 65,070,651 (GRCm39) V198A probably benign Het
Cux1 A G 5: 136,344,887 (GRCm39) M364T probably damaging Het
Dock8 T A 19: 25,141,716 (GRCm39) N1396K probably benign Het
Dync2h1 A C 9: 7,101,525 (GRCm39) F482V possibly damaging Het
Eif1ad19 T C 12: 87,740,491 (GRCm39) K23E possibly damaging Het
Fat4 T A 3: 39,035,423 (GRCm39) V3025E possibly damaging Het
Fbn1 T A 2: 125,187,894 (GRCm39) D1545V possibly damaging Het
Fbxw16 T G 9: 109,265,665 (GRCm39) I385L probably damaging Het
Fnbp1 T C 2: 30,923,143 (GRCm39) E341G probably damaging Het
Gm9845 T C 3: 39,412,642 (GRCm39) noncoding transcript Het
Gmps T C 3: 63,889,866 (GRCm39) Y82H possibly damaging Het
Habp4 C T 13: 64,321,917 (GRCm39) R185C probably damaging Het
Ift122 T A 6: 115,902,867 (GRCm39) S1209T probably benign Het
Ino80c T C 18: 24,254,752 (GRCm39) Y36C probably damaging Het
Inpp5b C T 4: 124,679,138 (GRCm39) T515I probably damaging Het
Kcnj6 G A 16: 94,633,886 (GRCm39) T75M probably damaging Het
Map2k4 A T 11: 65,581,607 (GRCm39) Y368* probably null Het
Mbd6 A G 10: 127,121,036 (GRCm39) probably benign Het
Mccc1 G A 3: 36,054,658 (GRCm39) R17W probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Ncoa3 T C 2: 165,901,639 (GRCm39) M1004T possibly damaging Het
Npnt C A 3: 132,612,524 (GRCm39) G87V probably damaging Het
Or14j1 T G 17: 38,146,848 (GRCm39) N319K probably benign Het
Ppp2r1a A T 17: 21,182,972 (GRCm39) D552V possibly damaging Het
Prb1b G A 6: 132,289,657 (GRCm39) P56S unknown Het
Rnf34 A G 5: 123,002,273 (GRCm39) H77R probably damaging Het
Samm50 T C 15: 84,076,575 (GRCm39) V4A probably damaging Het
Sdccag8 A T 1: 176,695,904 (GRCm39) R403* probably null Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Senp6 A G 9: 79,994,735 (GRCm39) R25G possibly damaging Het
Shc2 C T 10: 79,462,707 (GRCm39) V272I probably benign Het
Smarcd3 T A 5: 24,798,225 (GRCm39) K403* probably null Het
Srgap2 T A 1: 131,238,297 (GRCm39) I672F probably damaging Het
Ttn C T 2: 76,582,941 (GRCm39) V22651I probably damaging Het
Ubash3a T C 17: 31,450,444 (GRCm39) V373A probably benign Het
Vav3 A G 3: 109,535,355 (GRCm39) K36E probably benign Het
Vmn2r65 A G 7: 84,589,738 (GRCm39) V726A possibly damaging Het
Other mutations in Or10a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02167:Or10a4 APN 7 106,696,868 (GRCm39) missense probably benign 0.09
R0540:Or10a4 UTSW 7 106,696,933 (GRCm39) missense probably benign 0.25
R0607:Or10a4 UTSW 7 106,696,933 (GRCm39) missense probably benign 0.25
R1566:Or10a4 UTSW 7 106,696,759 (GRCm39) missense probably damaging 1.00
R1667:Or10a4 UTSW 7 106,696,977 (GRCm39) missense probably benign 0.00
R2122:Or10a4 UTSW 7 106,697,316 (GRCm39) missense probably damaging 1.00
R3825:Or10a4 UTSW 7 106,696,816 (GRCm39) missense possibly damaging 0.88
R4722:Or10a4 UTSW 7 106,696,777 (GRCm39) missense possibly damaging 0.88
R6253:Or10a4 UTSW 7 106,697,464 (GRCm39) missense possibly damaging 0.48
R6470:Or10a4 UTSW 7 106,696,951 (GRCm39) missense probably damaging 1.00
R7214:Or10a4 UTSW 7 106,697,619 (GRCm39) makesense probably null
R8976:Or10a4 UTSW 7 106,697,466 (GRCm39) missense possibly damaging 0.56
R9731:Or10a4 UTSW 7 106,696,786 (GRCm39) missense probably benign 0.00
Z1177:Or10a4 UTSW 7 106,697,048 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTCAAGCTTGTCCTATGAAGTACAGG -3'
(R):5'- AACCAAGAGGCAGCTGCTAG -3'

Sequencing Primer
(F):5'- GTCCTATGAAGTACAGGCTCTGC -3'
(R):5'- TAGCTGGGCACAGGATCTTC -3'
Posted On 2015-03-25