Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02993:Vmn1r234'

407018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r234

Ensembl Gene

ENSMUSG00000057203

Gene Name

vomeronasal 1 receptor 234

Synonyms

V1rf1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02993

Quality Score

Status

Chromosome

Chromosomal Location

21228826-21229815 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 21229703 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 293 (I293N)

Ref Sequence

ENSEMBL: ENSMUSP00000078579 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079633]

AlphaFold

Q8R298

Predicted Effect

probably damaging
Transcript: ENSMUST00000079633
AA Change: I293N

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000078579
Gene: ENSMUSG00000057203
AA Change: I293N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	25	315	2.8e-14	PFAM
Pfam:V1R	57	318	2.3e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177028

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	T	C	4: 42,971,719	Y351H	probably damaging	Het
5830411N06Rik	A	G	7: 140,296,573	T537A	probably benign	Het
Abcd3	A	C	3: 121,774,010	I434S	probably benign	Het
Actr2	C	T	11: 20,072,514	R319Q	probably damaging	Het
Atp13a5	G	T	16: 29,293,504	Y606*	probably null	Het
Baiap3	C	T	17: 25,250,082		probably null	Het
Cers2	A	G	3: 95,320,085	Y8C	probably benign	Het
Ces1g	T	A	8: 93,317,079	M411L	probably benign	Het
Chd6	A	G	2: 161,052,384		probably benign	Het
Cyp2d40	C	A	15: 82,761,521	K94N	probably benign	Het
Ddx51	T	C	5: 110,655,621	V323A	possibly damaging	Het
Dock1	G	A	7: 134,744,298	V190I	probably benign	Het
Evc2	A	G	5: 37,419,157	T1042A	probably benign	Het
Fat4	T	A	3: 38,957,155	S2135T	probably damaging	Het
Gpat2	T	C	2: 127,427,566	F46S	probably damaging	Het
Klhl38	T	A	15: 58,322,455	K293*	probably null	Het
Map4k4	T	C	1: 40,014,188	I916T	probably damaging	Het
Nrap	T	A	19: 56,345,533	K964M	probably damaging	Het
Osbpl5	T	C	7: 143,699,334		probably null	Het
Perm1	A	G	4: 156,217,779	Q260R	probably benign	Het
Ralgapb	T	A	2: 158,437,394	N133K	possibly damaging	Het
Slfn9	T	C	11: 82,981,196	S905G	probably benign	Het
Ssh2	C	T	11: 77,453,544	T785I	probably damaging	Het
Stk16	C	A	1: 75,213,004	Q69K	probably damaging	Het
Stk36	T	C	1: 74,622,287	L491P	probably benign	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tcp11	T	C	17: 28,070,516	N194D	probably damaging	Het
Trio	C	A	15: 27,830,239		probably benign	Het
Ugt2b1	A	G	5: 86,921,991	V297A	possibly damaging	Het
Ugt2b5	T	G	5: 87,137,232	H282P	probably damaging	Het
Usp53	A	G	3: 122,933,843	M1030T	probably damaging	Het
Vmn2r57	T	A	7: 41,428,074	T223S	probably benign	Het
Wdr20	G	T	12: 110,794,308	E543*	probably null	Het
Zbtb25	T	A	12: 76,349,417	N344Y	probably damaging	Het
Zcchc2	T	C	1: 106,030,168	F790L	probably damaging	Het

Other mutations in Vmn1r234

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn1r234	APN	17	21229598	missense	possibly damaging	0.95
IGL01485:Vmn1r234	APN	17	21228909	missense	possibly damaging	0.53
IGL02149:Vmn1r234	APN	17	21229007	missense	probably benign	0.00
IGL02291:Vmn1r234	APN	17	21228931	missense	probably benign	0.28
IGL03223:Vmn1r234	APN	17	21229391	missense	probably damaging	0.98
R0626:Vmn1r234	UTSW	17	21229745	missense	probably benign	0.17
R1274:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1275:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1288:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1289:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1319:Vmn1r234	UTSW	17	21228910	missense	probably benign	0.01
R1412:Vmn1r234	UTSW	17	21229250	missense	probably benign	0.01
R2323:Vmn1r234	UTSW	17	21229703	missense	probably benign	0.10
R3755:Vmn1r234	UTSW	17	21229009	missense	probably damaging	0.98
R4299:Vmn1r234	UTSW	17	21229021	missense	probably benign	0.03
R5301:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.11
R5741:Vmn1r234	UTSW	17	21229469	missense	probably benign	0.21
R6197:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.04
R6218:Vmn1r234	UTSW	17	21229721	missense	possibly damaging	0.71
R6486:Vmn1r234	UTSW	17	21229342	missense	probably benign	0.11
R7482:Vmn1r234	UTSW	17	21229375	missense	probably benign	0.07
R7635:Vmn1r234	UTSW	17	21229217	missense	probably damaging	1.00
R8295:Vmn1r234	UTSW	17	21228839	missense	probably benign	0.01
R9506:Vmn1r234	UTSW	17	21229241	missense	probably benign	0.03
R9530:Vmn1r234	UTSW	17	21228842	missense	probably damaging	0.99
X0028:Vmn1r234	UTSW	17	21228890	missense	probably benign	0.17

Posted On

2016-08-02