Mutagenetix > Incidental Mutation

Incidental Mutation 'R4295:Lcn11'

323243

Institutional Source

Beutler Lab

Gene Symbol

Lcn11

Ensembl Gene

ENSMUSG00000069080

Gene Name

lipocalin 11

Synonyms

MMRRC Submission

041084-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R4295 (G1)

Quality Score

187

Status

Not validated

Chromosome

Chromosomal Location

25667029-25670291 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 25668111 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 90 (A90T)

Ref Sequence

ENSEMBL: ENSMUSP00000088822 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091278] [ENSMUST00000211245]

AlphaFold

A2BHR2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000091278
AA Change: A90T

PolyPhen 2 Score 0.835 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000088822
Gene: ENSMUSG00000069080
AA Change: A90T

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Lipocalin	34	172	7.5e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211245

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.4%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,606,249 (GRCm39)	S164P	probably benign	Het
4933427D06Rik	A	G	6: 89,084,883 (GRCm39)		noncoding transcript	Het
Aldh1l2	C	T	10: 83,331,784 (GRCm39)	V674M	possibly damaging	Het
Angel1	A	G	12: 86,767,057 (GRCm39)	Y440H	probably damaging	Het
Atr	A	G	9: 95,756,479 (GRCm39)	I870V	probably benign	Het
Cd200r4	T	C	16: 44,653,239 (GRCm39)	V3A	probably damaging	Het
Celf2	T	C	2: 6,608,875 (GRCm39)	N302S	probably benign	Het
Cip2a	T	A	16: 48,833,612 (GRCm39)	F571Y	probably benign	Het
Dnah17	A	T	11: 118,009,598 (GRCm39)	I363N	probably damaging	Het
Fam98a	A	T	17: 75,848,342 (GRCm39)	M124K	probably damaging	Het
Fhdc1	C	A	3: 84,352,133 (GRCm39)	V1031F	probably benign	Het
Foxj3	G	T	4: 119,483,494 (GRCm39)	G555*	probably null	Het
Gm4841	T	C	18: 60,403,262 (GRCm39)	N277S	probably benign	Het
Kcnv1	G	A	15: 44,977,840 (GRCm39)	T66M	probably damaging	Het
Kif18a	T	C	2: 109,123,398 (GRCm39)	V224A	probably benign	Het
Lamb2	A	G	9: 108,363,410 (GRCm39)	D863G	probably benign	Het
Lbr	C	T	1: 181,648,267 (GRCm39)	C398Y	probably damaging	Het
Or14c46	A	T	7: 85,918,968 (GRCm39)	F10I	probably damaging	Het
Or2v2	T	A	11: 49,004,254 (GRCm39)	I100L	probably benign	Het
Or5m3	T	C	2: 85,838,614 (GRCm39)	Y165H	probably benign	Het
Or8d2b	A	G	9: 38,788,609 (GRCm39)	I46V	probably damaging	Het
Or9a4	T	A	6: 40,549,090 (GRCm39)	F257I	probably damaging	Het
Pcdhb5	T	A	18: 37,455,734 (GRCm39)	S705T	possibly damaging	Het
Pcgf2	A	T	11: 97,584,282 (GRCm39)	Y24*	probably null	Het
Phf14	C	T	6: 11,987,096 (GRCm39)	P559S	probably damaging	Het
Pigf	A	G	17: 87,331,184 (GRCm39)	I46T	probably benign	Het
Plpp4	A	G	7: 128,909,356 (GRCm39)	E22G	probably damaging	Het
Prdm10	A	G	9: 31,227,590 (GRCm39)	E65G	possibly damaging	Het
Sash1	A	G	10: 8,606,006 (GRCm39)	S795P	possibly damaging	Het
Slc22a21	T	C	11: 53,860,329 (GRCm39)	D34G	probably damaging	Het
Spata13	T	A	14: 60,947,004 (GRCm39)	M684K	probably damaging	Het
Srsf6	T	C	2: 162,776,636 (GRCm39)		probably benign	Het
Stk32c	T	C	7: 138,700,704 (GRCm39)		probably null	Het
Tjp1	T	C	7: 64,972,898 (GRCm39)	D514G	probably damaging	Het
Ttll11	TCGCCGCCGCCGCCGCCGCCGC	TCGCCGCCGCCGCCGCCGC	2: 35,869,564 (GRCm39)		probably benign	Het
Unc13c	A	G	9: 73,641,786 (GRCm39)	S1236P	probably damaging	Het
Utp20	G	T	10: 88,590,381 (GRCm39)	D2364E	possibly damaging	Het
Vmn1r192	T	A	13: 22,371,465 (GRCm39)	I252F	probably damaging	Het
Vmn1r76	T	C	7: 11,665,057 (GRCm39)	I52M	probably benign	Het
Xndc1	T	A	7: 101,730,694 (GRCm39)	L288M	possibly damaging	Het
Zfp451	A	T	1: 33,816,836 (GRCm39)	F154L	probably damaging	Het

Other mutations in Lcn11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02904:Lcn11	APN	2	25,669,278 (GRCm39)	missense	probably null	0.00
R0220:Lcn11	UTSW	2	25,667,843 (GRCm39)	missense	probably benign	0.02
R0607:Lcn11	UTSW	2	25,669,305 (GRCm39)	missense	probably benign	0.00
R1104:Lcn11	UTSW	2	25,669,115 (GRCm39)	unclassified	probably benign
R2021:Lcn11	UTSW	2	25,668,097 (GRCm39)	missense	probably benign	0.34
R2331:Lcn11	UTSW	2	25,670,188 (GRCm39)	missense	possibly damaging	0.79
R6109:Lcn11	UTSW	2	25,669,308 (GRCm39)	missense	possibly damaging	0.78
R6356:Lcn11	UTSW	2	25,668,132 (GRCm39)	nonsense	probably null
R6502:Lcn11	UTSW	2	25,669,103 (GRCm39)	missense	probably benign	0.08
R7754:Lcn11	UTSW	2	25,667,830 (GRCm39)	missense	probably benign	0.06
R7920:Lcn11	UTSW	2	25,669,343 (GRCm39)	missense	possibly damaging	0.70
R8389:Lcn11	UTSW	2	25,669,043 (GRCm39)	missense	probably damaging	0.97
R8752:Lcn11	UTSW	2	25,668,138 (GRCm39)	missense	probably damaging	1.00
R8765:Lcn11	UTSW	2	25,668,139 (GRCm39)	missense	probably damaging	1.00
R8881:Lcn11	UTSW	2	25,669,296 (GRCm39)	missense	probably benign	0.33
R8954:Lcn11	UTSW	2	25,669,265 (GRCm39)	missense	probably benign	0.01
Z1176:Lcn11	UTSW	2	25,667,736 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CTCTGAGAAGGCCTTGATGATCC -3'
(R):5'- GACTGAGGGAGCACAGTTTG -3'

Sequencing Primer
(F):5'- AGAAGGCCTTGATGATCCTGTTG -3'
(R):5'- ACAGTTTGGAGCCACATCGTG -3'

Posted On

2015-06-20