Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01394:Fbxw26'

79326

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw26

Ensembl Gene

ENSMUSG00000059547

Gene Name

F-box and WD-40 domain protein 26

Synonyms

Gm5163

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01394

Quality Score

Status

Chromosome

Chromosomal Location

109717566-109746089 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109717989 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 456 (Y456C)

Ref Sequence

ENSEMBL: ENSMUSP00000071811 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071917]

Predicted Effect

probably benign
Transcript: ENSMUST00000071917
AA Change: Y456C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: Y456C

Domain	Start	End	E-Value	Type
FBOX	5	45	2.54e-6	SMART
SCOP:d1tbga_	128	249	1e-5	SMART
Blast:WD40	137	176	4e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402N03Rik	G	A	7: 131,146,231	Q11*	probably null	Het
Acot5	T	C	12: 84,075,488	I282T	probably benign	Het
Adcy2	A	G	13: 68,982,402	V122A	probably damaging	Het
Aldh16a1	A	C	7: 45,145,513	S511A	probably benign	Het
Arid3b	T	C	9: 57,795,034	E480G	probably damaging	Het
Baz2a	T	C	10: 128,118,645	V723A	possibly damaging	Het
Bmpr1b	A	G	3: 141,862,981		probably null	Het
Ccdc83	T	C	7: 90,224,001	E382G	probably damaging	Het
Cfap46	A	G	7: 139,666,979	Y349H	probably damaging	Het
Clpx	T	C	9: 65,310,213	V21A	probably damaging	Het
Clstn1	A	G	4: 149,634,782	N356S	possibly damaging	Het
Ctnnd1	A	G	2: 84,605,256		probably benign	Het
Dock1	A	G	7: 134,766,216	N505S	probably benign	Het
Eaf2	G	A	16: 36,810,566	P82S	probably damaging	Het
Foxred2	T	C	15: 77,955,620	T157A	probably benign	Het
Fscb	A	T	12: 64,473,804	I296K	possibly damaging	Het
Gad1-ps	A	G	10: 99,445,562		noncoding transcript	Het
Golgb1	A	G	16: 36,931,564	E3120G	probably damaging	Het
Ift140	A	G	17: 25,094,702	D1369G	probably benign	Het
Kcnk13	T	C	12: 100,061,662	V332A	probably benign	Het
Lama3	T	A	18: 12,531,926	D661E	probably null	Het
Lum	A	T	10: 97,568,972	D243V	probably damaging	Het
Mgat4c	A	G	10: 102,385,114	T86A	possibly damaging	Het
Mpdz	A	T	4: 81,292,491	V1706D	possibly damaging	Het
Myrfl	T	C	10: 116,822,687	Q455R	probably benign	Het
Olfr420	T	C	1: 174,158,857	F28S	probably damaging	Het
Olfr898	T	A	9: 38,349,805	S241T	possibly damaging	Het
Papolg	G	A	11: 23,867,235	T654I	probably benign	Het
Pappa2	G	A	1: 158,765,104		probably benign	Het
Plekhh2	C	T	17: 84,557,430	T82I	probably benign	Het
Prrc2a	A	G	17: 35,153,104	V1773A	probably benign	Het
Psmb8	G	T	17: 34,200,729	V186L	probably damaging	Het
Rin3	T	C	12: 102,373,603	V604A	probably damaging	Het
Rtn1	T	C	12: 72,308,416	D252G	probably benign	Het
Sdk1	C	T	5: 141,613,215	H212Y	probably benign	Het
Slc5a5	G	T	8: 70,889,388	Y307*	probably null	Het
Slc9a9	T	A	9: 95,123,037	L499Q	probably benign	Het
Snx8	C	A	5: 140,352,179	G237V	probably benign	Het
Spata18	T	A	5: 73,679,345		probably null	Het
Stard9	A	G	2: 120,706,327	E417G	possibly damaging	Het
Ubr5	T	C	15: 38,009,631	D1034G	possibly damaging	Het
Upf2	A	G	2: 6,040,213		probably null	Het
Xrcc6	A	G	15: 82,025,661	K89R	possibly damaging	Het
Yeats2	T	C	16: 20,162,032	V237A	probably damaging	Het
Zdhhc6	A	G	19: 55,309,892	W178R	probably benign	Het
Zfp280b	C	A	10: 76,039,663	Q459K	probably damaging	Het
Zfp811	C	A	17: 32,797,820	K414N	probably damaging	Het

Other mutations in Fbxw26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00589:Fbxw26	APN	9	109717948	utr 3 prime	probably benign
IGL01072:Fbxw26	APN	9	109723837	missense	probably damaging	1.00
IGL01151:Fbxw26	APN	9	109721780	missense	possibly damaging	0.50
IGL01432:Fbxw26	APN	9	109717975	missense	probably benign	0.32
IGL02559:Fbxw26	APN	9	109722164	missense	probably benign	0.34
IGL02981:Fbxw26	APN	9	109744794	missense	probably benign	0.09
IGL03370:Fbxw26	APN	9	109746019	missense	probably damaging	1.00
R0023:Fbxw26	UTSW	9	109718011	missense	probably benign	0.01
R0087:Fbxw26	UTSW	9	109724938	missense	probably benign
R0369:Fbxw26	UTSW	9	109723712	critical splice donor site	probably null
R0446:Fbxw26	UTSW	9	109743720	missense	probably benign	0.03
R1844:Fbxw26	UTSW	9	109724878	missense	probably benign	0.42
R1891:Fbxw26	UTSW	9	109722164	missense	probably benign	0.34
R2042:Fbxw26	UTSW	9	109732704	missense	probably damaging	1.00
R3615:Fbxw26	UTSW	9	109743760	nonsense	probably null
R3616:Fbxw26	UTSW	9	109743760	nonsense	probably null
R4659:Fbxw26	UTSW	9	109744871	missense	probably damaging	0.97
R4785:Fbxw26	UTSW	9	109724800	missense	possibly damaging	0.50
R4898:Fbxw26	UTSW	9	109717969	missense	possibly damaging	0.95
R5791:Fbxw26	UTSW	9	109745153	missense	probably damaging	1.00
R5818:Fbxw26	UTSW	9	109732566	missense	probably benign
R5921:Fbxw26	UTSW	9	109746018	missense	probably damaging	1.00
R5983:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6145:Fbxw26	UTSW	9	109732623	missense	probably benign	0.09
R6209:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6412:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.97
R6842:Fbxw26	UTSW	9	109724920	missense	probably damaging	1.00
R7228:Fbxw26	UTSW	9	109724944	missense	possibly damaging	0.93
R7451:Fbxw26	UTSW	9	109732623	missense	probably benign	0.03
R7467:Fbxw26	UTSW	9	109732697	missense	probably benign	0.00
R8397:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.99
X0020:Fbxw26	UTSW	9	109732632	missense	probably damaging	1.00

Posted On

2013-11-05