Incidental Mutation 'R5898:Siglec1'
| ID |
501631 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
044097-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R5898 (G1)
|
| Quality Score |
147 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130915553 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 1346
(Y1346F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028794
AA Change: Y1346F
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: Y1346F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110227
AA Change: Y1346F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: Y1346F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.1745 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.9%
- 20x: 93.8%
|
| Validation Efficiency |
96% (86/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017N19Rik |
G |
T |
10: 100,448,762 (GRCm39) |
R158L |
possibly damaging |
Het |
| 1700017N19Rik |
G |
A |
10: 100,451,070 (GRCm39) |
M179I |
probably benign |
Het |
| Abhd12 |
T |
C |
2: 150,681,698 (GRCm39) |
I231V |
possibly damaging |
Het |
| Adsl |
A |
G |
15: 80,845,554 (GRCm39) |
|
probably null |
Het |
| Ahnak |
C |
A |
19: 8,991,131 (GRCm39) |
N4138K |
possibly damaging |
Het |
| Ahnak |
T |
C |
19: 8,995,575 (GRCm39) |
S5620P |
probably damaging |
Het |
| Akap13 |
C |
T |
7: 75,378,894 (GRCm39) |
T2145I |
probably damaging |
Het |
| Alpk2 |
T |
A |
18: 65,440,694 (GRCm39) |
Q700L |
probably damaging |
Het |
| Apobec1 |
T |
C |
6: 122,557,732 (GRCm39) |
Y159C |
probably damaging |
Het |
| Atg9a |
T |
C |
1: 75,162,916 (GRCm39) |
T395A |
probably damaging |
Het |
| Atp6v1f |
A |
G |
6: 29,467,957 (GRCm39) |
I48V |
probably benign |
Het |
| BC051665 |
A |
C |
13: 60,930,518 (GRCm39) |
V278G |
probably damaging |
Het |
| Bicd1 |
A |
T |
6: 149,415,201 (GRCm39) |
H638L |
probably damaging |
Het |
| Cacna2d4 |
A |
G |
6: 119,251,192 (GRCm39) |
Y460C |
probably damaging |
Het |
| Ccdc157 |
C |
A |
11: 4,094,538 (GRCm39) |
R496L |
probably benign |
Het |
| Cdcp3 |
T |
G |
7: 130,843,696 (GRCm39) |
|
probably null |
Het |
| Cep44 |
C |
G |
8: 56,994,056 (GRCm39) |
V174L |
probably damaging |
Het |
| Clca3a1 |
G |
T |
3: 144,722,522 (GRCm39) |
F283L |
possibly damaging |
Het |
| Csk |
T |
C |
9: 57,537,585 (GRCm39) |
T110A |
probably benign |
Het |
| Cspg4 |
T |
A |
9: 56,792,506 (GRCm39) |
|
probably null |
Het |
| Cutc |
A |
G |
19: 43,748,468 (GRCm39) |
I124V |
probably benign |
Het |
| Cyp2d9 |
A |
G |
15: 82,339,725 (GRCm39) |
T104A |
probably benign |
Het |
| Cyp2j9 |
G |
T |
4: 96,465,951 (GRCm39) |
T294K |
probably benign |
Het |
| D630003M21Rik |
T |
A |
2: 158,046,577 (GRCm39) |
|
probably null |
Het |
| Dcaf15 |
G |
T |
8: 84,825,081 (GRCm39) |
F450L |
probably damaging |
Het |
| Ddhd1 |
A |
T |
14: 45,840,125 (GRCm39) |
I723K |
probably damaging |
Het |
| Dnah17 |
C |
T |
11: 118,005,039 (GRCm39) |
A782T |
probably benign |
Het |
| Dnah3 |
T |
C |
7: 119,677,724 (GRCm39) |
D399G |
probably benign |
Het |
| Dync2h1 |
T |
C |
9: 7,148,717 (GRCm39) |
N909S |
probably benign |
Het |
| Erbin |
A |
G |
13: 103,975,813 (GRCm39) |
|
probably null |
Het |
| Fanci |
G |
A |
7: 79,083,069 (GRCm39) |
V682I |
probably benign |
Het |
| Fap |
A |
T |
2: 62,403,847 (GRCm39) |
F9L |
probably benign |
Het |
| Fat3 |
T |
C |
9: 15,849,757 (GRCm39) |
I3882V |
probably benign |
Het |
| Fkbp15 |
A |
T |
4: 62,244,294 (GRCm39) |
|
probably null |
Het |
| Fsd2 |
T |
C |
7: 81,186,975 (GRCm39) |
Y601C |
probably damaging |
Het |
| Gm5900 |
T |
C |
7: 104,599,468 (GRCm39) |
|
noncoding transcript |
Het |
| Gramd4 |
G |
T |
15: 85,984,985 (GRCm39) |
G82V |
probably damaging |
Het |
| Hc |
C |
T |
2: 34,887,449 (GRCm39) |
V1352I |
probably benign |
Het |
| Hsph1 |
A |
T |
5: 149,548,623 (GRCm39) |
N466K |
probably damaging |
Het |
| Ice2 |
T |
