Incidental Mutation 'IGL02981:Fbxw26'
ID406528
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw26
Ensembl Gene ENSMUSG00000059547
Gene NameF-box and WD-40 domain protein 26
SynonymsGm5163
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02981
Quality Score
Status
Chromosome9
Chromosomal Location109717566-109746089 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 109744794 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 97 (F97L)
Ref Sequence ENSEMBL: ENSMUSP00000071811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071917]
Predicted Effect probably benign
Transcript: ENSMUST00000071917
AA Change: F97L

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: F97L

DomainStartEndE-ValueType
FBOX 5 45 2.54e-6 SMART
SCOP:d1tbga_ 128 249 1e-5 SMART
Blast:WD40 137 176 4e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563D23Rik T C 16: 92,320,869 N177S probably benign Het
Abhd12 A G 2: 150,833,124 S392P probably benign Het
Adam23 G A 1: 63,570,953 V705I probably damaging Het
Ank2 C A 3: 126,955,870 E503D probably damaging Het
Ank2 T G 3: 126,934,562 D794A possibly damaging Het
Aqr T C 2: 114,134,824 probably benign Het
Atp9b A G 18: 80,754,289 V857A possibly damaging Het
Banp T C 8: 121,978,564 Y58H possibly damaging Het
Cacna1e T A 1: 154,471,425 N999Y probably benign Het
Cd14 T C 18: 36,726,479 probably benign Het
Crmp1 T C 5: 37,286,426 I447T probably damaging Het
Dip2a A G 10: 76,276,421 V1090A possibly damaging Het
Ep400 T A 5: 110,691,610 probably benign Het
Ep400 T A 5: 110,756,103 H210L possibly damaging Het
Fut8 C A 12: 77,475,038 P484T probably damaging Het
Golph3 A G 15: 12,349,464 E190G probably benign Het
Hectd1 A T 12: 51,768,887 D1472E possibly damaging Het
Hnrnpdl T C 5: 100,037,099 I298V possibly damaging Het
Jakmip2 C A 18: 43,562,530 probably null Het
Kcnj5 G A 9: 32,322,581 T146I probably damaging Het
Lyst T G 13: 13,634,911 F389V probably damaging Het
Myo1b A G 1: 51,778,373 S577P probably damaging Het
Myo3b T C 2: 70,108,625 V114A probably damaging Het
Olfr714 C A 7: 107,074,551 T241N probably damaging Het
Pappa2 C T 1: 158,851,144 G901R probably benign Het
Patz1 T C 11: 3,290,656 Y15H probably damaging Het
Pdp2 T C 8: 104,593,635 W39R probably benign Het
Poc5 T C 13: 96,401,757 probably null Het
Pou3f1 A G 4: 124,658,443 D246G probably damaging Het
Pramel5 T A 4: 144,272,860 Y219F probably benign Het
Prrc2c C T 1: 162,705,179 probably benign Het
Ptpn13 A G 5: 103,528,804 K678E probably damaging Het
Rps2 T C 17: 24,721,724 F271L probably benign Het
Serpina3k C A 12: 104,340,991 Q161K probably benign Het
Serpinb6b A G 13: 32,971,606 T101A probably benign Het
Tprkb T A 6: 85,927,879 D112E probably benign Het
Tubal3 A G 13: 3,933,257 T346A probably benign Het
Vwde A G 6: 13,193,113 F409S possibly damaging Het
Zbtb6 G A 2: 37,429,164 Q251* probably null Het
Other mutations in Fbxw26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Fbxw26 APN 9 109717948 utr 3 prime probably benign
IGL01072:Fbxw26 APN 9 109723837 missense probably damaging 1.00
IGL01151:Fbxw26 APN 9 109721780 missense possibly damaging 0.50
IGL01394:Fbxw26 APN 9 109717989 missense probably benign 0.00
IGL01432:Fbxw26 APN 9 109717975 missense probably benign 0.32
IGL02559:Fbxw26 APN 9 109722164 missense probably benign 0.34
IGL03370:Fbxw26 APN 9 109746019 missense probably damaging 1.00
R0023:Fbxw26 UTSW 9 109718011 missense probably benign 0.01
R0087:Fbxw26 UTSW 9 109724938 missense probably benign
R0369:Fbxw26 UTSW 9 109723712 critical splice donor site probably null
R0446:Fbxw26 UTSW 9 109743720 missense probably benign 0.03
R1844:Fbxw26 UTSW 9 109724878 missense probably benign 0.42
R1891:Fbxw26 UTSW 9 109722164 missense probably benign 0.34
R2042:Fbxw26 UTSW 9 109732704 missense probably damaging 1.00
R3615:Fbxw26 UTSW 9 109743760 nonsense probably null
R3616:Fbxw26 UTSW 9 109743760 nonsense probably null
R4659:Fbxw26 UTSW 9 109744871 missense probably damaging 0.97
R4785:Fbxw26 UTSW 9 109724800 missense possibly damaging 0.50
R4898:Fbxw26 UTSW 9 109717969 missense possibly damaging 0.95
R5791:Fbxw26 UTSW 9 109745153 missense probably damaging 1.00
R5818:Fbxw26 UTSW 9 109732566 missense probably benign
R5921:Fbxw26 UTSW 9 109746018 missense probably damaging 1.00
R5983:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6145:Fbxw26 UTSW 9 109732623 missense probably benign 0.09
R6209:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6412:Fbxw26 UTSW 9 109732647 missense probably damaging 0.97
R6842:Fbxw26 UTSW 9 109724920 missense probably damaging 1.00
R7228:Fbxw26 UTSW 9 109724944 missense possibly damaging 0.93
R7451:Fbxw26 UTSW 9 109732623 missense probably benign 0.03
R7467:Fbxw26 UTSW 9 109732697 missense probably benign 0.00
X0020:Fbxw26 UTSW 9 109732632 missense probably damaging 1.00
Posted On2016-08-02