|Institutional Source||Beutler Lab|
|Gene Name||zinc finger and BTB domain containing 16|
|Synonyms||Green's luxoid, Zfp145, PLZF|
|Is this an essential gene?||Possibly essential (E-score: 0.725)|
|Stock #||R0364 (G1)|
|Chromosomal Location||48654297-48836222 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 48743576 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000150887 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000093852] [ENSMUST00000216150]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (86/87)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Zbtb16||
(F):5'- GGTGGCTCTTCTGCAACATGGAAC -3'
(R):5'- GGGGATTGTCCCAGAATCAGGAATG -3'
(F):5'- AAAGCCCTGGTTGGCAGTG -3'
(R):5'- GGGATGAGACTCTTTCCAGTACC -3'