Incidental Mutation 'IGL02981:Fbxw26'
| ID |
406528 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fbxw26
|
| Ensembl Gene |
ENSMUSG00000059547 |
| Gene Name |
F-box and WD-40 domain protein 26 |
| Synonyms |
Gm5163 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02981
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
109546634-109575157 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109573862 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 97
(F97L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071811
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071917]
|
| AlphaFold |
Q8BI58 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071917
AA Change: F97L
PolyPhen 2
Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: F97L
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
5 |
45 |
2.54e-6 |
SMART |
|
SCOP:d1tbga_
|
128 |
249 |
1e-5 |
SMART |
|
Blast:WD40
|
137 |
176 |
4e-7 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd12 |
A |
G |
2: 150,675,044 (GRCm39) |
S392P |
probably benign |
Het |
| Adam23 |
G |
A |
1: 63,610,112 (GRCm39) |
V705I |
probably damaging |
Het |
| Ank2 |
T |
G |
3: 126,728,211 (GRCm39) |
D794A |
possibly damaging |
Het |
| Ank2 |
C |
A |
3: 126,749,519 (GRCm39) |
E503D |
probably damaging |
Het |
| Aqr |
T |
C |
2: 113,965,305 (GRCm39) |
|
probably benign |
Het |
| Atp9b |
A |
G |
18: 80,797,504 (GRCm39) |
V857A |
possibly damaging |
Het |
| Banp |
T |
C |
8: 122,705,303 (GRCm39) |
Y58H |
possibly damaging |
Het |
| Cacna1e |
T |
A |
1: 154,347,171 (GRCm39) |
N999Y |
probably benign |
Het |
| Cd14 |
T |
C |
18: 36,859,532 (GRCm39) |
|
probably benign |
Het |
| Crmp1 |
T |
C |
5: 37,443,770 (GRCm39) |
I447T |
probably damaging |
Het |
| Dip2a |
A |
G |
10: 76,112,255 (GRCm39) |
V1090A |
possibly damaging |
Het |
| Ep400 |
T |
A |
5: 110,903,969 (GRCm39) |
H210L |
possibly damaging |
Het |
| Ep400 |
T |
A |
5: 110,839,476 (GRCm39) |
|
probably benign |
Het |
| Fam243 |
T |
C |
16: 92,117,757 (GRCm39) |
N177S |
probably benign |
Het |
| Fut8 |
C |
A |
12: 77,521,812 (GRCm39) |
P484T |
probably damaging |
Het |
| Golph3 |
A |
G |
15: 12,349,550 (GRCm39) |
E190G |
probably benign |
Het |
| Hectd1 |
A |
T |
12: 51,815,670 (GRCm39) |
D1472E |
possibly damaging |
Het |
| Hnrnpdl |
T |
C |
5: 100,184,958 (GRCm39) |
I298V |
possibly damaging |
Het |
| Jakmip2 |
C |
A |
18: 43,695,595 (GRCm39) |
|
probably null |
Het |
| Kcnj5 |
G |
A |
9: 32,233,877 (GRCm39) |
T146I |
probably damaging |
Het |
| Lyst |
T |
G |
13: 13,809,496 (GRCm39) |
F389V |
probably damaging |
Het |
| Myo1b |
A |
G |
1: 51,817,532 (GRCm39) |
S577P |
probably damaging |
Het |
| Myo3b |
T |
C |
2: 69,938,969 (GRCm39) |
V114A |
probably damaging |
Het |
| Or10a2 |
C |
A |
7: 106,673,758 (GRCm39) |
T241N |
probably damaging |
Het |
| Pappa2 |
C |
T |
1: 158,678,714 (GRCm39) |
G901R |
probably benign |
Het |
| Patz1 |
T |
C |
11: 3,240,656 (GRCm39) |
Y15H |
probably damaging |
Het |
| Pdp2 |
T |
C |
8: 105,320,267 (GRCm39) |
W39R |
probably benign |
Het |
| Poc5 |
T |
C |
13: 96,538,265 (GRCm39) |
|
probably null |
Het |
| Pou3f1 |
A |
G |
4: 124,552,236 (GRCm39) |
D246G |
probably damaging |
Het |
| Pramel5 |
T |
A |
4: 143,999,430 (GRCm39) |
Y219F |
probably benign |
Het |
| Prrc2c |
C |
T |
1: 162,532,748 (GRCm39) |
|
probably benign |
Het |
| Ptpn13 |
A |
G |
5: 103,676,670 (GRCm39) |
K678E |
probably damaging |
Het |
| Rps2 |
T |
C |
17: 24,940,698 (GRCm39) |
F271L |
probably benign |
Het |
| Serpina3k |
C |
A |
12: 104,307,250 (GRCm39) |
Q161K |
probably benign |
Het |
| Serpinb6b |
A |
G |
