Incidental Mutation 'R5446:Zfp746'
ID 429069
Institutional Source Beutler Lab
Gene Symbol Zfp746
Ensembl Gene ENSMUSG00000057691
Gene Name zinc finger protein 746
Synonyms 2810407L07Rik
MMRRC Submission 043011-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.247) question?
Stock # R5446 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 48039329-48063527 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48041107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 539 (T539A)
Ref Sequence ENSEMBL: ENSMUSP00000145506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073124] [ENSMUST00000203609]
AlphaFold Q3U133
Predicted Effect probably damaging
Transcript: ENSMUST00000073124
AA Change: T540A

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000072868
Gene: ENSMUSG00000057691
AA Change: T540A

DomainStartEndE-ValueType
Pfam:DUF3669 11 81 3.4e-12 PFAM
KRAB 107 156 1.37e-12 SMART
low complexity region 168 183 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
ZnF_C2H2 454 474 3.65e1 SMART
low complexity region 481 511 N/A INTRINSIC
ZnF_C2H2 517 539 1.92e-2 SMART
ZnF_C2H2 545 567 1.82e-3 SMART
ZnF_C2H2 573 595 1.72e-4 SMART
low complexity region 601 623 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203033
Predicted Effect probably damaging
Transcript: ENSMUST00000203609
AA Change: T539A

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000145506
Gene: ENSMUSG00000057691
AA Change: T539A

DomainStartEndE-ValueType
Pfam:DUF3669 11 81 4.6e-9 PFAM
KRAB 107 156 5.7e-15 SMART
low complexity region 168 183 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
ZnF_C2H2 453 473 1.6e-1 SMART
low complexity region 480 510 N/A INTRINSIC
ZnF_C2H2 516 538 8e-5 SMART
ZnF_C2H2 544 566 7.8e-6 SMART
ZnF_C2H2 572 594 7.3e-7 SMART
low complexity region 600 622 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204771
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adar A G 3: 89,647,486 (GRCm39) N155S probably damaging Het
Ak9 A G 10: 41,296,505 (GRCm39) D1417G possibly damaging Het
Ankrd52 G T 10: 128,224,430 (GRCm39) C736F probably damaging Het
Arhgap15 T A 2: 43,718,772 (GRCm39) H85Q probably benign Het
Bcat2 G A 7: 45,234,569 (GRCm39) R110H possibly damaging Het
Bscl2 A G 19: 8,823,564 (GRCm39) H4R possibly damaging Het
Cdh2 T C 18: 16,779,684 (GRCm39) I126V probably damaging Het
Cnbd2 A C 2: 156,209,581 (GRCm39) E508A possibly damaging Het
Crb2 T C 2: 37,685,461 (GRCm39) I1191T probably benign Het
Dync2h1 T C 9: 7,144,217 (GRCm39) T1075A probably benign Het
Edil3 A C 13: 89,332,957 (GRCm39) H371P possibly damaging Het
Gm5134 T C 10: 75,831,670 (GRCm39) S370P probably damaging Het
Helz T C 11: 107,523,030 (GRCm39) V737A probably damaging Het
Jade2 A G 11: 51,707,786 (GRCm39) V809A probably benign Het
Klhl23 T A 2: 69,654,582 (GRCm39) C151S probably damaging Het
Krt75 T C 15: 101,479,502 (GRCm39) D276G probably null Het
Lipm C T 19: 34,095,287 (GRCm39) A294V possibly damaging Het
Med13l A G 5: 118,880,462 (GRCm39) N1185D possibly damaging Het
Mmp27 T A 9: 7,573,516 (GRCm39) probably benign Het
Mroh2a A T 1: 88,182,687 (GRCm39) N1205I possibly damaging Het
Muc21 T A 17: 35,933,395 (GRCm39) probably benign Het
Npnt A G 3: 132,614,130 (GRCm39) L191P probably damaging Het
Or4c10b A T 2: 89,711,893 (GRCm39) H241L probably damaging Het
Paip2b T C 6: 83,791,844 (GRCm39) I13V probably benign Het
Pcdhac2 T A 18: 37,278,253 (GRCm39) L411Q probably damaging Het
Plekhd1 A G 12: 80,767,410 (GRCm39) N266S probably benign Het
Pnpla8 A G 12: 44,337,368 (GRCm39) T454A possibly damaging Het
Prkcg A T 7: 3,378,780 (GRCm39) Y675F probably benign Het
Pwwp2b T A 7: 138,835,066 (GRCm39) I169N probably damaging Het
Rreb1 G A 13: 38,082,473 (GRCm39) R86H possibly damaging Het
Smok3c A C 5: 138,062,895 (GRCm39) L127F probably damaging Het
St6galnac1 T A 11: 116,657,095 (GRCm39) M427L probably benign Het
Synm T C 7: 67,385,722 (GRCm39) T205A probably benign Het
Tsbp1 T C 17: 34,659,867 (GRCm39) probably null Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Vmn2r112 A G 17: 22,837,231 (GRCm39) Y564C probably damaging Het
Vmn2r90 A C 17: 17,932,464 (GRCm39) T124P probably damaging Het
Vpreb1a A T 16: 16,686,554 (GRCm39) V112E probably damaging Het
Zfp451 A G 1: 33,816,609 (GRCm39) L447S probably damaging Het
Other mutations in Zfp746
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01993:Zfp746 APN 6 48,059,092 (GRCm39) missense probably damaging 0.99
R0020:Zfp746 UTSW 6 48,041,641 (GRCm39) missense probably benign 0.05
R0020:Zfp746 UTSW 6 48,041,641 (GRCm39) missense probably benign 0.05
R0734:Zfp746 UTSW 6 48,041,833 (GRCm39) missense probably damaging 0.97
R1109:Zfp746 UTSW 6 48,041,856 (GRCm39) missense possibly damaging 0.94
R1656:Zfp746 UTSW 6 48,041,411 (GRCm39) missense probably damaging 0.99
R1657:Zfp746 UTSW 6 48,059,108 (GRCm39) missense possibly damaging 0.94
R2474:Zfp746 UTSW 6 48,041,703 (GRCm39) missense probably damaging 1.00
R4748:Zfp746 UTSW 6 48,041,490 (GRCm39) missense probably benign 0.05
R5168:Zfp746 UTSW 6 48,041,329 (GRCm39) missense possibly damaging 0.88
R5386:Zfp746 UTSW 6 48,041,110 (GRCm39) missense possibly damaging 0.94
R5560:Zfp746 UTSW 6 48,059,108 (GRCm39) missense possibly damaging 0.94
R7251:Zfp746 UTSW 6 48,041,811 (GRCm39) missense probably damaging 1.00
R7524:Zfp746 UTSW 6 48,041,823 (GRCm39) missense possibly damaging 0.95
R9502:Zfp746 UTSW 6 48,041,397 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AAGTCCAGTCAGTCACAAGGTC -3'
(R):5'- ATACCCTGGCCGGACAAAAG -3'

Sequencing Primer
(F):5'- ACAAGGTCTGTGGAGGCC -3'
(R):5'- ACCTGCGGAAAGAGCTTC -3'
Posted On 2016-09-06