A |
9: 69,315,544 (GRCm39) |
D133E |
probably benign |
Het |
| Ifi213 |
T |
C |
1: 173,396,545 (GRCm39) |
M510V |
probably benign |
Het |
| Itpkb |
T |
G |
1: 180,248,880 (GRCm39) |
L861R |
probably damaging |
Het |
| Kbtbd3 |
T |
A |
9: 4,330,476 (GRCm39) |
D283E |
probably damaging |
Het |
| Man2a1 |
A |
G |
17: 64,932,375 (GRCm39) |
K154R |
probably benign |
Het |
| Masp1 |
T |
A |
16: 23,310,677 (GRCm39) |
I252F |
probably damaging |
Het |
| Megf11 |
G |
T |
9: 64,593,246 (GRCm39) |
C586F |
probably damaging |
Het |
| Myh2 |
C |
A |
11: 67,083,545 (GRCm39) |
A1476E |
possibly damaging |
Het |
| Myo18b |
A |
T |
5: 112,950,196 (GRCm39) |
|
probably null |
Het |
| Naip6 |
A |
T |
13: 100,435,829 (GRCm39) |
V898E |
possibly damaging |
Het |
| Nav1 |
T |
C |
1: 135,512,884 (GRCm39) |
M59V |
probably benign |
Het |
| Nlrp3 |
A |
T |
11: 59,437,678 (GRCm39) |
Y119F |
probably benign |
Het |
| Oxa1l |
T |
A |
14: 54,600,758 (GRCm39) |
I77N |
possibly damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,490,537 (GRCm39) |
D738E |
possibly damaging |
Het |
| Pdia5 |
A |
T |
16: 35,243,335 (GRCm39) |
W269R |
probably damaging |
Het |
| Peak1 |
T |
A |
9: 56,114,622 (GRCm39) |
T1440S |
probably benign |
Het |
| Piezo1 |
A |
G |
8: 123,214,682 (GRCm39) |
V1547A |
probably benign |
Het |
| Pkp1 |
T |
C |
1: 135,810,259 (GRCm39) |
Y437C |
probably damaging |
Het |
| Pla2r1 |
T |
C |
2: 60,253,104 (GRCm39) |
D1329G |
probably damaging |
Het |
| Ppip5k2 |
T |
C |
1: 97,671,887 (GRCm39) |
|
probably benign |
Het |
| Prrg4 |
C |
T |
2: 104,675,378 (GRCm39) |
S75N |
probably benign |
Het |
| Psmb9 |
T |
A |
17: 34,401,266 (GRCm39) |
I198F |
probably damaging |
Het |
| Rcbtb2 |
T |
A |
14: 73,399,405 (GRCm39) |
L23* |
probably null |
Het |
| Sbno1 |
A |
T |
5: 124,524,854 (GRCm39) |
|
probably benign |
Het |
| Scn3a |
T |
C |
2: 65,345,039 (GRCm39) |
E483G |
probably damaging |
Het |
| Sdccag8 |
T |
A |
1: 176,652,388 (GRCm39) |
D46E |
probably benign |
Het |
| Selenov |
A |
G |
7: 27,987,579 (GRCm39) |
F293L |
probably damaging |
Het |
| Septin2 |
A |
C |
1: 93,407,023 (GRCm39) |
D20A |
probably benign |
Het |
| Shc1 |
T |
A |
3: 89,334,274 (GRCm39) |
Y313* |
probably null |
Het |
| Slc22a5 |
T |
A |
11: 53,764,559 (GRCm39) |
I296F |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,365,123 (GRCm39) |
N152S |
probably damaging |
Het |
| Smoc1 |
C |
T |
12: 81,151,531 (GRCm39) |
R83* |
probably null |
Het |
| Ssx2ip |
A |
G |
3: 146,133,586 (GRCm39) |
D227G |
possibly damaging |
Het |
| Tbrg4 |
T |
C |
11: 6,567,372 (GRCm39) |
D576G |
probably damaging |
Het |
| Tbx20 |
T |
A |
9: 24,670,155 (GRCm39) |
Y226F |
probably damaging |
Het |
| Trav10d |
G |
T |
14: 53,048,929 (GRCm39) |
A107S |
probably damaging |
Het |
| Trim60 |
A |
T |
8: 65,453,016 (GRCm39) |
L411* |
probably null |
Het |
| Ttbk2 |
A |
T |
2: 120,575,521 (GRCm39) |
V1083D |
probably benign |
Het |
| Unc93a |
T |
A |
17: 13,344,464 (GRCm39) |
Q26L |
probably damaging |
Het |
| Usp14 |
T |
A |
18: 10,022,819 (GRCm39) |
N65I |
possibly damaging |
Het |
| Vip |
A |
T |
10: 5,593,988 (GRCm39) |
S114C |
probably damaging |
Het |
| Vmn1r237 |
A |
T |
17: 21,534,813 (GRCm39) |
I179F |
probably damaging |
Het |
| Wdr47 |
T |
A |
3: 108,545,201 (GRCm39) |
|
probably null |
Het |
| Zfp975 |
A |
T |
7: 42,311,963 (GRCm39) |
C217S |
probably damaging |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Siglec1
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2011:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4715:Siglec1
|
UTSW |
2 |
130,916,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTGCCATCACCCAGAGTC -3'
(R):5'- TAGCCATGAAGGTGGAGACC -3'
Sequencing Primer
(F):5'- CATCTTGCACTTGTAGTCGAAGAGC -3'
(R):5'- TGGAGACCAGGAACACTGCC -3'
|
| Posted On |
2017-12-01 |
Incidental Mutation