13: 33,155,589 (GRCm39) |
T101A |
probably benign |
Het |
| Tprkb |
T |
A |
6: 85,904,861 (GRCm39) |
D112E |
probably benign |
Het |
| Tubal3 |
A |
G |
13: 3,983,257 (GRCm39) |
T346A |
probably benign |
Het |
| Vwde |
A |
G |
6: 13,193,112 (GRCm39) |
F409S |
possibly damaging |
Het |
| Zbtb6 |
G |
A |
2: 37,319,176 (GRCm39) |
Q251* |
probably null |
Het |
|
| Other mutations in Fbxw26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00589:Fbxw26
|
APN |
9 |
109,547,016 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01072:Fbxw26
|
APN |
9 |
109,552,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01151:Fbxw26
|
APN |
9 |
109,550,848 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01394:Fbxw26
|
APN |
9 |
109,547,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01432:Fbxw26
|
APN |
9 |
109,547,043 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02559:Fbxw26
|
APN |
9 |
109,551,232 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL03370:Fbxw26
|
APN |
9 |
109,575,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0023:Fbxw26
|
UTSW |
9 |
109,547,079 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0087:Fbxw26
|
UTSW |
9 |
109,554,006 (GRCm39) |
missense |
probably benign |
|
|
R0369:Fbxw26
|
UTSW |
9 |
109,552,780 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0446:Fbxw26
|
UTSW |
9 |
109,572,788 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1844:Fbxw26
|
UTSW |
9 |
109,553,946 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1891:Fbxw26
|
UTSW |
9 |
109,551,232 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2042:Fbxw26
|
UTSW |
9 |
109,561,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3615:Fbxw26
|
UTSW |
9 |
109,572,828 (GRCm39) |
nonsense |
probably null |
|
|
R3616:Fbxw26
|
UTSW |
9 |
109,572,828 (GRCm39) |
nonsense |
probably null |
|
|
R4659:Fbxw26
|
UTSW |
9 |
109,573,939 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4785:Fbxw26
|
UTSW |
9 |
109,553,868 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4898:Fbxw26
|
UTSW |
9 |
109,547,037 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5791:Fbxw26
|
UTSW |
9 |
109,574,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5818:Fbxw26
|
UTSW |
9 |
109,561,634 (GRCm39) |
missense |
probably benign |
|
|
R5921:Fbxw26
|
UTSW |
9 |
109,575,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5983:Fbxw26
|
UTSW |
9 |
109,547,033 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6145:Fbxw26
|
UTSW |
9 |
109,561,691 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6209:Fbxw26
|
UTSW |
9 |
109,547,033 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6412:Fbxw26
|
UTSW |
9 |
109,561,715 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6842:Fbxw26
|
UTSW |
9 |
109,553,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Fbxw26
|
UTSW |
9 |
109,554,012 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7451:Fbxw26
|
UTSW |
9 |
109,561,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7467:Fbxw26
|
UTSW |
9 |
109,561,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8397:Fbxw26
|
UTSW |
9 |
109,561,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8912:Fbxw26
|
UTSW |
9 |
109,561,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9284:Fbxw26
|
UTSW |
9 |
109,550,962 (GRCm39) |
intron |
probably benign |
|
|
R9479:Fbxw26
|
UTSW |
9 |
109,561,625 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9694:Fbxw26
|
UTSW |
9 |
109,575,135 (GRCm39) |
start gained |
probably benign |
|
|
X0020:Fbxw26
|
UTSW |
9 |
109,561,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation