Incidental Mutation 'R3940:Or7a41'
ID 307416
Institutional Source Beutler Lab
Gene Symbol Or7a41
Ensembl Gene ENSMUSG00000060205
Gene Name olfactory receptor family 7 subfamily A member 41
Synonyms MOR139-3, Olfr57, GA_x6K02T2QGN0-2777431-2776472, IF12
MMRRC Submission 040922-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R3940 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 78870557-78871636 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78871038 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 136 (I136N)
Ref Sequence ENSEMBL: ENSMUSP00000144814 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082244] [ENSMUST00000203906]
AlphaFold Q8VGU7
Predicted Effect probably damaging
Transcript: ENSMUST00000082244
AA Change: I136N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000080872
Gene: ENSMUSG00000060205
AA Change: I136N

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.2e-49 PFAM
Pfam:7tm_1 42 291 6e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203906
AA Change: I136N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: I136N

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Meta Mutation Damage Score 0.2900 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 95% (35/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik C T X: 69,438,135 (GRCm39) A53T probably benign Het
Acsm3 A G 7: 119,373,109 (GRCm39) E204G probably benign Het
Acta2 A T 19: 34,220,880 (GRCm39) I276N possibly damaging Het
Ankrd16 T C 2: 11,789,192 (GRCm39) C260R probably benign Het
Ankrd42 T C 7: 92,240,996 (GRCm39) probably null Het
Atp13a2 T C 4: 140,733,733 (GRCm39) S1041P probably damaging Het
Brinp3 C A 1: 146,627,599 (GRCm39) D277E probably damaging Het
Calm5 A T 13: 3,904,485 (GRCm39) I37F possibly damaging Het
Casq1 A G 1: 172,047,103 (GRCm39) V52A possibly damaging Het
Col22a1 A T 15: 71,853,782 (GRCm39) L260* probably null Het
Cttnbp2 C A 6: 18,420,974 (GRCm39) V846L probably benign Het
Dnah12 A G 14: 26,444,754 (GRCm39) T627A probably benign Het
Eogt T C 6: 97,090,875 (GRCm39) I421M probably damaging Het
Fam135a T A 1: 24,096,556 (GRCm39) H63L probably damaging Het
Fmo3 T A 1: 162,791,555 (GRCm39) T241S probably benign Het
Frem3 T C 8: 81,341,649 (GRCm39) I1314T possibly damaging Het
Gm14393 T C 2: 174,903,420 (GRCm39) probably null Het
Kcna5 C T 6: 126,510,614 (GRCm39) V505I probably damaging Het
Kit A G 5: 75,769,978 (GRCm39) D130G probably benign Het
Neto2 G A 8: 86,400,747 (GRCm39) T16I probably damaging Het
Or8k40 T A 2: 86,584,275 (GRCm39) D269V possibly damaging Het
Pcdhb7 T C 18: 37,477,021 (GRCm39) L719P probably damaging Het
Pcdhga9 G A 18: 37,871,995 (GRCm39) R608H probably benign Het
Pik3ip1 A G 11: 3,281,987 (GRCm39) N48S probably damaging Het
Pkn2 G A 3: 142,499,672 (GRCm39) S951L probably damaging Het
Prrc2a T C 17: 35,376,474 (GRCm39) H772R possibly damaging Het
Ric1 T C 19: 29,548,162 (GRCm39) Y277H probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rnf123 A T 9: 107,941,234 (GRCm39) probably benign Het
Robo1 T C 16: 72,806,631 (GRCm39) S1166P probably benign Het
S100a10 A G 3: 93,468,383 (GRCm39) E38G probably benign Het
Slc34a1 A T 13: 55,560,983 (GRCm39) I483F probably damaging Het
Stim1 A G 7: 102,084,848 (GRCm39) N600S probably benign Het
Ube3c T A 5: 29,824,358 (GRCm39) N517K probably benign Het
Other mutations in Or7a41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01347:Or7a41 APN 10 78,871,445 (GRCm39) missense probably benign 0.05
IGL02230:Or7a41 APN 10 78,870,876 (GRCm39) missense probably damaging 0.99
IGL02283:Or7a41 APN 10 78,871,379 (GRCm39) missense probably damaging 1.00
IGL02878:Or7a41 APN 10 78,871,392 (GRCm39) missense probably benign 0.23
IGL02975:Or7a41 APN 10 78,870,867 (GRCm39) missense possibly damaging 0.83
IGL03259:Or7a41 APN 10 78,871,234 (GRCm39) nonsense probably null
R1366:Or7a41 UTSW 10 78,870,876 (GRCm39) missense probably damaging 1.00
R1438:Or7a41 UTSW 10 78,871,122 (GRCm39) missense possibly damaging 0.88
R1528:Or7a41 UTSW 10 78,871,398 (GRCm39) missense probably damaging 0.96
R1601:Or7a41 UTSW 10 78,871,338 (GRCm39) missense possibly damaging 0.56
R2032:Or7a41 UTSW 10 78,871,163 (GRCm39) missense possibly damaging 0.86
R2112:Or7a41 UTSW 10 78,871,248 (GRCm39) missense probably damaging 1.00
R2382:Or7a41 UTSW 10 78,870,968 (GRCm39) missense possibly damaging 0.52
R2967:Or7a41 UTSW 10 78,870,887 (GRCm39) missense probably damaging 1.00
R3773:Or7a41 UTSW 10 78,871,014 (GRCm39) missense possibly damaging 0.95
R4405:Or7a41 UTSW 10 78,871,244 (GRCm39) missense probably benign
R5944:Or7a41 UTSW 10 78,871,223 (GRCm39) missense probably benign 0.00
R6563:Or7a41 UTSW 10 78,871,051 (GRCm39) missense possibly damaging 0.67
R6614:Or7a41 UTSW 10 78,870,925 (GRCm39) nonsense probably null
R7181:Or7a41 UTSW 10 78,871,287 (GRCm39) missense probably damaging 0.98
R7639:Or7a41 UTSW 10 78,871,206 (GRCm39) missense probably damaging 0.99
R9427:Or7a41 UTSW 10 78,871,395 (GRCm39) missense probably damaging 0.99
R9508:Or7a41 UTSW 10 78,870,933 (GRCm39) missense probably damaging 1.00
R9652:Or7a41 UTSW 10 78,871,230 (GRCm39) missense probably benign 0.05
R9681:Or7a41 UTSW 10 78,871,577 (GRCm39) missense probably benign
R9767:Or7a41 UTSW 10 78,870,765 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- ATGGCCATCATTGTTGACTCCC -3'
(R):5'- TCAGAACAGGCCTGGTGTAC -3'

Sequencing Primer
(F):5'- GTTGACTCCCACCTGCACAC -3'
(R):5'- ACAGGCCTGGTGTACAACTTG -3'
Posted On 2015-04-17